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Journal Neurotoxicology

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Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: a birth cohort study.

Anne-Louise Ponsonby, Christos Symeonides, Richard Saffery, Jochen F Mueller, Martin O'Hely, Peter D Sly, Nicole Wardrop, Angela Pezic, Toby Mansell, Fiona Collier, David Burgner, Kristie Thompson, Soumini Vijayasarathy, Eva J Sugeng, Terence Dwyer, Sarath Ranganathan, Peter J Anderson, Vicki Anderson, Peter Vuillermin, ,

Prenatal phthalate chemicals may have adverse effects on brain development by various mechanisms including oxidant damage. However, birth cohort findings have been conflicting. This study aimed to (i) investigate the interplay between maternal prenatal phthalate levels, infant genetic vulnerability to oxidative stress, and child neurodevelopment and (ii) examine combined putative ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Prenatal exposure to alcohol impairs social play behavior in adolescent male mice.

Mara A P de Ávila, Rebeca M Gonçalves, Elisandra C C Nascimento, Layla D M Cabral, Fabiana C Vilela, Alexandre Giusti-Paiva,

Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring. Swiss mice were ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.

Zartashia Kazmi, Sara Zeeshan, Adnan Khan, Sumra Malik, Adeeb Shehzad, Eun Kyoung Seo, Salman Khan,

Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are critical factors for the development of epilepsy. Daidzin is well-known for its effective anti-inflammatory and antioxidant potential for centuries. The present study ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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The monofunctional platinum (II) compounds, phenanthriplatin and pyriplatin, modulate apoptosis signaling pathways in HEI-OC1 auditory hybridoma cells.

Jerry D Monroe, Alexandra M Johnston, Michael E Smith,

Cisplatin is a platinum(II) chemotherapy drug that can cause the side-effect of ototoxicity and hearing loss. The monofunctional platinum(II) complexes, phenanthriplatin and pyriplatin, have recently been investigated as anti-cancer agents but their side-effects are largely unknown. Here, we used the auditory hybridoma cell line, HEI-OC1, to investigate the ototoxicity of ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:104-109]

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Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice.

Chuanfeng Tang, Jia Zhang, Peiyu Liu, Yu Zhou, Qiaoyun Hu, Ying Zhong, Xiaoli Wang, Lei Chen,

Bisphenol-A (BPA) is an estrogenic chemical extensively used in industrial and household applications. The present study was conducted to investigate the effect of chronic exposure to BPA on the adult female neuroendocrine system. Herein, we found that expose of adult female mice to BPA (50 µg/kg) by oral gavage for 60 ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Preface to the NeuroToxicology Special Issue, "Mercury in Fish: The Seychelles Child Development Study".

Gary, Edwin, Steve, Joan, Pam, Remco,

Neurotoxicology (Neurotoxicology)
[2020, :]

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Tramadol-associated seizures in Egypt: Epidemiological, clinical, and radiological study.

Reham Mohammed Shamloul, Nervana Mohammed Elfayomy, Ehab Ismael Ali, Ahmed Mohammed Mohammed Elmansy, Mohammad A Farrag,

Neurotoxicology (Neurotoxicology)
[2020, :]

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Editorial: Special Issue on Fish, Mercury and Health.

Joan Spyker Cranmer,

Neurotoxicology (Neurotoxicology)
[2020, :]

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Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study.

Katerina Kotikova, Petr Klepis, Petr Ridzon, Jiri Hlusicka, Tomas Navratil, Jan Rulisek, Ivan Zak, Sergey Zakharov,

BACKGROUND:Methanol is a widely used industrial short-chain aliphatic alcohol with known neurotoxic properties. Mass poisoning outbreaks due to the consumption of methanol-adulterated alcoholic drinks present a challenge to healthcare providers due to the high mortality and serious central nervous system (CNS) damage in survivors. However, the impact of methanol exposure ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:67-74]

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Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-L-alanine (BMAA).

Alessandra Carion, Angèle Markey, Julie Hétru, Camille Carpentier, Victoria Suarez-Ulloa, Mathieu Denoël, Ryan L Earley, Frédéric Silvestre,

β-N-methylamino-L-alanine (BMAA), a neurotoxin naturally produced by cyanobacteria, diatoms and dinoflagellates, constitutes a serious environmental and health threat especially during acute blooms, which are becoming more frequent. This neurotoxin is implicated in several neurodegenerative diseases (ND) in humans through contaminated water or food consumption. Even low doses of neurotoxic compounds ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Neurotoxicity of sub-anesthetic doses of sevoflurane and dexmedetomidine co-administration in neonatal rats.

