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Journal J. Exp. Clin. Cancer Res.

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DTL promotes cancer progression by PDCD4 ubiquitin-dependent degradation.

Haoran Cui, Qin Wang, Zhenchuan Lei, Maoxiao Feng, Zhongxi Zhao, Yunshan Wang, Guangwei Wei,

BACKGROUND:Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may involve in the process of cancer development. Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in cell apoptosis, transformation, invasion and tumor progression. METHODS:Affinity-purification mass ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):350]

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Soluble fibrinogen-like protein 2 promotes the growth of hepatocellular carcinoma via attenuating dendritic cell-mediated cytotoxic T cell activity.

Muyang Yang, Zhongwei Zhang, Jiajia Chen, Mengying Xu, Jiaquan Huang, Ming Wang, Weina Li, Xiaoyang Wan, Man-Fung Yuen, Xiaoping Luo, Dong Xi, Qin Ning,

BACKGROUND:Soluble fibrinogen-like protein 2 (sFGL2), a secretory protein expressed by regulatory T cells (Tregs) with immunosuppressive activity, is highly expressed in both the peripheral blood and tumor tissue of patients with hepatocellular carcinoma (HCC); however, sFGL2 function in HCC remains largely unknown. Here, we elucidated the potential role of sFGL2 ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):351]

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Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation.

Jianghong Yan, Xiaoyun Dou, Jing Zhou, Yuanfeng Xiong, Ling Mo, Longhao Li, Yunlong Lei,

BACKGROUND:Tubeimoside-I (TBM), a plant-derived bioactive compound, shows antitumor activity in different tumors and can enhance the efficacy of chemotherapeutic agents. However, the detail mechanism underlying remains to be elucidated. METHODS:The cytotoxic potential of TBM towards CRC cells was examined by CCK8 assay, colony formation, LDH release assay, flow cytometry method ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):353]

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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy.

Peiye Song, Yanru Li, Yuan Dong, Yingying Liang, Huinan Qu, Da Qi, Yan Lu, Xiangshu Jin, Yantong Guo, Yiyang Jia, Xinqi Wang, Wenhong Xu, Chengshi Quan,

BACKGROUND:Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear. Claudin-6 (CLDN6), a tight junction protein, acts as a tumor suppressor gene in breast cancer. Our previous studies have found that 17β-estradiol ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):354]

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LncRNA FLVCR1-AS1 mediates miR-513/YAP1 signaling to promote cell progression, migration, invasion and EMT process in ovarian cancer.

Huan Yan, Hong Li, Maria A Silva, Yichun Guan, Li Yang, Linlin Zhu, Zhan Zhang, Genxia Li, Chenchen Ren,

BACKGROUND:Long noncoding RNAs (lncRNAs) have been reported to be associated with the proliferation of several cancer cells. The aim of this study was to investigate the role of FLVCR1-AS1 in ovarian serous cancer (OSC). METHODS:FLVCR1-AS1 expression was determined in human OSC tissues, serums and cell lines. The role of FLVCR1-AS1 ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):356]

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A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells.

Shengnan Yu, Jing Zhang, Yongxiang Yan, Xudong Yao, Lijuan Fang, Hui Xiong, Yang Liu, Qian Chu, Pengfei Zhou, Kongming Wu,

BACKGROUND:Human epidermal growth factor receptor 2 (HER2) is overexpressed in multiple cancers, which is associated with poor prognosis. Herceptin and other agents targeting HER2 have potent antitumor efficacy in patients with HER2-positive cancers. However, the development of drug resistance adversely impacts the efficacy of these treatments. It is therefore urgent ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):355]

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Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma.

Claudio Pulito, Etleva Korita, Andrea Sacconi, Mariacristina Valerio, Luca Casadei, Federica Lo Sardo, Federica Mori, Maria Ferraiuolo, Giuseppe Grasso, Anna Maidecchi, Jacopo Lucci, Marius Sudol, Paola Muti, Giovanni Blandino, Sabrina Strano,

BACKGROUND:Over the past decade, newly designed cancer therapies have not significantly improved the survival of patients diagnosed with Malignant Pleural Mesothelioma (MPM). Among a limited number of genes that are frequently mutated in MPM several of them encode proteins that belong to the HIPPO tumor suppressor pathway. METHODS:The anticancer effects ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):349]

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Correction to: Molecular pattern of lncRNAs in hepatocellular carcinoma.

Haoming Mai, Bin Zhou, Li Liu, Fu Yang, Carly Conran, Yuan Ji, Jinlin Hou, Deke Jiang,

In the original publication of this article [1], the author' affiliations need to be revised, because the first and second affiliations should combine as the same affiliation. ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):352]

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TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells.

