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Adsorption separation of heavier isotope gases in subnanometer carbon pores.

Sanjeev Kumar Ujjain, Abhishek Bagusetty, Yuki Matsuda, Hideki Tanaka, Preety Ahuja, Carla de Tomas, Motomu Sakai, Fernando Vallejos-Burgos, Ryusuke Futamura, Irene Suarez-Martinez, Masahiko Matsukata, Akio Kodama, Giovanni Garberoglio, Yury Gogotsi, J Karl Johnson, Katsumi Kaneko,

Isotopes of heavier gases including carbon (<sup>13</sup>C/<sup>14</sup>C), nitrogen (<sup>13</sup>N), and oxygen (<sup>18</sup>O) are highly important because they can be substituted for naturally occurring atoms without significantly perturbing the biochemical properties of the radiolabelled parent molecules. These labelled molecules are employed in clinical radiopharmaceuticals, in studies of brain disease and as ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):546]

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Reverse dark current in organic photodetectors and the major role of traps as source of noise.

Jonas Kublitski, Andreas Hofacker, Bahman K Boroujeni, Johannes Benduhn, Vasileios C Nikolis, Christina Kaiser, Donato Spoltore, Hans Kleemann, Axel Fischer, Frank Ellinger, Koen Vandewal, Karl Leo,

Organic photodetectors have promising applications in low-cost imaging, health monitoring and near-infrared sensing. Recent research on organic photodetectors based on donor-acceptor systems has resulted in narrow-band, flexible and biocompatible devices, of which the best reach external photovoltaic quantum efficiencies approaching 100%. However, the high noise spectral density of these devices ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):551]

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Stable inheritance of Sinorhizobium meliloti cell growth polarity requires an FtsN-like protein and an amidase.

Elizaveta Krol, Lisa Stuckenschneider, Joana M Kästle Silva, Peter L Graumann, Anke Becker,

In Rhizobiales bacteria, such as Sinorhizobium meliloti, cell elongation takes place only at new cell poles, generated by cell division. Here, we show that the role of the FtsN-like protein RgsS in S. meliloti extends beyond cell division. RgsS contains a conserved SPOR domain known to bind amidase-processed peptidoglycan. This ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):545]

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Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics.

Choong Yeon Kim, Min Jeong Ku, Raza Qazi, Hong Jae Nam, Jong Woo Park, Kum Seok Nam, Shane Oh, Inho Kang, Jae-Hyung Jang, Wha Young Kim, Jeong-Hoon Kim, Jae-Woong Jeong,

Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):535]

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Tunnel field-effect transistors for sensitive terahertz detection.

I Gayduchenko, S G Xu, G Alymov, M Moskotin, I Tretyakov, T Taniguchi, K Watanabe, G Goltsman, A K Geim, G Fedorov, D Svintsov, D A Bandurin,

The rectification of electromagnetic waves to direct currents is a crucial process for energy harvesting, beyond-5G wireless communications, ultra-fast science, and observational astronomy. As the radiation frequency is raised to the sub-terahertz (THz) domain, ac-to-dc conversion by conventional electronics becomes challenging and requires alternative rectification protocols. Here, we address this ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):543]

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Nonreciprocal charge transport up to room temperature in bulk Rashba semiconductor α-GeTe.

Yan Li, Yang Li, Peng Li, Bin Fang, Xu Yang, Yan Wen, Dong-Xing Zheng, Chen-Hui Zhang, Xin He, Aurélien Manchon, Zhao-Hua Cheng, Xi-Xiang Zhang,

Nonmagnetic Rashba systems with broken inversion symmetry are expected to exhibit nonreciprocal charge transport, a new paradigm of unidirectional magnetoresistance in the absence of ferromagnetic layer. So far, most work on nonreciprocal transport has been solely limited to cryogenic temperatures, which is a major obstacle for exploiting the room-temperature two-terminal ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):540]

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Molecular embroidering of graphene.

Tao Wei, Malte Kohring, Heiko B Weber, Frank Hauke, Andreas Hirsch,

Structured covalent two-dimensional patterning of graphene with different chemical functionalities constitutes a major challenge in nanotechnology. At the same time, it opens enormous opportunities towards tailoring of physical and chemical properties with limitless combinations of spatially defined surface functionalities. However, such highly integrated carbon-based architectures (graphene embroidery) are so far ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):552]

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A hybrid semiconducting organosilica-based O2 nanoeconomizer for on-demand synergistic photothermally boosted radiotherapy.

Wei Tang, Zhen Yang, Liangcan He, Liming Deng, Parinaz Fathi, Shoujun Zhu, Ling Li, Bo Shen, Zhantong Wang, Orit Jacobson, Jibin Song, Jianhua Zou, Ping Hu, Min Wang, Jing Mu, Yaya Cheng, Yuanyuan Ma, Longguang Tang, Wenpei Fan, Xiaoyuan Chen,

The outcome of radiotherapy is significantly restricted by tumor hypoxia. To overcome this obstacle, one prevalent solution is to increase intratumoral oxygen supply. However, its effectiveness is often limited by the high metabolic demand for O<sub>2</sub> by cancer cells. Herein, we develop a hybrid semiconducting organosilica-based O<sub>2</sub> nanoeconomizer pHPFON-NO/O<sub>2</sub> to ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):523]

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Halo-fluorescein for photodynamic bacteria inactivation in extremely acidic conditions.