Jose F Perez-Zoghbi, Wenbin Zhu, Viola Neudecker, Marjorie R Grafe, Ansgar M Brambrink,

BACKGROUND:Preclinical studies suggest that exposures of infant animals to general anesthetics cause acute neurotoxicity and affect their neurobehavioral development representing a potential risk to human infants undergoing anesthesia. Alternative or mitigating strategies to counteract such adverse effects are desirable. Dexmedetomidine (DEX) is a clinically established sedative with potential neuroprotective properties. ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:75-83]

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Application of the hard and soft, acids and bases (HSAB) theory as a method to predict cumulative neurotoxicity.

Fjodor Melnikov, Brian C Geohagen, Terrence Gavin, Richard M LoPachin, Paul T Anastas, Phillip Coish, David W Herr,

Xenobiotic electrophiles can form covalent adducts that may impair protein function, damage DNA, and may lead a range of adverse effects. Cumulative neurotoxicity is one adverse effect that has been linked to covalent protein binding as a Molecular Initiating Event (MIE). This paper describes a mechanistic in silico chemical screening ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:95-103]

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Association between aluminum in drinking water and incident Alzheimer's disease in the Canadian Study of Health and Aging cohort.

Nicole Van Dyke, Nagarajkumar Yenugadhati, Nicholas J Birkett, Joan Lindsay, Michelle C Turner, Calvin C Willhite, Daniel Krewski,

Epidemiological evidence linking aluminum in drinking water and Alzheimer's disease (AD) has been inconsistent, with previous studies often limited by small sample sizes. The present study addresses this issue using data from the Canadian Study of Health and Aging (CSHA), a prospective cohort of 10,263 subjects followed-up from 1991-1992 through ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Neurotoxic effects of high-dose piperine on hippocampal synaptic transmission and synaptic plasticity in a rat model of memory impairment.

Masoomeh Nazify, Manoochehr Ashrafpoor, Shahrbanoo Oryan, Delaram Eslimi Esfahani, Ali Akbar Moghadamnia,

In recent years, piperine has attracted much attention due to its various biological effects as a neuroprotective agent. Therefore, clarification of the possible side effects of piperine is important to identify its potential pharmacological action. The effects of piperine on the long-term plasticity of perforant pathway were studied to dentate ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, :]

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Targeting sirtuin activity with nicotinamide riboside reduces neuroinflammation in a GWI mouse model.

Utsav Joshi, James E Evans, Andrew Pearson, Nicole Saltiel, Adam Cseresznye, Teresa Darcey, Joseph Ojo, Andrew P Keegan, Sarah Oberlin, Benoit Mouzon, Daniel Paris, Nancy Klimas, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Laila Abdullah,

Gulf War Illness (GWI) affects 30% of veterans from the 1991 Gulf War (GW), who suffer from symptoms that reflect ongoing mitochondria dysfunction. Brain mitochondria bioenergetics dysfunction in GWI animal models corresponds with astroglia activation and neuroinflammation. In a pilot study of GW veterans (n = 43), we observed that blood nicotinamide ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:84-94]

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Neuropsychological Effects of Mercury Exposure in Children and Adolescents of the Amazon Region, Brazil.

Cassio Dos Santos-Lima, Dennys de Souza Mourão, Chrissie Ferreira de Carvalho, Breno Souza-Marques, Cláudia M Vega, Rodrigo Araújo Gonçalves, Nayara Argollo, José Antonio Menezes-Filho, Neander Abreu, Sandra de Souza Hacon,

BACKGROUND:Studies with children exposed to methylmercury (MeHg) through fish consumption in the Brazilian Amazon region report that the high levels of hair Hg are associated with significant decreases in intelligence, memory, attention, and visuospatial processing. OBJECTIVE:To investigate the relationship between mercury exposure and neuropsychological functions in riverside communities of the ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:48-57]

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Novel in vitro assay to investigate radiation induced changes in the functionality of human embryonic stem cell-derived neurospheres.

Margot Mayer, Onetsine Arrizabalaga, Manuel Ciba, Insa S Schroeder, Sylvia Ritter, Christiane Thielemann,

Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiological studies ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:40-47]

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Erratum to "A microstructural analysis distinguishes motor and motivational influences over voluntary running in animals chronically exposed to methylmercury and nimodipine" [Neurotoxicology 54, (2016) 127-139].

