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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(1):7]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(1):6]

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Perspectives on Neuroscience and Behavior.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(1):8-9]

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Blood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases.

Berta Segura-Collar, Pablo Mata-Martínez, Aurelio Hernández-Laín, Pilar Sánchez-Gómez, Ricardo Gargini,

The brain is endowed with a unique cellular composition and organization, embedded within a vascular network and isolated from the circulating blood by a specialized frontier, the so-called blood-brain barrier (BBB), which is necessary for its proper function. Recent reports have shown that increments in the permeability of the blood ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420985838]

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The Neurobiology of Pathological Fatigue: New Models, New Questions.

Annapoorna Kuppuswamy,

The last decade has seen the emergence of new theoretical frameworks to explain pathological fatigue, a much neglected, yet highly significant symptom across a wide range of diseases. While the new models of fatigue provide new hypotheses to test, they also raise a number of questions. The primary purpose of ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420985447]

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Neurological and Neuropsychological Changes Associated with SARS-CoV-2 Infection: New Observations, New Mechanisms.

Muhammad Ali Haidar, Hussam Jourdi, Zeinab Haj Hassan, Ohanes Ashekyan, Manal Fardoun, Zena Wehbe, Dina Maaliki, Maya Wehbe, Stefania Mondello, Samar Abdelhady, Shima Shahjouei, Maya Bizri, Yehia Mechref, Mark S Gold, Ghassan Dbaibo, Hassan Zaraket, Ali H Eid, Firas Kobeissy,

SARS-CoV-2 infects cells through angiotensin-converting enzyme 2 (ACE2), a ubiquitous receptor that interacts with the virus' surface S glycoprotein. Recent reports show that the virus affects the central nervous system (CNS) with symptoms and complications that include dizziness, altered consciousness, encephalitis, and even stroke. These can immerge as indirect immune ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420984106]

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Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target?

Mark M Rich, Stephen N Housley, Paul Nardelli, Randall K Powers, Timothy C Cope,

Both sepsis and treatment of cancer with chemotherapy are known to cause neurologic dysfunction. The primary defects seen in both groups of patients are neuropathy and encephalopathy; the underlying mechanisms are poorly understood. Analysis of preclinical models of these disparate conditions reveal similar defects in ion channel function contributing to ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420981866]

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Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, "Switches" That Alter the State of Target Networks.

Sayed Ausim Azizi,

How do monoamines influence the perceptual and behavioral aspects of brain function? A library of information regarding the genetic, molecular, cellular, and function of monoamines in the nervous system and other organs has accumulated. We briefly review monoamines' anatomy and physiology and discuss their effects on the target neurons and ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420974336]

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Does the Brain-Derived Neurotrophic Factor Val66Met Polymorphism Modulate the Effects of Physical Activity and Exercise on Cognition?

Bernat de Las Heras, Lynden Rodrigues, Jacopo Cristini, Maxana Weiss, Anna Prats-Puig, Marc Roig,

The Val66Met is a polymorphism of the brain-derived neurotrophic factor (BDNF) gene that encodes a substitution of a valine (Val) to methionine (Met) amino acid. Carrying this polymorphism reduces the activity-dependent secretion of the BDNF protein, which can potentially affect brain plasticity and cognition. We reviewed the biology of Val66Met ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420975712]

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Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease.

Jorge Arriagada-Diaz, Lorena Prado-Vega, Ana M Cárdenas Díaz, Alvaro O Ardiles, Arlek M Gonzalez-Jamett,

Dynamin superfamily proteins (DSPs) comprise a large group of GTP-ases that orchestrate membrane fusion and fission, and cytoskeleton remodeling in different cell-types. At the central nervous system, they regulate synaptic vesicle recycling and signaling-receptor turnover, allowing the maintenance of synaptic transmission. In the presynapses, these GTP-ases control the recycling of ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420974313]

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Cerebral Amyloid Angiopathy and Blood-Brain Barrier Dysfunction.

Monica Gireud-Goss, Alexis F Mack, Louise D McCullough, Akihiko Urayama,

Cerebral hemorrhage, a devastating subtype of stroke, is often caused by hypertension and cerebral amyloid angiopathy (CAA). Pathological evidence of CAA is detected in approximately half of all individuals over the age of 70 and is associated with cortical microinfarcts and cognitive impairment. The underlying pathophysiology of CAA is characterized ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420954811]

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Glucocorticoids in the Physiological and Transcriptional Regulation of 5-HT1A Receptor and the Pathogenesis of Depression.

Darakhshan Jabeen Haleem,

There is growing increase in the global prevalence of depression, but treatment outcome of this highly disabling disease is not satisfactory. Many patients are not benefitted by the currently prescribed antidepressants-together with this partial remission is very common. Improving treatment strategies and developing better therapeutic agents for treating depression is ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420975711]

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Giacomo Balla: A Painter in the Context of Neuroscience.