Ying Wang, Jiazhuo Li, Zhiwei Zhou, Ronghui Zhou, Qun Sun, Peng Wu,

Aciduric bacteria that can survive in extremely acidic conditions (pH < 4.0) are challenging to the current antimicrobial approaches, including antibiotics and photodynamic bacteria inactivation (PDI). Here, we communicate a photosensitizer design concept of halogenation of fluorescein for extremely acidic PDI. Upon halogenation, the well-known spirocyclization that controls the absorption ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):526]

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Point-to-point stabilized optical frequency transfer with active optics.

Benjamin P Dix-Matthews, Sascha W Schediwy, David R Gozzard, Etienne Savalle, François-Xavier Esnault, Thomas Lévèque, Charles Gravestock, Darlene D'Mello, Skevos Karpathakis, Michael Tobar, Peter Wolf,

Timescale comparison between optical atomic clocks over ground-to-space and terrestrial free-space laser links will have enormous benefits for fundamental and applied sciences. However, atmospheric turbulence creates phase noise and beam wander that degrade the measurement precision. Here we report on phase-stabilized optical frequency transfer over a 265 m horizontal point-to-point free-space ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):515]

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Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.

Faiz Rasul, Fan Zheng, Fenfen Dong, Jiajia He, Ling Liu, Wenyue Liu, Javairia Yousuf Cheema, Wenfan Wei, Chuanhai Fu,

The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex creates contact sites between the endoplasmic reticulum and mitochondria, playing crucial roles in interorganelle communication, mitochondrial fission, mtDNA inheritance, lipid transfer, and autophagy. The mechanism regulating the number of ERMES foci within the cell remains unclear. Here, we demonstrate that the mitochondrial membrane ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):521]

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CRISPR technologies and the search for the PAM-free nuclease.

Daphne Collias, Chase L Beisel,

The ever-expanding set of CRISPR technologies and their programmable RNA-guided nucleases exhibit remarkable flexibility in DNA targeting. However, this flexibility comes with an ever-present constraint: the requirement for a protospacer adjacent motif (PAM) flanking each target. While PAMs play an essential role in self/nonself discrimination by CRISPR-Cas immune systems, this ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):555]

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Detection of aberrant splicing events in RNA-seq data using FRASER.

Christian Mertes, Ines F Scheller, Vicente A Yépez, Muhammed H Çelik, Yingjiqiong Liang, Laura S Kremer, Mirjana Gusic, Holger Prokisch, Julien Gagneur,

Aberrant splicing is a major cause of rare diseases.  However, its prediction from genome sequence alone remains in most cases inconclusive. Recently, RNA sequencing has proven to be an effective complementary avenue to detect aberrant splicing. Here, we develop FRASER, an algorithm to detect aberrant splicing from RNA sequencing data. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):529]

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AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data.

Mathieu Quinodoz, Virginie G Peter, Nicola Bedoni, Béryl Royer Bertrand, Katarina Cisarova, Arash Salmaninejad, Neda Sepahi, Raquel Rodrigues, Mehran Piran, Majid Mojarrad, Alireza Pasdar, Ali Ghanbari Asad, Ana Berta Sousa, Luisa Coutinho Santos, Andrea Superti-Furga, Carlo Rivolta,

Homozygosity mapping is a powerful method for identifying mutations in patients with recessive conditions, especially in consanguineous families or isolated populations. Historically, it has been used in conjunction with genotypes from highly polymorphic markers, such as DNA microsatellites or common SNPs. Traditional software performs rather poorly with data from Whole Exome ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):518]

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Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress.

Stefan Rudloff, Mathilde Janot, Stephane Rodriguez, Kevin Dessalle, Willi Jahnen-Dechent, Uyen Huynh-Do,

Intrauterine growth restriction (IUGR) is associated with reduced kidney size at birth, accelerated renal function decline, and increased risk for chronic kidney and cardiovascular diseases in adults. Precise mechanisms underlying fetal programming of adult diseases remain largely elusive and warrant extensive investigation. Setting up a mouse model of hypoxia-induced IUGR, ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):549]

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Large organized chromatin lysine domains help distinguish primitive from differentiated cell populations.

Seyed Ali Madani Tonekaboni, Benjamin Haibe-Kains, Mathieu Lupien,

The human genome is partitioned into a collection of genomic features, inclusive of genes, transposable elements, lamina interacting regions, early replicating control elements and cis-regulatory elements, such as promoters, enhancers, and anchors of chromatin interactions. Uneven distribution of these features within chromosomes gives rise to clusters, such as topologically associating ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):499]

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Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.

