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A Novel HIV-1 RNA Testing Intervention to Detect Acute and Prevalent HIV Infection in Young Adults and Reduce HIV Transmission in Kenya: Protocol for a Randomized Controlled Trial.

Susan M Graham, Clara Agutu, Elise van der Elst, Amin S Hassan, Evanson Gichuru, Peter M Mugo, Carey Farquhar, Joseph B Babigumira, Steven M Goodreau, Deven T Hamilton, Thumbi Ndung'u, Martin Sirengo, Wairimu Chege, Eduard J Sanders,

BACKGROUND:Detection and management of acute HIV infection (AHI) is a clinical and public health priority, and HIV infections diagnosed among young adults aged 18 to 39 years are usually recent. Young adults with recent HIV acquisition frequently seek care for symptoms and could potentially be diagnosed through the health care ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e16198]

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Effects of Alternative Offers of Screening Sigmoidoscopy and Colonoscopy on Utilization and Yield of Endoscopic Screening for Colorectal Neoplasms: Protocol of the DARIO Randomized Trial.

Petra Schrotz-King, Michael Hoffmeister, Peter Sauer, Anja Schaible, Hermann Brenner,

BACKGROUND:Flexible sigmoidoscopy and colonoscopy are recommended screening options for colorectal cancer (CRC). Despite colonoscopy being offered for CRC screening in Germany, the uptake of this offer has been very limited. OBJECTIVE:The objective of this study was to assess the potential for increasing use of endoscopic CRC screening and the detection ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e17516]

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Usability Methods and Attributes Reported in Usability Studies of Mobile Apps for Health Care Education: Protocol for a Scoping Review.

Susanne Grødem Johnson, Thomas Potrebny, Lillebeth Larun, Donna Ciliska, Nina Rydland Olsen,

BACKGROUND:E-learning technologies, including mobile apps, are used to a large extent in health care education. Mobile apps can provide extendable learning environments and motivate students for adaptive and collaborative learning outside the classroom context. Developers should design practical, effective, and easy-to-use mobile apps. Usability testing is an important part of ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e19072]

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A Web-Based Positive Psychological Intervention to Improve Blood Pressure Control in Spanish-Speaking Hispanic/Latino Adults With Uncontrolled Hypertension: Protocol and Design for the ¡Alégrate! Randomized Controlled Trial.

Rosalba Hernandez, Michael Cohn, Alison Hernandez, Martha Daviglus, Lizet Martinez, Angela Martinez, Itzel Martinez, Ramon Durazo-Arvizu, Judith Moskowitz,

BACKGROUND:Growing evidence links psychological well-being and resilience with superior cardiac health, but there remains a critical scientific gap about whether (or how) interventions that aim to cultivate psychological well-being reduce cardiac risk. Hispanic/Latino people in the United States have high cardiovascular disease risk and poorly controlled blood pressure (BP) compared ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e17721]

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Evaluation of More Stamina, a Mobile App for Fatigue Management in Persons with Multiple Sclerosis: Protocol for a Feasibility, Acceptability, and Usability Study.

Guido Giunti, Octavio Rivera-Romero, Jan Kool, Jens Bansi, Jose Luis Sevillano, Anabel Granja-Dominguez, Guillermo Izquierdo-Ayuso, Diego Giunta,

BACKGROUND:Multiple sclerosis (MS) is one of the world's most common neurologic disorders leading to severe disability in young adults. MS-related fatigue directly impacts on the quality of life and activity levels of people with MS. Self-management strategies are used to support them in the care of their health. Mobile health ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e18196]

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An Evaluation of Parents' Experiences of Patient Engagement in Research to Develop a Digital Knowledge Translation Tool: Protocol for a Multi-Method Study.

Alison P Thompson, Shannon E MacDonald, Eytan Wine, Shannon D Scott,

BACKGROUND:The last decade has seen increasing calls for patient and public involvement in health-related research due to an ideological shift toward more equitable methods of knowledge development and an effort to increase the usability and relevance of knowledge by improving outcomes in clinical practice. Patient engagement includes simply informing patients ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e19108]

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Developing Effective Methods for Electronic Health Personalization: Protocol for Health Telescope, a Prospective Interventional Study.

