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ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer.

Guoqiang Hua, Aurélie Bergon, Pierre Cauchy, Brigitte Kahn-Perlès, François Bertucci, Daniel Birnbaum, Nadia Benkirane-Jessel, Jean Imbert,

The presence of nuclear ERBB2 receptor-type tyrosine kinase is one of the causes of the resistance to membrane ERBB2-targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at least two different mechanisms: proteolytic shedding of the extracellular domain of the full-length receptor and ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan.

Liangping Su, Tingting Zhao, Hongyuan Li, Hongmei Li, Xin Su, Xueqing Ba, Yu Zhang, Baiqu Huang, Jun Lu, Xiaoxue Li,

5O-GlcNAc transferase (OGT) is the enzyme catalyzing protein O-GlcNAcylation by addition of a single O-linked-β-N-acetylglucosamine molecule (O-GlcNAc) to nuclear and cytoplasmic targets, and it uses uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) as a donor. As UDP-GlcNAc is the final product of the nutrient-sensing hexosamine signaling pathway, overexpression or knockout of ogt in mammals ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Peptidyl inhibition of Spt4-Spt5: Protein-protein inhibitors for targeting the transcriptional pathway related to C9orf72 expansion repeats.

Alexey Rayevsky, Maxim Platonov, Vasyl Hurmach, Anastasia Yakovenko, Dmitriy Volochnyuk,

Spt4/Spt5 is an useful target as it is likely a transcription factor that has implications for long non-coding RNA repeats related to frontotemporal dementia (FTD) found in the C9orf72 disease pathology. Inhibitors for Spt4/Spt5 using peptides as a starting point for assays as a means for developing small molecules, which ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

Guodong Pan, Mandar Deshpande, Haiyan Pang, Paul M Stemmer, Nicholas J Carruthers, Colin T Shearn, Donald S Backos, Suresh S Palaniyandi,

Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation, reactive oxygen species (ROS)-induced lipid peroxidation results in the formation of reactive aldehydes, foremost of which is 4-hydroxy-2-nonenal (4HNE). 4HNE forms covalent adducts with proteins, negatively impacting cellular protein function. ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Circular RNA circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression.

Xiqiang Xu, Yuan Chen, Bingyi Tan, Dachuan Wang, Zenong Yuan, Feng Wang,

Circular RNAs (circRNAs) are a novel class of noncoding RNAs that are widely expressed in human disease. However, circRNAs expression profile and potential mechanism in osteoporosis pathogenesis remain to be further studied. In the present study, a total of 69 circRNAs were identified to be abnormally expressed in osteoporosis patient ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Protective effect of microRNA-134-3p on multiple sclerosis through inhibiting PRSS57 and promotion of CD34+ cell proliferation in rats.

Qihan Song, Fengli Zhao, Jingfan Yao, Hailin Dai, Lei Hu, Shun Yu,

MicroRNAs (miRs) have been extensively studied for their involvement in multiple sclerosis (MS). We investigated the involvement of miR-134-3p on MS. The MS rat model was established, and positive expression of interleukin-17 (IL-17) was detected using the immunohistochemical method while the expression of miR-134-3p and serine protease 57 (PRSS57) was ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Long noncoding RNA PRKCQ-AS1 promotes CRC cell proliferation and migration via modulating miR-1287-5p/YBX1 axis.

Guoce Cui, HongLi Zhao, Lina Li,

Colorectal cancer (CRC) brings more than 600 000 deaths every year around the globe, making itself the third most frequently occurred carcinoma. The great progress human achieved in diagnosis and treatment of various cancers has failed to reverse this trend. Fortunately, growing evidence has implied the relationship between lncRNAs and cancer ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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MicroRNA-10a promotes epithelial-to-mesenchymal transition and stemness maintenance of pancreatic cancer stem cells via upregulating the Hippo signaling pathway through WWC2 inhibition.

