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Journal Neurology

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SARS-CoV-2 Encephalitis Presenting as a Clinical Cerebellar Syndrome: A Case Report.

Katryn Oosthuizen, Elizabeth Christina Steyn, Lawrence Tucker, Innocent Vusumusi Ncube, Diana Hardie, Suzaan Marais,

Neurology (Neurology)
[2021, :]

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Teaching Video NeuroImages: Wilson Disease Presenting With Catatonia.

Roshni Abee Patel, Meagan Bailey,

Neurology (Neurology)
[2021, :]

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Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders.

Shahram Oveisgharan, Ana W Capuano, Sukriti Nag, Sonal Agrawal, Lisa L Barnes, David A Bennett, Zoe Arvanitakis, Julie A Schneider,

<h4>Objective</h4>We tested the hypothesis that an inverse association exists between diabetes mellitus (DM) and hemoglobin A1C (A1C) with Transactive response DNA binding protein 43 (TDP-43) levels in older adults.<h4>Methods</h4>We leveraged antemortem and postmortem data of decedents from three community-based clinical-pathological studies. DM status, A1C levels, and medications for DM were ... Read more >>

Neurology (Neurology)
[2021, :]

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Pearls & Oy-sters: Moyamoya Vasculopathy and Its Association With Congenital Heart Disease.

Justus Osterloh, Christian Heim, Gabriela Siedler, Tobias Engelhorn, Arnd Doerfler, Stefan Schwab, Bernd Kallmünzer,

Neurology (Neurology)
[2021, :]

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Trajectory-Based Classification of Recovery in Sensorimotor Complete Traumatic Cervical Spinal Cord Injury.

Blessing N R Jaja, Jetan Badhiwala, James Guest, James Harrop, Chris Shaffrey, Max Boakye, Shekar Kurpad, Robert Grossman, Elizabeth Toups, Fred Geisler, Brian Kwon, Bizhan Aarabi, Mark Kotter, Michael G Fehlings, Jefferson R Wilson,

<h4>Objective</h4>To test the hypothesis that sensorimotor complete traumatic cervical spinal cord injury is a heterogenous clinical entity comprising several subpopulations that follow fundamentally different trajectories of neurologic recovery.<h4>Methods</h4>We analyzed demographic and injury data from 655 patients who were pooled from 4 prospective longitudinal multicenter studies. Group based trajectory modeling was ... Read more >>

Neurology (Neurology)
[2021, :]

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Clinical Reasoning: A 71-year-old Male with Horizontal Gaze Palsy, Anarthria, and Quadriparesis.

Ikreet Cheema, Nicole Ng, Tychicus Chen,

Neurology (Neurology)
[2021, :]

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Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort.

Jack F V Hunt, Nicholas M Vogt, Erin M Jonaitis, William R Buckingham, Rebecca L Koscik, Megan Zuelsdorff, Lindsay R Clark, Carey E Gleason, Menggang Yu, Ozioma Okonkwo, Sterling C Johnson, Sanjay Asthana, Barbara B Bendlin, Amy J H Kind,

<h4>Objective</h4>To test the hypothesis that neighborhood-level disadvantage is associated with longitudinal measures of neurodegeneration and cognitive decline in an unimpaired cohort.<h4>Methods</h4>Longitudinal MRI and cognitive testing data were collected from 601 cognitively unimpaired participants in the Wisconsin Registry for Alzheimer's Prevention study and the Wisconsin Alzheimer's Disease Research Center clinical cohort. ... Read more >>

Neurology (Neurology)
[2021, :]

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Clinical Reasoning: A 70-year-old Man with Right Arm and Leg Shaking.

Jessica Frey, Eric Seachrist,

Neurology (Neurology)
[2021, :]

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Brain MRI and Ophthalmic Biomarkers of Intracranial Pressure.