Letizia Maria Cupini, Paolo Calabresi,

Giacomo Balla, a famous Italian Futurist painter, was a great observer of both human motion and emotion. He showed a profound interest toward neurophysiological and neurological sciences. During his search of his personal artistic style, he attended the lessons of Cesare Lombroso, a criminal anthropologist, who at the time was ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420976380]

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Synaptic Dysfunction in Huntington's Disease: Lessons from Genetic Animal Models.

Carlos Cepeda, Michael S Levine,

The understanding of the functional and structural changes occurring in the cerebral cortex and basal ganglia in Huntington's disease (HD) has benefited considerably from the generation of genetic animal models. Most studies of synaptic alterations in HD models have focused on the striatum, but a more complete picture of synaptic ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420972662]

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Why Severe COVID-19 Patients Are at Greater Risk of Developing Depression: A Molecular Perspective.

Ana P Bouças, Jakeline Rheinheimer, Jim Lagopoulos,

The prevailing evidence suggests that patients with severe COVID-19 seem to have an overreaction of the immune system demonstrating exacerbated levels of inflammation caused by a "cytokine storm." At this early stage, the mechanisms underpinning COVID-19 are still subject to intense scrutiny and the long-term mental health consequences as a ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420967892]

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Drug Repurposing in Neurological Disorders: Implications for Neurotherapy in Traumatic Brain Injury.

Zaynab Shakkour, Karl John Habashy, Moussa Berro, Samira Takkoush, Samar Abdelhady, Nadia Koleilat, Ali H Eid, Kazem Zibara, Makram Obeid, Deborah Shear, Stefania Mondello, Kevin K Wang, Firas Kobeissy,

Traumatic brain injury (TBI) remains a significant leading cause of death and disability among adults and children globally. To date, there are no Food and Drug Administration-approved drugs that can substantially attenuate the sequelae of TBI. The innumerable challenges faced by the conventional de novo discovery of new pharmacological agents ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420961078]

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The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury.

Petr Krupa, Ahad M Siddiqui, Peter J Grahn, Riazul Islam, Bingkun K Chen, Nicolas N Madigan, Anthony J Windebank, Igor A Lavrov,

Evidence from preclinical and clinical research suggest that neuromodulation technologies can facilitate the sublesional spinal networks, isolated from supraspinal commands after spinal cord injury (SCI), by reestablishing the levels of excitability and enabling descending motor signals via residual connections. Herein, we evaluate available evidence that sublesional and supralesional spinal circuits ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420966276]

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Ugo Cerletti (1877-1963): An Early Italian Father of Electroshock and a Pioneer in Many Other Ways.

Konstantina Kotsaki, Aristidis Diamantis, Emmanouil Magiorkinis,

This article provides a biographical review of the life and the professional achievements of the Italian doctor Ugo Cerletti and an introduction on electroshock. Throughout his medical career, he travelled and studied in many countries all over the world. Building upon his systematic and comprehensive analysis of mental diseases, Cerletti ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420958381]

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Circular RNAs in the Brain: A Possible Role in Memory?

Esmi L Zajaczkowski, Timothy W Bredy,

Higher-order organisms possess information processing capabilities that are only made possible by their biological complexity. Emerging evidence indicates a critical role for regulatory RNAs in coordinating many aspects of cellular function that are directly involved in experience-dependent neural plasticity. Here, we focus on a structurally distinct class of RNAs known ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420963028]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, 26(5-6):385-386]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, 26(5-6):386]

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Matisse and the Organoids: The Art of Science.

María Lacalle-Aurioles,

Over the past few decades, scientists have transformed the way they do and understand science. They are now exploring their more creative side. This approach has accelerated fascinating discoveries such as human induced pluripotent stem cells and brain organoids; however, they have not been able to jump over the communication ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420961362]

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The COVID-19 Effect on the Immune System and Mitochondrial Dynamics in Diabetes, Obesity, and Dementia.

Katherine Holder, P Hemachandra Reddy,

The coronavirus disease 2019 (COVID-19) is a pandemic disease, originated in Wuhan City, China. It is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) and its biology is still poorly understood. Currently, there are no vaccines and drugs/or agents that can reduce severity of this new disease. Recent ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420960443]

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Neural Oscillations: Understanding a Neural Code of Pain.

Junseok A Kim, Karen D Davis,

Neural oscillations play an important role in the integration and segregation of brain regions that are important for brain functions, including pain. Disturbances in oscillatory activity are associated with several disease states, including chronic pain. Studies of neural oscillations related to pain have identified several functional bands, especially alpha, beta, ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, :1073858420958629]

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Perspectives on Neuroscience and Behavior.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, 26(5-6):392-393]

Cited: 0 times

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