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Journal Neurol Clin Pract

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Pediatric and adult neurologist perspectives on the challenges of sustaining a transfer clinic.

Tadeu A Fantaneanu, Claire S Jacobs, Claudio De Gusmao, Ann M Bergin, Tracey A Milligan, Phillip L Pearl, Barbara A Dworetzky,

We present a novel epilepsy fellow-driven transfer clinic model and discuss the challenges experienced in finding sustainability; this is timely as many pioneering transition clinics are dissolving across North America. The goal of this clinic was to improve patient care and satisfaction, as measured by a post-visit telephone survey. Unfortunately, ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):356-361]

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Disease severity and quality of life in homebound people with advanced Parkinson disease: A pilot study.

Jori E Fleisher, Meghan M Sweeney, Sarah Oyler, Talia Meisel, Naomi Friede, Alessandro Di Rocco, Joshua Chodosh,

Background:As Parkinson disease (PD) progresses, symptoms increase, quality of life (QoL) declines, and individuals may become homebound, often losing access to neurologic care. We aimed to determine whether facilitating expert in-home care could improve our understanding of disease progression, treatment options, and unmet needs in this vulnerable population, and whether ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):277-286]

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Optical coherence tomography-guided flow diversion for aneurysmal treatment.

Christopher R Pasarikovski, Leodante da Costa, Vitor M Pereira, Joel Ramjist, Yuta Dobashi, Victor X D Yang,

(Neurology. Clinical practice)
[2020, 10(4):e30-e32]

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Clinical utility of therapeutic drug monitoring of antiepileptic drugs: Systematic review.

Zanab Al-Roubaie, Elena Guadagno, Agnihotram V Ramanakumar, Afsheen Q Khan, Kenneth A Myers,

Objective:To systematically review and evaluate the available evidence supporting or refuting clinical use of therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) in patients with epilepsy. Methods:We searched MEDLINE, Embase, BIOSIS, Cochrane, PubMed, Africa-Wide Information, Web of Science, and grey literature. Randomized controlled studies and observational studies that compared the ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):344-355]

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Diagnostic experience reported by caregivers of patients with frontotemporal degeneration.

Lilah M Besser, James E Galvin,

Objective:To describe the experience of obtaining a diagnosis of frontotemporal degeneration (FTD) for patients and caregivers. Methods:Data came from a 2017 web-based survey of 698 FTD caregivers. Clinical characteristics and diagnostic experiences were described according to the phenotype of the patient with FTD (behavioral variant FTD, primary progressive aphasia, FTD ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):298-306]

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Trigeminal trophic syndrome: A possible dermatologic manifestation of stroke deficits.

Patrick Carr, Seth Martin, Jeanne Young, Nicole Chiota-McCollum,

(Neurology. Clinical practice)
[2020, 10(4):e27-e29]

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Deep brain stimulation for orthostatic tremor: A single-center case series.

Angela L Hewitt, Bryan T Klassen, Kendall H Lee, Jamie J Van Gompel, Anhar Hassan,

Background:Orthostatic tremor (OT) is a high-frequency weight-bearing tremor of the legs and trunk associated with progressive disability and is often refractory to medications. Case reports suggest that thalamic deep brain stimulation (DBS) is effective. We report 5 female patients with medication-refractory OT who underwent bilateral thalamic DBS at the Mayo ... Read more >>

(Neurology. Clinical practice)
[2020, 10(4):324-332]

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Life-threatening risk of using Kambó in alternative medicine.

María Florencia Alamos, Ruth H Walker, Marcelo Miranda,

(Neurology. Clinical practice)
[2020, 10(4):e35-e37]

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Practice Current: How do you manage mild cognitive impairment?

Aravind Ganesh, Padmaja Genesh, Malik M Adil, Malavika Varma, Eric E Smith,

Mild cognitive impairment (MCI) is characterized by evidence of cognitive impairment with minimal disruption of instrumental activities of daily living and carries a substantial risk of progression of dementia. Whereas current guidelines support a relatively minimalistic workup to identify reversible or structural causes, the field has witnessed the rapid development ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):362-370]

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Association between recent cannabinoid use and acute ischemic stroke.

