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Journal J. Neurosci. Res.

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Age-dependent effects of dopamine receptor inactivation on cocaine-induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity.

Cynthia A Crawford, Angie Teran, Goretti I Ramirez, Caitlin G Katz, Alena Mohd-Yusof, Shannon E Eaton, Vanessa Real, Sanders A McDougall,

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), which irreversibly inactivates dopamine (DA) receptors, causes pronounced age-dependent behavioral effects in rats. For example, EEDQ either augments or does not affect the DA agonist-induced locomotor activity of preweanling rats while attenuating the locomotion of adolescent and adult rats. The twofold purpose of this study was to determine ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease.

Tobore Onojighofia Tobore,

Huntington's disease (HD) is a rare autosomal dominant disorder affecting the corticostriatal area of the brain. HD is driven by elongated cytosine-adenine-guanine (CAG) repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in the Huntingtin gene (HTTg) which encode the huntingtin protein (HTT). Although the polyglutamine expansion ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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The effects of age and sex on the detection of pure tones by adult CBA/CaJ mice (Mus musculus).

Anastasiya Kobrina, Micheal L Dent,

Age-related hearing loss (ARHL) is a neurodegenerative disorder characterized by a gradual decrease in hearing sensitivity. Previous electrophysiological and behavioral studies have demonstrated that the CBA/CaJ mouse strain is an appropriate model for the late-onset hearing loss found in humans. However, few studies have characterized hearing in these mice behaviorally ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Dysfunctional striatal dopamine signaling in Huntington's disease.

Ellen T Koch, Lynn A Raymond,

Dopamine signaling in the striatum is critical for a variety of behaviors including movement, behavioral flexibility, response to reward and many forms of learning. Alterations to dopamine transmission contribute to pathological features of many neurological diseases, including Huntington's disease (HD). HD is an autosomal dominant genetic disorder caused by a ... Read more >>

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[2019, :]

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Neurofilaments form flexible bundles during neuritogenesis in culture and in mature axons in situ.

Sangmook Lee, Joel Eyer, Franck Letournel, Edward Boumil, Garth Hall, Thomas B Shea,

Neurofilaments (NFs) undergo cation-dependent phospho-mediated associations with each other and other cytoskeletal elements that support axonal outgrowth. Progressive NF-NF associations generate a resident, bundled population that undergoes exchange with transporting NFs. We examined the properties of bundled NFs. Bundles did not always display a fully linear profile but curved and ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Corticostriatal plasticity in the nucleus accumbens core.

Nigel S Bamford, Wengang Wang,

Small fluctuations in striatal glutamate and dopamine are required to establish goal-directed behaviors and motor learning, while large changes appear to underlie many neuropsychological disorders, including drug dependence and Parkinson's disease. A better understanding of how variations in neurotransmitter availability can modify striatal circuitry will lead to new therapeutic targets ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

Nicholas R Franich, Miriam A Hickey, Chunni Zhu, Georgina F Osborne, Nadira Ali, Tiffany Chu, Nicholas H Bove, Vincent Lemesre, Renata P Lerner, Scott O Zeitlin, David Howland, Andreas Neueder, Christian Landles, Gillian P Bates, Marie-Francoise Chesselet,

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.

George Zakhary, Prativa Sherchan, Qian Li, Jiping Tang, John H Zhang,

Neurosurgical procedures result in surgically induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of cytokines that indirectly cause the stimulation of kynurenine 3-monooxygenase (KMO) and the release of neurotoxic quinolinic acid (QUIN). This study ... Read more >>

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[2019, :]

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Inflammation-regulatory microRNAs: Valuable targets for intracranial atherosclerosis.

Jia Li, Keshen Li, Xiangyan Chen,

Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and unstable inflammatory process within ... Read more >>

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[2019, :]

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The pleiotropic effects of Innexin genes expressed in Drosophila glia encompass wing chemosensory sensilla.

Hussein Raad, Alain Robichon,

The neuroanatomy of Drosophila wing chemosensilla and the analysis of their sensory organ precursor cell lineage have demonstrated that they are surprisingly related to taste perception. The microarchitecture of wing bristles limits the use of electrophysiology methods to investigate wing chemosensory mechanisms. However, by monitoring the fluorescence of the complex ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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BDNF-overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro.

Verena Scheper, Jana Schwieger, Anika Hamm, Thomas Lenarz, Andrea Hoffmann,

The use of neurotrophic factors as therapeutic agents for neurodegenerative diseases is considered as an approach aimed at restoring and maintaining neuronal function in the peripheral and central nervous system. Since the neuroprotective effect is depending on chronic delivery of the neurotrophic factors a sustained application, e.g., via cell-based delivery ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Thermal conditions during neonatal anoxia affect the endogenous level of brain-derived neurotrophic factor.

Hanna Kletkiewicz, Justyna Maliszewska, Krzysztof Jaworski, Łukasz Jermacz, Dariusz J Smoliński, Justyna Rogalska,

Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive response such as HIF-1α activation. Currently, ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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The effects of trauma on brain and body: A unifying role for the midbrain periaqueductal gray.

Braeden A Terpou, Sherain Harricharan, Margaret C McKinnon, Paul Frewen, Rakesh Jetly, Ruth A Lanius,

Post-traumatic stress disorder (PTSD), a diagnosis that may follow the experience of trauma, has multiple symptomatic phenotypes. Generally, individuals with PTSD display symptoms of hyperarousal and of hyperemotionality in the presence of fearful stimuli. A subset of individuals with PTSD; however, elicit dissociative symptomatology (i.e., depersonalization, derealization) in the wake ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, 97(9):1110-1140]

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Task load modulates tDCS effects on language performance.