Linda D'Antona, Hasan Asif, Claudia Louise Craven, James Alexander McHugh, Anna Vassiliou, Lewis Thorne, Manjit Singh Matharu, Laurence Dale Watkins, Fion Bremner, Ahmed Kassem Toma,

<h4>Objective</h4>To evaluate the utility of brain MRI and ophthalmic biomarkers for the prediction of intracranial hypertension, we have studied the association between six biomarkers and 24-hour intracranial pressure (ICP) monitoring results in 45 patients.<h4>Methods</h4>This single-centre observational study includes patients who underwent 24-hour ICP monitoring, brain MRI (within three months) and ... Read more >>

Neurology (Neurology)
[2021, :]

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Vagus Nerve Stimulation and Seizure Outcomes in Pediatric Refractory Epilepsy: Systematic Review and Meta-Analysis.

Puneet Jain, Ravindra Arya,

<h4>Objective</h4>We synthesized evidence for effectiveness of vagus nerve stimulation (VNS) as adjuvant therapy in pediatric drug-resistant epilepsy (DRE) by obtaining pooled estimates for seizure outcomes and analyzing their determinants.<h4>Methods</h4>MEDLINE, EMBASE, and Cochrane databases were searched up to July 2019, for original research on VNS in pediatric (≤18 years-of-age) epilepsy. The ... Read more >>

Neurology (Neurology)
[2021, :]

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Pearls & Oy-sters: Rosai-Dorfman Disease of the Central Nervous System.

Kia Gilani, Stephanie Kuntz, David G Munoz, Raphael Schneider,

Neurology (Neurology)
[2021, :]

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Clinical Reasoning: A 7-year-Old Boy with Acute Onset Altered Mental Status.

Gregory J Wong, Cristina M Gaudioso, Eleanor Castro, Nima Sharifai, Sonika Dahiya, Louis P Dehner, Jennifer L Griffith,

Neurology (Neurology)
[2021, :]

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Cardiac Autonomic Dysfunction and Risk of Sudden Unexpected Death in Epilepsy.

William Szurhaj, Alexandre Leclancher, Anca Nica, Bertille Périn, Philippe Derambure, Philippe Convers, Laure Mazzola, Bertrand Godet, Marie Faucanie, Marie-Christine Picot, Julien De Jonckheere,

<h4>Objective</h4>We aimed to test whether patients who died from sudden unexpected death in epilepsy (SUDEP) had an abnormal cardiac autonomic response to sympathetic stimulation by hyperventilation.<h4>Methods</h4>We conducted a retrospective, observational, case-control study of a group of patients who died from SUDEP and controls who were matched with the patients for ... Read more >>

Neurology (Neurology)
[2021, :]

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Pearls & Oy-sters:Hickam's Dictum in Genetic Myopathies: When a Proven Pathogenic Mutation does not Explain the Phenotype.

Daniel Sánchez-Tejerina, Luísa Panadés-de Oliveira, Miguel A Martín, María I Álvarez-Mora, Aurelio Hernández-Lain, Cristina Domínguez-González,

Neurology (Neurology)
[2021, :]

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In Vivo Diagnosis of Synucleinopathies: A Comparative Study of Skin Biopsy and RT-QuIC.

Vincenzo Donadio, Zerui Wang, Alex Incensi, Giovanni Rizzo, Enrico Fileccia, Veria Vacchiano, Sabina Capellari, Martina Magnani, Cesa Scaglione, Michelangelo Stanzani Maserati, Patrizia Avoni, Rocco Liguori, Wenquan Zou,

<h4>Objective</h4>To determine whether: 1) the immunofluorescence (IF) is a reproducible technique in detecting misfolded α-synuclein (α-syn) in skin nerves; and subsequently 2) IF and RT-QuIC (both in skin and CSF) show a comparable in vivo diagnostic accuracy in distinguish synucleinopathies (SOPs) from non-synucleinopathies (non-SOPs) in a large cohort of patients.<h4>Methods</h4>We ... Read more >>

Neurology (Neurology)
[2021, :]

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Modulation of Retinal Atrophy With Rituximab in Multiple Sclerosis.