Carmela V San Luis, Christa O'Hana S Nobleza, Shashank Shekhar, Rebecca Sugg, Darren J Villareal, Tapan Mehta, Shreyas Gangadhara,

Background:Studies that have analyzed the association between cannabis use and acute ischemic stroke (AIS) have provided conflicting results. In this study, we aim to determine the association of recent cannabis use detected through urine drug screen (UDS) among patients admitted with AIS. Methods:A retrospective observational study was performed using the ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):333-339]

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Ultrasound-guided lumbar puncture improves success rate and efficiency in overweight patients.

Yi Li, Raphael A Carandang, Swetha Ade, Julie Flahive, Kate Daniello,

Background:Approximately 400,000 diagnostic lumbar punctures (LPs) are performed by neurologists yearly in the United States. There has been a transition from neurologists performing >40% of LPs 2 decades ago to now <15% of the time. High body mass index (BMI) is one of the key obstacles of LP for neurology ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):307-313]

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Teriflunomide-exposed pregnancies in a French cohort of patients with multiple sclerosis.

Astrid Barataud-Reilhac, Sandrine Kerbrat, Jonathan Roux, Alice Guilleux, Elisabeth Polard, Emmanuelle Leray,

Objective:To describe pregnancies exposed to teriflunomide (TERIF) in women with multiple sclerosis (MS) in France over the period 2014-2016. Methods:All 15- to 49-year-old women with MS in the national health insurance database were included. Pregnancies that had started between August 2014 and March 2016 were identified from their outcomes. Three ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):287-297]

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Selective plasma exchange for multiple sclerosis with optic neuritis.

Masahiro Mimori, Takeo Sato, Shusaku Omoto, Kenichiro Sakai, Hidetaka Mitsumura, Yasuyuki Iguchi,

(Neurology. Clinical practice)
[2020, 10(4):e38-e40]

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Looking ahead: The risk of neurologic complications due to COVID-19.

Carlos A Pérez,

The rapid spread of Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a public health emergency of international concern. The outbreak was characterized as a pandemic by the World Health Organization (WHO) in March 2020. The most characteristic symptom of patients with COVID-19 is ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):371-374]

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Cervical spinal dural fistulas leading to remote thoracolumbar myelopathy: A diagnostic pitfall.

Mesha Martinez, Abderrahmane Hedjoudje, Carlos Pardo, Rafael J Tamargo, Philippe Gailloud,

Purpose of review:Spinal dural arteriovenous fistulas (SDAVFs) are abnormal connections between 1 or more radiculomeningeal arteries and a single radiculomedullary vein draining into the perimedullary venous system. SDAVFs present in older patients with a progressive myelopathy caused by diffuse spinal venous hypertension. The discrepancy between the focal nature of the ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):340-343]

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Cognitive outcomes following laser interstitial therapy for mesiotemporal epilepsies.

Christin I Bermudez, Walter J Jermakowicz, John Paul G Kolcun, Samir Sur, Iahn Cajigas, Carlos Millan, Ramses Ribot, Enrique A Serrano, Naymee Velez-Ruiz, Merredith R Lowe, Leticia Tornes, Maru Palomeque, Andres M Kanner, Jonathan R Jagid, Gustavo J Rey,

Objective:To provide a review of cognitive outcomes across a full neuropsychological profile in patients who underwent laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). Methods:We examined cognitive outcomes following LiTT for mTLE by reviewing a consecutive series of 26 patients who underwent dominant or nondominant hemisphere procedures. Each patient's ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(4):314-323]

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Can an epilepsy transfer clinic be sustained in the United States?

W Allen Hauser, Carol S Camfield, Peter R Camfield,

(Neurology. Clinical practice)
[2020, 10(4):274-276]

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Making public and patient involvement in clinical trials more than aspirational.

