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Journal Mol. Cell. Biochem.

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Leptin promotes endothelial dysfunction in chronic kidney disease by modulating the MTA1-mediated WNT/β-catenin pathway.

Bing Liu, Jiao Qiao, Jinxiu Hu, Minghua Fan, Yanfang Zhao, Hong Su, Ziyang Wang, Qun Yu, Qiqi Ma, Yanmei Li, Zhimei Lv, Rong Wang,

Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Silencing of long non-coding RNA CRNDE promotes autophagy and alleviates neonatal hypoxic-ischemic brain damage in rats.

Chun-Hua Fu, Fang-Fang Lai, Sai Chen, Cai-Xia Yan, Bing-Hong Zhang, Cheng-Zhi Fang, Gao-Hua Wang,

Hypoxic-ischemic (HI) brain damage (HIBD) leads to high neonatal mortality and severe neurologic morbidity. Autophagy is involved in the pathogenesis of HIBD. This study aims to investigate the effect of long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) on HIBD and to validate whether autophagy is involved in this process. ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Mechanism analysis of toxicity of sodium sulfite to human hepatocytes L02.

Xu Han, Feifei Zhu, Liang Chen, Hong Wu, Tao Wang, Keping Chen,

Food additives are widely used in various food products to preserve the taste, color, and other qualities. However, if they are used improperly or exceed the standard, they will cause damage to the human body. Sulfite is a commonly used food additive to prevent oxidation from deteriorating the nutrients in ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage.

Chao Tian, Xiaobo Han, Lang He, Feng Tang, Rongqi Huang, Zuoxian Lin, Shuai Li, Sihao Deng, Junjie Xu, Hualin Huang, Huifang Zhao, Zhiyuan Li,

P2X7 receptor (P2X7R) is an ATP-gated non-selective cation channel which mediates ATP-induced inflammation in macrophages. Transient receptor potential (TRP) receptors are nociceptors in cellular membrane which can perceive the stimuli of environmental irritant. The interaction between TRP channels and P2X7R has been found while the details about inflammation are still ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Secreted frizzled-related protein 2 prevents pressure-overload-induced cardiac hypertrophy by targeting the Wnt/β-catenin pathway.

Wen-Ying Wei, Qing Zhao, Wen-Zhong Zhang, Mao-Jing Wang, Yan Li, Shi-Zhong Wang, Ning Zhang,

BACKGROUND AND AIM:Secreted frizzled-related protein 2 (sFRP2) has been reported to be involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by pressure overload is still elusive. We aimed to examine the role of sFRP2 in the development of cardiac hypertrophy in vivo and in vitro. METHODS AND ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Insulin growth factor-1 pathway in cervical carcinoma cancer stem cells.

Shifa Javed, Shalmoli Bhattacharyya, Rashmi Bagga, Radhika Srinivasan,

Cancer stem cells (CSC) drive tumour progression and are implicated in relapse and resistance to conventional cancer therapies. Identification of differentially expressed genes by gene expression (GEP) profiling may help identify the differentially activated signalling pathways in cancer stem cells as opposed to bulk tumour cells which will provide new ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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LncRNA SNHG14 aggravates invasion and migration as ceRNA via regulating miR-656-3p/SIRT5 pathway in hepatocellular carcinoma.

Shu-Juan Tang, Jing-Bo Yang,

Recurrence and adverse events after hepatocellular carcinoma (HCC) treatment occur frequently even treated with the most efficient therapy for HCC, liver transplantation. Therefore, better understanding of HCC progression is required to advance the therapeutic strategy of HCC. This study aims to explore the effect and mechanism of small nucleolar RNA ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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LncRNA SNHG6 promotes LMO3 expression by sponging miR-543 in glioma.

Yin Zhang, Jiayin An, Yuchun Pei,

Small nucleolar RNA host gene 6 (SNHG6) was a newly discovered long non-coding RNA, which was involved in the occurrence and development of a variety of cancers and was on the rise in human cancers. However, the molecular mechanism of SNHG6 in glioma required further investigation. The levels of SNHG6, ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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IL-6 induces tumor suppressor protein tyrosine phosphatase receptor type D by inhibiting miR-34a to prevent IL-6 signaling overactivation.

Fan Zhang, Bo Wang, Tao Qin, Lu Wang, Qingqing Zhang, Ying Lu, Bo Song, Xiaotang Yu, Lianhong Li,

Protein tyrosine phosphatase receptor type D (PTPRD) is a tumor suppressor gene that is epigenetically silenced and mutated in several cancers, including breast cancer. Since IL-6/STAT3 signaling is often hyperactivated in breast cancer and STAT3 is a direct PTPRD substrate, we investigated the role of PTPRD in breast cancer and ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Protective effects of acetylcholine on hypoxia-induced endothelial-to-mesenchymal transition in human cardiac microvascular endothelial cells.

