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Serum Neuron-Specific-Enolase Thresholds for Predicting Postcardiac Arrest Outcome: A Systematic Review and Meta-analysis.

Kartavya Sharma, Merin John, Song Zhang, Gary Gronseth,

To determine thresholds of serum neuron-specific-enolase (NSE) for prediction of poor outcome after cardiac arrest with > 95% specificity using a unique method of multiple thresholds meta-analysis. Data from a systematic review by the European Resuscitation Council (ERC 2014) were updated with literature searches from PubMed, Cochrane, and Scopus until ... Read more >>

Neurology (Neurology)
[2021, :]

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Synaptic Damage and Its Clinical Correlates in People With Early Huntington Disease: A PET Study.

Aline Delva, Laura Michiels, Michel Koole, Koen Van Laere, Wim Vandenberghe,

Synaptic damage has been proposed to play a major role in the pathophysiology of Huntington's disease (HD), but in vivo evidence in humans is lacking. We performed a PET imaging study to assess synaptic damage and its clinical correlates in early HD in vivo. METHODS: In this cross-sectional study, premanifest ... Read more >>

Neurology (Neurology)
[2021, :]

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Fatigue in Patients With Multiple System Atrophy: A Prospective Cohort Study.

Lingyu Zhang, Bei Cao, Yanbing Hou, Xiaojing Gu, Qian-Qian Wei, Ruwei Ou, Bi Zhao, Wei Song, Huifang Shang,

Non-motor symptoms are common in patients with multiple system atrophy (MSA), but there is limited knowledge regarding fatigue in MSA. This study aimed to investigate the frequency and evolution of fatigue and the factors related to fatigue and its progression in patients with MSA at an early stage. Patients with ... Read more >>

Neurology (Neurology)
[2021, :]

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CNS Involvement in Hereditary Transthyretin Amyloidosis.

Luísa Sousa, Teresa Coelho, Ricardo Taipa,

Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is predominantly a disease of the peripheral nerves, heart, kidney and eye. CNS involvement has been a marginal issue in research and the clinical setting, until recently. Growing evidence shows that leptomeningeal amyloid accumulation is frequent and present from early stages of ATTRv amyloidosis. Several ... Read more >>

Neurology (Neurology)
[2021, :]

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Cryptogenic Pediatric Ischemic Stroke: What's the Hole Story?

Lisa R Sun, Lori C Jordan,

Neurology (Neurology)
[2021, :]

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Racial, Socioeconomic, and Geographic Disparities in Acute Stroke Care in the United States: Miles to Go Before We Sleep.

Cumara Barahona O'Carroll, Bart Demaerschalk,

Neurology (Neurology)
[2021, :]

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Acute Ischemic Stroke Interventions in the United States and Racial, Socioeconomic, and Geographic Disparities.

Adam de Havenon, Kevin Sheth, Karen C Johnston, Alen Delic, Eric Stulberg, Jennifer Majersik, Mohammad Anadani, Shadi Yaghi, David Tirschwell, John Ney,

<h4>Background and objectives</h4>In ischemic stroke (IS) patients, intravenous alteplase (tPA) and endovascular thrombectomy (EVT) reduce long-term disability, but their utilization has not been fully optimized. Prior research has also demonstrated disparities in the use of tPA and EVT specific to sex, race/ethnicity, socioeconomic status, and geographic location. We sought to ... Read more >>

Neurology (Neurology)
[2021, :]

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Life Expectancy in Duchenne Muscular Dystrophy: Reproduced Individual Patient Data Meta-analysis.

Jonathan Broomfield, Micki Hill, Michela Guglieri, Michael Crowther, Keith Abrams,

<h4>Objective</h4>Duchenne Muscular Dystrophy (DMD) is a rare progressive disease, which is often diagnosed in early childhood, and leads to considerably reduced life-expectancy; due to its rarity, research literature and patient numbers are limited. To fully characterise the natural history, it is crucial to obtain appropriate estimates of the life-expectancy and ... Read more >>

Neurology (Neurology)
[2021, :]

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CT Hypoperfusion-Hypodensity Mismatch to Identify Patients With Acute Ischemic Stroke Within 4.5 Hours of Symptom Onset.

