Full Text Journal Articles in
Journal Nat Commun

Advertisement

Find full text journal articles






Initiating polyketide biosynthesis by on-line methyl esterification.

Pengwei Li, Meng Chen, Wei Tang, Zhengyan Guo, Yuwei Zhang, Min Wang, Geoff P Horsman, Jin Zhong, Zhaoxin Lu, Yihua Chen,

Aurantinins (ARTs) are antibacterial polyketides featuring a unique 6/7/8/5-fused tetracyclic ring system and a triene side chain with a carboxyl terminus. Here we identify the art gene cluster and dissect ART's C-methyl incorporation patterns to study its biosynthesis. During this process, an apparently redundant methyltransferase Art28 was characterized as a ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4499]

Cited: 0 times

View full text PDF listing >>



Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells.

Mi-Ok Lee, Su-Gi Lee, Cho-Rok Jung, Ye Seul Son, Jae-Woon Ryu, Kwang Bo Jung, Jun-Ho Ahn, Jung-Hwa Oh, Hyang-Ae Lee, Jung Hwa Lim, Janghwan Kim, Insu Jang, Jinhyuk Choi, Jaeeun Jung, Kunhyang Park, Byungwook Lee, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho,

Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models in drug development and regenerative medicine. For a simple and reproducible analysis of the quality ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4492]

Cited: 0 times

View full text PDF listing >>



Advertisement

Mechanistic insight into bacterial entrapment by septin cage reconstitution.

Damián Lobato-Márquez, Jingwei Xu, Gizem Özbaykal Güler, Adaobi Ojiakor, Martin Pilhofer, Serge Mostowy,

Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes and sense micron-scale membrane curvature. During infection with Shigella flexneri, an invasive enteropathogen, septins restrict actin tail formation by entrapping bacteria in cage-like structures. Here, we reconstitute septin cages in vitro using purified recombinant septin complexes (SEPT2-SEPT6-SEPT7), and study how these ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4511]

Cited: 0 times

View full text PDF listing >>



Rapid discovery of self-assembling peptides with one-bead one-compound peptide library.

Pei-Pei Yang, Yi-Jing Li, Yan Cao, Lu Zhang, Jia-Qi Wang, Ziwei Lai, Kuo Zhang, Diedra Shorty, Wenwu Xiao, Hui Cao, Lei Wang, Hao Wang, Ruiwu Liu, Kit S Lam,

Self-assembling peptides have shown tremendous potential in the fields of material sciences, nanoscience, and medicine. Because of the vast combinatorial space of even short peptides, identification of self-assembling sequences remains a challenge. Herein, we develop an experimental method to rapidly screen a huge array of peptide sequences for self-assembling property, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4494]

Cited: 0 times

View full text PDF listing >>



Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores.

Ganna Leonenko, Emily Baker, Joshua Stevenson-Hoare, Annerieke Sierksma, Mark Fiers, Julie Williams, Bart de Strooper, Valentina Escott-Price,

Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4506]

Cited: 0 times

View full text PDF listing >>



Heterogeneity-stabilized homogeneous states in driven media.

Zachary G Nicolaou, Daniel J Case, Ernest B van der Wee, Michelle M Driscoll, Adilson E Motter,

Understanding the relationship between symmetry breaking, system properties, and instabilities has been a problem of longstanding scientific interest. Symmetry-breaking instabilities underlie the formation of important patterns in driven systems, but there are many instances in which such instabilities are undesirable. Using parametric resonance as a model process, here we show that ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4486]

Cited: 0 times

View full text PDF listing >>



Quantum gravitational decoherence from fluctuating minimal length and deformation parameter at the Planck scale.

Luciano Petruzziello, Fabrizio Illuminati,

Schemes of gravitationally induced decoherence are being actively investigated as possible mechanisms for the quantum-to-classical transition. Here, we introduce a decoherence process due to quantum gravity effects. We assume a foamy quantum spacetime with a fluctuating minimal length coinciding on average with the Planck scale. Considering deformed canonical commutation relations ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4449]

Cited: 0 times

View full text PDF listing >>



Harmful R-loops are prevented via different cell cycle-specific mechanisms.

Marta San Martin-Alonso, María E Soler-Oliva, María García-Rubio, Tatiana García-Muse, Andrés Aguilera,

Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase, whereas the Sen1 DNA-RNA helicase prevents them only in S-phase. Interestingly, damage accumulates asymmetrically downstream ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4451]

Cited: 0 times

View full text PDF listing >>



Ternary aromatic and anti-aromatic clusters derived from the hypho species [Sn2Sb5]3.

