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Perspectives on Neuroscience and Behavior.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(3):213]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(3):210]

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Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective.

Li-Da Su, Na Wang, Junhai Han, Ying Shen,

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to fine-tuning of synaptic efficacy and control the accuracy and sharpness of neurotransmission. Among eight subtypes, mGluR1 and mGluR5 belong to group 1 (Gp1) family, and are implicated ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211021018]

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Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications.

Mohammad-Reza Ghovanloo, Peter C Ruben,

Voltage-gated sodium (Nav) channels initiate action potentials in excitable tissues. Altering these channels' function can lead to many pathophysiological conditions. Nav channels are composed of several functional and structural domains that could be targeted pharmacologically as potential therapeutic means against various neurological conditions. Mutations in Nav channels have been suggested ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211017009]

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Unravelling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids.

Jing-Han Ng, Alfred Sun, Hyunsoo Shawn Je, Eng-King Tan,

Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the pathophysiology of COVID-19 in the central nervous system remains unclear. Brain organoid models derived from human pluripotent stem cells are potentially useful for the study of complex physiological and pathological processes associated with severe acute respiratory syndrome ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211015136]

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The Pioneer Neuropharmacologist Alfred Fröhlich (1871-1953) and the Origins of Neuroendocrinology: A Sesquicentennial Remembrance.

Lazaros C Triarhou,

The birth of neuroendocrinology as a scientific discipline is traced back to 1900-1901, when Joseph Babinski, Alfred Fröhlich, and Harvey Cushing independently identified adiposogenital dystrophy (Fröhlich syndrome), and related gonadal underdevelopment and obesity to a tumor near the pituitary gland. This discovery prompted decades of research into the brain mechanisms ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211016777]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(3):211-212]

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Crowdsourcing in Cognitive and Systems Neuroscience.

Brian P Johnson, Eran Dayan, Nitzan Censor, Leonardo G Cohen,

Behavioral research in cognitive and human systems neuroscience has been largely carried out in-person in laboratory settings. Underpowering and lack of reproducibility due to small sample sizes have weakened conclusions of these investigations. In other disciplines, such as neuroeconomics and social sciences, crowdsourcing has been extensively utilized as a data ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211017018]

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Alzheimer's Disease: Innovative Therapeutic Approaches Based on Peptides and Nanoparticles.

Isabela F L Mota, Larissa S de Lima, Bruna de M Santana, Giovanna de A M Gobbo, João V M L Bicca, Juliana R M Azevedo, Letícia G Veras, Rodrigo de A A Taveira, Gabriela B Pinheiro, Márcia R Mortari,

Alzheimer's disease (AD) is the main cause of dementia in the world and its etiology is not yet fully understood. The pathology of AD is primarily characterized by intracellular neurofibrillary tangles and extracellular amyloid-β plaques. Unfortunately, few treatment options are available, and most treat symptoms, as is the case of ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211016409]

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Corrigendum.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211019630]

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Non-Motor Symptoms of Parkinson's Disease: The Neurobiology of Early Psychiatric and Cognitive Dysfunction.

Ayan Hussein, Christopher A Guevara, Pamela Del Valle, Swati Gupta, Deanna L Benson, George W Huntley,

Parkinson's disease (PD) is a progressive neurodegenerative disorder that has been recognized for over 200 years by its clinically dominant motor system impairment. There are prominent non-motor symptoms as well, and among these, psychiatric symptoms of depression and anxiety and cognitive impairment are common and can appear earlier than motor ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211011979]

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

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The Neurobiology of Modern Viral Scourges: ZIKV and COVID-19.

Swapnil Mittal, Hannah G Federman, David Sievert, Joseph G Gleeson,

The interactions of viruses with the nervous system were thought to be well understood until the recent outbreaks of Zika and SARS-CoV-2. In this review, we consider these emerging pathogens, the range and mechanisms of the neurological disease in humans, and how the biomedical research enterprise has pivoted to answer ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211009149]

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Perspectives on Neuroscience and Behavior.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(2):111-112]

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The Neuroscientist Comments.

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, 27(2):110]

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Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches.

Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Raquel Sanchez-Varo, Juan Antonio Garcia-Leon, Cristina Nuñez-Diaz, Jose Carlos Davila, Javier Vitorica, Frank M LaFerla, Ines Moreno-Gonzalez, Antonia Gutierrez, David Baglietto-Vargas,

Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biology of the human disease ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211001753]

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Neuroscience: The New English Major?

Kristin F Phillips, Harald Sontheimer,

Once strictly the domain of medical and graduate education, neuroscience has made its way into the undergraduate curriculum with over 230 colleges and universities now offering a bachelor's degree in neuroscience. The disciplinary focus on the brain teaches students to apply science to the understanding of human behavior, human interactions, ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211003992]

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Alzheimer's Dementia: The Emerging Role of Positron Emission Tomography.

Shailendra Mohan Tripathi, Alison D Murray,

Alzheimer's disease (AD) is the most common cause of dementia and accounts for approximately 50% to 80% of all cases of dementia. The diagnosis of probable AD is based on clinical criteria and overlapping clinical features pose a challenge to accurate diagnosis. However, neuroimaging has been included as a biomarker ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421997035]

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Brains that Fire Together Wire Together: Interbrain Plasticity Underlies Learning in Social Interactions.

Simone G Shamay-Tsoory,

Social interactions are powerful determinants of learning. Yet the field of neuroplasticity is deeply rooted in probing changes occurring in synapses, brain structures, and networks within an individual brain. Here I synthesize disparate findings on network neuroplasticity and mechanisms of social interactions to propose a new approach for understanding interaction-based ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421996682]

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

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Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson's Disease.

Valeria C Gonçalves, Lorena Cuenca-Bermejo, Emiliano Fernandez-Villalba, Sebastian Martin-Balbuena, Maria Jose da Silva Fernandes, Carla A Scorza, Maria-Trinidad Herrero,

It has been more than 200 years since James Parkinson made the first descriptions of the disease that bears his name. Since then, knowledge about Parkinson's disease has been improved, and its pathophysiology, diagnosis, and treatments are well described in the scientific and medical literature. However, there is no way ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421990000]

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Inflammatory Mechanisms in Parkinson's Disease: From Pathogenesis to Targeted Therapies.

Stellina Y H Lee, Nathanael J Yates, Susannah J Tye,

Inflammation is a critical factor contributing to the progressive neurodegenerative process observed in Parkinson's disease (PD). Microglia, the immune cells of the central nervous system, are activated early in PD pathogenesis and can both trigger and propagate early disease processes via innate and adaptive immune mechanisms such as upregulated immune ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421992265]

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Complex Inclusion Bodies and Defective Proteome Hubs in Neurodegenerative Disease: New Clues, New Challenges.

Arun Upadhyay, Naveen Sundaria, Rohan Dhiman, Vijay Kumar Prajapati, Amit Prasad, Amit Mishra,

A healthy physiological environment of cells represents the dynamic homeostasis of crowded molecules. A subset of cellular proteome forms protein quality control (PQC) machinery to maintain an uninterrupted synthesis of new polypeptides and targeted elimination of old or defective proteins. The process of PQC may get overwhelmed under specific genetic ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421989582]

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Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

Mingchao Shi, Fengna Chu, Xiaoping Tian, Qiaolifan Aerqin, Feiqi Zhu, Jie Zhu,

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the pathogenic factors unsuccessful over past decades. It has been evidenced that the innate immune is strongly implicated in the pathogenesis of AD. However, the role of adaptive ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858420987224]

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Neuroinflammation in Parkinson's Disease: Triggers, Mechanisms, and Immunotherapies.

Tai Wang, Changhe Shi, Haiyang Luo, Huimin Zheng, Liyuan Fan, Mibo Tang, Yun Su, Jing Yang, Chengyuan Mao, Yuming Xu,

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple etiologies and pathogenesis, in which neuroinflammation is a common factor. Both preclinical experiments and clinical studies provide evidence for the involvement of neuroinflammation in the pathophysiology of PD, although there are a number of key issues related to neuroinflammatory processes ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421991066]

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