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Journal Nitric Oxide

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Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.

Göran Hedenstierna, Luni Chen, Magnus Hedenstierna, Robert Lieberman, David H Fine,

It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 103:1-3]

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Electrophilic nitrated fatty acids are potential therapeutic candidates for inflammatory and fibrotic lung diseases.

Kalpana Panati, Lokesh V Thimmana, Venkata Ramireddy Narala,

Several types of exposures can cause acute or chronic inflammatory reactions in the lungs often leading to asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), acute lung injury, lung cancer, and other deleterious health outcomes. Current therapy, with inhaled or oral glucocorticoids, successfully targets inflammation but also produces adverse effects ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, :]

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Role of Neuronal Nitric Oxide Synthase on Cardiovascular Functions in Physiological and Pathophysiological States.

Ahmmed Ally, Isabella Powell, Minori M Ally, Kevin Chaitoff, Surya Nauli,

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on the central nervous system, particularly on brain regions such as the ventrolateral medulla (VLM) and the periaqueductal gray matter (PAG), and on blood vessels and the heart that are involved in the regulation and control of ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, :]

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Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes.

Thiago Santos Rosa, Rodrigo Vanerson Passos Neves, Lysleine Alves Deus, Caio Victor Sousa, Samuel da Silva Aguiar, Michel Kendy de Souza, Milton Rocha Moraes, Érica Carine Campos Caldas Rosa, Rosangela Vieira Andrade, Marko T Korhonen, Herbert Gustavo Simões,

PURPOSE:Studies have shown a positive influence of intense athletic training on several biomarkers of aging, but it remains unclear whether this influence is dependent of exercise-training-mode. This study compared redox balance, cytokine levels and biomarkers of aging between master sprinters and endurance athletes, as well as in young and middle-aged ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 102:42-51]

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Tackle the free radicals damage in COVID-19.

Jun Wu,

COVID-19 is a severe pandemic which has caused a devastating amount of loss in lives around the world, and yet we still don't know how to appropriately treat this disease. We know very little about the pathogenesis of SARS-CoV-2, the virus which induces the COVID-19. However, COVID-19 does share many ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 102:39-41]

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Estrogen receptor (ESR1 and ESR2)-mediated activation of eNOS-NO-cGMP pathway facilitates high altitude acclimatization.

Pooja, Manish Sharma, Krishan Singh, Gidugu Himashree, Gopinath Bhaumik, Bhuvnesh Kumar, Niroj Kumar Sethy,

Higher levels of circulatory nitric oxide (NO) and NO metabolites reportedly facilitate high altitude acclimatization. But the underlying factors and molecular pathways promoting NO production at high altitude has been poorly characterized. Studying healthy lowlanders at sea level (C, lowlander) and high altitude (3500 m, after day 1, 4 and 7 ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 102:12-20]

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Venous occlusion during blood collection decreases plasma nitrite but not nitrate concentration in humans.

Luke Liddle, Mia C Burleigh, Chris Monaghan, David J Muggeridge, Chris Easton,

BACKGROUND:To maintain vascular tone and blood flow when tissue oxygenation is reduced, nitrite anions are reduced to nitric oxide (NO). From a practical perspective, it is unclear how the application of a tourniquet during blood collection might influence measurement of NO metabolites. Accordingly, this study evaluated the effect of venous ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 102:21-27]

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Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gut microbiome.

Weili Wang, Liang Hu, Shimin Chang, Linsha Ma, Xiangchun Li, Zi Yang, Conglin Du, Xingmin Qu, Chunmei Zhang, Songlin Wang,

Inorganic dietary nitrate plays vital roles in biological functions via the exogenous NO3-/NO2-/NO pathway under hypoxia and ischemia. We previously verified the antioxidative effects of inorganic nitrate in a mouse model of total body irradiation (TBI). Accordingly, in this study, we evaluated the effects of inorganic nitrate on prevention of ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 102:1-11]

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Fractional exhaled nitric oxide in adult congenital heart disease.

Akihito Saito, Eisuke Amiya, Katsura Soma, Toshiro Inaba, Hisataka Maki, Masaru Hatano, Atsushi Yao, Hiroyuki Morita, Issei Komuro,

BACKGROUND:Fractional exhaled nitric oxide levels are related to various clinical diseases. This study investigated the associations between the clinical characteristics and the level of fractional exhaled nitric oxide in patients with adult congenital heart disease. METHODS AND RESULTS:Fractional exhaled nitric oxide values were measured in 30 adult patients with stable ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:45-49]

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Systemic NOS inhibition reduces contracting muscle oxygenation more in intact female than male rats.