Yu-He Xu, Nikolay V Tkachenko, Ivan A Popov, Lei Qiao, Alvaro Muñoz-Castro, Alexander I Boldyrev, Zhong-Ming Sun,

Heterometallic clusters have attracted broad interests in the synthetic chemistry due to their various coordination modes and potential applications in heterogeneous catalysis. Here we report the synthesis, experimental, and theoretical characterizations of four ternary clusters ([M<sub>2</sub>(CO)<sub>6</sub>Sn<sub>2</sub>Sb<sub>5</sub>]<sup>3-</sup> (M = Cr, Mo), and [(MSn<sub>2</sub>Sb<sub>5</sub>)<sub>2</sub>]<sup>4-</sup>, (M = Cu, Ag)) in the process of ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4465]

Cited: 0 times

View full text PDF listing >>



Massive carbon storage in convergent margins initiated by subduction of limestone.

Chunfei Chen, Michael W Förster, Stephen F Foley, Yongsheng Liu,

Remobilization of sedimentary carbonate in subduction zones modulates arc volcanism emissions and thus Earth's climate over geological timescales. Although limestones (or chalk) are thought to be the major carbon reservoir subducted to subarc depths, their fate is still unclear. Here we present high-pressure reaction experiments between impure limestone (7.4 wt.% ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4463]

Cited: 0 times

View full text PDF listing >>



Quantifying the contribution of Neanderthal introgression to the heritability of complex traits.

Evonne McArthur, David C Rinker, John A Capra,

Eurasians have ~2% Neanderthal ancestry, but we lack a comprehensive understanding of the genome-wide influence of Neanderthal introgression on modern human diseases and traits. Here, we quantify the contribution of introgressed alleles to the heritability of more than 400 diverse traits. We show that genomic regions in which detectable Neanderthal ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4481]

Cited: 0 times

View full text PDF listing >>



Neonatal thyroxine activation modifies epigenetic programming of the liver.

Tatiana L Fonseca, Tzintzuni Garcia, Gustavo W Fernandes, T Murlidharan Nair, Antonio C Bianco,

The type 2 deiodinase (D2) in the neonatal liver accelerates local thyroid hormone triiodothyronine (T3) production and expression of T3-responsive genes. Here we show that this surge in T3 permanently modifies hepatic gene expression. Liver-specific Dio2 inactivation (Alb-D2KO) transiently increases H3K9me3 levels during post-natal days 1-5 (P1-P5), and results in ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4446]

Cited: 0 times

View full text PDF listing >>



Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.

Timo W M De Groof, Elizabeth G Elder, Eleanor Y Lim, Raimond Heukers, Nick D Bergkamp, Ian J Groves, Mark Wills, John H Sinclair, Martine J Smit,

Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in immunosuppressed solid organ and stem cell transplant patients often results in morbidity. Here, we report the killing of latently infected cells via ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4436]

Cited: 0 times

View full text PDF listing >>



Kinetically driven successive sodic and potassic alteration of feldspar.

Gan Duan, Rahul Ram, Yanlu Xing, Barbara Etschmann, Joël Brugger,

The dynamic evolutions of fluid-mineral systems driving large-scale geochemical transformations in the Earth's crust remain poorly understood. We observed experimentally that successive sodic and potassic alterations of feldspar can occur via a single self-evolved, originally Na-only, hydrothermal fluid. At 600 °C, 2 kbar, sanidine ((K<sub>,</sub>Na)AlSi<sub>3</sub>O<sub>8</sub>) reacted rapidly with a NaCl fluid to ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4435]

Cited: 0 times

View full text PDF listing >>



Small RNA mediated gradual control of lipopolysaccharide biosynthesis affects antibiotic resistance in Helicobacter pylori.

Sandy R Pernitzsch, Mona Alzheimer, Belinda U Bremer, Marie Robbe-Saule, Hilde De Reuse, Cynthia M Sharma,

The small, regulatory RNA RepG (Regulator of polymeric G-repeats) regulates the expression of the chemotaxis receptor TlpB in Helicobacter pylori by targeting a variable G-repeat in the tlpB mRNA leader. Here, we show that RepG additionally controls lipopolysaccharide (LPS) phase variation by also modulating the expression of a gene (hp0102) ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4433]

Cited: 0 times

View full text PDF listing >>



Experimental observation of topological Z2 exciton-polaritons in transition metal dichalcogenide monolayers.

Mengyao Li, Ivan Sinev, Fedor Benimetskiy, Tatyana Ivanova, Ekaterina Khestanova, Svetlana Kiriushechkina, Anton Vakulenko, Sriram Guddala, Maurice Skolnick, Vinod M Menon, Dmitry Krizhanovskii, Andrea Alù, Anton Samusev, Alexander B Khanikaev,

The rise of quantum science and technologies motivates photonics research to seek new platforms with strong light-matter interactions to facilitate quantum behaviors at moderate light intensities. Topological polaritons (TPs) offer an ideal platform in this context, with unique properties stemming from resilient topological states of light strongly coupled with matter. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4425]

Cited: 0 times

View full text PDF listing >>



Single-atom Pt-I3 sites on all-inorganic Cs2SnI6 perovskite for efficient photocatalytic hydrogen production.

