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Journal Nat. Chem. Biol.

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Three's company.

Caitlin Deane,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1037]

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Uncovering nature's electronics.

Thomas A Clarke, Marcus J Edwards,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1041-1042]

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Toward spatially resolved metabolomics.

Bennett W Fox, Frank C Schroeder,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1039-1040]

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Made fresh in-house.

Yiyun Song,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1037]

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Importin pain relief.

Mirella Bucci,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1037]

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Shifting the balance.

Grant Miura,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(10):1037]

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Designer adhesion GPCR tells its signaling story.

Eugenia V Gurevich, Vsevolod V Gurevich,

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.

Xiaofeng Qi, Lucas Friedberg, Ryan De Bose-Boyd, Tao Long, Xiaochun Li,

Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine-rich domain (CRD) and to several sites in the seven transmembrane helices (7-TMs) of SMO. However, the mechanism by which sterols regulate SMO via multiple sites ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Optogenetic control of the lac operon for bacterial chemical and protein production.

Makoto A Lalwani, Samantha S Ip, César Carrasco-López, Catherine Day, Evan M Zhao, Hinako Kawabe, José L Avalos,

Control of the lac operon with isopropyl β-D-1-thiogalactopyranoside (IPTG) has been used to regulate gene expression in Escherichia coli for countless applications, including metabolic engineering and recombinant protein production. However, optogenetics offers unique capabilities, such as easy tunability, reversibility, dynamic induction strength and spatial control, that are difficult to obtain ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Covalent inhibition of NSD1 histone methyltransferase.

Huang Huang, Christina A Howard, Sergei Zari, Hyo Je Cho, Shirish Shukla, Hao Li, Juliano Ndoj, Paula González-Alonso, Caroline Nikolaidis, Joshua Abbott, David S Rogawski, Mykhaylo A Potopnyk, Katarzyna Kempinska, Hongzhi Miao, Trupta Purohit, Andrew Henderson, Anna Mapp, Maria Luisa Sulis, Adolfo Ferrando, Jolanta Grembecka, Tomasz Cierpicki,

The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their catalytic SET domains exist in autoinhibited conformation, presenting notable challenges for inhibitor development. Here, we employed a fragment-based screening strategy ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Peaking at the right time.

Grant Miura,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):933]

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Author Correction: The bottromycin epimerase BotH defines a group of atypical α/β-hydrolase-fold enzymes.

Asfandyar Sikandar, Laura Franz, Sebastian Adam, Javier Santos-Aberturas, Liliya Horbal, Andriy Luzhetskyy, Andrew W Truman, Olga V Kalinina, Jesko Koehnke,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):1034]

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Repair switches.

Yiyun Song,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):933]

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Living cells as test tubes.

Roshan Mammen Regy, Jeetain Mittal,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):934-935]

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Histones do double duty.

Caitlin Deane,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):933]

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Expanding the membrane-protein NMR toolkit.

Ricky C Cheng, Merritt Maduke,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):937-938]

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Modulating the microbiota.

Mirella Bucci,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):933]

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Channeling a complex question.

Martin St Maurice,

Nat. Chem. Biol. (Nature chemical biology)
[2020, 16(9):935-937]

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Bariatric surgery works through a novel bile acid.

Bethany P Cummings,

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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A bio-inspired cell-free system for cannabinoid production from inexpensive inputs.

Meaghan A Valliere, Tyler P Korman, Mark A Arbing, James U Bowie,

Moving cannabinoid production away from the vagaries of plant extraction and into engineered microbes could provide a consistent, purer, cheaper and environmentally benign source of these important therapeutic molecules, but microbial production faces notable challenges. An alternative to microbes and plants is to remove the complexity of cellular systems by ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Permissive epigenomes endow reprogramming competence to transcriptional regulators.

Kee-Pyo Kim, Jinmi Choi, Juyong Yoon, Jan M Bruder, Borami Shin, Jonghun Kim, Marcos J Arauzo-Bravo, Dong Han, Guangming Wu, Dong Wook Han, Johnny Kim, Patrick Cramer, Hans R Schöler,

Identifying molecular and cellular processes that regulate reprogramming competence of transcription factors broadens our understanding of reprogramming mechanisms. In the present study, by a chemical screen targeting major epigenetic pathways in human reprogramming, we discovered that inhibiting specific epigenetic roadblocks including disruptor of telomeric silencing 1-like (DOT1L)-mediated H3K79/K27 methylation, but ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Targeted glycan degradation potentiates the anticancer immune response in vivo.

Melissa A Gray, Michal A Stanczak, Natália R Mantuano, Han Xiao, Johan F A Pijnenborg, Stacy A Malaker, Caitlyn L Miller, Payton A Weidenbacher, Julia T Tanzo, Green Ahn, Elliot C Woods, Heinz Läubli, Carolyn R Bertozzi,

Currently approved immune checkpoint inhibitor therapies targeting the PD-1 and CTLA-4 receptor pathways are powerful treatment options for certain cancers; however, most patients across cancer types still fail to respond. Consequently, there is interest in discovering and blocking alternative pathways that mediate immune suppression. One such mechanism is an upregulation ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Overcoming epigenetic roadblocks.

Maximilian W D Raas, Dick W Zijlmans, Hendrik Marks,

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Targeted self-destruction.

Emily Rodrigues, Matthew S Macauley,

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.

Mariluz Soula, Ross A Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Frederick Yen, Henrik Molina, Javier Garcia-Bermudez, Derek A Pratt, Kıvanç Birsoy,

Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes that modulate the response to lipid peroxidation are poorly defined. Using genetic screens, we compared metabolic genes essential for proliferation upon inhibition of cystine uptake or glutathione peroxidase-4 (GPX4). ... Read more >>

Nat. Chem. Biol. (Nature chemical biology)
[2020, :]

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