Babak Moghimi, Sakunthala Muthugounder, Samy Jambon, Rachelle Tibbetts, Long Hung, Hamid Bassiri, Michael D Hogarty, David M Barrett, Hiroyuki Shimada, Shahab Asgharzadeh,

The ability to utilize preclinical models to predict the clinical toxicity of chimeric antigen receptor (CAR) T cells in solid tumors is tenuous, thereby necessitating the development and evaluation of gated systems. Here we found that murine GD2 CAR-T cells, specific for the tumor-associated antigen GD2, induce fatal neurotoxicity in ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):511]

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Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.

David E Place, R K Subbarao Malireddi, Jieun Kim, Peter Vogel, Masahiro Yamamoto, Thirumala-Devi Kanneganti,

Chronic inflammation during many diseases is associated with bone loss. While interferons (IFNs) are often inhibitory to osteoclast formation, the complex role that IFN and interferon-stimulated genes (ISGs) play in osteoimmunology during inflammatory diseases is still poorly understood. We show that mice deficient in IFN signaling components including IFN alpha ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):496]

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The Rustenburg Layered Suite formed as a stack of mush with transient magma chambers.

Zhuosen Yao, James E Mungall, M Christopher Jenkins,

The Rustenburg Layered Suite of the Bushveld Complex of South Africa is a vast layered accumulation of mafic and ultramafic rocks. It has long been regarded as a textbook result of fractional crystallization from a melt-dominated magma chamber. Here, we show that most units of the Rustenburg Layered Suite can ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):505]

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An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease.

Ariella T Cohain, William T Barrington, Daniel M Jordan, Noam D Beckmann, Carmen A Argmann, Sander M Houten, Alexander W Charney, Raili Ermel, Katyayani Sukhavasi, Oscar Franzen, Simon Koplev, Carl Whatling, Gillian M Belbin, Jialiang Yang, Ke Hao, Eimear E Kenny, Zhidong Tu, Jun Zhu, Li-Ming Gan, Ron Do, Chiara Giannarelli, Jason C Kovacic, Arno Ruusalepp, Aldons J Lusis, Johan L M Bjorkegren, Eric E Schadt,

Elevated plasma cholesterol and type 2 diabetes (T2D) are associated with coronary artery disease (CAD). Individuals treated with cholesterol-lowering statins have increased T2D risk, while individuals with hypercholesterolemia have reduced T2D risk. We explore the relationship between lipid and glucose control by constructing network models from the STARNET study with sequencing ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):547]

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RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia.

Vasily V Grinev, Farnaz Barneh, Ilya M Ilyushonak, Sirintra Nakjang, Job Smink, Anita van Oort, Richard Clough, Michael Seyani, Hesta McNeill, Mojgan Reza, Natalia Martinez-Soria, Salam A Assi, Tatsiana V Ramanouskaya, Constanze Bonifer, Olaf Heidenreich,

The fusion oncogene RUNX1/RUNX1T1 encodes an aberrant transcription factor, which plays a key role in the initiation and maintenance of acute myeloid leukemia. Here we show that the RUNX1/RUNX1T1 oncogene is a regulator of alternative RNA splicing in leukemic cells. The comprehensive analysis of RUNX1/RUNX1T1-associated splicing events identifies two principal ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):520]

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Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival.

Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B Tobin, David A Fidock,

The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, and metabolomics to a panel of isogenic K13 mutant or wild-type P. falciparum lines, we provide evidence that K13 ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):530]

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High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale.

Damien J Downes, Robert A Beagrie, Matthew E Gosden, Jelena Telenius, Stephanie J Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel Roberts, Arun Shivalingam, Afaf El-Sagheer, A Marieke Oudelaar, Tom Brown, Veronica J Buckle, James O J Davies, Jim R Hughes,

Chromosome conformation capture (3C) provides an adaptable tool for studying diverse biological questions. Current 3C methods generally provide either low-resolution interaction profiles across the entire genome, or high-resolution interaction profiles at limited numbers of loci. Due to technical limitations, generation of reproducible high-resolution interaction profiles has not been achieved at ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):531]

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SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques.

Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Brian A Schmidt, Timothy D Carroll, Kourtney D Weaver, Justin C Smith, Anil Verma, Jesse D Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J Olstad, J Rachel Reader, Zhong-Min Ma, Nancy K Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O'Connor, Stephen J McSorley, John H Morrison, Nam K Tran, Graham Simmons, Michael P Busch, Pamela A Kozlowski, Koen K A Van Rompay, Christopher J Miller, Smita S Iyer,

CD4 T follicular helper (T<sub>fh</sub>) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates T<sub>fh</sub> cells and stimulates the germinal center (GC) response is an important question as we investigate vaccine induced immunity against COVID-19. Here, we report that ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):541]

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Constraining tectonic uplift and advection from the main drainage divide of a mountain belt.

Chuanqi He, Ci-Jian Yang, Jens M Turowski, Gang Rao, Duna C Roda-Boluda, Xiao-Ping Yuan,

One of the most conspicuous features of a mountain belt is the main drainage divide. Divide location is influenced by a number of parameters, including tectonic uplift and horizontal advection. Thus, the topography of mountain belts can be used as an archive to extract tectonic information. Here we combine numerical ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):544]

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