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Understanding COVID-19 vaccine hesitancy.

Shingai Machingaidze, Charles Shey Wiysonge,

Nat Med (Nature medicine)
[2021, :]

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An implant to treat cluster headaches.

Karen O'Leary,

Nat Med (Nature medicine)
[2021, :]

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A new treatment combination for liver cancer.

Karen O'Leary,

Nat Med (Nature medicine)
[2021, :]

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Alcohol consumption and cancer.

Karen O'Leary,

Nat Med (Nature medicine)
[2021, :]

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mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar.

Hiam Chemaitelly, Hadi M Yassine, Fatiha M Benslimane, Hebah A Al Khatib, Patrick Tang, Mohammad R Hasan, Joel A Malek, Peter Coyle, Houssein H Ayoub, Zaina Al Kanaani, Einas Al Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F Abdul Rahim, Gheyath K Nasrallah, Mohamed Ghaith Al Kuwari, Hamad Eid Al Romaihi, Mohamed H Al-Thani, Abdullatif Al Khal, Adeel A Butt, Roberto Bertollini, Laith J Abu-Raddad,

The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with 'wild-type' variants in a randomized clinical trial. Here, we assess the real-world effectiveness of this vaccine against SARS-CoV-2 variants of ... Read more >>

Nat Med (Nature medicine)
[2021, :]

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100 years of insulin: celebrating the past, present and future of diabetes therapy.

Emily K Sims, Alice L J Carr, Richard A Oram, Linda A DiMeglio, Carmella Evans-Molina,

The year 2021 marks the centennial of Banting and Best's landmark description of the discovery of insulin. This discovery and insulin's rapid clinical deployment effectively transformed type 1 diabetes from a fatal diagnosis into a medically manageable chronic condition. In this Review, we describe key accomplishments leading to and building ... Read more >>

Nat Med (Nature medicine)
[2021, 27(7):1154-1164]

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Another COVID-19 vaccine to boost rollout.

Karen O'Leary,

Nat Med (Nature medicine)
[2021, :]

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Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.

Ryunosuke Saiki, Yukihide Momozawa, Yasuhito Nannya, Masahiro M Nakagawa, Yotaro Ochi, Tetsuichi Yoshizato, Chikashi Terao, Yutaka Kuroda, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Atsushi Niida, Seiya Imoto, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Shuichi Matsuda, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa,

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based ... Read more >>

Nat Med (Nature medicine)
[2021, 27(7):1239-1249]

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Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.

Nicholas A Vitanza, Adam J Johnson, Ashley L Wilson, Christopher Brown, Jason K Yokoyama, Annette Künkele, Cindy A Chang, Stephanie Rawlings-Rhea, Wenjun Huang, Kristy Seidel, Catherine M Albert, Navin Pinto, Juliane Gust, Laura S Finn, Jeffrey G Ojemann, Jason Wright, Rimas J Orentas, Michael Baldwin, Rebecca A Gardner, Michael C Jensen, Julie R Park,

Locoregional delivery of chimeric antigen receptor (CAR) T cells has resulted in objective responses in adults with glioblastoma, but the feasibility and tolerability of this approach is yet to be evaluated for pediatric central nervous system (CNS) tumors. Here we show that engineering of a medium-length CAR spacer enhances the ... Read more >>

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[2021, :]

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Publisher Correction: A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.

Yuanmeng Jin, Krishna Ratnam, Peter Y Chuang, Ying Fan, Yifei Zhong, Yan Dai, Amin R Mazloom, Edward Y Chen, Vivette D'Agati, Huabao Xiong, Michael J Ross, Nan Chen, Avi Ma'ayan, John Cijiang He,

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[2021, :]

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A French cohort for assessing COVID-19 vaccine responses in specific populations.

Paul Loubet, Linda Wittkop, Eric Tartour, Beatrice Parfait, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Marie Lachâtre, David-Axel Laplaud, Martine Laville, Bruno Laviolle, Jean-Daniel Lelievre, Jacques Morel, Stéphanie Nguyen, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, François Vrtovsnik, Xavier de Lamballerie, Odile Launay,

Nat Med (Nature medicine)
[2021, :]

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Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota.

