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Journal Oncogene

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Small extracellular vesicles containing miR-30a-3p attenuate the migration and invasion of hepatocellular carcinoma by targeting SNAP23 gene.

Chengdong Liu, Xiaohan Zhou, Qian Long, Hanyi Zeng, Qingcan Sun, Yuting Chen, Dehua Wu, Li Liu,

Cancer cells under hypoxic, endoplasmic reticulum, and reactive oxygen species stress secrete copious amounts of small extracellular vesicles (sEVs) to promote tumor metastasis. The effects of blocking stress-induced sEV release on tumor metastasis remain unknown. We found that miR-30a-3p was selectively sorted into sEVs by hepatocellular carcinoma (HCC) cells under ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1+ prostate luminal cells.

Oh-Joon Kwon, Li Zhang, Deyong Jia, Li Xin,

Prostate adenocarcinoma undergoes neuroendocrine differentiation to acquire resistance toward antihormonal therapies. The underlying mechanisms have been investigated extensively, among which Sox2 has been shown to play a critical role. However, genetic evidence in mouse models for prostate cancer to support the crucial role of Sox2 is missing. The adult mouse ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Genome-wide CRISPR screen identifies LGALS2 as an oxidative stress-responsive gene with an inhibitory function on colon tumor growth.

Haiwen Li, Lixia Zhao, Yeh Siang Lau, Chen Zhang, Renzhi Han,

Colorectal cancer is the third leading cause of cancer-related deaths in the United States and the third most common cancer in men and women. Around 20% colon cancer cases are closely linked with colitis. Both environmental and genetic factors are thought to contribute to colon inflammation and tumor development. However, ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma.

Rama Krishna Nimmakayala, Frank Leon, Satyanarayana Rachagani, Sanchita Rauth, Palanisamy Nallasamy, Saravanakumar Marimuthu, Gautam K Shailendra, Yashpal S Chhonker, Seema Chugh, Ramakanth Chirravuri, Rohitesh Gupta, Kavita Mallya, Dipakkumar R Prajapati, Subodh M Lele, Thomas C Caffrey, Jean L Grem, Paul M Grandgenett, Michael A Hollingsworth, Daryl J Murry, Surinder K Batra, Moorthy P Ponnusamy,

Pancreatic ductal adenocarcinoma (PDAC) metastasizes to distant organs, which is the primary cause of mortality; however, specific features mediating organ-specific metastasis remain unexplored. Emerging evidence demonstrates that cancer stem cells (CSCs) and cellular metabolism play a pivotal role in metastasis. Here we investigated the role of distinct subtypes of pancreatic ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.

Che-Pei Kung, Kyle A Cottrell, Sua Ryu, Emily R Bramel, Raleigh D Kladney, Emily A Bao, Eric C Freeman, Thwisha Sabloak, Leonard Maggi, Jason D Weber,

Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other types of breast cancer that can be effectively treated by targeted therapies, no such targeted therapy exists for all TNBC patients. The ADAR1 enzyme carries out A-to-I editing of RNA to prevent sensing of endogenous double-stranded RNAs. ... Read more >>

Oncogene (Oncogene)
[2020, :]

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EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation.

Jun Chen, Zefeng Xuan, Wenfeng Song, Weili Han, Hao Chen, Yehui Du, Haiyang Xie, Yongchao Zhao, Shusen Zheng, Penghong Song,

Ether-à-go-go-1 (EAG1), one of the potassium channels, is involved in various physiological processes and plays an important role in the tumorigenesis of many kinds of cancer. EAG1 is highly expressed in hepatocarcinoma cells and is closely related to clinical prognosis, but the molecular mechanism remains elusive. In this study, we ... Read more >>

Oncogene (Oncogene)
[2020, :]

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p21CIP1 controls the squamous differentiation response to replication stress.

