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Garcinia cambogia suppresses adipogenesis in 3T3-L1 cells by inhibiting p90RSK and Stat3 activation during mitotic clonal expansion.

Joo-Hui Han, Keun-Woo Jang, Min-Ho Park, Chang-Seon Myung,

Obesity is associated with an increase in adipose tissue, which is mediated by hyperplasia and hypertrophy. Therefore, inhibiting cell proliferation during mitotic clonal expansion (MCE) is one of the major strategies for preventing obesity. The antagonistic effects of Garcinia cambogia (G. cambogia) on obesity have been studied in animal experimental ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, :]

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PACAP ameliorates fertility in obese male mice via PKA/CREB pathway-dependent Sirt1 activation and p53 deacetylation.

Qiuxia Yan, Hongke Huang, Shiyin Lu, Biqian Ou, Jia Feng, Wailan Shan, Huixian Li, Zixian Wang, An Hong, Yi Ma,

Obesity is strongly linked to male infertility. Testicular spermatogenic cell apoptosis plays an important role in obesity-related male infertility. Pituitary adenylate cyclase-activating peptide (PACAP) has been recently shown to exhibit antiapoptotic and antidiabetic effects. However, the effects of PACAP on obesity-related male infertility remain unknown. The purpose of the current ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(10):7465-7483]

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miRNA-192 and -215 activate Wnt/β-catenin signaling pathway in gastric cancer via APC.

Shiqi Deng, Xiaojing Zhang, Ying Qin, Wangchun Chen, Hu Fan, Xianling Feng, Jian Wang, Ruibin Yan, Yanqiu Zhao, Yulan Cheng, Yanjie Wei, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Stephen J Meltzer, Song Li, Kuan Li, Yin Peng, Zhe Jin,

Although great progress has been made in surgical techniques, traditional radiotherapy, and chemotherapy, gastric cancer (GC) is still the most common malignant tumor and has a high mortality, which highlights the importance of novel diagnostic markers. Emerging studies suggest that different microRNAs (miRNAs) are involved in tumorigenesis of GC. In ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(9):6218-6229]

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Silencing of long noncoding RNA LEF1-AS1 prevents the progression of hepatocellular carcinoma via the crosstalk with microRNA-136-5p/WNK1.

Hui Dong, Peng Jian, Mengchu Yu, Lixin Wang,

Long noncoding RNAs (lncRNAs) have been recognized as cancer-associated biological molecules, favoring hepatocellular carcinoma (HCC) progression. This study was conducted to elucidate the effects lncRNA lymphoid enhancer-binding Factor 1 antisense RNA (LEF1-AS1) on the pathological development of HCC, along with the crosstalk involving microRNA-136-5p (miR-136-5p) and with-no-K (lysine) kinase 1 ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(10):6548-6562]

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Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscle.

Baoyi Zhu, Fatima Daoud, Shaohua Zeng, Ljubica Matic, Ulf Hedin, Bengt Uvelius, Catarina Rippe, Sebastian Albinsson, Karl Swärd,

Smooth muscle cells (SMCs) are characterized by a high degree of phenotypic plasticity. Contractile differentiation is governed by myocardin-related transcription factors (MRTFs), in particular myocardin (MYOCD), and when their drive is lost, the cells become proliferative and synthetic with an expanded endoplasmic reticulum (ER). ER is responsible for assembly and ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(10):7370-7382]

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Putative promoters within gene bodies control exon expression via TET1-mediated H3K36 methylation.

Ling Ma, Tahir Muhammad, Hongyang Wang, Guangyuan Du, Ali Sakhawat, Yazi Wei, Aamir Ali Khan, Xianling Cong, Yinghui Huang,

Hypermethylation of gene promoter has been indicated for the contribution of gene silencing, and DNA demethylating drugs, such as 5-aza-2'-deoxycytidine (DAC), has been used clinically for cancer treatment. However, the reason why a proportion of genes with hypermethylated promoter exhibit high expression levels remains unclear and this drug is not ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(10):6711-6724]

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Excessive "orthotopic" fat accumulation: Links with cardiometabolic diseases and potential drug treatment.