Zhiyang Li, Xuelian Li, Yeqian Zhu, Qiushi Chen, Bingong Li, Fengxiang Zhang,

Endothelial-to-mesenchymal transition (EndMT) has been reported as a key factor in myocardial fibrosis. Acetylcholine (ACh), a neurotransmitter of the vagus nerve, has been confirmed to exert cardio-protective properties with unclear mechanisms. In this study, the specific markers of cell injury, EndMT, inflammation, and autophagy were measured. We found that treatment ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Upregulation of long non-coding RNA MEG3 in type 2 diabetes mellitus complicated with vascular disease: a case-control study.

Wei-Wei Chang, Liu Zhang, Xin-Ming Yao, Yan Chen, Li-Jun Zhu, Zheng-Mei Fang, Ying Zhao, Ying-Shui Yao, Yue-Long Jin,

Previous studies have indicated that long non-coding RNAs (lncRNAs) were closely related to diabetes. In this study, we aimed to explore the possible role and mechanism of lncRNA MEG3 in the occurrence and development of type 2 diabetes mellitus (T2DM) and its vascular complications. A case-control study involving 115 subjects ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Long-chain free fatty acids inhibit ischaemic preconditioning of the isolated rat heart.

Amanda Lochner, Sonia Genade, Amanda Genis, Erna Marais, Ruduwaan Salie,

We recently reported that non-preconditioned hearts from diet-induced obese rats showed, compared to controls, a significant reduction in infarct size after ischaemia/reperfusion, whilst ischaemic preconditioning was without effect. In view of the high circulating FFA concentration in diet rats, the aims of the present study were to: (i) compare the ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.

Yesim Kaya, Seren Kucukvardar, Aysegul Yildiz,

Abnormal activity of ERK/MAPK and PI3K/AKT pathways is one of the most important factors for the development of many cancer types including neuroblastoma cancer. Apart from these two pathways, some cell cycle regulators such as Speedy/RINGO also contribute to neuroblastoma development. There is data reinforcing the possible communication of the ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Osmolarity controls the differentiation of adipose-derived stem cells into nucleus pulposus cells via histone demethylase KDM4B.

Yujie Zhang, Yanyan Wang, Xiaopeng Zhou, Jingkai Wang, Mingmin Shi, Jian Wang, Fangcai Li, Qixin Chen,

Adipose-derived stem cells (ADSCs) are an ideal source of cells for intervertebral disc (IVD) regeneration, but the effect of an increased osmotic microenvironment on ADSC differentiation remains unclear. Here, we aimed to elucidate whether hyperosmolarity facilitates ADSC nucleus pulposus (NP)-like differentiation and whether histone demethylase KDM4B is involved in this ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Correction to: Telomerase reconstitution contributes to resetting of circadian rhythm in fibroblasts.

Yi Qu, Meng Mao, Xihong Li, Yanyou Liu, Jianmin Ding, Zhou Jiang, Chaomin Wan, Lin Zhang, Zhengrong Wang, Dezhi Mu,

In the original article, Fig. 4b was published incorrectly in which four to five lanes in Pi-ERK and Pi-CREB panels look very similar to each other (Telomerase reconstitution contributes to resetting of circadian rhythm in fibroblasts, Mol Cell Biochem, 2008, 313:11-18). Since this image was stored in The Experiment Center of ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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The calcium channel agonist Bay K 8644 promotes the growth of human liver cancer HepG2 cells in vitro: suppression with overexpressed regucalcin.

Masayoshi Yamaguchi, Tomiyasu Murata, Joe W Ramos,

Hepatocellular carcinoma is one of the most prevalent malignant diseases and causes a third of cancer-related death. The consequences of altered calcium homeostasis in cancer cells may contribute to tumor progression. Regucalcin plays an inhibitory role in calcium signaling linked to transcription regulation. Regucalcin gene expression is downregulated in the ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Inflammation suppression by dexamethasone via inhibition of CD147-mediated NF-κB pathway in collagen-induced arthritis rats.