Jeffrey Lambe, Hunter Risher, Angeliki G Filippatou, Olwen C Murphy, Elias S Sotirchos, Henrik Ehrhardt, Esther Ogbuokiri, Nicole Pellegrini, Brandon Toliver, Nicholas J Luciano, Simidele Davis, Nicholas Fioravante, Ohemaa Kwakyi, Jerry L Prince, Peter A Calabresi, Kathryn C Fitzgerald, Shiv Saidha,

<h4>Objective</h4>To investigate the effects of rituximab on retinal atrophy in patients with relapsing-remitting multiple sclerosis (RRMS), we performed serial optical coherence tomography (OCT) scans among a cohort of RRMS patients on rituximab, and compared rates of ganglion cell+inner plexiform layer (GCIPL) atrophy to those observed among age- and sex-matched glatiramer ... Read more >>

Neurology (Neurology)
[2021, :]

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Pearls & Oy-sters: Cerebral Microbleeds Caused by Adrenocortical Adenoma-related Primary Aldosteronism.

Sun Min Lee, Yong Jun Choi, Kihwang Lee, Hyeung Kyoo Kim, Jin-Sun Park, Yong Cheol Lim, Jang-Hee Kim, So Young Moon,

Neurology (Neurology)
[2021, :]

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Added Value of Quantitative Apparent Diffusion Coefficient Values for Neuroprognostication After Cardiac Arrest.

Anke Wouters, Lauranne Scheldeman, Sam Plessers, Ronald Peeters, Sarah Cappelle, Philippe Demaerel, Wim Van Paesschen, Bert Ferdinande, Matthias Dupont, Jo Dens, Stefan Janssens, Koen Ameloot, Robin Lemmens,

<h4>Objective</h4>To test the prognostic value of brain MRI in addition to clinical and electrophysiological variables in post-cardiac arrest (CA) patients, we explored data from the randomized Neuroprotect post-CA trial (NCT02541591).<h4>Methods</h4>In this trial brain MRI's were prospectively obtained. We calculated receiver operating characteristic curves for the average Apparent Diffusion Coefficient (ADC) ... Read more >>

Neurology (Neurology)
[2021, :]

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Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.

Julio C Rojas, Ping Wang, Adam M Staffaroni, Carolin Heller, Yann Cobigo, Amy Wolf, Sheng-Yang M Goh, Peter A Ljubenkov, Hilary W Heuer, Jamie C Fong, Joanne B Taylor, Eliseo Veras, Linan Song, Andreas Jeromin, David Hanlon, Lili Yu, Arvind Khinikar, Rajeev Sivasankaran, Agnieszka Kieloch, Marie-Anne Valentin, Anna M Karydas, Laura L Mitic, Rodney Pearlman, John Kornak, Joel H Kramer, Bruce L Miller, Kejal Kantarci, David S Knopman, Neill Graff-Radford, Leonard Petrucelli, Rosa Rademakers, David J Irwin, Murray Grossman, Eliana Marisa Ramos, Giovanni Coppola, Mario F Mendez, Yvette Bordelon, Bradford C Dickerson, Nupur Ghoshal, Edward D Huey, Ian R Mackenzie, Brian S Appleby, Kimiko Domoto-Reilly, Ging-Yuek R Hsiung, Arthur W Toga, Sandra Weintraub, Daniel I Kaufer, Diana Kerwin, Irene Litvan, Chiadikaobi U Onyike, Alexander Pantelyat, Erik D Roberson, Maria C Tartaglia, Tatiana Foroud, Weiping Chen, Julie Czerkowicz, Danielle L Graham, John C van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B Rowe, Mario Masellis, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris R Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, David M Cash, Rhian S Convery, Martina Bocchetta, Martha Foiani, Greaves Caroline V, Georgia Peakman, Lucy Russell, Imogen Swift, Emily Todd, Jonathan D Rohrer, Bradley F Boeve, Howard J Rosen, Adam L Boxer,