Ayaka Tabuchi, Jesse C Craig, Daniel M Hirai, Trenton D Colburn, Yutaka Kano, David C Poole, Timothy I Musch,

Females respond to baroreceptor stimulation with enhanced modulation of heart rate (HR) to regulate blood pressure and also express greater reliance on nitric oxide (NO) for vascular control compared to males. Sex differences in muscle oxygenation consequent to central hemodynamic challenge induced by systemic NO synthase (NOS) inhibition are unknown. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:38-44]

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Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology.

Jade D Bailey, Andrew Shaw, Eileen McNeill, Thomas Nicol, Marina Diotallevi, Surawee Chuaiphichai, Jyoti Patel, Ashley Hale, Keith M Channon, Mark J Crabtree,

Macrophages are mononuclear phagocytes derived from haematopoietic progenitors that are widely distributed throughout the body. These cells participate in both innate and adaptive immune responses and lie central to the processes of inflammation, development, and homeostasis. Macrophage physiology varies depending on the environment in which they reside and they exhibit ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:17-29]

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Changes of nNOS expression in the tuberal hypothalamic nuclei during ageing.

Konstantin Yu Moiseev, Polina A Vishnyakova, Valentina V Porseva, Andrey P Masliukov, Andrey A Spirichev, Andrey I Emanuilov, Petr M Masliukov,

The hypothalamus is the most important integrator of autonomic and endocrine regulation in the body and it also has a fundamental role in ageing development and lifespan control. In order to better understand the role of NO-ergic system in the hypothalamic regulation of ageing, the purpose of this study was ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:1-6]

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Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment.

James Auta, Eleonora Gatta, John M Davis, Huaibo Zhang, Subhash C Pandey, Alessandro Guidotti,

The cerebellum is widely known as a motor structure because it regulates and controls motor learning, coordination, and balance. However, it is also critical for non-motor functions such as cognitive processing, sensory discrimination, addictive behaviors and mental disorders. The cerebellum has the highest relative abundance of neuronal nitric oxide synthase ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:50-56]

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Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium.

Lei Peng, Dong-Dong Gao, Jia-Wen Xu, Jian-Bang Xu, Li-Jiao Ke, Zhuo-Er Qiu, Yun-Xin Zhu, Yi-Lin Zhang, Wen-Liang Zhou,

Epididymal epithelium possesses active ion transport properties conducive to the maintenance of appropriate epididymal intraluminal microenvironment. The endogenous gasotransmitter carbon monoxide (CO) regulates numerous cellular processes including water and electrolyte transport in various epithelia. However, the functional role of CO in epididymal epithelium is still elusive. This study aims to ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:30-37]

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Insights into nitric oxide-mediated water balance, antioxidant defence and mineral homeostasis in rice (Oryza sativa L.) under chilling stress.

Abdullah Al Mamun Sohag, Md Tahjib-Ul-Arif, Sonya Afrin, Md Kawsar Khan, Md Abdul Hannan, Milan Skalicky, Md Golam Mortuza, Marian Brestic, M Afzal Hossain, Yoshiyuki Murata,

Being a chilling-sensitive staple crop, rice (Oryza sativa L.) is vulnerable to climate change. The competence of rice to withstand chilling stress should, therefore, be enhanced through technological tools. The present study employed chemical intervention like application of sodium nitroprusside (SNP) as nitric oxide (NO) donor and elucidated the underlying ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 100-101:7-16]

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Influence of muscle oxygenation and nitrate-rich beetroot juice supplementation on O2 uptake kinetics and exercise tolerance.

Stuart P Cocksedge, Brynmor C Breese, Paul T Morgan, Leonardo Nogueira, Christopher Thompson, Lee J Wylie, Andrew M Jones, Stephen J Bailey,

We tested the hypothesis that acute supplementation with nitrate (NO3-)-rich beetroot juice (BR) would improve quadriceps muscle oxygenation, pulmonary oxygen uptake (V˙O2) kinetics and exercise tolerance (Tlim) in normoxia and that these improvements would be augmented in hypoxia and attenuated in hyperoxia. In a randomised, double-blind, cross-over study, ten healthy ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 99:25-33]

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Peroxynitrite is a novel risk factor and treatment target of glaucoma.

Yuan Lei, Yanting Gao, Maomao Song, Wenjun Cao, Xinghuai Sun,

To investigate the association between systemic nitrotyrosine (NT) levels and primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) and the mechanism involved. A case control study was conducted in the Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Fudan University from April 2017 to December 2017. A ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 99:17-24]

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Repeated but not acute exposure with a low dose range of the nitric oxide (NO) donor sodium nitroprusside (SNP) induces anxiolytic-like behaviour in a dose-independent manner in two different rat models of anxiety.