Peter B Sporns, André Kemmling, Heike Minnerup, Lennart Meyer, Christos Krogias, Volker Puetz, Kolja Thierfelder, Marco Duering, Daniel Kaiser, Soenke Langner, Christina Massoth, Alex Brehm, Lukas Rotkopf, Wolfgang G Kunz, André Karch, Jens Fiehler, Walter Heindel, Peter Schramm, Georg Royl, Heinz Wiendl, Marios Psychogios, Jens Minnerup,

ObjectiveTo test the hypothesis that CT hypoperfusion-hypodensity mismatch identifies patients with ischemic stroke within 4.5 hours of symptom onset.MethodsWe therefore performed the "retrospective multicenter hypoperfusion-hypodensity mismatch for the identification of patients with stroke within 4.5 hours study" of patients with acute ischemic stroke and known time of symptom onset. The ... Read more >>

Neurology (Neurology)
[2021, :]

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Heart Rate Controversies in Epilepsy: Autonomic Metrics and Predictions.

Roland D Thijs, Josemir Sander,

Neurology (Neurology)
[2021, :]

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Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.

Chadwick W Christine, R Mark Richardson, Amber D Van Laar, Marin E Thompson, Elisabeth M Fine, Omar S Khwaja, Chunming Li, Grace S Liang, Andreas Meier, Eiry W Roberts, Madeline L Pfau, Josh R Rodman, Krystof S Bankiewicz, Paul S Larson,

<h4>Objective</h4>To report final, 36-month safety and clinical outcomes from the PD-1101 trial of NBIb-1817 (VY-AADC01) in participants with moderately advanced Parkinson's disease (PD) and motor fluctuations.<h4>Methods</h4>PD-1101 was a phase 1b, open-label, dose escalation trial of VY-AADC01, an experimental AAV2 gene therapy encoding the human aromatic L-amino acid decarboxylase (AADC) enzyme. ... Read more >>

Neurology (Neurology)
[2021, :]

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Association Between Time to Endovascular Therapy and Outcomes in Patients With Acute Basilar Artery Occlusion.

Hong Fei Sang, Jun Jie Yuan, Zhongming Qiu, Min Zhang, Xiao Gang Hu, Wen Hua Liu, Ning Wang, Hong Xing Han, Tie Yu Tang, Guo Yong Zeng, Hui Dong, Xing Min Long, Ling Fei Li, Feng Li Li, Shuai Liu, Wei Dong Luo, Jia Cheng Huang, Jia Xing Song, Lin Yu Li, Lu Ming Chen, Dong Jing Xie, De Ping Wu, Fang Fei Li, Wen Jie Zi, Qingwu Yang,

<h4>Objective</h4>To characterize the association of onset to puncture time (OPT) with clinical outcomes among patients with acute basilar artery occlusion receiving endovascular therapy (EVT) in clinical practice.<h4>Methods</h4>Using the EVT for Acute Basilar Artery Occlusion (BASILAR) study, we identified consecutive patients with acute basilar artery occlusion receiving EVT in 47 comprehensive ... Read more >>

Neurology (Neurology)
[2021, :]

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Clinical Reasoning: A 56-Year-Old Man With Unusual Presentation of Subacute Encephalopathy and Seizure.

Tian Wang, Amy Li Safadi, Earn Chun Christabel Lee, Nathan Bicher, Brian Barry, Bilaal Sirdar, Gholam K Motamedi, Benjamin Osborne,

Neurology (Neurology)
[2021, :]

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Prevalence of Patent Foramen Ovale in a Cohort of Children With Cryptogenic Ischemic Stroke.

Evelyn K Shih, Lauren A Beslow, Shobha S Natarajan, Christine B Falkensammer, Steven R Messe, Rebecca N Ichord,

<h4>Objective</h4>To determine the significance of patent foramen ovale (PFO) in childhood stroke, we compared PFO prevalence, PFO features, and stroke recurrence risk in 25 children with cryptogenic arterial ischemic stroke (AIS), 54 children with AIS from a known etiology, and 209 healthy controls.<h4>Methods</h4>We performed a case-control analysis of a 14-year ... Read more >>

Neurology (Neurology)
[2021, :]

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Lifestyle Factors and Parkinson Disease Risk: Korean Nationwide Cohort Study With Repeated Health Screening Data.

