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Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women.

, Leila Dorling, Sara Carvalho, Jamie Allen, Anna González-Neira, Craig Luccarini, Cecilia Wahlström, Karen A Pooley, Michael T Parsons, Cristina Fortuno, Qin Wang, Manjeet K Bolla, Joe Dennis, Renske Keeman, M Rosario Alonso, Nuria Álvarez, Belen Herraez, Victoria Fernandez, Rocio Núñez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Törngren, Patricia A Harrington, Caroline Baynes, Don M Conroy, Brennan Decker, Laura Fachal, Nasim Mavaddat, Thomas Ahearn, Kristiina Aittomäki, Natalia N Antonenkova, Norbert Arnold, Patrick Arveux, Margreet G E M Ausems, Päivi Auvinen, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Marina Bermisheva, Katarzyna Białkowska, Carl Blomqvist, Natalia V Bogdanova, Nadja Bogdanova-Markov, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Michael Bremer, Ignacio Briceno, Thomas Brüning, Barbara Burwinkel, David A Cameron, Nicola J Camp, Archie Campbell, Angel Carracedo, Jose E Castelao, Melissa H Cessna, Stephen J Chanock, Hans Christiansen, J Margriet Collée, Emilie Cordina-Duverger, Sten Cornelissen, Kamila Czene, Thilo Dörk, Arif B Ekici, Christoph Engel, Mikael Eriksson, Peter A Fasching, Jonine Figueroa, Henrik Flyger, Asta Försti, Marike Gabrielson, Manuela Gago-Dominguez, Vassilios Georgoulias, Fabian Gil, Graham G Giles, Gord Glendon, Encarna B Gómez Garcia, Grethe I Grenaker Alnæs, Pascal Guénel, Andreas Hadjisavvas, Lothar Haeberle, Eric Hahnen, Per Hall, Ute Hamann, Elaine F Harkness, Jaana M Hartikainen, Mikael Hartman, Wei He, Bernadette A M Heemskerk-Gerritsen, Peter Hillemanns, Frans B L Hogervorst, Antoinette Hollestelle, Weang Kee Ho, Maartje J Hooning, Anthony Howell, Keith Humphreys, Faiza Idris, Anna Jakubowska, Audrey Jung, Pooja Middha Kapoor, Michael J Kerin, Elza Khusnutdinova, Sung-Won Kim, Yon-Dschun Ko, Veli-Matti Kosma, Vessela N Kristensen, Kyriacos Kyriacou, Inge M M Lakeman, Jong Won Lee, Min Hyuk Lee, Jingmei Li, Annika Lindblom, Wing-Yee Lo, Maria A Loizidou, Artitaya Lophatananon, Jan Lubiński, Robert J MacInnis, Michael J Madsen, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Arjen R Mensenkamp, Kyriaki Michailidou, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Heli Nevanlinna, William G Newman, Børge G Nordestgaard, Pei-Sze Ng, Jan C Oosterwijk, Sue K Park, Tjoung-Won Park-Simon, Jose I A Perez, Paolo Peterlongo, David J Porteous, Karolina Prajzendanc, Darya Prokofyeva, Paolo Radice, Muhammad U Rashid, Valerie Rhenius, Matti A Rookus, Thomas Rüdiger, Emmanouil Saloustros, Elinor J Sawyer, Rita K Schmutzler, Andreas Schneeweiss, Peter Schürmann, Mitul Shah, Christof Sohn, Melissa C Southey, Harald Surowy, Maija Suvanto, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Thérèse Truong, Maria Tzardi, Yana Valova, Christi J van Asperen, Rob M Van Dam, Ans M W van den Ouweland, Lizet E van der Kolk, Elke M van Veen, Camilla Wendt, Justin A Williams, Xiaohong R Yang, Sook-Yee Yoon, M Pilar Zamora, D Gareth Evans, Miguel de la Hoya, Jacques Simard, Antonis C Antoniou, Åke Borg, Irene L Andrulis, Jenny Chang-Claude, Montserrat García-Closas, Georgia Chenevix-Trench, Roger L Milne, Paul D P Pharoah, Marjanka K Schmidt, Amanda B Spurdle, Maaike P G Vreeswijk, Javier Benitez, Alison M Dunning, Anders Kvist, Soo H Teo, Peter Devilee, Douglas F Easton,

<h4>Background</h4>Genetic testing for breast cancer susceptibility is widely used, but for many genes, evidence of an association with breast cancer is weak, underlying risk estimates are imprecise, and reliable subtype-specific risk estimates are lacking.<h4>Methods</h4>We used a panel of 34 putative susceptibility genes to perform sequencing on samples from 60,466 women ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, :]

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Addressing Child Hunger When School Is Closed - Considerations during the Pandemic and Beyond.

