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Umbelliprenin relieves paclitaxel-induced neuropathy.

Jafar Shahraki, Ramin Rezaee, Sabereh Mohammadzehi Kenar, Samaneh Setoodeh Nezhad, Gholamreza Bagheri, Hosseinali Jahantigh, Konstantinos Tsarouhas, Mahmoud Hashemzaei,

OBJECTIVES:Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant and inhibits lipoxygenase managing the inflammation pathways, while in vivo it exerts anti-inflammatory activities. METHODS:In this study, neuropathic pain was induced by four intraperitoneal doses of 2 mg/kg per day of paclitaxel (PTX) on days 1, 3, 5 ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Catechol protects against iron-mediated oxidative brain injury by restoring antioxidative metabolic pathways; and modulation of purinergic and cholinergic enzymes activities.

Veronica F Salau, Ochuko L Erukainure, Neil A Koorbanally, Md Shahidul Islam,

OBJECTIVES:This study was aimed at investigating neuroprotective effect of catechol on redox imbalance, cholinergic dysfunctions, nucleotide hydrolysing enzymes activities, and dysregulated metabolic pathways in iron-mediated oxidative brain injury. METHODS:Oxidative injury was induced in brain tissues by incubating with 0.1 mm FeSO4 and treated with different concentrations of catechol. KEY FINDINGS:Catechol significantly ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Losartan and azelastine either alone or in combination as modulators for endothelial dysfunction and platelets activation in diabetic hyperlipidemic rats.

Mohamed M Elseweidy, Gehad M Elnagar, Marwa M Elsawy, Abdelmoneim A Ali, Nabila Zein,

AIM:The present study aimed mainly to demonstrate the effect of the antihistamine azelastine (AZ) and Angiotensin receptor blocker ( ARB), represented by losartan (LOS) either alone or in combined form on certain metabolic aspects, endothelial dysfunction and platelets activation markers in diabetic hyperlipidemic rat model. METHODS:Rats were randomly classified to ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Corrigendum.

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(9):1287]

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Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin.

Thamires Barros Tavares, Izabelle Barcellos Santos, Graziele Freitas de Bem, Dayane Teixeira Ognibene, Ana Paula Machado da Rocha, Roberto Soares de Moura, Angela de Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar da Costa,

OBJECTIVES:Obesity is considered a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). The hydroalcoholic extract obtained from the açai seed (ASE), rich in proanthocyanidins, has been shown a potential body weight regulator with antioxidant properties. This study aimed to investigate the therapeutic effect of ASE in obesity-associated ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Preclinical studies indicate that INFLATIV, an herbal medicine cream containing Pereskia aculeata, presents potential to be marketed as a topical anti-inflammatory agent and as adjuvant in psoriasis therapy.

Nícolas de Castro Campos Pinto, Mariana de Souza Ferreira Maciel, Nathalia Dos Santos Rezende, Ana Paula do Nascimento Duque, Renata de Freitas Mendes, Jucélia Barbosa da Silva, Monique de Rezende Evangelista, Luana Cahon Monteiro, Josiane Mello da Silva, Juliana de Carvalho da Costa, Elita Scio,

OBJECTIVES:A previous study reported that the hexane fraction (HF) obtained from Pereskia aculeata leaves showed promising topical anti-inflammatory activity. Intending its future use in clinical practice, a herbal medicine cream named INFLATIV was developed. Its anti-inflammatory and antipsoriatic potential were investigated. INFLATIV was subjected to preliminary accelerated stability tests and ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence.

Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva,

OBJECTIVE:To study the radiosensitizing potential of Berberine and the underlying mechanism in human hepatocarcinoma (HepG2) cells. METHODS:HepG2 cells were challenged with X-rays in combination with Berberine treatment and several in vitro assays were performed. Alteration in cell viability was determined by MTT assay. Changes in intracellular ROS levels, mitochondrial membrane ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Geniposide in Gardenia jasminoides var. radicans Makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors.

Yang Fu, Pei-Pei Yuan, Yan-Gang Cao, Ying-Ying Ke, Qi Zhang, Ying Hou, Yan-Li Zhang, Wei-Sheng Feng, Xiao-Ke Zheng,

OBJECTIVES:To investigate the effects of geniposide in an iridoid found in Gardenia jasminoides var. radicans Makino (GJRM) in spontaneous hypertensive rat (SHR) and explore the possible mechanisms. METHODS:In this study, we detected the content of geniposide in GJRM by high-performance liquid chromatography (HPLC). Then, we used acute diuretic experiments to ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis.

Shareen Singh, Thakur Gurjeet Singh, Kriti Mahajan, Sonia Dhiman,

OBJECTIVES:Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self-neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self-epitopes as biomarkers in RA provides a better ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, 72(10):1306-1327]

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Recombinant ling zhi-8 enhances Tregs function to restore glycemic control in streptozocin-induced diabetic rats.