Peng Zhou, Hui Chen, Yuguang Chao, Qinghua Zhang, Weiyu Zhang, Fan Lv, Lin Gu, Qiang Zhao, Ning Wang, Jinshu Wang, Shaojun Guo,

Organic-inorganic lead halide perovskites are a new class of semiconductor materials with great potential in photocatalytic hydrogen production, however, their development is greatly plagued by their low photocatalytic activity, instability of organic component and lead toxicity in particular. Herein, we report an anti-dissolution environmentally friendly Cs<sub>2</sub>SnI<sub>6</sub> perovskite anchored with a ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4412]

Cited: 0 times

View full text PDF listing >>



Contextualizing genetic risk score for disease screening and rare variant discovery.

Dan Zhou, Dongmei Yu, Jeremiah M Scharf, Carol A Mathews, Lauren McGrath, Edwin Cook, S Hong Lee, Lea K Davis, Eric R Gamazon,

Studies of the genetic basis of complex traits have demonstrated a substantial role for common, small-effect variant polygenic burden (PB) as well as large-effect variants (LEV, primarily rare). We identify sufficient conditions in which GWAS-derived PB may be used for well-powered rare pathogenic variant discovery or as a sample prioritization ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4418]

Cited: 0 times

View full text PDF listing >>



Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin.

Tracy Tabib, Mengqi Huang, Nina Morse, Anna Papazoglou, Rithika Behera, Minxue Jia, Melissa Bulik, Daisy E Monier, Panayiotis V Benos, Wei Chen, Robyn Domsic, Robert Lafyatis,

Skin and lung fibrosis in systemic sclerosis (SSc) is driven by myofibroblasts, alpha-smooth muscle actin expressing cells. The number of myofibroblasts in SSc skin correlates with the modified Rodnan skin score, the most widely used clinical measure of skin disease severity. Murine fibrosis models indicate that myofibroblasts can arise from ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4384]

Cited: 0 times

View full text PDF listing >>



A deep learning model for predicting next-generation sequencing depth from DNA sequence.

Jinny X Zhang, Boyan Yordanov, Alexander Gaunt, Michael X Wang, Peng Dai, Yuan-Jyue Chen, Kerou Zhang, John Z Fang, Neil Dalchau, Jiaming Li, Andrew Phillips, David Yu Zhang,

Targeted high-throughput DNA sequencing is a primary approach for genomics and molecular diagnostics, and more recently as a readout for DNA information storage. Oligonucleotide probes used to enrich gene loci of interest have different hybridization kinetics, resulting in non-uniform coverage that increases sequencing costs and decreases sequencing sensitivities. Here, we ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4387]

Cited: 0 times

View full text PDF listing >>



The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo.

Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao, Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias,

Poised enhancers (PEs) represent a genetically distinct set of distal regulatory elements that control the expression of major developmental genes. Before becoming activated in differentiating cells, PEs are already bookmarked in pluripotent cells with unique chromatin and topological features that could contribute to their privileged regulatory properties. However, since PEs ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4344]

Cited: 0 times

View full text PDF listing >>



Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage.

Xiao Wu, Bin Wang,

Although homologous recombination (HR) is indicated as a high-fidelity repair mechanism, break-induced replication (BIR), a subtype of HR, is a mutagenic mechanism that leads to chromosome rearrangements. It remains poorly understood how cells suppress mutagenic BIR. Trapping of Topoisomerase 1 by camptothecin (CPT) in a cleavage complex on the DNA ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4373]

Cited: 0 times

View full text PDF listing >>



Understanding potential-dependent competition between electrocatalytic dinitrogen and proton reduction reactions.

Changhyeok Choi, Geun Ho Gu, Juhwan Noh, Hyun S Park, Yousung Jung,

A key challenge to realizing practical electrochemical N<sub>2</sub> reduction reaction (NRR) is the decrease in the NRR activity before reaching the mass-transfer limit as overpotential increases. While the hydrogen evolution reaction (HER) has been suggested to be responsible for this phenomenon, the mechanistic origin has not been clearly explained. Herein, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4353]

Cited: 0 times

View full text PDF listing >>



Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.

Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng,

Metabolic programming and mitochondrial dynamics along with T cell differentiation affect T cell fate and memory development; however, how to control metabolic reprogramming and mitochondrial dynamics in T cell memory development is unclear. Here, we provide evidence that the SUMO protease SENP1 promotes T cell memory development via Sirt3 deSUMOylation. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4371]

Cited: 0 times

View full text PDF listing >>



Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles.

Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang, Depeng Zhao,

Nitrogen heterocycle represents a ubiquitous skeleton in natural products and drugs. Late-stage C(sp<sup>3</sup>)-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern chemical synthesis and pharmaceutical chemistry. Here, we demonstrate copper-catalysed late-stage C(sp<sup>3</sup>)-H functionalizaion of N-heterocycles using commercially available catalysts under mild ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):4342]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9187 s