Jian Wu, Hongzhe Li, Minmin Shi, Youwei Zhu, Yang Ma, Yiming Zhong, Cheng Xiong, Hao Chen, Chenghong Peng,

BACKGROUND:Ten-eleven translocation 1 (TET1) is a dioxygenase that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) to induce DNA demethylation. TET1 has been reported to be absent in cancers, and to influence various oncogenes and anti-oncogenes. However the function of TET1 in pancreatic tumor remains poorly understood. In this study, we investigated ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):348]

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TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells.

Ruizhi He, Min Wang, Chunle Zhao, Ming Shen, Yahong Yu, Li He, Yan Zhao, Hua Chen, Xiuhui Shi, Min Zhou, Shutao Pan, Yuhui Liu, Xingjun Guo, Xu Li, Renyi Qin,

BACKGROUND:Pancreatic ductal adenocarcinoma is one of the most aggressive cancers, with a 5-year survival rate of less than 8%. The complicated tumor microenvironment, particularly TGF-β, provides possible convenience for the progression of PC cells. TGF-β regulates critical cellular processes, including autophagy. However, the mechanism and effects of TGF-β-mediated autophagy are ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):340]

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Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits.

Zhiqiang Wu, Zhuang Liu, Xiangli Jiang, Zeyun Mi, Maobin Meng, Hui Wang, Jinlin Zhao, Boyu Zheng, Zhiyong Yuan,

BACKGROUND:Prostate tumor over expressed gene 1 (PTOV1) has been reported as an oncogene in several human cancers. However, the clinical significance and biological role of PTOV1 remain elusive in non-small cell lung cancer (NSCLC). METHODS:The Cancer Genome Atlas (TCGA) data and NCBI/GEO data mining, western blotting analysis and immunohistochemistry were ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):341]

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HDACs control RUNX2 expression in cancer cells through redundant and cell context-dependent mechanisms.

Gloria Manzotti, Federica Torricelli, Benedetta Donati, Valentina Sancisi, Mila Gugnoni, Alessia Ciarrocchi,

BACKGROUND:RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid and breast gland. Consistent evidence indicates that RUNX2 expression is aberrantly reactivated in cancer and supports tumor progression. The mechanisms leading to RUNX2 expression in cancer has only recently began to ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):346]

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NR1B2 suppress kidney renal clear cell carcinoma (KIRC) progression by regulation of LATS 1/2-YAP signaling.

Lei Yin, Wenjia Li, Guangchun Wang, Heng Shi, Keyi Wang, Huan Yang, Bo Peng,

BACKGROUND:Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role of NR1B2 in KIRC. METHODS:NR1B2 expression in TCGA database were ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):343]

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Long non-coding RNA GAS5 inhibits DDP-resistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis.

Xiaoran Long, Keqi Song, Hao Hu, Qi Tian, Wenjing Wang, Qian Dong, Xia Yin, Wen Di,

BACKGROUND:Epithelial ovarian cancer (EOC) is the malignant tumor of the female reproductive system with the highest fatality rate. Tolerance of chemotherapeutic drugs like cisplatin (DDP) occurring in very early stage is one of the important factors of the poor prognosis of epithelial ovarian cancer. Here we aim to study the ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):345]

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The small molecule WNT/β-catenin inhibitor CWP232291 blocks the growth of castration-resistant prostate cancer by activating the endoplasmic reticulum stress pathway.

Sahyun Pak, Sejun Park, Yunlim Kim, Jung-Hyuck Park, Chan-Hee Park, Kyoung-June Lee, Choung-Soo Kim, Hanjong Ahn,

BACKGROUND:Androgen receptor (AR)-targeted treatments improve the survival of castration-resistant prostate cancer (CRPC) patients; however, secondary resistance to these agents ultimately occurs in virtually all patients. Therefore, alternative therapeutic targets are urgently needed. Since growing evidence demonstrates that WNT/β-catenin signaling plays an important role in CRPC, the antitumor activity and mechanism ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):342]

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PLCε regulates prostate cancer mitochondrial oxidative metabolism and migration via upregulation of Twist1.

Jiaxin Fan, Yanru Fan, Xiao Wang, Lingfang Niu, Limei Duan, Jinxiao Yang, Luo Li, Yingying Gao, Xiaohou Wu, Chunli Luo,

BACKGROUND:Metabolic rewiring is a common feature of many cancer types, including prostate cancer (PCa). Alterations in master genes lead to mitochondrial metabolic rewiring and provide an appealing target to inhibit cancer progression and improve survival. Phospholipase C (PLC)ε is a regulator of tumor generation and progression. However, its role in ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):337]

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GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.