Hongyu Xiao, Zhi Fang, Xueling He, Ping Ding, Yongkai Cao, Shamyuen Chan, Shaozhen Hou, Jian Liang,

OBJECTIVES:To explore the effect of recombinant LZ-8 (rLZ-8) on streptozocin (STZ)-induced diabetic rats and further illustrate its underlying mechanism. METHODS:Rats were intraperitoneally injected with single-dose STZ 50 mg/kg for induction of type 1 diabetes (T1D), and then, the diabetic rats were treated with rLZ-8 for 3 months. The clinical symptoms, fasting blood ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Inhibiting the PI3K/Akt, NF-κB signalling pathways with syringic acid for attenuating the development of oral squamous cell carcinoma cells SCC131.

Periyannan Velu, Annamalai Vijayalakshmi, Veerasamy Vinothkumar,

OBJECTIVES:To evaluate the anti-inflammatory and antiproliferative effect of syringic acid (SRA) on oral squamous cell carcinoma (OSCC) SCC131 cells via suppression of NF-κB-induced PI3K/Akt signalling pathway. METHODS:The present study assesses the anticancer effects of SRA alongside human oral cancer (HOC) SCC131 cells through the fabrication of reactive oxygen species (ROS) ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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9-PAN promotes tubulin- and ROS-mediated cell death in human triple-negative breast cancer cells.

Prachi Verma, Praveen Kumar Reddy Nagireddy, Shweta Shyam Prassanawar, Jesuthankaraj Grace Nirmala, Ankita Gupta, Srinivas Kantevari, Manu Lopus,

OBJECTIVES:To examine the antiproliferative effect of a rationally designed, novel noscapine analogue, 9-((perfluorophenyl)methylene) aminonoscapine, '9-PAN') on MDA-MB-231 breast cancer cell line, and to elucidate the underlying mechanism of action. METHODS:The rationally designed Schiff base-containing compound, 9-PAN, was characterized using IR, NMR and mass spectra analysis. The effect of the compound ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Population pharmacokinetics of micafungin over repeated doses in critically ill patients: a need for a loading dose?

Iasonas Kapralos, Efstratios Mainas, Efthymios Neroutsos, Stella Apostolidi, Maria Siopi, Olympia Apostolopoulou, George Dimopoulos, Helen Sambatakou, Georgia Valsami, Joseph Meletiadis, Aristides Dokoumetzidis,

OBJECTIVES:To study the population pharmacokinetics of micafungin in critically ill patients, evaluate and optimize dosage regimens. METHODS:An HPLC-fluorescence bioassay for micafungin was developed, fully validated and applied to a pharmacokinetic study conducted in 14 ICU patients. Dense blood sampling was performed from days 1 to 7. A population pharmacokinetic model ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Recent trends in targeting miRNAs for cancer therapy.

Vandit Shah, Jigna Shah,

OBJECTIVES:MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the expression of numerous genes. Over the past decade, the study of miRNA biology in the context of cancer has led to the development ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Investigation on the metabolic characteristics of isobavachin in Psoralea corylifolia L. (Bu-gu-zhi) and its potential inhibition against human cytochrome P450s and UDP-glucuronosyltransferases.

Han Xing, Jing Yang, Kaidi Ren, Zifei Qin, Peile Wang, Xiaojian Zhang, Zhihong Yao, Frank J Gonzalez, Xinsheng Yao,

OBJECTIVES:Isobavachin is a phenolic with anti-osteoporosis activity. This study aimed to explore its metabolic fates in vivo and in vitro, and to investigate the potential drug-drug interactions involving CYPs and UGTs. METHODS:Metabolites of isobavachin in mice were first identified and characterized. Oxidation and glucuronidation study were performed using liver and ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Modulation of NADPH oxidase and Nrf2/HO-1 pathway by vanillin in cisplatin-induced nephrotoxicity in rats.

Nahla N Younis, Nehal M Elsherbiny, Mohamed A Shaheen, Mohamed M Elseweidy,

OBJECTIVES:To investigate the protective effect of vanillin in cisplatin (CP)-induced nephrotoxicity in rats and elucidate the role of nrf-2 and its downstream antioxidant molecules. METHODS:Rats received vanillin (100 mg/kg orally) for 10 constitutive days and CP (7.5 mg/kg, once, ip) on day 6 of vanillin administration. KEY FINDINGS:Cisplatin suppressed body weight gain, ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Immunomodulatory and antitumour bioactive labdane diterpenoids from Leonurus japonicus.

Grace Gar-Lee Yue, Xin-Xin Liang, Xiao-Li Li, Julia Kin-Ming Lee, Si Gao, Hin-Fai Kwok, Clara Bik-San Lau, Wei-Lie Xiao,

OBJECTIVES:Two labdane diterpenoids, leojapone B and heteronone B, were isolated from Leonurus japonicus Houtt., and their biological activity were evaluated in this study. METHODS:Human and mouse cancer cells, human peripheral blood mononuclear cells (PBMCs) and mouse macrophages (RAW264.7 cells) were used to evaluate the activity of leojapone B and heteronone ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Characterization of lignans in Forsythiae Fructus and their metabolites in rats by ultra-performance liquid chromatography coupled time-of-flight mass spectrometry.

