Full Text Journal Articles in
Journal Neural Regen Res

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Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons.

Qian-Ru He, Meng Cong, Fan-Hui Yu, Yu-Hua Ji, Shu Yu, Hai-Yan Shi, Fei Ding,

Peripheral nerve fibroblasts play a critical role in nerve development and regeneration. Our previous study found that peripheral nerve fibroblasts have different sensory and motor phenotypes. Fibroblasts of different phenotypes can guide the migration of Schwann cells to the same sensory or motor phenotype. In this study, we analyzed the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1833-1840]

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Mice lacking perforin have improved regeneration of the injured femoral nerve.

Igor Jakovcevski, Monika von Düring, David Lutz, Maja Vulović, Mohammad Hamad, Gebhard Reiss, Eckart Förster, Melitta Schachner,

The role that the immune system plays after injury of the peripheral nervous system is still not completely understood. Perforin, a natural killer cell- and T-lymphocyte-derived enzyme that mediates cytotoxicity, plays important roles in autoimmune diseases, infections and central nervous system trauma, such as spinal cord injury. To dissect the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1802-1808]

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Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies.

Wei-Tao Yan, Yan-Di Yang, Xi-Min Hu, Wen-Ya Ning, Lyu-Shuang Liao, Shuang Lu, Wen-Juan Zhao, Qi Zhang, Kun Xiong,

Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome. This allows all the components of PANoptosis to be regulated simultaneously. PANoptosis provides a new way to study the regulation of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1761-1768]

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A novel approach in preventing vascular leakage and angiogenesis in wet age-related macular degeneration.

Kaori H Yamada,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1751-1752]

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High mobility group box protein 1 and white matter injury following traumatic brain injury: perspectives on mechanisms and therapeutic strategies.

Ronak Ved, Susruta Manivannan, Imogen Tasker, Malik Zaben,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1739-1740]

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Vascular inflammation in the central nervous system.

Xinying Guo, Zhen Zhao,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1728-1730]

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The brain as a source and a target of prolactin in mammals.

Ana R Costa-Brito, Isabel Gonçalves, Cecília R A Santos,

Prolactin is a polypeptide hormone associated with an extensive variety of biological functions. Among the roles of prolactin in vertebrates, some were preserved throughout evolution. This is the case of its function in the brain, where prolactin receptors, are expressed in different structures of the central nervous system. In the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1695-1702]

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Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases.

Fatemeh Zahedipour, Seyede Atefe Hosseini, Neil C Henney, George E Barreto, Amirhossein Sahebkar,

Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders. Tumor necrosis factor alpha has been reported to play a major role in the central nervous system in Alzheimer's disease, Parkinson's disease ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1675-1684]

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Motor neuron replacement therapy for amyotrophic lateral sclerosis.

Bochao Liu, Mo Li, Lingyan Zhang, Zhiguo Chen, Paul Lu,

Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig's disease in the United States, Charcot's disease in France, and motor neuron disease in the UK. The loss of motor neurons causes muscle wasting, paralysis, and eventually death, which is commonly related to respiratory ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1633-1639]

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Acupuncture enhances brain function in patients with mild cognitive impairment: evidence from a functional-near infrared spectroscopy study.

M N Afzal Khan, Usman Ghafoor, Ho-Ryong Yoo, Keum-Shik Hong,

Mild cognitive impairment (MCI) is a precursor to Alzheimer's disease. It is imperative to develop a proper treatment for this neurological disease in the aging society. This observational study investigated the effects of acupuncture therapy on MCI patients. Eleven healthy individuals and eleven MCI patients were recruited for this study. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1850-1856]

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Reducing host aldose reductase activity promotes neuronal differentiation of transplanted neural stem cells at spinal cord injury sites and facilitates locomotion recovery.

Kun Zhang, Wen-Can Lu, Ming Zhang, Qian Zhang, Pan-Pan Xian, Fang-Fang Liu, Zhi-Yang Chen, Chung Sookja Kim, Sheng-Xi Wu, Hui-Ren Tao, Ya-Zhou Wang,

Neural stem cell (NSC) transplantation is a promising strategy for replacing lost neurons following spinal cord injury. However, the survival and differentiation of transplanted NSCs is limited, possibly owing to the neurotoxic inflammatory microenvironment. Because of the important role of glucose metabolism in M1/M2 polarization of microglia/macrophages, we hypothesized that ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1814-1820]

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Essential role of MALAT1 in reducing traumatic brain injury.