<h4>Objective</h4>We tested the hypothesis that plasma neurofilament light chain (NfL) identifies asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)-causing mutations at risk of disease progression.<h4>Methods</h4>Baseline plasma NfL concentrations were measured with Simoa in original (n = 277) and validation (n = 297) cohorts. <i>C9orf72</i>, <i>GRN</i> and <i>MAPT</i> mutation carriers and ... Read more >>

Neurology (Neurology)
[2021, :]

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Effect of Adrenomedullin on Migraine-like Attacks in Patients With Migraine: A Randomized Crossover Study.

Hashmat Ghanizada, Mohammad Al-Mahdi Al-Karagholi, Nanna Arngrim, Mette Mørch-Rasmussen, Christopher S Walker, Debbie L Hay, Messoud Ashina,

ObjectiveTo determine whether the intravenous infusion of adrenomedullin, a potent vasodilator belonging to calcitonin family of peptides, provokes attacks of migraine in patients.MethodsTwenty migraine without aura patients participated in a placebo-controlled and double-blinded clinical study. In a randomized and crossover design the patients received an intravenous infusion of human adrenomedullin ... Read more >>

Neurology (Neurology)
[2021, :]

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Teaching Video NeuroImages: Paroxysmal Noctural Dyskinesias: A Characteristic Feature of ADCY5 Mutation.

Tamara M Pringsheim, Nicholas Cothros, Emmanuel Roze,

Neurology (Neurology)
[2021, :]

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Association of Cortical Hyperexcitability and Cognitive Impairment in Patients with ALS.

Mana Higashihara, Nathan Pavey, Mehdi van den Bos, Parvathi Menon, Matthew C Kiernan, Steve Vucic,

<h4>Objective</h4>To determine whether cortical hyperexcitability was more prominent in cognitively impaired amyotrophic lateral sclerosis (ALS) patients.<h4>Methods</h4>Threshold tracking transcranial magnetic stimulation (TMS) was utilised to assess cortical excitability, while cognitive function determined by the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Cognitive impairment was defined by ECAS<105. ALS patients, defined by ... Read more >>

Neurology (Neurology)
[2021, :]

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Dual Sensory Impairment and Cognitive Impairment in the Korean Longitudinal Elderly Cohort.

Gihwan Byeon, Gyu Han Oh, Jin Hyeong Jhoo, Jae-Won Jang, Jong Bin Bae, Ji Won Han, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Dong Young Lee, Ki Woong Kim,

<h4>Objective</h4>To investigate the effects of single sensory impairment (SSI; visual or auditory) or dual sensory impairment (DSI; visual and auditory) on dementia and longitudinal changes of neuropsychological test scores.<h4>Methods</h4>In this nationwide, prospective, community-based elderly cohort study, Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), 6,520 elderly individuals (58-101 year) ... Read more >>

Neurology (Neurology)
[2021, :]

Cited: 0 times

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Is OCT a Viable Tool to Monitor Disease-Modifying Treatments in RRMS Yet?

Ahmed T Toosy, Kush Kapur, Kavita V Nair,

Neurology (Neurology)
[2021, :]

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Stroke in Pregnancy and Puerperium: Validated Incidence Trends With Risk Factor Analysis in Finland 1987-2016.

Liisa Karjalainen, Minna Tikkanen, Kirsi Rantanen, Karoliina Aarnio, Aino Korhonen, Anna Saaros, Hannele Laivuori, Mika Gissler, Petra Ijäs,

<h4>Objective</h4>To investigate whether previously reported increasing incidence of pregnancy-associated stroke (PAS) is observed in chart-validated register data in Finland. In an exploratory analysis, we studied risk factors for PAS.<h4>Methods</h4>We performed a retrospective population-based cohort study and nested case-control study in Finland 1987-2016. The Medical Birth Register (MBR) was linked with ... Read more >>

Neurology (Neurology)
[2021, :]

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