Niki Katsiki, Dimitri P Mikhailidis,

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(9):6321-6322]

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α-Mangostin attenuates stemness and enhances cisplatin-induced cell death in cervical cancer stem-like cells through induction of mitochondrial-mediated apoptosis.

Hung-Ju Chien, Tsung-Ho Ying, Shu-Ching Hsieh, Chia-Liang Lin, Yung-Luen Yu, Shao-Hsuan Kao, Yi-Hsien Hsieh,

Cancer stem cells (CSCs) exhibit specific characteristics including decontrolled self-renewal, tumor-initiating, promoting, and metastatic potential, abnormal stemness signaling, and chemotherapy resistance. Thus, targeting CSC is becoming an emerging cancer treatment. α-Mangostin has been shown to have potent and multiple anticancer activities. Accordingly, we hypothesized that α-mangostin may diminish the stemness and ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(7-8):5590-5601]

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Prospects for the involvement of cancer stem cells in the pathogenesis of osteosarcoma.

Sama Izadpanah, Parastoo Shabani, Ali Aghebati-Maleki, Amir Baghbanzadeh, Ali Fotouhi, Amir Bisadi, Leili Aghebati-Maleki, Behzad Baradaran,

Osteosarcoma (OS) is one of the most common bone tumors in children and adolescents that cause a high rate of mortality in this age group and tends to be metastatic, in spite of chemotherapy and surgery. The main reason for this can be returned to a small group of malignant ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(5):4167-4182]

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circRNA-associated ceRNA network construction reveals the circRNAs involved in the progression and prognosis of breast cancer.

Xiaoran Ma, Cun Liu, Chundi Gao, Jie Li, Jing Zhuang, Lijuan Liu, Huayao Li, Xue Wang, Xiaoming Zhang, Shixia Dong, Chao Zhou, Changgang Sun,

Recently, increasing evidences show that circular RNAs (circRNAs) are important regulators of various diseases, especially cancer. However, the regulatory role and the potential mechanism of action of circRNAs in breast cancer remain largely unknown. In this study, weighted gene co-expression network analysis was conducted with the differentially expressed miRNAs and ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(4):3973-3983]

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Role of Sonic hedgehog signaling in cell cycle, oxidative stress, and autophagy of temozolomide resistant glioblastoma.

Jessica R Honorato, Rachel A Hauser-Davis, Enrico M Saggioro, Fábio V Correia, Sidney F Sales-Junior, Lorena O S Soares, Leandro da R Lima, Vivaldo Moura-Neto, Giselle P de F Lopes, Tania C L de S Spohr,

The first-line chemotherapy treatment for Glioblastoma (GBM) - the most aggressive and frequent brain tumor - is temozolomide (TMZ). The Sonic hedgehog (SHH) pathway is involved with GBM tumorigenesis and TMZ chemoresistance. The role of SHH pathway inhibition in the potentiation of TMZ's effects using T98G, U251, and GBM11 cell ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(4):3798-3814]

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Cytotoxic and apoptotic properties of a novel nano-toxin formulation based on biologically synthesized silver nanoparticle loaded with recombinant truncated pseudomonas exotoxin A.

Navid Gholami, Reza Ahangari Cohan, Alireza Razavi, Razieh Bigdeli, Aziz Dashbolaghi, Vahid Asgary,

Bacterial toxins have received a great deal of attention in the development of antitumor agents. Currently, these protein toxins were used in the immunotoxins as a cancer therapy strategy. Despite the successful use of immunotoxins, immunotherapy strategies are still expensive and limited to hematologic malignancies. In the current study, for ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(4):3711-3720]

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Long noncoding RNA MIAT2 alleviates lipopolysaccharide-induced inflammatory damage in WI-38 cells by sponging microRNA-15.