Bastiaan Johannes Paulus Cornelis Willemse, Maurits Clemens Kaptein, Fleur Hasaart,

BACKGROUND:Existing evaluations of the effects of mobile apps to encourage physical activity have been criticized owing to their common lack of external validity, their short duration, and their inability to explain the drivers of the observed effects. This protocol describes the setup of Health Telescope, a longitudinal panel study in ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e16471]

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Self-Myofascial Release Intervention and Mobile App in Patients With Hemophilic Ankle Arthropathy: Protocol for a Randomized Controlled Trial.

Antonio Javier Meroño-Gallut, Rubén Cuesta-Barriuso, Raúl Pérez-Llanes, Elena Donoso-Úbeda, José-Antonio López-Pina,

BACKGROUND:Hemophilic ankle arthropathy is manifested by degenerative functional alterations and chronic pain. Myofascial release techniques are used to treat soft tissue adhesions, relieve pain, and reduce tissue sensitivity. OBJECTIVE:This study aims to evaluate the safety and efficacy of a protocol using self-myofascial release with a foam roller to be applied ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e15612]

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Development of a Short Instrument for Measuring Health-Related Quality of Life in Oncological Patients for Clinical Use: Protocol for an Observational Study.

Theresa Schrage, Mirja Görlach, Christian Stephan Betz, Carsten Bokemeyer, Nicolaus Kröger, Volkmar Mueller, Cordula Petersen, Andreas Krüll, Holger Schulz, Christiane Bleich,

BACKGROUND:Cancer patients often suffer from the physical and psychological burden of their disease and its treatment. This is frequently insufficiently identified and addressed in clinical practice. In the context of improving patient-centered care in oncological patients, patient-reported outcomes (PROs) represent an important addition to current routine care. So far, available ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e17854]

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Evaluating the Effectiveness of an Intervention Integrating Technology and In-Person Sexual Health Education for Adolescents (In the Know): Protocol for a Cluster Randomized Controlled Trial.

Martha J Decker, Abigail Gutmann-Gonzalez, Melisa Price, Julio Romero, Bhupendra Sheoran, Jennifer Yarger,

BACKGROUND:Access to a smartphone is nearly universal among American adolescents, and most of them have used the internet to seek health information. Integrating digital technologies into health program delivery may expand opportunities for youth to receive important health information, yet there are few rigorous studies assessing the effectiveness of this ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e18060]

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Alterations of Gut Microbiota and the Brain-Immune-Intestine Axis in Patients With Relapsing-Remitting Multiple Sclerosis After Treatment With Oral Cladribine: Protocol for a Prospective Observational Study.

Jeske van Pamelen, Lynn van Olst, Andries E Budding, , Helga E de Vries, Leo H Visser,

BACKGROUND:Immunological factors are the key to the pathogenesis of multiple sclerosis (MS). Conjointly, environmental factors are known to affect MS disease onset and progression. Several studies have found that the intestinal microbiota in MS patients differs from that of control subjects. One study found a trend toward lower species richness ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e16162]

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Remote Assessment of Functional Mobility and Strength in Older Cancer Survivors: Protocol for a Validity and Reliability Study.

Cindy Blair, Elizabeth Harding, Carla Herman, Tawny Boyce, Wendy Demark-Wahnefried, Sally Davis, Anita Kinney, Vernon Pankratz,

BACKGROUND:Older cancer survivors, faced with both age- and treatment-related morbidity, are at increased and premature risk for physical function limitations. Physical performance is an important predictor of disability, quality of life, and premature mortality, and thus is considered an important target of interventions designed to prevent, delay, or attenuate physical ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, :]

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Visual Fixations and Motion Sensitivity: Protocol for an Exploratory Study.

Shikha Chaudhary, Nicola Saywell, Arun Kumar, Denise Taylor,

BACKGROUND:Motion sensitivity after vestibular disorders is associated with symptoms of nausea, dizziness, and imbalance in busy environments. Dizziness and imbalance are reported in places such as supermarkets and shopping malls which have unstable visual backgrounds; however, the mechanism of motion sensitivity is poorly understood. OBJECTIVE:The main aim of this exploratory ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e16805]

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Notifications to Improve Engagement With an Alcohol Reduction App: Protocol for a Micro-Randomized Trial.

