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Journal Lancet Neurol

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Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.

Mitchell G Miglis, Charles H Adler, Elena Antelmi, Dario Arnaldi, Luca Baldelli, Bradley F Boeve, Matteo Cesari, Irene Dall'Antonia, Nico J Diederich, Kathrin Doppler, Petr Dušek, Raffaele Ferri, Jean-François Gagnon, Ziv Gan-Or, Wiebke Hermann, Birgit Högl, Michele T Hu, Alex Iranzo, Annette Janzen, Anastasia Kuzkina, Jee-Young Lee, Klaus L Leenders, Simon J G Lewis, Claudio Liguori, Jun Liu, Christine Lo, Kaylena A Ehgoetz Martens, Jiri Nepozitek, Giuseppe Plazzi, Federica Provini, Monica Puligheddu, Michal Rolinski, Jan Rusz, Ambra Stefani, Rebekah L S Summers, Dallah Yoo, Jennifer Zitser, Wolfgang H Oertel,

Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal α-synuclein deposition occurs early in the neurodegenerative process across the central and ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):671-684]

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Journey down memory lane.

Hannah K Warming, Erin M Schuman, Arpan R Mehta,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):602]

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Intraparenchymal haemorrhages as a primary outcome measure - Authors' reply.

Benjamin Maïer, Jean-Philippe Desilles, Mikael Mazighi, ,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):595-596]

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Management of Alzheimer's disease takes a leap forward.

Giovanni B Frisoni, Oskar Hansson,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):586-587]

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Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study.

Anne M Fagan, Rachel L Henson, Yan Li, Anna H Boerwinkle, Chengjie Xiong, Randall J Bateman, Alison Goate, Beau M Ances, Eric Doran, Bradley T Christian, Florence Lai, H Diana Rosas, Nicole Schupf, Sharon Krinsky-McHale, Wayne Silverman, Joseph H Lee, William E Klunk, Benjamin L Handen, Ricardo F Allegri, Jasmeer P Chhatwal, Gregory S Day, Neill R Graff-Radford, Mathias Jucker, Johannes Levin, Ralph N Martins, Colin L Masters, Hiroshi Mori, Catherine J Mummery, Yoshiki Niimi, John M Ringman, Stephen Salloway, Peter R Schofield, Mikio Shoji, Ira T Lott, , ,

<h4>Background</h4>Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increased life expectancy compared with adults with Down ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):615-626]

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Modelling dementia.

Udani Samarasekera,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):599-600]

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Hope for progressive multifocal leukoencephalopathy.

David B Clifford,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):589-591]

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Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study.

Eveline Janine Anna Wiegers, Hester Floor Lingsma, Jilske Antonia Huijben, David James Cooper, Giuseppe Citerio, Shirin Frisvold, Raimund Helbok, Andrew Ian Ramsay Maas, David Krishna Menon, Elizabeth Madeleine Moore, Nino Stocchetti, Diederik Willem Dippel, Ewout Willem Steyerberg, Mathieu van der Jagt, , ,

<h4>Background</h4>Fluid therapy-the administration of fluids to maintain adequate organ tissue perfusion and oxygenation-is essential in patients admitted to the intensive care unit (ICU) with traumatic brain injury. We aimed to quantify the variability in fluid management policies in patients with traumatic brain injury and to study the effect of this ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):627-638]

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V Wee Yong: a journey of rediscovery.

Tony Kirby,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):601]

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Redefining use of MRI for patients with multiple sclerosis.

Jun-Ichi Kira,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):591-592]

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Correction to Lancet Neurol 2021; 20: 526-36.

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):e5]

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Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study.

