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Journal Metab Brain Dis

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Correction to: Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury.

Ochuko L Erukainure, Veronica F Salau, Opeyemi O Alabi, Osaretin A T Ebuehi, Neil A Koorbanally, Md Shahidul Islam,

Author "Shahidul Islam" should be "Md. Shahidul Islam". ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1429]

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Correction to: Shuangxia decoction alleviates p-chlorophenylalanine induced insomnia through the modification of serotonergic and immune system.

Yujie Sun, Wenhui Pei, Na Zhang, Yuxia Qu, Yijia Cao, Jianhao Li, Yuwei Yang, Tiange Yang, Fang Fang, Yikun Sun,

The original article contains mistake. The authors want to add Wenhui Pei as first co-author and Fang Fang as co-corresponding author. ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1433]

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Additional methodological considerations regarding optimization of the dose of intracerebroventricular streptozotocin A response to: "Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats" by Ghosh et al., Metab Brain Dis 2020 July 21.

Jan Homolak, Ana Babic Perhoc, Ana Knezovic, Jelena Osmanovic Barilar, Melita Salkovic-Petrisic,

A recent article by Ghosh et al. entitled "Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats" provides an important new set of information on neuroinflammation and cognitive deficit in a rat model of sporadic Alzheimer's disease (sAD) based on intracerebroventricular administration of streptozotocin (STZ-icv) in Charles-Foster rats in ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Administration of branched-chain amino acids alters epigenetic regulatory enzymes in an animal model of Maple Syrup Urine Disease.

Emilio L Streck, Felipe P Bussular, Leticia B Wessler, Mariane B Duarte, Victoria L Rezende, Matheus S Rodrigues, Carolina A Torres, Isabela S Lemos, Gabriela Candiotto, Fernanda F Gava, Jade de Oliveira, Samira S Valvassori,

Maple Syrup Urine Disease (MSUD) is an autosomal recessive inherited disorder that affects the activity of the branched-chainα-keto acid dehydrogenase complex (BCDK). This deficiency on BCDK complex results in the accumulation of branched-chain amino acids (BCAA) leucine, isoleucine, valine, and their corresponding α-keto acids. Epigenetic changes can negatively affect the ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Physical exercise protocols in animal models of Alzheimer's disease: a systematic review.

Ricardo Augusto Leoni De Sousa, Cíntia Maria Rodrigues, Bruno Ferreira Mendes, Alex Cleber Improta-Caria, Marco Fabrício Dias Peixoto, Ricardo Cardoso Cassilhas,

Several animal studies have showed the beneficial effects of physical exercise (PE) on brain function and health. Alzheimer's Disease (AD) is the most common type of dementia, characterized by the presence of aggregated extracellular amyloid-beta (Aβ) and neurofibrillary tangles, with progressive cognitive decline. Therapeutic approaches such as PE showed to ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Epilepsy in inherited neurotransmitter disorders: Spotlights onpathophysiology and clinical management.

Mario Mastrangelo,

Inborn errors of neurotransmitter metabolism are ultrarare disorders affecting neurotransmitter biosynthesis, breakdown or transport or their essential cofactors. Neurotransmitter dysfunctions could also result from the impairment of neuronal receptors, intracellular signaling, vesicle release or other synaptic abnormalities. Epilepsy is the main clinical hallmark in some of these diseases (e.g. disorders ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Clinical, biochemical and molecular findings of 24 Brazilian patients with glutaric acidemia type 1: 4 novel mutations in the GCDH gene.

Angela Sitta, Gilian Guerreiro, Daniella de Moura Coelho, Vitoria Volfart da Rocha, Bianca Gomes Dos Reis, Carmen Sousa, Laura Vilarinho, Moacir Wajner, Carmen Regla Vargas,

Glutaric aciduria type 1 (GA-1) is a rare but treatable inherited disease caused by deficiency of glutaryl-CoA dehydrogenase activity due to GCDH gene mutations. In this study, we report 24 symptomatic GA-1 Brazilian patients, and present their clinical, biochemical, and molecular findings. Patients were diagnosed by high levels of glutaric ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Amelioration of oxidative stress and neuroinflammation in lipopolysaccharide-induced memory impairment using Rosmarinic acid in mice.