Lauren Bell, Claire Garnett, Tianchen Qian, Olga Perski, Henry W W Potts, Elizabeth Williamson,

BACKGROUND:Drink Less is a behavior change app that aims to help users in the general adult population reduce hazardous and harmful alcohol consumption. The app includes a daily push notification, delivered at 11 am, asking users to "Please complete your mood and drinking diaries." Previous analysis of Drink Less engagement ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e18690]

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Using Machine Learning to Optimize the Quality of Survey Data: Protocol for a Use Case in India.

Neha Shah, Diwakar Mohan, Jean Juste Harisson Bashingwa, Osama Ummer, Arpita Chakraborty, Amnesty E LeFevre,

BACKGROUND:Data quality is vital for ensuring the accuracy, reliability, and validity of survey findings. Strategies for ensuring survey data quality have traditionally used quality assurance procedures. Data analytics is an increasingly vital part of survey quality assurance, particularly in light of the increasing use of tablets and other electronic tools, ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e17619]

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Lung Function Variability in Children and Adolescents With and Without Asthma (LUV Study): Protocol for a Prospective, Nonrandomized, Clinical Trial.

Eirini-Sofia Frima, Ilias Theodorakopoulos, Dimos Gidaris, Nikolaos Karantaglis, Grigorios Chatziparasidis, Panagiotis Plotas, Michael Anthracopoulos, Sotirios Fouzas,

BACKGROUND:Variability analysis of peak expiratory flow (PEF) and forced expiratory volume at 1 second (FEV1) has been used in research to predict exacerbations in adults with asthma. However, there is a paucity of data regarding PEF and FEV1 variability in healthy children and adolescents and those with asthma. OBJECTIVE:The objective ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e20350]

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Individualized Apartment Accommodation for People With Intellectual Disability: Protocol for a Qualitative Study Examining the Well-Being and Support Outcomes Linking Housing and Health.

Phillippa Carnemolla,

BACKGROUND:Understanding the outcomes associated with both receiving and providing support to people with intellectual disability in specific settings can facilitate the alignment of health providers, community care providers, architects, and urban planners to strengthen levels of autonomy and community participation of people with intellectual disability living in the community. This ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e18248]

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Prevalence of Mental Disorders, Cognitive Impairment, and Dementia Among Older Adults in Egypt: Protocol for a Systematic Review.

Opeyemi Odejimi, George Tadros, Noha Sabry,

BACKGROUND:In Egypt, the population of older adults is rapidly growing. The last census in 2017 indicated that older adults numbered 94.8 million, which is a 2.56% increase from the 2006 census. There is growing evidence that the older population is at greater risk for some forms of mental disorders such ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e14637]

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Gaining First Insights on Secondary Progressive Multiple Sclerosis Patients Treated With Siponimod in Clinical Routine: Protocol of the Noninterventional Study AMASIA.

Tjalf Ziemssen, Olaf Hoffmann, Luisa Klotz, Herbert Schreiber, Martin S Weber, Benedict Rauser,

BACKGROUND:A high proportion of patients with relapsing remitting multiple sclerosis convert to secondary progressive multiple sclerosis (SPMS) characterized by irreversibly progressing disability and cognitive decline. Siponimod (Mayzent), a selective sphingosine-1-phosphate receptor modulator, was recently approved by the European Medicines Agency for the treatment of adult SPMS patients with active disease, ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e19598]

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Metabolic syndrome parameters, determinants, and biomarkers in adult survivors of childhood cancer: methodology of the Dutch Childhood Cancer Survivor Study Metabolic Syndrome (Dutch LATER METS Study).

Vincent Pluimakers, Marta Fiocco, Jenneke Van Atteveld, Monique Hobbelink, Dorine Bresters, Eline Van Dulmen-den Broeder, Margriet Van der Heiden-van der Loo, Geert Janssens, Leontien Kremer, Jacqueline Loonen, Marloes Louwerens, Heleen Van der Pal, Ceciel Ronckers, Hanneke Van Santen, Birgitta Versluijs, Andrica De Vries, Marry Van den Heuvel-Eibrink, Sebastian Neggers,

BACKGROUND:Potential long-term effects of treatment for childhood cancer include adiposity, insulin resistance, dyslipidemia and hypertension. These risk factors cluster together as metabolic syndrome (MetS) and increase the risk for development of diabetes mellitus and cardio- and cerebrovascular disease. Knowledge on risk factors, timely diagnosis and preventive strategies is of importance ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, :]

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Patient Portal Functionalities and Uptake: Systematic Review Protocol.

