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Pyrotinib or Lapatinib Combined With Capecitabine in HER2-Positive Metastatic Breast Cancer With Prior Taxanes, Anthracyclines, and/or Trastuzumab: A Randomized, Phase II Study.

Fei Ma, Quchang Ouyang, Wei Li, Zefei Jiang, Zhongsheng Tong, Yunjiang Liu, Huiping Li, Shiying Yu, Jifeng Feng, Shusen Wang, Xichun Hu, Jianjun Zou, Xiaoyu Zhu, Binghe Xu,

Pyrotinib, an irreversible pan-ErbB inhibitor, showed promising antitumor activity and acceptable tolerability in a phase I trial. We assessed the efficacy and tolerability of pyrotinib versus lapatinib, both in combination with capecitabine, in women with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer in an open-label, multicenter, randomized ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900108]

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Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia: A Pooled Analysis of Individual Patient Data From Nine International Cohorts.

Linus Angenendt, Christoph Röllig, Pau Montesinos, David Martínez-Cuadrón, Eva Barragan, Raimundo García, Carmen Botella, Pilar Martínez, Farhad Ravandi, Tapan Kadia, Hagop M Kantarjian, Jorge Cortes, Gunnar Juliusson, Vladimir Lazarevic, Martin Höglund, Sören Lehmann, Christian Recher, Arnaud Pigneux, Sarah Bertoli, Pierre-Yves Dumas, Hervé Dombret, Claude Preudhomme, Jean-Baptiste Micol, Christine Terré, Zdeněk Ráčil, Jan Novák, Pavel Žák, Andrew H Wei, Ing S Tiong, Meaghan Wall, Elihu Estey, Carole Shaw, Rita Exeler, Lisa Wagenführ, Friedrich Stölzel, Christian Thiede, Matthias Stelljes, Georg Lenz, Jan-Henrik Mikesch, Hubert Serve, Gerhard Ehninger, Wolfgang E Berdel, Michael Kramer, Utz Krug, Christoph Schliemann,

Nucleophosmin 1 (NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene (FLT3) is absent (FLT3-ITDneg) or present with a low allelic ratio (FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900416]

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Asymptomatic Waldenström Macroglobulinemia: Should We Consider a Different Terminology?

Frederick D Leonard,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901392]

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Reply to F.D. Leonard.

Mark Bustoros, Romanos Sklavenitis-Pistofidis, Jorge J Castillo, Steven P Treon, Irene M Ghobrial,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901708]

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Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405.

Brendan J Guercio, Sui Zhang, Fang-Shu Ou, Alan P Venook, Donna Niedzwiecki, Heinz-Josef Lenz, Federico Innocenti, Bert H O'Neil, James E Shaw, Blase N Polite, Howard S Hochster, James N Atkins, Richard M Goldberg, Kaori Sato, Kimmie Ng, Erin Van Blarigan, Robert J Mayer, Charles D Blanke, Eileen M O'Reilly, Charles S Fuchs, Jeffrey A Meyerhardt,

PURPOSE:Regular physical activity is associated with reduced risk of recurrence and mortality in patients with nonmetastatic colorectal cancer. Its influence on patients with advanced/metastatic colorectal cancer (mCRC) has been largely unexplored. PATIENTS AND METHODS:We conducted a prospective cohort study nested in Cancer and Leukemia Group B (Alliance)/SWOG 80405 (ClinicalTrials.gov identifier: ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901019]

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Two Ministers, 26 Years: A Reflection on Engaged Hope in Cancer.

Peter Yuichi Clark,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900472]

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Phase II Trial of De-Intensified Chemoradiotherapy for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma.

Bhishamjit S Chera, Robert J Amdur, Rebecca Green, Colette Shen, Gaorav Gupta, Xianming Tan, Mary Knowles, David Fried, Neil Hayes, Jared Weiss, Juneko Grilley-Olson, Shetal Patel, Adam Zanation, Trevor Hackman, Jose Zevallos, Jeffrey Blumberg, Samip Patel, Mohit Kasibhatla, Nathan Sheets, Mark Weissler, Wendell Yarbrough, William Mendenhall,

PURPOSE:To report the results of a phase II clinical trial of de-intensified chemoradiotherapy for patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma. MATERIALS AND METHODS:Major inclusion criteria were (1) having American Joint Committee on Cancer (AJCC) 7th edition T0-T3, N0-N2c, M0 (AJCC 8th edition T0-T3, N0-N2, M0), (2) being p16 ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901007]

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Axitinib in Combination With Toripalimab, a Humanized Immunoglobulin G4 Monoclonal Antibody Against Programmed Cell Death-1, in Patients With Metastatic Mucosal Melanoma: An Open-Label Phase IB Trial.