Daniel J Hoffman, M Christopher Newland,

Neurotoxicology (Neurotoxicology)
[2020, :]

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Effects of prenatal ethanol exposure on acoustic characteristics of play fighting-induced ultrasonic vocalizations in juvenile rats.

Mohd Ashik Shahrier, Hiromi Wada,

Juvenile rats display rough-and-tumble playing with conspecifics (play fighting behavior) and produce 22 and 50 kHz ultrasonic vocalizations (USVs). The 22 kHz USV is considered to reflect negative emotionality such as anxiety, fear, and distress, whereas the 50 kHz USV is considered to reflect positive emotionality such as joy, happiness, ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:25-39]

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Fenobucarb-induced developmental neurotoxicity and mechanisms in zebrafish.

Xiao-Yu Zhu, Yu-Ying Wu, Bo Xia, Ming-Zhu Dai, Yan-Feng Huang, Hua Yang, Chun-Qi Li, Ping Li,

Fenobucarb (2-sec-butylphenyl methylcarbamate, BPMC) is an extensively used carbamate insecticide. Its developmental neurotoxicity and the underlying mechanisms have not been well investigated. In this study, zebrafish embryos were exposed to various concentrations of BPMC from 6 hpf (hours post fertilization, hpf) to 120 hpf. BPMC induced developmental toxicity with reduced ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:11-19]

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Use of new psychoactive substances to mimic prescription drugs: The trend in France.

Anne Batisse, Celine Eiden, Helene Peyriere, Samira Djezzar, ,

Among the expanding world of New Psychoactive Substances (NPS), Designer Medicines (DM) are designed to mimic psychoactive drugs and might lead to adverse events of various severity. The DM category includes designer benzodiazepines (DB), phenmetrazine, modafinil, methylphenidate analogs, and novel synthetic opioids (NSO). To investigate DM-related complications in France, all ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:20-24]

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Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.

Emily N Dunn, Liana M Matson, Kari M Haines, Kimberly A Whitten, Robyn B Lee-Stubbs, Kyle E Berger, Hilary S McCarren, Cherish E Ardinger, Cecelia E Jackson Piercy, Stephanie M Miller-Smith, John H McDonough,

Multiple recent instances of nerve agent (NA) exposure in civilian populations have occurred, resulting in a variety of negative effects and lethality in both adult and pediatric populations. Seizures are a prominent effect of NAs that can result in neurological damage and contribute to their lethality. Current anticonvulsant treatments for ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 79:58-66]

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Visual contrast sensitivity in school-age Guadeloupean children exposed to chlordecone.

Dave Saint-Amour, Gina Muckle, Avril Gagnon-Chauvin, Florence Rouget, Christine Monfort, Leah Michineau, Jean-Pierre Thomé, Philippe Kadhel, Luc Multigner, Sylvaine Cordier,

Recent evidence suggests that prenatal exposure to chlordecone, a persistent organochlorine pesticide that was used intensively in the French West Indies, affects infant neurodevelopment. The aim of the present study was to evaluate the association between prenatal and postnatal chlordecone exposures on visual contrast sensitivity in 285 children aged from ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 78:195-201]

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Respirator usage protects brain white matter from welding fume exposure: A pilot magnetic resonance imaging study of welders.

Elza Rechtman, Paul Curtin, Lynn C Onyebeke, Victoria X Wang, Demetrios M Papazaharias, Danielle Hazeltine, Erik de Water, Ismail Nabeel, Venkatesh Mani, Norman Zuckerman, Roberto G Lucchini, Denise Gaughan, Cheuk Y Tang, Megan K Horton,

Welding fume exposure has been associated with structural brain changes and a wide variety of clinical and sub-clinical outcomes including cognitive, behavioral and motor abnormalities. Respirator use has been shown to decrease exposure to welding fumes; however, the associations between respirator use and health outcomes, particularly neurologic health, have been ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 78:202-208]

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Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice.

Lihua Yang, Ningning Guo, Wei Fan, Chunmin Ni, Mengbing Huang, Liping Bai, Le Zhang, Xianwen Zhang, Yunbo Wen, Ye Li, Xiaoshuang Zhou, Jie Bai,

Methamphetamine (METH) has been reported to induce endoplasmic reticulum (ER) stress and neuronal apoptosis in the central nervous system (CNS) during the development of addiction. Thioredoxin-1 (Trx-1) is a redox regulating protein and plays an important role in inhibiting apoptosis and protects neurons from cytotoxicity through ER and mitochondria-mediated pathways. ... Read more >>

Neurotoxicology (Neurotoxicology)
[2020, 78:163-169]

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