Alkiviadis Papageorgoulis, Panagiota Fallon, Nikolaos Mpalantes, Despoina Papageorgouli, Nikolaos Pitsikas,

Sodium nitroprusside (SNP) is a nitric oxide (NO) donor which actually is under assessment as a potential candidate for the treatment of schizophrenia. It is well documented that anxiety symptoms are a prominent future in various psychiatric diseases comprising schizophrenia. Prior research has shown that acute challenge with SNP (1-3 mg/kg) ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 99:1-6]

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The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein.

Susana Rojas, Emerita Basualto, Luz Valdivia, Natalia Vallejos, Karen Ceballos, Eduardo Peña, Coralia Rivas, Francisco Nualart, Enrique Guzmán-Gutiérrez, Carlos Escudero, Fernando Toledo, Luis Sobrevia, Marcela Cid, Marcelo González,

Insulin regulates the l-arginine/nitric oxide (NO) pathway in human umbilical vein endothelial cells (HUVECs), increasing the plasma membrane expression of the l-arginine transporter hCAT-1 and inducing vasodilation in umbilical and placental veins. Placental vascular relaxation induced by insulin is dependent of large conductance calcium-activated potassium channels (BKCa), but the role ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 99:7-16]

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Effect of nitric oxide inhibition in Bacillus Calmette-Guerin bladder cancer treatment.

Yanina Verónica Langle, Natalia Patricia Balarino, Denise Belgorosky, Pablo Damián Cresta Morgado, Eduardo Omar Sandes, Lina Marino, Erica Rojas Bilbao, Macarena Zambrano, Catalina Lodillinsky, Ana María Eiján,

BACKGROUND:Bacillus Calmette-Guerin (BCG) is the standard treatment for patients with high-risk non-muscle invasive bladder cancer (BC). Despite its success, about 30-50% of patients are refractory. It was reported that inducible nitric oxide synthase (iNOS) tumor expression is presented in 50% of human BC, associated with bad prognosis and BCG failure. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:50-59]

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S-nitrosothiol-terminated poly(vinyl alcohol): Nitric oxide release and skin blood flow response.

Leonardo P Giglio, Guilherme F Picheth, Kaja Borup Løvschall, Alexander N Zelikin, Marcelo G de Oliveira,

Polymeric biomaterials capable of delivering nitric oxide (NO) topically can be used to enhance skin blood flow (SkBF) and accelerate wound healing. Herein, we used reversible addition-fragmentation chain transfer radical (RAFT) polymerization to synthesize the first poly(vinyl alcohol) (PVA) functionalized with terminal NO-releasing S-nitrosothiol (RSNO) groups for topical NO delivery. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:41-49]

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Blockade of nitric oxide signalling promotes resilience to the effects of social defeat stress on the conditioned rewarding properties of MDMA in mice.

M P García-Pardo, M LLansola, V Felipo, J E De la Rubia Ortí, M A Aguilar,

MDMA abuse continues being a serious problem in our society. Environmental factors, such as stress, increase the vulnerability of individuals to develop drug abuse and we have observed that exposure to social defeat (SD) stress alters the sensitivity of mice to the rewarding effects of MDMA in the conditioned place ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:29-32]

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Decreased expression of neuronal nitric oxide synthase contributes to the endothelial dysfunction associated with cigarette smoking in human.

Eduardo D Costa, Josiane F Silva, Daniela C Garcia, Alberto J Wainstein, Bruno A Rezende, Rita C Tostes, Mauro M Teixeira, Steyner F Cortes, Virginia S Lemos,

Endothelial nitric oxide synthase (eNOS) malfunctioning has been proposed to contribute to the endothelial damage produced by cigarette. Besides eNOS, neuronal NOS (nNOS) is also expressed in most vascular tissues and plays an important role in the endothelium-dependent vascular relaxation. We hypothesize that nNOS may contribute to the endothelium dysfunction ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:20-28]

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"Removal of nitrate and nitrite by hemodialysis in end-stage renal disease and by sustained low-efficiency dialysis in acute kidney injury".

Agustina Heredia Martinez, Guillermo Rosa Diez, Veronica Ferraris, Paula A Coccia, Jorge R Ferraris, Antonio Checa, Craig E Wheelock, Jon O Lundberg, Eddie Weitzberg, Mattias Carlström, Rafael T Krmar,

BACKGROUND & PURPOSE:It is well established that end-stage renal disease (ESRD) is associated with increased cardiovascular morbidity and mortality both in the adult and pediatric population. Although the underlying molecular mechanisms are poorly understood, compromised nitric oxide (NO) bioactivity has been suggested as a contributing factor. With this in mind, ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:33-40]

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Recent developments of fluorescent probes for detection and bioimaging of nitric oxide.

Yi Chen,

Nitric oxide (NO) is an important signaling molecule implicated in numerous physiological and pathological conditions. NO homeostasis is crucial to its proper functions and misregulation of NO production is implicated in a large number of pathologies. The effect of NO depends on the cell microenvironment as well as its concentration, ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 98:1-19]

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