Na Wu, Chong-Jie Cheng, Jian-Jun Zhong, Jun-Chi He, Zhao-Si Zhang, Zhi-Gang Wang, Xiao-Chuan Sun, Han Liu,

As a highly evolutionary conserved long non-coding RNA, metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was first demonstrated to be related to lung tumor metastasis by promoting angiogenesis. To investigate the role of MALAT1 in traumatic brain injury, we established mouse models of controlled cortical impact and cell models of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1776-1784]

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Ocular therapies for neuronal ceroid lipofuscinoses: more than meets the eye.

Samantha J Murray, Nadia L Mitchell,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1755-1756]

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Designing nanocarriers to overcome the limitations in conventional drug administration for Parkinson's disease.

Rafael A Garcia-Munoz, Joseph McConnell, Victoria Morales, Raul Sanz,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1743-1744]

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Elucidating the pathological mechanisms of neurodegeneration in the lethal serpinopathy FENIB.

Elena Miranda, Giovanna Galliciotti,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1733-1734]

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Myeloperoxidase: a new target for the treatment of stroke?

Yun-Chang Wang, Yu-Bao Lu, Xiao-Lan Huang, Yong-Feng Lao, Lu Zhang, Jun Yang, Mei Shi, Hai-Long Ma, Ya-Wen Pan, Yi-Nian Zhang,

Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke, including damage to the blood-brain barrier and brain. As a specific inflammatory marker, myeloperoxidase can be used in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1711-1716]

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Astrocyte in prion disease: a double-edged sword.

Waqas Tahir, Simrika Thapa, Hermann M Schatzl,

Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein (PrP<sup>C</sup>) into the pathologic isoform PrP<sup>Sc</sup>. Pathologic hallmarks of prion disease are depositions of pathological prion protein PrP<sup>Sc</sup>, neuronal loss, spongiform degeneration and astrogliosis in the brain. Prion diseases ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1659-1665]

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Estrogen rapid effects: a window of opportunity for the aging brain?

Ivanny Marchant, Jana Stojanova, Lilian Acevedo, Pablo Olivero,

Estrogen produces several beneficial effects in healthy neurological tissues and exhibits cardioprotective effects. Hormone therapy has been widely used to treat menopausal estrogen deficiency for more than 80 years. Despite high initial expectations of cardioprotective effects, there has been substantial distrust following important randomized clinical trials, such as the Women's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1629-1632]

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Effects of targeted muscle reinnervation on spinal cord motor neurons in rats following tibial nerve transection.

Wei Lu, Jian-Ping Li, Zhen-Dong Jiang, Lin Yang, Xue-Zheng Liu,

Targeted muscle reinnervation (TMR) is a surgical procedure used to transfer residual peripheral nerves from amputated limbs to targeted muscles, which allows the target muscles to become sources of motor control information for function reconstruction. However, the effect of TMR on injured motor neurons is still unclear. In this study, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1827-1832]

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Oxidized low-density lipoprotein receptor 1: a novel potential therapeutic target for intracerebral hemorrhage.

Hui-Yuan Zhang, Xi Lu, Yue-Han Hao, Ling Tang, Zhi-Yi He,

Oxidized low-density lipoprotein receptor 1 (OLR1) is upregulated in neurons and participates in hypertension-induced neuronal apoptosis. OLR1 deletion exerts protective effects on cerebral damage induced by hypertensive-induced stroke. Therefore, OLR1 is likely involved in the progress of intracerebral hemorrhage. In this study, we examined the potential role of OLR1 in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1795-1801]

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Melatonin, circadian rhythms and glaucoma: current perspective.

Denis Gubin, Dietmar Weinert,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1759-1760]

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Flow cytometry and stroke: from current methodology to future applications.

Sylvie Amu, Kyle Malone,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1748-1750]

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The second brain in Parkinson's disease: fact or fantasy?

Nehal Yemula, Paul Njoku, Joseph Takyi,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1737-1738]

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Monodelphis domestica: a new source of mammalian primary neurons in vitro.

Jelena Ban, Miranda Mladinic,

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1726-1727]

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Construction and imaging of a neurovascular unit model.

Taiwei Dong, Min Li, Feng Gao, Peifeng Wei, Jian Wang,

In 2001, the concept of the neurovascular unit was introduced at the Stroke Progress Review Group meeting. The neurovascular unit is an important element of the health and disease status of blood vessels and nerves in the central nervous system. Since then, the neurovascular unit has attracted increasing interest from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(8):1685-1694]

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