Isabel de Pedro, Jesús Galán-Vidal, Ana Freije, Ernesto de Diego, Alberto Gandarillas,

The control of cell fate is critical to homeostasis and cancer. Cell cycle cdk inhibitor p21CIP1 has a central and paradoxical role in the regulatory crossroads leading to senescence, apoptosis, or differentiation. p21 is an essential target of tumor suppressor p53, but it also is regulated independently. In squamous self-renewal ... Read more >>

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[2020, :]

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Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma.

Johann von Felden, Amanda J Craig, Teresa Garcia-Lezana, Ismail Labgaa, Philipp K Haber, Delia D'Avola, Amon Asgharpour, Douglas Dieterich, Antoinette Bonaccorso, Miguel Torres-Martin, Daniela Sia, Max W Sung, Parissa Tabrizian, Myron Schwartz, Josep M Llovet, Augusto Villanueva,

Little is known about the mutational landscape of advanced hepatocellular carcinoma (HCC), and predictive biomarkers of response to systemic therapies are lacking. We aimed to describe the mutational landscape of advanced HCC and to identify predictors of primary resistance to systemic therapies using circulating tumor DNA (ctDNA). We prospectively enrolled ... Read more >>

Oncogene (Oncogene)
[2020, :]

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The pro-oncogenic effect of the lncRNA H19 in the development of chronic inflammation-mediated hepatocellular carcinoma.

Lika Gamaev, Lina Mizrahi, Tomer Friehmann, Nofar Rosenberg, Orit Pappo, Devorah Olam, Evelyne Zeira, Keren Bahar Halpern, Stefano Caruso, Jessica Zucman-Rossi, Jonathan H Axelrod, Eithan Galun, Daniel S Goldenberg,

The oncofetal long noncoding RNA (lncRNA) H19 is postnatally repressed in most tissues, and re-expressed in many cancers, including hepatocellular carcinoma (HCC). The role of H19 in carcinogenesis is a subject of controversy. We aimed to examine the role of H19 in chronic inflammation-mediated hepatocarcinogenesis using the Mdr2/Abcb4 knockout (Mdr2-KO) ... Read more >>

Oncogene (Oncogene)
[2020, :]

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MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.

Mahsa Zarei, Krinio Giannikou, Heng Du, Heng-Jia Liu, Melissa Duarte, Sneha Johnson, Amin H Nassar, Hans R Widlund, Elizabeth P Henske, Henry W Long, David J Kwiatkowski,

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by tumor development in multiple organs, including renal angiomyolipoma. Biallelic loss of TSC1 or TSC2 is a known genetic driver of angiomyolipoma development, however, whether an altered transcriptional repertoire contributes to TSC-associated tumorigenesis is unknown. RNA-seq analyses showed ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation.

Qingyu Zhang, Wei Zhou, Shan Yu, Yaojun Ju, Sally Kit Yan To, Alice Sze Tsai Wong, Yufei Jiao, Terence Chuen Wai Poon, Kin Yip Tam, Leo Tsz On Lee,

As a result of the hostile microenvironment, metabolic alterations are required to enable the malignant growth of cancer cells. To understand metabolic reprogramming during metastasis, we conducted shotgun proteomic analysis of highly metastatic (HM) and non-metastatic (NM) ovarian cancer cells. The results suggest that the genes involved in fatty-acid (FA) ... Read more >>

Oncogene (Oncogene)
[2020, :]

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A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma.

Nicholas J Eustace, Joshua C Anderson, Jason M Warram, Hayley N Widden, Rune T Pedersen, Hasan Alrefai, Zeel Patel, Patricia H Hicks, William J Placzek, G Yancey Gillespie, Anita B Hjelmeland, Christopher D Willey,

Glioblastoma (GBM) is an aggressive malignancy with limited effectiveness of standard of care therapies including surgery, radiation, and temozolomide chemotherapy necessitating novel therapeutics. Unfortunately, GBMs also harbor several signaling alterations that protect them from traditional therapies that rely on apoptotic programmed cell death. Because almost all GBM tumors have dysregulated ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Tenascin C promotes cancer cell plasticity in mesenchymal glioblastoma.