Lílian Rodrigues de Almeida, Paul A Pope, Peter C Hansen,

Transcranial direct current stimulation (tDCS) effects in cognition are inconsistent across studies. This study aimed to discuss why typical models might be insufficient to explain these effects, and to investigate a brain state factor, task load, with behavioral experiments on phonological processing. The motor theory of speech perception states that ... Read more >>

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[2019, :]

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Translating striatal activity from brain slice to whole animal neurophysiology: A guide for neuroscience research integrating diverse levels of analysis.

Howard Casey Cromwell,

An important goal of this review is highlighting research in neuroscience as examples of multilevel functional and anatomical analyses addressing basic science issues and applying results to the understanding of diverse disorders. The research of Dr. Michael Levine, a leader in neuroscience, exemplifies this approach by uncovering fundamental properties of ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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High-potassium preconditioning enhances tolerance to focal cerebral ischemia-reperfusion injury through anti-apoptotic effects in male rats.

Xiao-Feng Tan, Tao Qin, Nuo Li, Ye-Gui Yang, Jun-Hui Zheng, Lu Xie, Meng-Hua Chen,

Imbalances between cellular K+ efflux and influx are considered to be involved in cerebral ischemia-reperfusion (I/R) injury. High-potassium pretreatment alleviates this injury, but the underlying molecular mechanism is unclear. In this study, we sought to investigate whether high-potassium preconditioning enhances cerebral tolerance to I/R injury through an anti-apoptotic mechanism. Adult ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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TGF-β1 enhances the activity of acid-sensing ion channel in rat primary sensory neurons.

Chun-Yu Qiu, Ting-Ting Liu, Shuang Wei, Yi-Mei Zhou, Lei Wu, Ying Jin, Wang-Ping Hu,

Transforming growth factor-β1 (TGF-β1) is an important member of multifunctional growth factor superfamily. It has been implicated in pain signaling, but little is known about the underlying mechanisms. Herein, we report that TGF-β1 can exert a sustained enhancing effect on the functional activity of acid-sensing ion channels (ASICs) in rat ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Physiological aging at striatal synapses.

John P Walsh, Garnik Akopian,

Mike Levine's body of work guides thinking on how the basal ganglia process information to create coordinated movements and skill learning throughout the life span and in disease. This special issue is a nod to Mike's career and a well-deserved gesture by the neuroscience community thanking him for the impact ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Genetic tools to study complexity of striatal function.

Chiara Ciriachi, David Svane-Petersen, Mattias Rickhag,

As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in two main subpopulations, based on their neurochemical characterization and projection targets. These ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Exercise induces region-specific remodeling of astrocyte morphology and reactive astrocyte gene expression patterns in male mice.

Adam J Lundquist, Jacqueline Parizher, Giselle M Petzinger, Michael W Jakowec,

Astrocytes are essential mediators of many aspects of synaptic transmission and neuroplasticity. Exercise has been demonstrated to induce neuroplasticity and synaptic remodeling, such as through mediating neurorehabilitation in animal models of neurodegeneration. However, the effects of exercise on astrocytic function, and how such changes may be relevant to neuroplasticity remain ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, 97(9):1081-1094]

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Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.

Emil Jakobsen, Sofie C Lange, Lasse K Bak,

Mitochondria produce the bulk of the ATP in most cells, including brain cells. Regulating this complex machinery to match the energetic needs of the cell is a complicated process that we have yet to understand in its entirety. In this context, 3',5'-cyclic AMP (cAMP) has been suggested to play a ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, 97(8):1018-1038]

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Basal ganglia involvement in the playfulness of juvenile rats.

Stephen M Siviy,

Play is an important part of normal childhood development and can be readily studied in the laboratory rat in the form of rough-and-tumble play. Given the robust nature of rough-and-tumble play, it has often been assumed that the basal ganglia would have a prominent role in modulating this behavior. Recent ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Annexin A1 attenuates neuroinflammation through FPR2/p38/COX-2 pathway after intracerebral hemorrhage in male mice.

Yan Ding, Jerry Flores, Damon Klebe, Peng Li, Devin W McBride, Jiping Tang, John H Zhang,

Spontaneous intracerebral hemorrhage (ICH) is the deadliest stroke subtype and neuroinflammation is a critical component of the pathogenesis following ICH. Annexin A1-FPR2 signaling has been shown to play a protective role in animal stroke models. This study aimed to assess whether Annexin A1 attenuated neuroinflammation and brain edema after ICH ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Protective roles of carbonic anhydrase 8 in Machado-Joseph Disease.

Mingli Hsieh, Benjamin Y Hsieh, Chung-Yung Ma, Yi-Ting Li, Chin-San Liu, Che-Min Lo,

Machado-Joseph disease (MJD)/Spinocerebellar ataxia type 3 (SCA3) is an inherited neurodegenerative disease that can lead to a regression of motor coordination and muscle control in the extremities. It is known that expansion of CAG repeats encodes abnormally long polyQ in mutant ataxin-3, the disease protein. It is also noted that ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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Opto-chemogenetics with luminopsins: A novel avenue for targeted control of neuronal activity.

Ken Berglund, Robert E Gross,

J. Neurosci. Res. (Journal of neuroscience research)
[2019, :]

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