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Journal Nat Chem Biol

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Delimiting lipids.

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1279]

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Making use of surplus sugar.

Niels Agerbirk,

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1283-1284]

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Designer adhesion GPCR tells its signaling story.

Eugenia V Gurevich, Vsevolod V Gurevich,

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1280-1281]

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Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.

Signe Mathiasen, Tiago Palmisano, Nicole A Perry, Hannah M Stoveken, Alex Vizurraga, Dyke P McEwen, Najeah Okashah, Tobias Langenhan, Asuka Inoue, Nevin A Lambert, Gregory G Tall, Jonathan A Javitch,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1440]

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Targeted self-destruction.

Emily Rodrigues, Matthew S Macauley,

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1281-1283]

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YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression.

Lin Li, Preston Williams, Wendan Ren, Michelle Y Wang, Zi Gao, Weili Miao, Ming Huang, Jikui Song, Yinsheng Wang,

The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes, including DNA replication, transcription and maintenance of genome stability. Here, we showed that Yin and Yang 1 (YY1) can bind directly to G4 structures. ChIP-seq results revealed that YY1-binding sites overlap extensively with G4 structure loci in chromatin. ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Cholesterol access in cellular membranes controls Hedgehog signaling.

Arun Radhakrishnan, Rajat Rohatgi, Christian Siebold,

The Hedgehog (Hh) signaling pathway coordinates cell-cell communication in development and regeneration. Defects in this pathway underlie diseases ranging from birth defects to cancer. Hh signals are transmitted across the plasma membrane by two proteins, Patched 1 (PTCH1) and Smoothened (SMO). PTCH1, a transporter-like tumor-suppressor protein, binds to Hh ligands, ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1303-1313]

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Cell type-selective secretome profiling in vivo.

Wei Wei, Nicholas M Riley, Andrew C Yang, Joon T Kim, Stephanie M Terrell, Veronica L Li, Marta Garcia-Contreras, Carolyn R Bertozzi, Jonathan Z Long,

Secreted polypeptides are a fundamental axis of intercellular and endocrine communication. However, a global understanding of the composition and dynamics of cellular secretomes in intact mammalian organisms has been lacking. Here, we introduce a proximity biotinylation strategy that enables labeling, detection and enrichment of secreted polypeptides in a cell type-selective ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes.

James Schiemer, Reto Horst, Yilin Meng, Justin I Montgomery, Yingrong Xu, Xidong Feng, Kris Borzilleri, Daniel P Uccello, Carolyn Leverett, Stephen Brown, Ye Che, Matthew F Brown, Matthew M Hayward, Adam M Gilbert, Mark C Noe, Matthew F Calabrese,

Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein degraders represent a mechanism of growing interest in drug discovery. Critical to the mechanism of action is the formation of a ternary complex ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Ion channels as lipid sensors: from structures to mechanisms.

Mackenzie J Thompson, John E Baenziger,

Ion channels play critical roles in cellular function by facilitating the flow of ions across the membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid bilayer, which can modulate or define their function. Recent technical advancements have led to the solution of numerous ion channel ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1331-1342]

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The conformational cycle of a prototypical voltage-gated sodium channel.

William A Catterall, Goragot Wisedchaisri, Ning Zheng,

Electrical signaling was a dramatic development in evolution, allowing complex single-cell organisms like Paramecium to coordinate movement and early metazoans like worms and jellyfish to send regulatory signals rapidly over increasing distances. But how are electrical signals generated in biology? In fact, voltage-gated sodium channels conduct sodium currents that initiate ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1314-1320]

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Chemically informed analyses of metabolomics mass spectrometry data with Qemistree.

Anupriya Tripathi, Yoshiki Vázquez-Baeza, Julia M Gauglitz, Mingxun Wang, Kai Dührkop, Mélissa Nothias-Esposito, Deepa D Acharya, Madeleine Ernst, Justin J J van der Hooft, Qiyun Zhu, Daniel McDonald, Asker D Brejnrod, Antonio Gonzalez, Jo Handelsman, Markus Fleischauer, Marcus Ludwig, Sebastian Böcker, Louis-Félix Nothias, Rob Knight, Pieter C Dorrestein,

Untargeted mass spectrometry is employed to detect small molecules in complex biospecimens, generating data that are difficult to interpret. We developed Qemistree, a data exploration strategy based on the hierarchical organization of molecular fingerprints predicted from fragmentation spectra. Qemistree allows mass spectrometry data to be represented in the context of ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Defining new chemical space for drug penetration into Gram-negative bacteria.