Caiyan Wang, Wen Yin, Hui Liu,

MicroRNAs (miRNAs)-mediated cancer stem cells (CSCs) have drawn wide attention. This study aimed to probe the role of miR-10a in epithelial-mesenchymal transition (EMT) and stemness maintenance of pancreatic CSCs (PCSCs). Differentially expressed miRs and genes in pancreatic cancer (PC) were predicted via an online database, and the miR-10a and WW ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress-dependent neuronal death.

Vanessa Castelli, Francesco Melani, Claudio Ferri, Michele d'Angelo, Mariano Catanesi, Davide Grassi, Elisabetta Benedetti, Antonio Giordano, Annamaria Cimini, Giovambattista Desideri,

Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H2 O2 in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Thrombospondin-5 and fluvastatin promote angiogenesis and are protective against endothelial cell apoptosis.

Furqan Muqri, Alex Helkin, Kristopher G Maier, Vivian Gahtan,

The thrombospondins (TSPs), multifunctional matricellular proteins, are known mediators of endothelial cell (EC) angiogenesis and apoptosis. TSP-1, an antiangiogenic molecule, is important in the progression of vascular disease, in part by inducing EC apoptosis. TSP-2, although less studied, also induces EC apoptosis and inhibits angiogenesis. The effects of TSP-5 are ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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MiR-543 regulates myoblast proliferation and differentiation of C2C12 cells by targeting KLF6.

Tingting Kang, Wenkai Xing, Yu Xi, Kun Chen, Mengsi Zhan, Xiaoyin Tang, Yueying Wang, Ruirui Zhang, Minggang Lei,

MicroRNA-543 (miR-543) has been found to play a suppressive role in various human cancers in many studies, whereas the specific functions of miR-543 in muscle development remain poorly understood. Here, we found that the expression of miR-543 was high in skeletal muscle and increased during the differentiation of C2C12 cells. Overexpression of ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Construction and evaluation of a prognosis lncRNA model for hepatocellular carcinoma.

Fulei Li, Lu Bai, Shasha Li, Yanling Chen, Xiaofei Xue, Zujiang Yu,

Current studies indicate that long non-coding RNA (lncRNA) is often abnormally expressed in hepatocellular carcinoma (HCC). We intend to generate a multi-lncRNA signal to improve the prognosis of HCC. By analyzing 12 pairs of HCC and adjacent normal mucosal tissues, 3900 differentially expressed lncrnas were identified as candidate biomarkers for ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Long noncoding RNA SOX21-AS1 regulates the progression of triple-negative breast cancer through regulation of miR-520a-5p/ORMDL3 axis.

Xia Liu, Jingyong Song, Yu Kang, Yaojia Wang, Anyue Chen,

Recently, long noncoding RNAs (lncRNAs) have been reported as a new kind of controllers about cancer processes in biology. In spite of the dysregulation of lncRNAs in various kinds of cancers, only a little of the information was effective on the expression configuration and inner effects of lncRNAs in triple-negative ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Exosomes derived from RPE cells under oxidative stress mediate inflammation and apoptosis of normal RPE cells through Apaf1/caspase-9 axis.

Yifeng Ke, Xiaoe Fan, Hao Rui, Ren Xinjun, Wen Dejia, Zheng Chuanzhen, Xiaorong Li,

This study aims to explore the effects of exosomes, secreted by retinal pigment epithelial (RPE) cells under oxidative stress (OS), on apoptosis and inflammation of normal RPE cells. Exosomes secreted by normal RPE cells (named as exo) and rotenone (2.5 µmol/L) stimulated RPE cells (named as rot-exo) were isolated and extracted ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Construction of lncRNA-associated ceRNA networks to identify prognostic lncRNA biomarkers for glioblastoma.

Zhendong Liu, Xiaoxiong Wang, Guang Yang, Chen Zhong, Ruotian Zhang, Junyi Ye, Yingqiang Zhong, Junlong Hu, Beylerli Ozal, Shiguang Zhao,

Long noncoding RNAs (lncRNAs) serve as competitive endogenous RNAs (ceRNAs) that play significant regulatory roles in the pathogenesis of tumors. However, the role of lncRNAs, especially the lncRNA-related ceRNA regulatory network, in glioblastoma (GBM) has not been fully elucidated. The goal of the current study was to construct lncRNA-microRNA-mRNA-related ceRNA networks ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, 121(7):3502-3515]

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LncRNA MALAT1 targeting miR-124-3p regulates DAPK1 expression contributes to cell apoptosis in Parkinson's Disease.