Hong Zhang, Jing Zhao, Peng Shao,

Neonatal pneumonia is a high neonatal mortality disease. We studied the function and mechanism of long noncoding RNA myocardial infarction-associated transcript 2 (lncRNA MIAT2) on lipopolysaccharide (LPS)-induced inflammation in WI-38 cells. Cell Counting Kit-8 and apoptosis assay were respectively used to detect the functions of LPS, MIAT2, and microRNA-15 (miR-15) ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(4):3690-3697]

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YAP/TEAD3 signal mediates cardiac lineage commitment of human-induced pluripotent stem cells.

Zhenbo Han, Ying Yu, Benzhi Cai, Zihang Xu, Zhengyi Bao, Ying Zhang, Djibril Bamba, Wenya Ma, Xinlu Gao, Ye Yuan, Lai Zhang, Meixi Yu, Shenzhen Liu, Gege Yan, Mengyu Jin, Qi Huang, Xiuxiu Wang, Bingjie Hua, Fan Yang, Zhenwei Pan, Haihai Liang, Yu Liu,

Cardiomyocytes differentiated from human-induced pluripotent stem cells (hiPSCs) hold great potential for therapy of heart diseases. However, the underlying mechanisms of its cardiac differentiation have not been fully elucidated. Hippo-YAP signal pathway plays important roles in cell differentiation, tissue homeostasis, and organ size. Here, we identify the role of Hippo-YAP ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(3):2753-2760]

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Immortalized Hertwig's epithelial root sheath cell line works as model for epithelial-mesenchymal interaction during tooth root formation.

Sicheng Zhang, Xuebing Li, Shikai Wang, Yan Yang, Weihua Guo, Guoqing Chen, Weidong Tian,

Hertwig's epithelial root sheath (HERS) is critical for epithelial-mesenchymal interaction (EMI) during tooth root formation. However, the exact roles of HERS in odontogenic differentiation by EMI have not been well characterized, because primary HERS cells are difficult to obtain. Immortalized cell lines constitute crucial scientific tools, while there are few ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, 235(3):2698-2709]

Cited: 1 time

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miR-409-5p negatively regulates Wnt/Beta catenin signaling pathway by targeting Lrp-8.

Ravi Prakash, Aijaz A John, Divya Singh,

Signaling pathways like Wnt play a vital part in all aspects of skeletal development which include osteoblastogenesis and osteoclastogenesis. Inactivation of Wnt signaling pathway leads to bone-related disorders, whereas activation of Wnt signaling pathway can cure bone pathologies like osteoporosis. Certain microRNA(s) have been identified that commune with Wnt signaling ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(12):23507-23517]

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S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro.

Jingbao Kan, Cuiping Zhao, Shan Lu, Geqian Shen, Jie Yang, Pei Tong, Ling Xi, Rihua Zhang, Xiubin Liang, Dongming Su, Dong Li, Yun Liu,

To investigate the role of S100 calcium-binding protein A16 (S100A16) in hepatic lipid metabolism, S100a16 transgenic, S100a16 knockdown, and wildtype C57BL/6 mice were fed either a high-fat diet (HFD) or normal-fat diet (NFD) for 16 weeks. The results showed that for HFD-fed mice, S100a16 transgenic mice showed significantly more severe ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(11):21395-21406]

Cited: 1 time

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FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression.

Yuling Hong, Haifeng Qin, Yin Li, Yuhai Zhang, Xunrong Zhuang, Lei Liu, Kun Lu, Long Li, Xiaoling Deng, Fan Liu, Songlin Shi, Guoyan Liu,

Circular RNAs (circRNAs) are a new class of RNAs, and many studies have identified thousands of circRNAs in tumor cells. Fibronectin type III domain-containing protein 3B (FNDC3B) circular RNA (circFNDC3B, circBase ID: hsa_circ_0006156) circularizes with exons 5 and 6. Gibson Assembly DNA technology was used to construct a circFNDC3B expression ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(11):19895-19910]

Cited: 10 times

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Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes.