Chetan Thingore, Viplav Kshirsagar, Archana Juvekar,

Oxidative stress plays a pivotal part in the manifestation of neuroinflammation, which further leads to neurodegenerative diseases like Alzheimer's disease (AD). Systemic administration of lipopolysaccharide (LPS) induces neuroinflammation resulting in memory impairment (MI) and cognitive decline. In this study, we evaluated whether prophylactic administration of Rosmarinic acid (RA), a naturally ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Current and emerging therapeutic targets for Parkinson's disease.

Tanvi Pingale, Girdhari Lal Gupta,

Parkinson's disease (PD) is characterized by gradual neurodegeneration and forfeiture of dopamine neurons in substantia nigra pars compacta which ultimately leads to depletion of dopamine levels. PD patients not only display motor features such as rigidity, tremor, and bradykinesia but also non-motor features such as depression, anxiety, etc. Various treatments ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Correction to: Ghrelin ameliorates nerve growth factor Dysmetabolism and inflammation in STZ-induced diabetic rats.

Yuxing Zhao, Zhaoxing Shen, Dongling Zhang, Huiqiong Luo, Jinliang Chen, Yue Sun, Qian Xiao,

In the original published article: A wrong GFAP immunohistochemistry staining image was inadvertently chosen to present as Control group image (the published Fig.1B). ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1431-1432]

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Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis.

Michelle S Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Amanda Lopez Moreira, Silvana Peterini Boeira, Leandro Cattelan Souza,

Hesperidin is a flavonoid glycoside that is frequently found in citrus fruits. Our group have demonstrated that hesperidin has neuroprotective effect in 6-hydroxydopamine (6-OHDA) model of Parkinson's disease (PD), mainly by antioxidant mechanisms. Although the pathophysiology of PD remains uncertain, a large body of evidence has demonstrated that mitochondrial dysfunction ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Advances in intervention methods and brain protection mechanisms of in situ and remote ischemic postconditioning.

Chun-Yan Li, Wei Ma, Kuang-Pin Liu, Jin-Wei Yang, Xian-Bin Wang, Zhen Wu, Tong Zhang, Jia-Wei Wang, Wei Liu, Jie Liu, Yu Liang, Xing-Kui Zhang, Jun-Jun Li, Jian-Hui Guo, Li-Yan Li,

Ischemic postconditioning (PostC) conventionally refers to a series of brief blood vessel occlusions and reperfusions, which can induce an endogenous neuroprotective effect and reduce cerebral ischemia/reperfusion (I/R) injury. Depending on the site of adaptive ischemic intervention, PostC can be classified as in situ ischemic postconditioning (ISPostC) and remote ischemic postconditioning ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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The metabolic effect of α-ketoisocaproic acid: in vivo and in vitro studies.

Hémelin R Farias, Joice R Gabriel, Maria Laura Cecconi, Isabela S Lemos, Victoria L de Rezende, Letícia B Wessler, Mariane B Duarte, Giselli Scaini, Jade de Oliveira, Emilio L Streck,

Maple syrup urine disease (MSUD) is characterized by a deficiency in the mitochondrial branched-chain α-keto acid dehydrogenase complex activity and, consequently, accumulation of the branched-chain amino acids and their respective branched-chain α-keto acids in fluids and the tissue. MSUD clinical symptoms include neurological alterations. KIC is considered one of the ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia.

Yener Akyuva, Mustafa Nazıroğlu, Kenan Yıldızhan,

Microglia as the primary immune cells of brain act protective effects against injuries and infections in the central nervous system. Inflammation via excessive Ca2+ influx and oxygen radical species (ROS) generation is a known factor in many neurodegenerative disorders. Importantly, the Ca2+ permeable TRPM2 channel is activated by oxidative stress. Thus, ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Mood disorders are associated with the reduction of brain derived neurotrophic factor in the hypocampus in rats submitted to the hipercaloric diet.

Rafael Tamborena Malheiros, Helena Oliveira Delgado, Daniel Tassinari Felber, Scheila Iria Kraus, Adair Roberto Soares Dos Santos, Vanusa Manfredini, Morgana Duarte da Silva,

Adipose tissue accumulation, resulting from the consumption of hypercaloric foods, can cause a dysfunction of the endocrine system. Such endocrine changes can influence the expression of various neurochemicals including brain-derived neurotrophic factor (BDNF) - associated with cognitive and emotional problems. Here, we investigated the effects of a hypercaloric diet on ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Insulin resistance: a connecting link between Alzheimer's disease and metabolic disorder.