Ziqiang Zhang, Hongyuan Xue, Yuanqiang Dong, Jun Zhang, Yida Pan, Liubin Shi, Panpan Xiong, Jie Zhu, Wenshuai Li, Wanwei Zheng, Jie Liu, Jianjun Du,

BACKGROUND:The GKN2 is a secretory protein, whose levels decrease in gastric cancer. The present study aimed to investigate the expression, function and mechanism of action of GKN2 in gastric cancer. METHODS:Molecular biology assays were performed to elucidate the function and underlying mechanisms of GKN2 in gastric cancer under stress-induced condition ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):338]

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Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

Aleksandra Adamska, Alice Domenichini, Emily Capone, Verena Damiani, Begum Gokcen Akkaya, Kenneth J Linton, Pierluigi Di Sebastiano, Xi Chen, Adam B Keeton, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Gary A Piazza, Vincenzo De Laurenzi, Gianluca Sala, Marco Falasca,

BACKGROUND:Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse events. It is therefore pivotal to investigate novel and safe pharmacological approaches. We have recently identified the ABC transporter, ABCC3, whose expression ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):312]

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Correction to: Minichromosome maintenance 3 promotes hepatocellular carcinoma radioresistance by activating the NF-κB pathway.

Qing Yang, Binhui Xie, Hui Tang, Wei Meng, Changchang Jia, Xiaomei Zhang, Yi Zhang, Jianwen Zhang, Heping Li, Binsheng Fu,

In the original publication of this article [1], the authors reported the order of the authors was incorrect and needs to be revised. The original article has been updated to rectify this error. ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):336]

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RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer.

Qingyuan Li, Qiuhua Lai, Chengcheng He, Yuxin Fang, Qun Yan, Yue Zhang, Xinke Wang, Chuncai Gu, Yiqing Wang, Liangying Ye, Lu Han, Xin Lin, Junsheng Chen, Jianqun Cai, Aimin Li, Side Liu,

BACKGROUND:Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been suggested to contribute to the carcinogenesis of colorectal cancer (CRC). However, the mechanism remains unclear. METHODS:The expression of RUNX1 in CRC and normal tissues was detected by ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):334]

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Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms.

Yifan Zhao, Xiao Shen, Ying Zhu, Anqi Wang, Yajie Xiong, Long Wang, Yao Fei, Yan Wang, Wenjuan Wang, Fang Lin, Zhongqin Liang,

BACKGROUND:Cathepsin L (CTSL) is a cysteine protease known to have important roles in regulating cancer cellular resistance to chemotherapy. However mechanism underlying which regulates CTSL-mediated drug resistance remain largely unknown. METHODS:We used NSCLC cell lines: A549, A549/TAX (paclitaxel-resistant), A549/DDP (cisplatin-resistant), H460 and PC9 cells, to evaluate CTSL and drug resistance ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):333]

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RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer.

Veenita Khare, Shaheda Tabassum, Uttara Chatterjee, Sandip Chatterjee, Mrinal K Ghosh,

BACKGROUND:RelA/p65 a crucial member of NF-κB signaling pathway plays diverse role in mediating oncogenesis. Limited knowledge prevails on the mechanistic insights of RelA gene regulation. RNA helicase p68 apart from being a vital player of RNA metabolism acts as a transcriptional coactivator of several oncogenic transcription factors including β-catenin and ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):330]

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Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B.

Lawrence H Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A Mohamedali, Yu J Cao, Walter N Hittelman, Michael G Rosenblum,

BACKGROUND:Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types. After complex recognition of target cells by T and B cells, delivery of the serine protease ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):332]

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Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancer.

Zhichao Tong, Anuja Sathe, Benedikt Ebner, Pan Qi, Christian Veltkamp, Juergen E Gschwend, Per Sonne Holm, Roman Nawroth,

BACKGROUND:CDK4/6 inhibitors are a promising treatment strategy in tumor therapy but are hampered by resistance mechanisms. This study was performed to reveal predictive markers, mechanisms of resistance and to develop rational combination therapies for a personalized therapy approach in bladder cancer. METHODS:A genome-scale CRISPR-dCas9 activation screen for resistance to the ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):322]

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RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target.

Pavana Thomas, Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava,

Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and metastasis. These cells have a distinct, signaling network active at every stage of progression. It is difficult to envisage ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):328]

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