Holly E Hinson, Roy H Hamilton, David B Matchar,

(Neurology. Clinical practice)
[2020, 10(3):188-189]

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Late-onset ataxia plus syndromes: Extending the phenotype of senataxin-related disease.

Duncan Street, Mary O'Driscoll, Malcolm Taylor, David Nicholl,

(Neurology. Clinical practice)
[2020, 10(3):e22-e24]

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Technology-enabled assessments to enhance multiple sclerosis clinical care and research.

Gabrielle Macaron, Brandon P Moss, Hong Li, Laura E Baldassari, Stephen M Rao, David Schindler, Jay L Alberts, Malory Weber, Malissa Ayers, François Bethoux, Adrienne Boissy, Desiree Chizmadia, Devon S Conway, Charlene Fink, Robert J Fox, Shauna Gales, Bethany Green, Claire Hara-Cleaver, Neal Jordan, Kedar R Mahajan, Marisa P McGinley, Deborah M Miller, Marie Namey, Alexander Rae-Grant, Mary Rensel, Hilary Young, Mary A Willis, Daniel Ontaneda, Jeffrey A Cohen, Robert A Bermel,

Background:Comprehensive and efficient assessments are necessary for clinical care and research in chronic diseases. Our objective was to assess the implementation of a technology-enabled tool in MS practice. Method:We analyzed prospectively collected longitudinal data from routine multiple sclerosis (MS) visits between September 2015 and May 2018. The MS Performance Test, ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(3):222-231]

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Can and should neurologists screen their patients for depression? Yes, and….

John P Ney, Saty Satya-Murti,

(Neurology. Clinical practice)
[2020, 10(3):186-187]

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A case of co-occurrence of radiation-induced leukoencephalopathy and CADASIL.

Laura Donker Kaat, Jacqueline C F van der Wielen-Jongen, Mark C Kruit, Jacoline E C Bromberg, Frank Baas, Saskia A M J Lesnik Oberstein,

(Neurology. Clinical practice)
[2020, 10(3):e19-e21]

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Treatment and outcome of childhood cerebral sinovenous thrombosis.

Ryan J Felling, Sahar M A Hassanein, Jennifer Armstrong, Luis Aversa, Lori Billinghurst, Neil A Goldenberg, Jo Ellen Lee, Emily C Maxwell, Michael J Noetzel, Warren Lo,

Objective:To test our hypothesis that anticoagulation is associated with better neurologic outcomes in childhood cerebral sinovenous thrombosis (CSVT), we analyzed treatment and outcomes in a population of 410 children from the International Pediatric Stroke Study (IPSS). Methods:We included patients enrolled in the IPSS registry with a diagnosis of CSVT at ... Read more >>

Neurol Clin Pract (Neurology. Clinical practice)
[2020, 10(3):232-244]

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Achieving effective patient and public involvement in international clinical trials in neurology.

Emma C Tallantyre, Nikos Evangelou, Clare Bale, Burhan Z Chaudhry, Emma H Gray, Nicholas LaRocca, Sue Pavitt, Deborah M Miller, Sarah M Planchon, Daniel Ontaneda, Ana Manzano,

There is a growing need for patient and public involvement (PPI) to inform the way that research is developed and performed. International randomized controlled trials are particularly likely to benefit from PPI, but guidance is lacking on how or when it should be incorporated. In this article, we describe the ... Read more >>

(Neurology. Clinical practice)
[2020, 10(3):265-272]

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Quality improvement strategies improve pediatric neurology inpatient discharges before noon.

Padmavati Eksambe, Yash D Shah, Kanwaljit Singh, Joy Stennett, Emma Lauretta, Rose Marrie Sy-Kho, Joshua Kim, Catherine Ascher, Shefali Karkare, Sanjeev Kothare,

Background:Early hospital discharge is an important quality improvement (QI) measure that has not been well studied in pediatric neurology. The objective of our study was to implement strategies to improve hospital discharge times for patients admitted to the pediatric neurology service. Methods:This was a pilot QI study of hospital discharge ... Read more >>

(Neurology. Clinical practice)
[2020, 10(3):214-221]

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