Viplav Kshirsagar, Chetan Thingore, Archana Juvekar,

Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD brains due to insulin resistance, ultimately resulting in the formation of neurofibrillary tangles (NFTs). AD and T2DM are connected at molecular, clinical, and ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Linking chronic kidney disease and Parkinson's disease: a literature review.

Jesús D Meléndez-Flores, Ingrid Estrada-Bellmann,

Chronic kidney disease (CKD) has been typically implicated in cardiovascular risk, considering the function the kidney has related to blood pressure, vitamin D, red blood cell metabolism, and electrolyte and acid-base regulation. However, neurological consequences are also attributed to this disease. Among these, recent large epidemiological studies have demonstrated an ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Laterality and sex differences in the expression of brain-derived neurotrophic factor in developing rat hippocampus.

Reza Sardar, Zahra Zandieh, Zeinab Namjoo, Mansoureh Soleimani, Reza Shirazi, Javad Hami,

Brain-derived neurotrophic factor (BDNF), as a member of neurotrophin family, plays an important role in neurogenesis, neuronal survival and synaptic plasticity. BDNF is strongly expressed in the hippocampus, where has been associated with memory consolidation, learning, and cognition. In this study, Real-time PCR, immunohistochemistry, and stereology were used to evaluate ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates.

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amer Alhaideri, Michael Maes,

Physiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, schizophrenia symptom ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Circulating sortilin levels are associated with inflammation in patients with moyamoya disease.

Wenxiu Han, Yi Qiao, Hailiang Zhang, Chunmei Geng, Xing Zhu, Dehua Liao, Yujin Guo, Mengqi Yang, Dan Chen, Pei Jiang,

BACKGROUND:Systemic inflammation has been implicated in the pathogenesis of moyamoya disease (MMD). Sortilin is a critical regulator of proinflammatory cytokine secretion in several cell types. The present study investigated the association between circulating sortilin and proinflammatory cytokine levels and the occurrence of MMD. METHODS:Forty-two MMD cases and 76 age- and ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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One drug to treat many diseases: unlocking the economic trap of rare diseases.

Karolina Pierzynowska, Teresa Kamińska, Grzegorz Węgrzyn,

There are two major problems with the development of therapies for rare diseases. First, among over 7000 such diseases, the vast majority are caused by genetic defects and/or include neurodegeneration, making them very difficult to treat. Second, drugs for rare diseases, so-called orphan drugs, are extremely expensive, as only a ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1237-1240]

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The neuroprotective effect of betanin in trimethyltin-induced neurodegeneration in mice.

Wachiryah Thong-Asa, Supakorn Prasartsri, Nattakan Klomkleaw, Nutnicha Thongwan,

Betanin, a natural food colorant with powerful antioxidative properties, has not been studied in terms of neurodegenerative disease intervention. Therefore, the present study aimed to investigate the neuroprotective effects of betanin against trimethyltin chloride (TMT) -induced neurodegeneration in mice. Forty male ICR mice were randomly divided into four groups: Sham-veh, ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1395-1405]

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Changes in expressions of genes involved in the regulation of cellular processes in mucopolysaccharidoses as assessed by fibroblast culture-based transcriptomic analyses.

Lidia Gaffke, Karolina Pierzynowska, Karolina Krzelowska, Ewa Piotrowska, Grzegorz Węgrzyn,

Recent studies indicated that apart from lysosomal storage of glycosaminoglycans (GAGs), secondary and tertiary changes in cellular processes may significantly contribute to development of disorders and symptoms occurring in mucopolysaccharidoses (MPS), a group of lysosomal storage diseases in which neurodegeneration is specific for most types and subtypes. In this report, ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, 35(8):1353-1360]

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LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression.

Xiongfei Yue, Ce Dong, Zhanying Ye, Lin Zhu, Xiaoyang Zhang, Xiaoyan Wang, Feng Mo, Zheng Li, Baogen Pan,

This study aimed to characterize the expression status and potentially mechanistic involvement of SNHG7 in pituitary adenoma. Relative expression of SNHG7 and miR-449a was analyzed by real-time PCR. Cell viability was measured with Cell Counting Kit-8 (CCK-8). Cell apoptosis was determined by PI/Annexin V double staining followed by flow cytometry ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.

Lovedeep Singh, Anudeep Kaur, Saweta Garg, Rajbir Bhatti,

Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies. Thus, there is a need to develop an efficacious alternate treatment regimen for pain-depression dyad. Skimmetin and osthole are molecules of natural origin that have been explored for an anti-hyperglycemic, ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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