Seo Yeon Yoon, You Hyun Park, Hyo Jeong Lee, Dae Ryong Kang, Yong Wook Kim,

<h4>Objective</h4>Many previous studies, mostly performed in Western countries, on the effects of lifestyle factors on Parkinson's disease, used baseline lifestyle characteristics without directly accounting for changes in covariate values over time. The objective of this study was to evaluate the association of repeatedly measured lifestyle factors with Parkinson's disease risk ... Read more >>

Neurology (Neurology)
[2021, :]

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Functional Eloquence Weighted Imaging, a Novel Modality to Select Large Vessel Occlusion Stroke Patients.

Kalyan Chekravarthy Sajja, Shailesh Male,

Neurology (Neurology)
[2021, :]

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Hemiplegic Migraine Associated With PRRT2 Mutations: A Clinical and Genetic Study.

Florence Riant, Caroline Roos, Agathe Roubertie, Cécile Barbance, Jessica Hadjadj, Stéphane Auvin, Guillaume Baille, Marion Beltramone, Cécile Boulanger, Alice Cahn, Florina Cata, Emmanuel Cheuret, Jean-Christophe Cuvellier, Antoine Defo, Genevieve Demarquay, Anne Donnet, Nicolas Gaillard, Evelyne Massardier, Nathalie Guy, Sylvie Lamoureux, Laurence Le Moigno, Christian Lucas, Diana Ratiu, Sylvain Redon, Caroline Rey, Christel Thauvin, François Viallet, Elisabeth Tournier-Lasserve, Anne Ducros,

<h4>Background and objective</h4>PRRT2 variants have been reported in a few cases of patients with hemiplegic migraine. To clarify the role of <i>PRRT2</i> in familial hemiplegic migraine, we studied this gene in a large cohort of affected probands.<h4>Methods</h4><i>PRRT2</i> was analyzed in 860 probands with hemiplegic migraine and <i>PRRT2</i> mutations were identified ... Read more >>

Neurology (Neurology)
[2021, :]

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Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy.

Basile Kerleroux, Joseph Benzakoun, Kévin Janot, Cyril Dargazanli, Dimitri Daly Eraya, Wagih Ben Hassen, François Zhu, Benjamin Gory, Hak Jean-Francois, Charline Perot, Lili Detraz, Romain Bourcier, Rouchaud Aymeric, Géraud Forestier, Gaultier Marnat, Florent Gariel, Pasquale Mordasini, Pierre Seners, Guillaume Turc, Johannes Kaesmacher, Catherine Oppenheim, Olivier Naggara, Gregoire Boulouis, ,

<h4>Objective</h4>Individualized patient selection for mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) and large ischemic core (LIC) at baseline is an unmet need.We tested the hypothesis, that assessing the functional relevance of both the infarcted and hypo-perfused brain tissue, would improve the selection framework of patients with LIC ... Read more >>

Neurology (Neurology)
[2021, :]

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Association of Short-term Heart Rate Variability and Sudden Unexpected Death in Epilepsy.

Shobi Sivathamboo, Daniel Friedman, Juliana Laze, Russell Nightscales, Zhibin Chen MBiostat, Levin Kuhlmann, Sasha Devore, Vaughan Macefield, Patrick Kwan, Wendyl D'Souza, Samuel F Berkovic, Piero Perucca, Terence J O'Brien, Orrin Devinsky, ,

<h4>Objective</h4>We compared heart rate variability (HRV) in sudden unexpected death in epilepsy (SUDEP) cases and living epilepsy controls.<h4>Methods</h4>This international, multicenter, retrospective, nested case-control study examined patients admitted for video-EEG monitoring (VEM) between January 1, 2003 and December 31, 2014, and subsequently died of SUDEP. Time-domain and frequency-domain components were extracted ... Read more >>

Neurology (Neurology)
[2021, :]

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Mechanisms of Network Changes in Cognitive Impairment in Multiple Sclerosis.