Mary Kathryn Poole, Sheila E Fleischhacker, Sara N Bleich,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Beyond Tuskegee - Vaccine Distrust and Everyday Racism.

Simar Singh Bajaj, Fatima Cody Stanford,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Covid-19 Vaccine Injuries - Preventing Inequities in Compensation.

Katharine Van Tassel, Carmel Shachar, Sharona Hoffman,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Vaccinating Children against Covid-19 - The Lessons of Measles.

Perri Klass, Adam J Ratner,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Who Goes First? Government Leaders and Prioritization of SARS-CoV-2 Vaccines.

Mark T Hughes, Jeffrey Kahn, Allen Kachalia,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure.

Olav L Schjørring, Thomas L Klitgaard, Anders Perner, Jørn Wetterslev, Theis Lange, Martin Siegemund, Minna Bäcklund, Frederik Keus, Jon H Laake, Matthew Morgan, Katrin M Thormar, Søren A Rosborg, Jannie Bisgaard, Annette E S Erntgaard, Anne-Sofie H Lynnerup, Rasmus L Pedersen, Elena Crescioli, Theis C Gielstrup, Meike T Behzadi, Lone M Poulsen, Stine Estrup, Jens P Laigaard, Cheme Andersen, Camilla B Mortensen, Björn A Brand, Jonathan White, Inge-Lise Jarnvig, Morten H Møller, Lars Quist, Morten H Bestle, Martin Schønemann-Lund, Maj K Kamper, Mathias Hindborg, Alexa Hollinger, Caroline E Gebhard, Núria Zellweger, Christian S Meyhoff, Mathias Hjort, Laura K Bech, Thorbjørn Grøfte, Helle Bundgaard, Lars H M Østergaard, Maria A Thyø, Thomas Hildebrandt, Bülent Uslu, Christoffer G Sølling, Nette Møller-Nielsen, Anne C Brøchner, Morten Borup, Marjatta Okkonen, Willem Dieperink, Ulf G Pedersen, Anne S Andreasen, Lone Buus, Tayyba N Aslam, Robert R Winding, Joerg C Schefold, Stine B Thorup, Susanne A Iversen, Janus Engstrøm, Maj-Brit N Kjær, Bodil S Rasmussen, ,

<h4>Background</h4>Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated with supplemental oxygen, but the benefits and harms of different oxygenation targets are unclear. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao<sub>2</sub>) would result in lower mortality than using a ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, :]

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A Population-Based Study of Genes Previously Implicated in Breast Cancer.

Chunling Hu, Steven N Hart, Rohan Gnanaolivu, Hongyan Huang, Kun Y Lee, Jie Na, Chi Gao, Jenna Lilyquist, Siddhartha Yadav, Nicholas J Boddicker, Raed Samara, Josh Klebba, Christine B Ambrosone, Hoda Anton-Culver, Paul Auer, Elisa V Bandera, Leslie Bernstein, Kimberly A Bertrand, Elizabeth S Burnside, Brian D Carter, Heather Eliassen, Susan M Gapstur, Mia Gaudet, Christopher Haiman, James M Hodge, David J Hunter, Eric J Jacobs, Esther M John, Charles Kooperberg, Allison W Kurian, Loic Le Marchand, Sara Lindstroem, Tricia Lindstrom, Huiyan Ma, Susan Neuhausen, Polly A Newcomb, Katie M O'Brien, Janet E Olson, Irene M Ong, Tuya Pal, Julie R Palmer, Alpa V Patel, Sonya Reid, Lynn Rosenberg, Dale P Sandler, Christopher Scott, Rulla Tamimi, Jack A Taylor, Amy Trentham-Dietz, Celine M Vachon, Clarice Weinberg, Song Yao, Argyrios Ziogas, Jeffrey N Weitzel, David E Goldgar, Susan M Domchek, Katherine L Nathanson, Peter Kraft, Eric C Polley, Fergus J Couch,

<h4>Background</h4>Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants.<h4>Methods</h4>In a population-based case-control study, we performed sequencing using a custom multigene amplicon-based panel to identify germline pathogenic variants in 28 ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, :]

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Which Genes for Hereditary Breast Cancer?

Steven A Narod,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Incarceration and Social Death - Restoring Humanity in the Clinical Encounter.

Bisan A Salhi, Anwar D Osborne,

N Engl J Med (The New England journal of medicine)
[2021, 384(3):201-203]

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Testing in a Pandemic - Improving Access, Coordination, and Prioritization.

Yolanda Botti-Lodovico, Eric Rosenberg, Pardis C Sabeti,

N Engl J Med (The New England journal of medicine)
[2021, 384(3):197-199]

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Pelvic Splenosis.