Thomas Vogl, Shelley Klompus, Sigal Leviatan, Iris N Kalka, Adina Weinberger, Cisca Wijmenga, Jingyuan Fu, Alexandra Zhernakova, Rinse K Weersma, Eran Segal,

Serum antibodies can recognize both pathogens and commensal gut microbiota. However, our current understanding of antibody repertoires is largely based on DNA sequencing of the corresponding B-cell receptor genes, and actual bacterial antigen targets remain incompletely characterized. Here we have profiled the serum antibody responses of 997 healthy individuals against ... Read more >>

Nat Med (Nature medicine)
[2021, :]

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A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.

Lu Wang, David Sievert, Alex E Clark, Sangmoon Lee, Hannah Federman, Benjamin D Gastfriend, Eric V Shusta, Sean P Palecek, Aaron F Carlin, Joseph G Gleeson,

Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Here we show that pericyte-like cells (PLCs), when integrated into a cortical organoid, are ... Read more >>

Nat Med (Nature medicine)
[2021, :]

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COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries.

Julio S Solís Arce, Shana S Warren, Niccolò F Meriggi, Alexandra Scacco, Nina McMurry, Maarten Voors, Georgiy Syunyaev, Amyn Abdul Malik, Samya Aboutajdine, Opeyemi Adeojo, Deborah Anigo, Alex Armand, Saher Asad, Martin Atyera, Britta Augsburg, Manisha Awasthi, Gloria Eden Ayesiga, Antonella Bancalari, Martina Björkman Nyqvist, Ekaterina Borisova, Constantin Manuel Bosancianu, Magarita Rosa Cabra García, Ali Cheema, Elliott Collins, Filippo Cuccaro, Ahsan Zia Farooqi, Tatheer Fatima, Mattia Fracchia, Mery Len Galindo Soria, Andrea Guariso, Ali Hasanain, Sofía Jaramillo, Sellu Kallon, Anthony Kamwesigye, Arjun Kharel, Sarah Kreps, Madison Levine, Rebecca Littman, Mohammad Malik, Gisele Manirabaruta, Jean Léodomir Habarimana Mfura, Fatoma Momoh, Alberto Mucauque, Imamo Mussa, Jean Aime Nsabimana, Isaac Obara, María Juliana Otálora, Béchir Wendemi Ouédraogo, Touba Bakary Pare, Melina R Platas, Laura Polanco, Javaeria Ashraf Qureshi, Mariam Raheem, Vasudha Ramakrishna, Ismail Rendrá, Taimur Shah, Sarene Eyla Shaked, Jacob N Shapiro, Jakob Svensson, Ahsan Tariq, Achille Mignondo Tchibozo, Hamid Ali Tiwana, Bhartendu Trivedi, Corey Vernot, Pedro C Vicente, Laurin B Weissinger, Basit Zafar, Baobao Zhang, Dean Karlan, Michael Callen, Matthieu Teachout, Macartan Humphreys, Ahmed Mushfiq Mobarak, Saad B Omer,

Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) ... Read more >>

Nat Med (Nature medicine)
[2021, :]

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Asian healthcare workers in the COVID-19 pandemic: a long road to recovery.

Jo-Hsuan Wu,

Nat Med (Nature medicine)
[2021, 27(7):1135]

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Author Correction: Dysregulated ribonucleoprotein granules promote cardiomyopathy in RBM20 gene-edited pigs.

Jay W Schneider, Saji Oommen, Muhammad Y Qureshi, Sean C Goetsch, David R Pease, Rhianna S Sundsbak, Wei Guo, Mingming Sun, Han Sun, Hidehito Kuroyanagi, Dennis A Webster, Alexander W Coutts, Kimberly A Holst, Brooks S Edwards, Nikolas Newville, Matthew A Hathcock, Tamene Melkamu, Francesca Briganti, Wu Wei, Maria G Romanelli, Scott C Fahrenkrug, Doug E Frantz, Timothy M Olson, Lars M Steinmetz, Daniel F Carlson, Timothy J Nelson, ,

Nat Med (Nature medicine)
[2021, 27(7):1309]

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Author Correction: Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson-Gilford progeria syndrome.

Madaiah Puttaraju, Michaela Jackson, Stephanie Klein, Asaf Shilo, C Frank Bennett, Leslie Gordon, Frank Rigo, Tom Misteli,

Nat Med (Nature medicine)
[2021, 27(7):1309]

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SARS-CoV-2 variants of concern are emerging in India.