Inbar Angel, Ori Pilo Kerman, Liat Rousso-Noori, Dinorah Friedmann-Morvinski,

Interconversion of transformed non-stem cells to cancer stem cells, termed cancer cell plasticity, contributes to intra-tumor heterogeneity and its molecular mechanisms are currently unknown. Here, we have identified Tenascin C (TNC) to be upregulated and secreted in mesenchymal glioblastoma (MES GBM) subtype with high NF-κB signaling activity. Silencing TNC decreases ... Read more >>

Oncogene (Oncogene)
[2020, :]

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MCU-dependent negative sorting of miR-4488 to extracellular vesicles enhances angiogenesis and promotes breast cancer metastatic colonization.

Xianchong Zheng, Sitong Lu, Zhanxin He, Hehai Huang, Zhuocheng Yao, Yutian Miao, Chunqing Cai, Fei Zou,

Based on Stephen Paget's well-established theory, both cell-autonomous and non-cell-autonomous mechanisms are crucial for metastasis. Although the mitochondrial calcium uniporter (MCU) has been suggested to be involved in breast cancer (BC) progression via cell-autonomous mechanisms, whether it assists the metastasis of BC cells through non-cell-autonomous mechanisms remains unclear. This study ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Genome-wide profiling of BK polyomavirus integration in bladder cancer of kidney transplant recipients reveals mechanisms of the integration at the nucleotide level.

Yu Jin, Yi Zhou, Wenfeng Deng, Yuchen Wang, Richard J Lee, Yanna Liu, Nahel Elias, Yangcheng Hu, Min-Hua Luo, Rumin Liu, Bowen Guan, Jian Geng, Jian Xu, Junfeng Ma, Jiapeng Zhou, Na Liu, Michael L Blute, Robert B Colvin, Chin-Lee Wu, Yun Miao,

Chronic BK polyomavirus (BKPyV) infection is recognized as a potential oncogenic factor of urothelial carcinoma (UC) in renal transplant recipients. Recent studies have reported a positive correlation among BKPyV integration, persistent overexpression of viral large T antigen (TAg), and malignancy, yet little is known about the specific integration mechanisms and ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Emerging role of bacterial extracellular vesicles in cancer.

Antonios Chronopoulos, Raghu Kalluri,

Shedding of microbial extracellular vesicles constitutes a universal mechanism for inter-kingdom and intra-kingdom communication that is conserved among prokaryotic and eukaryotic microbes. In this review we delineate fundamental aspects of bacterial extracellular vesicles (BEVs) including their biogenesis, cargo composition, and interactions with host cells. We critically examine the evidence that ... Read more >>

Oncogene (Oncogene)
[2020, :]

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OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer.

Yang Li, Lei Li, Jun Qin, Junyi Wu, Xueming Dai, Junming Xu,

Oxidative stress-responsive kinase 1 (OSR1) plays a critical role in multiple carcinogenic signal pathways, and its overexpression has been found in various types of cancer; however, the pathophysiological role of OSR1 in breast cancer has not been evaluated. This study aims to elaborate on the role of OSR1 in breast ... Read more >>

Oncogene (Oncogene)
[2020, :]

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LncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α.

Linguo Xu, Lin Huan, Tianan Guo, Yangjun Wu, Yanfang Liu, Qifeng Wang, Shenglin Huang, Ye Xu, Linhui Liang, Xianghuo He,

Epigenetic alteration is one of the hallmarks of colorectal cancer (CRC). Many driver genes are regulated by DNA methylation in CRC. However, the role of DNA methylation regulating lncRNAs remain elusive. Here, we identify that SNHG11 (small nucleolar RNA host gene 11) is upregulated by promotor hypomethylation in CRC and ... Read more >>

Oncogene (Oncogene)
[2020, :]

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The next tier of EGFR resistance mutations in lung cancer.

