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Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.

Mihai Ciubotaru, David G Schatz,

V(D)J recombination requires binding and synapsis of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins, aided by a high-mobility group protein, HMG1 or HMG2. Double-strand DNA cleavage within this synaptic, or paired, complex is thought to involve DNA distortion or melting near the ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2004, 24(19):8727-8744]

Cited: 10 times

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