Feng-Xiang Zhang, Zi-Ting Li, Chang Li, Min Li, Zhi-Hong Yao, Xin-Sheng Yao, Yi Dai,

OBJECTIVES:This study was designed to profile the chemical information of Forsythiae Fructus (FF) and investigate the in-vivo FF-related xenobiotics, especially for lignans. METHODS:Rats were oral administrated of FF and pinoresinol-4-O-glucoside, respectively. Blood and urine samples were collected after ingestion, and xenobiotics was profiled by an UPLC/Qtof MS method. KEY FINDINGS:A ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Black mulberry fruit extract alleviates streptozotocin-induced diabetic nephropathy in rats: targeting TNF-α inflammatory pathway.

Tarek Kamal Abouzed, Kadry M Sadek, Emad Waded Ghazy, Walied Abdo, Mohmed Atef Kassab, Salma Hago, Samia Abdel-Wahab, Engy A Mahrous, Essam Abdel-Sattar, Doaa H Assar,

OBJECTIVES:This study was designed to investigate the effect of Morus nigra fruit extract in retarding the progression of diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. METHODS:Diabetic male Wistar rats were injected with black mulberry fruit extract (BMFE) at doses of 150 and 300 mg/kg body weight. After 4 weeks, microalbuminuria was estimated ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.

Lijun Hu, Zongtao Zhou, Liming Deng, Qiang Ren, Zongyu Cai, Bin Wang, Zheng Li, Guangji Wang,

OBJECTIVES:Nonalcoholic fatty liver (NAFLD), a chronic progressive liver disease, is highly correlated with pathoglycemia, dyslipidemia and oxidative stress. The free fatty acid receptor 1 (FFA1) agonists have been reported to improve liver steatosis and fibrosis, and the peroxisome proliferator-activated receptor δ (PPARδ) plays a synergistic role with FFA1 in energy ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats.

Ning Tiang, Mohamad Anuar Ahad, Vikneswaran Murugaiyah, Zurina Hassan,

OBJECTIVES:Xanthones isolated from the pericarp of Garcinia mangostana has been reported to exhibit neuroprotective effect. METHODS:In this study, the effect of xanthone-enriched fraction of Garcinia mangostana (XEFGM) and α-mangostin (α-MG) were investigated on cognitive functions of the chronic cerebral hypoperfusion (CCH) rats. KEY FINDINGS:HPLC analysis revealed that XEFGM contained 55.84% ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties.

Wei Wang, Ru-Feng Yue, Zhen Jin, Li-Min He, Rong Shen, Dan Du, You-Zhi Tang,

OBJECTIVES:Chamomile has long been used as a medicinal plant due to its antioxidative and anti-inflammatory activity. Apigenin-7-O-glucoside (AG) is one of the major ethanol extract components from chamomile; however, the underlying mechanism remains unclear. METHODS:In this study, the antioxidant potential and the anti-inflammatory activities of AG were analysed and compared ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice.

Ping Liu, Lei Zhu, Limei Zhou, Xinyu Bai,

OBJECTIVES:To determine whether ecto-5'-nucleotidase (e5NT) contributes to the release of adenosine and uridine and whether is establishes the role of e5NT in acute restraint stress-induced depression and anxiety-like behaviours in mice. METHODS:Acute restraint stress was induced to detect the level of nucleoside in the hippocampus. Mouse hippocampal brain proteins were ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Modulation of non-steroidal anti-inflammatory drug-induced, ER stress-mediated apoptosis in Caco-2 cells by different polyphenolic antioxidants: a mechanistic study.

Cherdsak Boonyong, Nontima Vardhanabhuti, Suree Jianmongkol,

OBJECTIVES:Direct scavenging of reactive oxygen species could not prevent ER stress-associated cytotoxicity of indomethacin or diclofenac in Caco-2 cells. This study investigated the effects of three polyphenolic antioxidants epigallocatechin gallate (EGCG), phyllanthin and hypophyllathin in non-steroidal anti-inflammatory drug-induced Caco-2 apoptosis. METHODS:Cells were treated with ER stressors (indomethacin, diclofenac, tunicamycin or ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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Pharmacogenetic impact of UGT1A1 polymorphisms on pulmonary neuroendocrine tumours treated with metronomic irinotecan-based chemotherapy in Chinese populations.

Xu Ma, Sen Han, Ying Liu, Jing-Tao Liu, Jian Fang, Yan-Hua Zhang,

OBJECTIVES:To evaluate the effects of UGT1A1*6 and UGT1A1*28 polymorphisms on the safety and efficacy of metronomic irinotecan-based chemotherapy (IBC) in Chinese patients with pulmonary neuroendocrine tumours (PNTs). METHODS:Sixty-eight PNT patients who received metronomic IBC were observed. The quantitative fluorescent polymerase chain reaction was used to detect UGT1A1*6 and UGT1A1*28 polymorphisms. ... Read more >>

J. Pharm. Pharmacol. (The Journal of pharmacy and pharmacology)
[2020, :]

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