Hannah L Tumbrink, Alena Heimsoeth, Martin L Sos,

EGFR mutations account for the majority of druggable targets in lung adenocarcinoma. Over the past decades the optimization of EGFR inhibitors revolutionized the treatment options for patients suffering from this disease. The pace of this development was largely dictated by the inevitable emergence of resistance mutations during drug treatment. As ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Multi-color clonal tracking reveals intra-stage proliferative heterogeneity during mammary tumor progression.

Stefanie Tiede, Ravi Kiran Reddy Kalathur, Fabiana Lüönd, Luca von Allmen, Barbara Maria Szczerba, Mathias Hess, Tatjana Vlajnic, Benjamin Müller, James Canales Murillo, Nicola Aceto, Gerhard Christofori,

Despite major progress in breast cancer research, the functional contribution of distinct cancer cell clones to malignant tumor progression and metastasis remains largely elusive. We have assessed clonal heterogeneity within individual primary tumors and metastases and also during the distinct stages of malignant tumor progression using clonal tracking of cancer ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers.

Samar Alsafadi, Stephane Dayot, Malcy Tarin, Alexandre Houy, Dorine Bellanger, Michele Cornella, Michel Wassef, Joshua J Waterfall, Erik Lehnert, Sergio Roman-Roman, Marc-Henri Stern, Tatiana Popova,

Genes involved in 3'-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading to usage of cryptic 3'-splice sites and subsequent aberrant junctions. For a comprehensive determination of alterations leading to ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis.

Haruki Horiguchi, Tsuyoshi Kadomatsu, Keishi Miyata, Kazutoyo Terada, Michio Sato, Daisuke Torigoe, Jun Morinaga, Toshiro Moroishi, Yuichi Oike,

Previous studies show that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) functions as a tumor promoter in some cancer contexts. However, we recently reported that host ANGPTL2 also shows tumor suppressive activity by enhancing dendritic cell-mediated CD8+ T cell anti-tumor immune responses in mouse kidney cancer and murine syngeneic models. However, ... Read more >>

Oncogene (Oncogene)
[2020, :]

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SIX4 promotes hepatocellular carcinoma metastasis through upregulating YAP1 and c-MET.

Qin He, Zhuoying Lin, Zhihui Wang, Wenjie Huang, Dean Tian, Mei Liu, Limin Xia,

Metastasis is the main reason for high mortality in hepatocellular carcinoma (HCC) patients and the molecular mechanism remains unclear. Therefore, it is important to elucidate the mechanism underlying HCC metastasis. Here, we report a novel role of SIX homeobox 4 (SIX4), one of the SIX gene family, in promoting HCC ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Molecular tracing of prostate cancer lethality.

Yuanshuo Alice Wang, John Sfakianos, Ashutosh K Tewari, Carlos Cordon-Cardo, Natasha Kyprianou,

Prostate cancer is diagnosed mostly in men over the age of 50 years, and has favorable 5-year survival rates due to early cancer detection and availability of curative surgical management. However, progression to metastasis and emergence of therapeutic resistance are responsible for the majority of prostate cancer mortalities. Recent advancement ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell.

Shoichi Ukai, Ririno Honma, Naoya Sakamoto, Yusuke Yamamoto, Quoc Thang Pham, Kenji Harada, Tsuyoshi Takashima, Daiki Taniyama, Ryuichi Asai, Kaho Fukada, Kazuhito Naka, Kazuaki Tanabe, Hideki Ohdan, Wataru Yasui,

5-FU is one of the key drugs in the treatment of gastric cancer (GC). Much evidence has shown that cancer stem cells (CSCs) play a key role in the acquisition of drug resistance. The organoid is a novel 3D cell culture system technology that sustains stem-cell-driven formation of near-physiological, self-renewing ... Read more >>

Oncogene (Oncogene)
[2020, :]

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