Abrar Alturkistani, Geva Greenfield, Felix Greaves, Shirin Aliabadi, Rosemary H Jenkins, Ceire Costelloe,

BACKGROUND:Patient portals are digital health tools adopted by health care organizations. The portals are generally connected to the electronic health record of the health care organization and offer patients functionalities such as access to the medical record, ability to order repeat prescriptions, make appointments, or message the health care provider. ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e14975]

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Learning Integrated Health System to Mobilize Context-Adapted Knowledge With a Wiki Platform to Improve the Transitions of Frail Seniors From Hospitals and Emergency Departments to the Community (LEARNING WISDOM): Protocol for a Mixed-Methods Implementation Study.

Patrick Michel Archambault, Josée Rivard, Pascal Y Smith, Samir Sinha, Michèle Morin, Annie LeBlanc, Yves Couturier, Isabelle Pelletier, El Kebir Ghandour, France Légaré, Jean-Louis Denis, Don Melady, Daniel Paré, Josée Chouinard, Chantal Kroon, Maxime Huot-Lavoie, Laetitia Bert, Holly O Witteman, Audrey-Anne Brousseau, Clémence Dallaire, Marie-Josée Sirois, Marcel Émond, Richard Fleet, Sam Chandavong, ,

BACKGROUND:Elderly patients discharged from hospital experience fragmented care, repeated and lengthy emergency department (ED) visits, relapse into their earlier condition, and rapid cognitive and functional decline. The Acute Care for Elders (ACE) program at Mount Sinai Hospital in Toronto, Canada uses innovative strategies, such as transition coaches, to improve the ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e17363]

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Immediate and Long-Term Effects of an 8-Week Digital Mental Health Intervention on Adults With Poorly Managed Type 2 Diabetes: Protocol for a Randomized Controlled Trial.

Eliane Boucher, Judith T Moskowitz, Gina M Kackloudis, Julia L Stafford, Ian Kwok, Acacia C Parks,

BACKGROUND:Diabetes is a leading cause of years of life lost and accounts for approximately one-fourth of health care dollars spent in the United States. Many of these costs are related to poor medication adherence and lack of self-care behaviors and are thus preventable. Depression, which is more prevalent among people ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(8):e18578]

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An Evaluation of Agreement of Breathing Rates Measured by a Novel Device, Manual Counting, and Other Techniques Used in Clinical Practice: Protocol for the Observational VENTILATE Study.

Matthew T Jones, Emily Heiden, Carole Fogg, Paul Meredith, Gary Smith, Nicola Sayer, Lisa Toft, Emma Williams, Matthew Williams, Thomas Brown, Jessica Gates, David Lodge, Paul Bassett, Mark Amos, Milan Chauhan, Selina Begum, Madeleine Rason, Jonathan Winter, Jayne Longstaff, Anoop J Chauhan,

BACKGROUND:Respiratory rate (RR) is the most sensitive physiological observation to predict clinical deterioration on hospital wards, and poor clinical monitoring has been highlighted as a primary contributor to avoidable mortality. Patients in intensive care have their RR monitored continuously, but this equipment is rarely available on general hospital wards. OBJECTIVE:The ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e15437]

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Identification of Potential Biomarkers of Chronic Kidney Disease in Individuals with Diabetes: Protocol for a Cross-sectional Observational Study.

Ashani R Lecamwasam, Mohammadreza Mohebbi, Elif I Ekinci, Karen M Dwyer, Richard Saffery,

BACKGROUND:The importance of identifying people with diabetes and progressive kidney dysfunction relates to the excess morbidity and mortality of this group. Rates of cardiovascular disease are much higher in people with both diabetes and kidney dysfunction than in those with only one of these conditions. By the time these people ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(7):e16277]

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