Shibin Zhao, Justyna W Adamiak, Vincent Bonifay, Jitender Mehla, Helen I Zgurskaya, Derek S Tan,

We live in the era of antibiotic resistance, and this problem will progressively worsen if no new solutions emerge. In particular, Gram-negative pathogens present both biological and chemical challenges that hinder the discovery of new antibacterial drugs. First, these bacteria are protected from a variety of structurally diverse drugs by ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1293-1302]

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Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide.

Francesco Fiorentino, Joshua B Sauer, Xingyu Qiu, Robin A Corey, C Keith Cassidy, Benjamin Mynors-Wallis, Shahid Mehmood, Jani R Bolla, Phillip J Stansfeld, Carol V Robinson,

Lipopolysaccharide (LPS) transport to the outer membrane (OM) is a crucial step in the biogenesis of microbial surface defenses. Although many features of the translocation mechanism have been elucidated, molecular details of LPS insertion via the LPS transport (Lpt) OM protein LptDE remain elusive. Here, we integrate native MS with ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Structural and functional consequences of reversible lipid asymmetry in living membranes.

Milka Doktorova, Jessica L Symons, Ilya Levental,

Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM) bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely associated with cell death. However, increasing evidence points to the physiological importance of non-apoptotic, transient changes in PM asymmetry. Such transient scrambling ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1321-1330]

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The importance of the membrane for biophysical measurements.

Dror S Chorev, Carol V Robinson,

Within cell membranes numerous protein assemblies reside. Among their many functions, these assemblies regulate the movement of molecules between membranes, facilitate signaling into and out of cells, allow movement of cells by cell-matrix attachment, and regulate the electric potential of the membrane. With such critical roles, membrane protein complexes are ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, 16(12):1285-1292]

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Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.

Hiroki Kobayashi, Hideyuki Hatakeyama, Haruna Nishimura, Mutsumi Yokota, Sadafumi Suzuki, Yuri Tomabechi, Mikako Shirouzu, Hiroyuki Osada, Masakazu Mimaki, Yu-Ichi Goto, Minoru Yoshida,

Mitochondrial DNA (mtDNA) mutations are the major cause of mitochondrial diseases. Cells harboring disease-related mtDNA mutations exhibit various phenotypic abnormalities, such as reduced respiration and elevated lactic acid production. Induced pluripotent stem cell (iPSC) lines derived from patients with mitochondrial disease, with high proportions of mutated mtDNA, exhibit defects in ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Launching the missile.

Yiyun Song,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1153]

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Discovering Nature's super glue.

Zhi Zeng, Ting Han,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1155-1156]

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Clarifying the translational potential of B-I09.

Juan R Del Valle, Brian C Betts, Xue-Zhong Yu, Sophie Janssens, Bart N Lambrecht, M Celeste Simon, Chih-Chi Andrew Hu,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1152]

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Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli.

Jeongchan Lee, Joonwon Kim, Ji Eun Song, Won-Suk Song, Eun-Jung Kim, Yun-Gon Kim, Hee-Jin Jeong, Hye Rim Kim, Kwon-Young Choi, Byung-Gee Kim,

Tyrian purple, mainly composed of 6,6'-dibromoindigo (6BrIG), is an ancient dye extracted from sea snails and was recently demonstrated as a biocompatible semiconductor material. However, its synthesis remains limited due to uncharacterized biosynthetic pathways and the difficulty of regiospecific bromination. Here, we introduce an effective 6BrIG production strategy in Escherichia ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Synthetic yeast brews neuroactive compounds.

Yang Gu, Peng Xu,

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.

Petr Rathner, Marc Fahrner, Linda Cerofolini, Herwig Grabmayr, Ferdinand Horvath, Heinrich Krobath, Agrim Gupta, Enrico Ravera, Marco Fragai, Matthias Bechmann, Thomas Renger, Claudio Luchinat, Christoph Romanin, Norbert Müller,

The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. On activation, STIM1 C terminus changes from an inactive, tight to an active, extended conformation. A coiled-coil clamp involving the CC1 and CC3 domains is essential in controlling STIM1 activation, with CC1 as the ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Fine-tuning adhesives.

Grant Miura,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1153]

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A two-pronged attack.

Joshua J Feng, Chao Zhang,

Nat Chem Biol (Nature chemical biology)
[2020, 16(11):1154-1155]

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