Lin Wu, Yue Wang, Gefu Chi, Bingyu Shen, Ye Tian, Zheng Li, Lu Han, Qiaoling Zhang, Haihua Feng,

Morin (MO), a natural bioflavinoid, exists in many herbs. Previous studies have acclaimed MO's anti-inflammatory, antidiabetic, antioxidant, antifibrotic, anticancer, and antihyperglycemic biological effects. This study aimed to assess the molecular mechanism of MO involved in the oleic acid (OA)-induced inflammatory damage and lipid accumulation in HepG2 cell and tyloxapol (Ty)-induced ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(11):19785-19798]

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Autophagy in pulmonary hypertension: Emerging roles and therapeutic implications.

Chun-Fang Zhang, Fang-Yun Zhao, Shuang-Lan Xu, Jie Liu, Xi-Qian Xing, Jiao Yang,

Autophagy is an important mechanism for cellular self-digestion and basal homeostasis. This gene- and modulator-regulated pathway is conserved in cells. Recently, several studies have shown that autophagic dysfunction is associated with pulmonary hypertension (PH). However, the relationship between autophagy and PH remains controversial. In this review, we mainly introduce the ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(10):16755-16767]

Cited: 2 times

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Use of stem cells as carriers of oncolytic viruses for cancer treatment.

Elham Zendedel, Stephen L Atkin, Amirhossein Sahebkar,

Therapeutic application of stem cells and oncolytic viruses in cancer treatment has rapidly increased in the last decade. Oncolytic viruses are considered as a new class of anticancer agents because of their ability to selectively infect and destroy cancer cells. Furthermore, regarding the specific migratory capacity of stem cells, they ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, :]

Cited: 4 times

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Positive correlation between vitamin D receptor gene TaqI variant and gastric cancer predisposition in a sample of Iranian population.

Negin Parsamanesh, Maryam Moossavi, Tahmineh Tavakkoli, Hossein Javdani, Tahereh Fakharian, Seyedeh Zahra Moossavi, Mohsen Naseri,

Gastric cancer is the second cause of cancer-related mortality and the fourth most common cancers worldwide. Owing to the immune modulatory effect of vitamin D in the body, the role of vitamin D receptor gene in vitamin D regulation receives a great deal of research interest. The aim of the ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, :]

Cited: 1 time

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The role of arsenic in obesity and diabetes.

Tahereh Farkhondeh, Saeed Samarghandian, Mohsen Azimi-Nezhad,

As many individuals worlwide are exposed to arsenic, it is necessary to unravel the role of arsenic in the risk of obesity and diabetes. Therefore, the present study reviewed the effects of arsenic exposure on the risk and potential etiologic mechanisms of obesity and diabetes. It has been suggested that ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(8):12516-12529]

Cited: 1 time

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The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial-mesenchymal transition and is silenced in colorectal cancer.

Qin Xiang, Xiaoqian He, Junhao Mu, Haixi Mu, Dishu Zhou, Jun Tang, Qian Xiao, Yu Jiang, Guosheng Ren, Tingxiu Xiang, Weiyan Peng,

In this study, we found that the phospholipase C delta1 (PLCD1) protein expression is reduced in colorectal tumor tissues compared with paired surgical margin tissues. PLCD1-promoted CpG methylation was detected in 29/64 (45%) primary colorectal tumors, but not in nontumor tissues. The PLCD1 RNA expression was also reduced in three ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(8):13906-13916]

Cited: 1 time

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Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta-analysis.

Mohsen Heidary, Mohammad Javad Nasiri, Mehdi Mirsaeidi, Faramarz Masjedian Jazi, Saeed Khoshnood, Michel Drancourt, Davood Darban-Sarokhalil,

BACKGROUND:Mycobacterium avium-intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV. METHODS:Embase, PubMed, and Web of Science were searched for relevant studies. All statistical ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(7):9994-10001]

Cited: 1 time

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