Jasdeep Singh, Syed Asad Rahman, Nasreen Z Ehtesham, Subhash Hira, Seyed E Hasnain,

Nat Med (Nature medicine)
[2021, 27(7):1131-1133]

Cited: 2 times

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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer.

Paula Voabil, Marjolein de Bruijn, Lisanne M Roelofsen, Sanne H Hendriks, Simone Brokamp, Marlous van den Braber, Annegien Broeks, Joyce Sanders, Petra Herzig, Alfred Zippelius, Christian U Blank, Koen J Hartemink, Kim Monkhorst, John B A G Haanen, Ton N Schumacher, Daniela S Thommen,

Inhibitors of the PD-1-PD-L1 axis have been approved as therapy for many human cancers. In spite of the evidence for their widespread clinical activity, little is known about the immunological alterations that occur in human cancer tissue after PD-1 blockade. We developed and employed a patient-derived tumor fragment platform to ... Read more >>

Nat Med (Nature medicine)
[2021, 27(7):1250-1261]

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Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease.

Benjamin M Scott, Cristina Gutiérrez-Vázquez, Liliana M Sanmarco, Jessica A da Silva Pereira, Zhaorong Li, Agustín Plasencia, Patrick Hewson, Laura M Cox, Madelynn O'Brien, Steven K Chen, Pedro M Moraes-Vieira, Belinda S W Chang, Sergio G Peisajovich, Francisco J Quintana,

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intestinal inflammation and pathology. Based on the role of eATP in intestinal inflammation, we developed yeast-based engineered probiotics that express ... Read more >>

Nat Med (Nature medicine)
[2021, 27(7):1212-1222]

Cited: 2 times

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Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination.

Joana Barros-Martins, Swantje I Hammerschmidt, Anne Cossmann, Ivan Odak, Metodi V Stankov, Gema Morillas Ramos, Alexandra Dopfer-Jablonka, Annika Heidemann, Christiane Ritter, Michaela Friedrichsen, Christian Schultze-Florey, Inga Ravens, Stefanie Willenzon, Anja Bubke, Jasmin Ristenpart, Anika Janssen, George Ssebyatika, Günter Bernhardt, Jan Münch, Markus Hoffmann, Stefan Pöhlmann, Thomas Krey, Berislav Bošnjak, Reinhold Förster, Georg M N Behrens,

Currently approved viral vector-based and mRNA-based vaccine approaches against coronavirus disease 2019 (COVID-19) consider only homologous prime-boost vaccination. After reports of thromboembolic events, several European governments recommended using AstraZeneca's ChAdOx1-nCov-19 (ChAd) only in individuals older than 60 years, leaving millions of already ChAd-primed individuals with the decision to receive either ... Read more >>

Nat Med (Nature medicine)
[2021, :]

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Giving voice to Black women in science and medicine.

Eseosa T Ighodaro, Erica L Littlejohn, Adesuwa I Akhetuamhen, Richard Benson,

Nat Med (Nature medicine)
[2021, :]

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Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.

C S Pramesh, Giridhara R Babu, Joyeeta Basu, Indu Bhushan, Christopher M Booth, Girish Chinnaswamy, Randeep Guleria, S P Kalantri, Gagandeep Kang, Pavitra Mohan, Nachiket Mor, Madhukar Pai, Manu Prakash, Priscilla Rupali, Priya Sampathkumar, Manju Sengar, Richard Sullivan, Priya Ranganathan,

Nat Med (Nature medicine)
[2021, :]

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Emergence of measles during the COVID-19 pandemic threatens Pakistan's children and the wider region.

Muhammad Suleman Rana, Muhammad Masroor Alam, Aamer Ikram, Muhammad Salman, Mohammad Osama Mere, Muhammad Usman, Massab Umair, Syed Sohail Zahoor Zaidi, Yasir Arshad,

Nat Med (Nature medicine)
[2021, 27(7):1127-1128]

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Fine-scale genetic ancestry as a potential new tool for precision medicine.

Nicholas P Tatonetti, Noémie Elhadad,

Nat Med (Nature medicine)
[2021, 27(7):1152-1153]

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