Maria Carmona-Iragui, Daniel Alcolea, Isabel Barroeta, Laura Videla, Laia Muñoz, Kathyrn L Van Pelt, Frederick A Schmitt, Donita D Lightner, Lisa M Koehl, Gregory Jicha, Silvia Sacco, Clotilde Mircher, Sarah E Pape, Rosalyn Hithersay, Isabel C H Clare, Anthony J Holland, Georg Nübling, Johannes Levin, Shahid H Zaman, Andre Strydom, Anne-Sophie Rebillat, Elizabeth Head, Rafael Blesa, Alberto Lleó, Juan Fortea,

<h4>Background</h4>Adults with Down syndrome are at an ultra-high risk of Alzheimer's disease, but diagnosis of Alzheimer's disease in this population is challenging. We aimed to validate the clinical utility of plasma neurofilament light chain (NfL) for the diagnosis of symptomatic Alzheimer's disease in Down syndrome, assess its prognostic value, and ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):605-614]

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Intraparenchymal haemorrhages as a primary outcome measure.

Mayank Goyal, Johanna Maria Ospel, Andrew Demchuk, Rosalie Victoria McDonough,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):595]

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Fluid therapy after brain injury: the pendulum swings again.

Patrick M Kochanek, Ruchira M Jha,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):587-589]

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BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot study.

Irene Cortese, Erin S Beck, Omar Al-Louzi, Joan Ohayon, Frances Andrada, Ikesinachi Osuorah, Jenifer Dwyer, B Jeanne Billioux, Nigar Dargah-Zada, Matthew K Schindler, Kyle Binder, Lauren Reoma, Gina Norato, Yoshimi Enose-Akahata, Bryan R Smith, Maria Chiara Monaco, Eugene O Major, Steven Jacobson, David Stroncek, Steven Highfill, Sandhya Panch, Daniel S Reich, John Barrett, Avindra Nath, Pawel Muranski,

<h4>Background</h4>Progressive multifocal leukoencephalopathy, a rare disease of the CNS caused by JC virus and occurring in immunosuppressed people, is typically fatal unless adaptive immunity is restored. JC virus is a member of the human polyomavirus family and is closely related to the BK virus. We hypothesised that use of partly ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):639-652]

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Anli Liu.

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):602]

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Identifying the best biomarkers for α-synucleinopathies.

Yves Dauvilliers,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):593-594]

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A contentious FDA ruling for Alzheimer's disease.

The Lancet Neurology,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):585]

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Off-label use of aducanumab for cerebral amyloid angiopathy.

Steven M Greenberg, Charlotte Cordonnier, Julie A Schneider, Eric E Smith, Mark A van Buchem, Susanne J van Veluw, Marcel M Verbeek, Anand Viswanathan, David J Werring,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(8):596-597]

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Progress towards therapies for disease modification in Parkinson's disease.

Nirosen Vijiaratnam, Tanya Simuni, Oliver Bandmann, Huw R Morris, Thomas Foltynie,

The development of interventions to slow or halt the progression of Parkinson's disease remains a priority for patients and researchers alike. To date, no agents have been shown to have unequivocal evidence of disease-modifying effects in Parkinson's disease. The absence of disease-modifying treatments might relate not only to inadequate approaches ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):559-572]

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Could SARS-CoV-2 cause tauopathy?

James Pratt, Evan Lester, Roy Parker,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):506]

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Pioglitazone for prevention of cognitive impairment: results and lessons.

Raquel Sánchez-Valle,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):500-502]

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Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial.

James F Howard, Vera Bril, Tuan Vu, Chafic Karam, Stojan Peric, Temur Margania, Hiroyuki Murai, Malgorzata Bilinska, Roman Shakarishvili, Marek Smilowski, Antonio Guglietta, Peter Ulrichts, Tony Vangeneugden, Kimiaki Utsugisawa, Jan Verschuuren, Renato Mantegazza, ,

<h4>Background</h4>There is an unmet need for treatment options for generalised myasthenia gravis that are effective, targeted, well tolerated, and can be used in a broad population of patients. We aimed to assess the safety and efficacy of efgartigimod (ARGX-113), a human IgG1 antibody Fc fragment engineered to reduce pathogenic IgG ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):526-536]

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Form and function in the brain.

Karl Deisseroth, Jane E Haley, Arpan R Mehta,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):508]

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Prehospital scales in acute ischaemic stroke management - Authors' reply.

Martijne H C Duvekot, Esmee Venema, Henk Kerkhoff, Diederik W J Dippel, Bob Roozenbeek,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(7):504-505]

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