Xinan Sheng, Xieqiao Yan, Zhihong Chi, Lu Si, Chuanliang Cui, Bixia Tang, Siming Li, Lili Mao, Bin Lian, Xuan Wang, Xue Bai, Li Zhou, Yan Kong, Jie Dai, Kai Wang, Xiongwen Tang, Huaning Zhou, Hai Wu, Hui Feng, Sheng Yao, Keith T Flaherty, Jun Guo,

PURPOSE:Metastatic mucosal melanoma responds poorly to anti-programmed cell death-1 (PD-1) monotherapy. Vascular endothelial growth factor (VEGF) has been shown to play an important immunosuppressive role in the tumor microenvironment. The combination of VEGF inhibition and PD-1 blockade provides therapeutic opportunities for patients refractory to either therapy alone. PATIENTS AND METHODS:We ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900210]

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The DNA Repair Pathway as a Target for Novel Drugs in Gynecologic Cancers.

Stephanie Lheureux, Mansoor Mirza, Robert Coleman,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900347]

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Immunotherapy in Ovarian Cancer: Are We There Yet?

Lana E Kandalaft, Kunle Odunsi, George Coukos,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900508]

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Management of Platinum-Resistant, Relapsed Epithelial Ovarian Cancer and New Drug Perspectives.

Eric Pujade-Lauraine, Susana Banerjee, Sandro Pignata,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900194]

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Role of Intraperitoneal Therapy in the Initial Management of Ovarian Cancer.

Deborah K Armstrong, Joan L Walker,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900671]

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Evidence-Based Treatment Paradigms for Management of Invasive Cervical Carcinoma.

Krishnansu S Tewari, Bradley J Monk,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1802303]

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T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study.

Stacey L Doran, Sanja Stevanović, Sabina Adhikary, Jared J Gartner, Li Jia, Mei Li M Kwong, William C Faquin, Stephen M Hewitt, Richard M Sherry, James C Yang, Steven A Rosenberg, Christian S Hinrichs,

PURPOSE:Genetically engineered T-cell therapy is an emerging treatment of hematologic cancers with potential utility in epithelial cancers. We investigated T-cell therapy for the treatment of metastatic human papillomavirus (HPV)-associated epithelial cancers. METHODS:This phase I/II, single-center trial enrolled patients with metastatic HPV16-positive cancer from any primary tumor site who had received ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1802424]

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Art of Precision Medicine.

Joseph C Murray,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901397]

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Gefitinib Versus Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Mutated Lung Cancer.

Vanita Noronha, Vijay Maruti Patil, Amit Joshi, Nandini Menon, Anuradha Chougule, Abhishek Mahajan, Amit Janu, Nilendu Purandare, Rajiv Kumar, Sucheta More, Supriya Goud, Nandkumar Kadam, Nilesh Daware, Atanu Bhattacharjee, Srushti Shah, Akanksha Yadav, Vaishakhi Trivedi, Vichitra Behel, Amit Dutt, Shripad Dinanath Banavali, Kumar Prabhash,

PURPOSE:Standard first-line therapy for EGFR-mutant advanced non-small-cell lung cancer (NSCLC) is an epidermal growth factor receptor (EGFR)-directed oral tyrosine kinase inhibitor. Adding pemetrexed and carboplatin chemotherapy to an oral tyrosine kinase inhibitor may improve outcomes. PATIENTS AND METHODS:This was a phase III randomized trial in patients with advanced NSCLC harboring ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901154]

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Management of Rare Ovarian Cancer Histologies.

David M Gershenson, Aikou Okamoto, Isabelle Ray-Coquard,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1802419]

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Advances in the Management of Platinum-Sensitive Relapsed Ovarian Cancer.

Sara Bouberhan, Eric Pujade-Lauraine, Stephen A Cannistra,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900314]

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Progress and Promise in Treating Gynecologic Cancers.

Stephen A Cannistra, Eric Pujade-Lauraine,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1901097]

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Role of Neoadjuvant Chemotherapy in Advanced Epithelial Ovarian Cancer.

Andreas du Bois, Thaïs Baert, Ignace Vergote,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900022]

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Evolving Concepts in the Management of Newly Diagnosed Epithelial Ovarian Cancer.

Charlie Gourley, Michael A Bookman,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900337]

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Is There a Role for Intraperitoneal Chemotherapy, Including HIPEC, in the Management of Ovarian Cancer?

Ignace Vergote, Philipp Harter, Luis Chiva,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900091]

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Update on Genetic Testing in Gynecologic Cancer.

Susan M Domchek, Mark E Robson,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900363]

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Uterine Cancer: Adjuvant Therapy and Management of Metastatic Disease.

Carien L Creutzberg, Karen H Lu, Gini F Fleming,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900037]

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Long-Term Risk of Infections After Treatment of Childhood Leukemia: A Population-Based Cohort Study Using Administrative Health Data.

Marie-Claude Pelland-Marcotte, Jason D Pole, Jeremiah Hwee, Rinku Sutradhar, Michelle Science, Paul C Nathan, Lillian Sung,

PURPOSE:Infections are a frequent complication during childhood leukemia treatment. Little is known about the infectious risk in survivors. We compared the relative rate (RR) of infections after treatment completion between pediatric leukemia survivors and the general population. METHODS:We performed a retrospective, population-based cohort study of children diagnosed with leukemia between ... Read more >>

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, :JCO1900570]

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