Qishan Wang, Bingxin Xu, Kaijian Fan, Jing Wu, Tingyu Wang,

Dexamethasone (Dex) exhibits broad-spectrum anti-inflammatory effects in chronic destructive rheumatoid arthritis. We present in vivo and in vitro evidence supporting the preventive effects and underlying mechanisms of Dex on collagen-induced arthritis (CIA)-induced synovial injuries. After successful induction of CIA, Wistar rats were administered Dex intraperitoneally (1 mg/kg) three times a week ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Correction to: Overexpression of Shrm4 promotes proliferation and differentiation of neural stem cells through activation of GABA signaling pathway.

Runhui Tian, Kaimin Guo, Bo Wu, Hongbo Wang,

The original publication of the article includes an error in Fig. 2. The correct version of the Fig. 2 is provided in this correction. ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Purification and biochemical characterization of a novel secretory dipeptidyl peptidase IV from porcine serum.

Divya Kumar, Vivek K Hamse, K N Neema, Priya Babu Shubha, D M Chetan, Nanjunda Swamy Shivananju,

Purification of DPP-IV enzyme from porcine serum, is presented in this study for the first time. The high molecular weight DPP-IV from porcine serum was fractioned using Sephadex G-75 gel filtration followed by DEAE Sephadex anion exchange and Sephadex G-100 gel filtration chromatography columns with a final yield of 11.25%. The ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, 471(1-2):71-80]

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Evaluation of the Wnt signaling pathway as a prognostic marker in patients with urosepsis.

Jungho Shin, Yoosik Yoon, Dong-Jin Oh,

The Wnt signaling pathway has critical roles in dysregulated inflammation during sepsis; however, its impacts on clinical outcomes remain uncertain. This prospective observational study investigated the association between the Wnt pathway and clinical outcomes in patients with urosepsis. The study included 38 patients with urosepsis and 20 healthy individuals. Wnt3a ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Growth factor receptor bound protein-7 regulates proliferation, cell cycle, and mitochondrial apoptosis of thyroid cancer cells via MAPK/ERK signaling.

Haili Tang, Ping Yang, Xiaojun Yang, Shujia Peng, Xi'e Hu, Guoqiang Bao,

It is of great significance to explore the molecular mechanism of thyroid cancer (TC) pathogenesis for its improvement and therapy. Growth factor receptor bound protein-7 (GRB7) has been regarded as an important regulatory gene in the developments of various malignant tumors. Our study aimed to illustrate the role of GRB7 ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Plasma lipoprotein(a) concentration as an independent predictor of hemodynamic progression of aortic valve stenosis.

Vesela D Tomova, Margarita L Alexandrova, Milena A Atanasova, Maria L Tzekova, Tihomir R Rashev, Sarfraz Ahmad,

Calcific aortic valve disease (CAVD) is a common cardiovascular disorder of high social significance. This study aimed to identify independent predictors of hemodynamic progression of CAVD. The relationship between some risk factors, including the rs10455872 polymorphism in the intron 25 of the lipoprotein(a) [Lp(a)] coding region and the plasma Lp(a) ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Knockdown of LINC00657 inhibits ox-LDL-induced endothelial cell injury by regulating miR-30c-5p/Wnt7b/β-catenin.

Haojie Wu, Tingting Liu, Hong Hou,

Long noncoding RNAs (lncRNAs) play pivotal roles in the pathogenesis, development, and treatment of atherosclerosis (AS). The endothelial cell injury is a feature of AS. However, the role and mechanism of lncRNA LINC00657 in oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell injury remain unclear. The serum samples were collected from 32 ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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Hydrogen sulfide alleviates oxidative stress injury and reduces apoptosis induced by MPP+ in Parkinson's disease cell model.

Lin Liu, Jin Wang, Heng Wang,

Hydrogen sulfide (H2S), an endogenously produced gas, is a cardioprotective agent against neurotoxin-induced neurodegeneration in Parkinson's disease (PD). However, the roles of H2S in 1-methyl-4-phenylpyridinium ion (MPP+)-treated SH-SY5Y cells with the involvement of reactive oxygen species-nitric oxide (ROS-NO) signaling pathway in PD remain unclear. For this study, a MPP+-treated SH-SY5Y ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53.

Bin-Hua Xue, Yi Liu, Hu Chen, Yun Sun, Wei-Li Yu,

Acute pancreatitis (AP) is an inflammatory disease caused by the abnormal activation of pancreatic enzymes in the pancreas, with a considerably high morbidity and mortality. However, the etiological factor and pathogenesis of AP are still unclear. This study was aimed to explore the role and mechanism of interferon regulatory factor 9 (IRF9) in the occurrence of AP ... Read more >>

Mol. Cell. Biochem. (Molecular and cellular biochemistry)
[2020, :]

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