Danka Jandric, Ilona Lipp, David Paling, David Rog, Gloria Castellazzi, Hamied Haroon, Laura Parkes, Geoff Parker, Valentina Tomassini, Nils Muhlert,

<h4>Background and objectives</h4>Cognitive impairment in multiple sclerosis (MS) is associated with functional connectivity abnormalities. While there have been calls to use functional connectivity measures as biomarkers there remains to be a full understanding of why they are affected in MS. In this cross-sectional study we tested the hypothesis that functional ... Read more >>

Neurology (Neurology)
[2021, :]

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Assessment of Sacsin Turnover in Patients With ARSACS: Implications for Molecular Diagnosis and Pathogenesis.

Fabiana Longo, Daniele De Ritis, Annarita Miluzio, Davide Fraticelli, Jonathan Baets, Marina Scarlato, Filippo M Santorelli, Stefano Biffo, Francesca Maltecca,

<h4>Background and objectives</h4>Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in <i>SACS</i> gene encoding sacsin, a huge multimodular protein of unknown function. More than 200 <i>SACS</i> mutations have been described worldwide to date. Since ARSACS presents phenotypic variability, previous empirical studies attempted to correlate the nature and ... Read more >>

Neurology (Neurology)
[2021, :]

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Representation of Women in Stroke Clinical Trials: A Review of 281 Trials Involving More Than 500,000 Participants.

Cheryl Carcel, Katie Harris, Sanne Ae Peters, Else Charlotte Sandset, Grace Balicki, Cheryl D Bushnell, Virginia J Howard, Mathew J Reeves, Craig S Anderson, Peter J Kelly, Mark Woodward,

<h4>Objective</h4>Women have been under-represented in clinical trials areas of cardiovascular disease but there is less certainty over the level of disparity specifically in stroke. We examined the participation of women in trials according to stroke prevalence in the population.<h4>Methods</h4>Published randomized controlled trials with ≥100 participants enrolled between 1990 and 2020 ... Read more >>

Neurology (Neurology)
[2021, :]

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Training in Neurology: Resident Perception of the Utility and Applicability of Global Neurology Morning Reports.

Andrew M Agostini, Michael R Halstead, Arun Venkatesan, Deanna R Saylor,

Interest in global health is increasing among neurology residents. However, funding, time, and, recently, COVID-19 travel restrictions, remain barriers to widespread participation. To meet this need, we instituted virtual global neurology morning reports with the objectives of (1) improving knowledge about neurological diseases common in sub-Saharan Africa; and (2) developing ... Read more >>

Neurology (Neurology)
[2021, :]

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Association of Hemodynamic and Cerebrovascular Responses to Exercise With Symptom Severity in Adolescents and Young Adults With Concussion.

David R Howell, Danielle L Hunt, Stacey E Aaron, Jason W Hamner, William P Meehan, Can Ozan Tan,

<h4>Background and objectives</h4>Aerobic exercise has become a useful method to assist with post-concussion management. Exercise can exacerbate concussion symptoms even when symptoms are not apparent at rest. Few studies have examined the reasons for symptom exacerbation during exercise following a concussion. We had two primary objectives. 1) To delineate cardiopulmonary ... Read more >>

Neurology (Neurology)
[2021, :]

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Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy.

Gaspard Gerschenfeld, Didier Smadja, Guillaume Turc, Stephane Olindo, François-Xavier Laborne, Marion Yger, Jildaz Caroff, Bruno Gonçalves, Pierre Seners, Marie Cantier, Yann L'Hermitte, Manvel Aghasaryan, Cosmin Alecu, Gaultier Marnat, Wagih Ben Hassen, Erwah Kalsoum, Frédéric Clarençon, Michel Piotin, Laurent Spelle, Christian Denier, Igor Sibon, Sonia Alamowitch, Nicolas Chausson, ,

<h4>Objective</h4>To investigate in routine care the efficacy and safety of IV thrombolysis (IVT) with tenecteplase prior to mechanical thrombectomy (MT) in patients with large vessel occlusion acute ischemic strokes (LVO-AIS), either secondarily transferred after IVT or directly admitted to a comprehensive stroke center (CSC).<h4>Methods</h4>We retrospectively analyzed clinical and procedural data ... Read more >>

Neurology (Neurology)
[2021, :]

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