Yanpeng Wang, Heping Shen,

N Engl J Med (The New England journal of medicine)
[2021, 384(3):e7]

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Injuries from Less-Lethal Weapons during the George Floyd Protests in Minneapolis.

Erika A Kaske, Samuel W Cramer, Isabela Pena Pino, Truong H Do, Bryan M Ladd, Dylan T Sturtevant, Aliya Ahmadi, Birra Taha, David Freeman, Joel T Wu, Brooke A Cunningham, Rachel R Hardeman, David J Satin, David P Darrow,

N Engl J Med (The New England journal of medicine)
[2021, :]

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CMS Innovation Center at 10 Years - Progress and Lessons Learned.

Brad Smith,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease.

Aaron Waxman, Ricardo Restrepo-Jaramillo, Thenappan Thenappan, Ashwin Ravichandran, Peter Engel, Abubakr Bajwa, Roblee Allen, Jeremy Feldman, Rahul Argula, Peter Smith, Kristan Rollins, Chunqin Deng, Leigh Peterson, Heidi Bell, Victor Tapson, Steven D Nathan,

<h4>Background</h4>No therapies are currently approved for the treatment of pulmonary hypertension in patients with interstitial lung disease. The safety and efficacy of inhaled treprostinil for patients with this condition are unclear.<h4>Methods</h4>We enrolled patients with interstitial lung disease and pulmonary hypertension (documented by right heart catheterization) in a multicenter, randomized, double-blind, ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, :]

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(A Little) Clarity on Convalescent Plasma for Covid-19.

Louis M Katz,

N Engl J Med (The New England journal of medicine)
[2021, :]

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The Future of Drug-Pricing Transparency.

William B Feldman, Benjamin N Rome, Jerry Avorn, Aaron S Kesselheim,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Optimism for Interstitial Lung Disease-Associated Pulmonary Hypertension?

Darren B Taichman,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism.

Luisa N Borrell, Jennifer R Elhawary, Elena Fuentes-Afflick, Jonathan Witonsky, Nirav Bhakta, Alan H B Wu, Kirsten Bibbins-Domingo, José R Rodríguez-Santana, Michael A Lenoir, James R Gavin, Rick A Kittles, Noah A Zaitlen, David S Wilkes, Neil R Powe, Elad Ziv, Esteban G Burchard,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Open Schools, Covid-19, and Child and Teacher Morbidity in Sweden.

Jonas F Ludvigsson, Lars Engerström, Charlotta Nordenhäll, Emma Larsson,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Misrepresenting Race - The Role of Medical Schools in Propagating Physician Bias.

Christina Amutah, Kaliya Greenidge, Adjoa Mante, Michelle Munyikwa, Sanjna L Surya, Eve Higginbotham, David S Jones, Risa Lavizzo-Mourey, Dorothy Roberts, Jennifer Tsai, Jaya Aysola,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults.

Romina Libster, Gonzalo Pérez Marc, Diego Wappner, Silvina Coviello, Alejandra Bianchi, Virginia Braem, Ignacio Esteban, Mauricio T Caballero, Cristian Wood, Mabel Berrueta, Aníbal Rondan, Gabriela Lescano, Pablo Cruz, Yvonne Ritou, Valeria Fernández Viña, Damián Álvarez Paggi, Sebastián Esperante, Adrián Ferreti, Gastón Ofman, Álvaro Ciganda, Rocío Rodriguez, Jorge Lantos, Ricardo Valentini, Nicolás Itcovici, Alejandra Hintze, M Laura Oyarvide, Candela Etchegaray, Alejandra Neira, Ivonne Name, Julieta Alfonso, Rocío López Castelo, Gisela Caruso, Sofía Rapelius, Fernando Alvez, Federico Etchenique, Federico Dimase, Darío Alvarez, Sofía S Aranda, Clara Sánchez Yanotti, Julián De Luca, Sofía Jares Baglivo, Sofía Laudanno, Florencia Nowogrodzki, Ramiro Larrea, María Silveyra, Gabriel Leberzstein, Alejandra Debonis, Juan Molinos, Miguel González, Eduardo Perez, Nicolás Kreplak, Susana Pastor Argüello, Luz Gibbons, Fernando Althabe, Eduardo Bergel, Fernando P Polack, ,

<h4>Background</h4>Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.<h4>Methods</h4>We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, :]

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In Search of a Better Equation - Performance and Equity in Estimates of Kidney Function.

James A Diao, Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Neil R Powe, Arjun K Manrai,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Beyond Politics - Promoting Covid-19 Vaccination in the United States.

Stacy Wood, Kevin Schulman,

N Engl J Med (The New England journal of medicine)
[2021, :]

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Visible Intestinal Peristalsis in a Neonate.

Seigo Okada, Shunji Hasegawa,

N Engl J Med (The New England journal of medicine)
[2021, 384(1):e1]

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