Yi Lu, Zhongying Gong, Xiaojie Jin, Peng Zhao, Yuting Zhang, Zhiyun Wang,

Death associated protein kinase 1 (DAPK1) was initially discovered in the progress of gamma-interferon induced programmed cell death, it is a key factor in the central nervous system, including Parkinson's disease (PD). However, the underlying mechanisms of DAPK1 in PD remain unclear and this research work aims to explore the potential ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory feedback circuit influences the invasion and migration of cervical cancer HeLa cells.

Ya Jie Xu, He Yu, Guang Xin Liu,

Circular RNA (circRNA) molecules contain microRNA (miRNA) response elements that are able to competitively bind miRNAs as well as function as miRNA sponges within cells, which can reduce miRNA inhibition of target genes, thereby increasing their expression. TargetScan and miRanda bioinformatic tools were used to analyze the binding sites between genes. ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Teneligliptin inhibits IL-1β-induced degradation of extracellular matrix in human chondrocytes.

Feng Gao, Yanbing Wang, Minfei Wu,

The mechanisms driving the pathologic progression of osteoarthritis (OA) have not yet to be fully elucidated. Excessive and irreversible breakdown of the extracellular matrix is the main hallmark of OA. Inhibitors of DPP-4 have been widely used for over a decade as a treatment for type-2 diabetes, but the promising ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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IRX5 prompts genomic instability in colorectal cancer cells.

Xun Sun, Xinying Jiang, Jianzhong Wu, Rong Ma, Yiqi Wu, Haixia Cao, Zhuo Wang, Siwen Liu, Junying Zhang, Yang Wu, Yuan Zhang, Jifeng Feng, Ting Wang,

The Iroquois homeobox gene 5 (IRX5), one of the members of the Iroquois homeobox family, has been identified to correlate with worse prognosis in many cancers, including colorectal cancer (CRC). In this study, upregulation of IRX5 revealed a great reduction in the proliferation of CRC colorectal cancer cell line SW480 ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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FAM20C phosphorylation of the RGDSVVYGLR motif in osteopontin inhibits interaction with the αvβ3 integrin.

Gitte N Schytte, Brian Christensen, Ida Bregenov, Katarzyna Kjøge, Carsten Scavenius, Steen V Petersen, Jan J Enghild, Esben S Sørensen,

Osteopontin (OPN) is a ubiquitously expressed, multifunctional, and highly phosphorylated protein. OPN contains two neighboring integrin-binding motifs, RGD and SVVYGLR, which mediate interaction with cells. Phosphorylation and proteolytic processing affect the integrin-binding activities of OPN. Here we report that the kinase, FAM20C, phosphorylates Ser146 in the 143 RGDSVVYGLR152 motif of ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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Functions of beta2-adrenergic receptor in human periodontal ligament cells.

Sayuri Hamano, Atsushi Tomokiyo, Daigaku Hasegawa, Asuka Yuda, Hideki Sugii, Shinichiro Yoshida, Hiromi Mitarai, Naohisa Wada, Hidefumi Maeda,

Adrenergic receptors (ARs) are receptors of noradrenalin and adrenalin, of which there are nine different subtypes. In particular, β2 adrenergic receptor (β2-AR) is known to be related to the restoration and maintenance of homeostasis in bone and cardiac tissues; however, the functional role of signaling through β2-AR in periodontal ligament ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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The immunomodulatory effects of tachykinins and their receptors.

Sahar Khorasani, Nadia Boroumand, Fahimeh Lavi Arab, Seyed Isaac Hashemy,

Tachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non-neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune-related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, 121(5-6):3031-3041]

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Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.

Dongping Xu, Yutong Wu, Xiufang Wang, Xiaoyun Hu, Wenyan Qin, Yalun Li, Yilin Wang, Zhen Zhang, Senxu Lu, Tong Sun, Zhikun Wu, Dandan Fu, Boshi Fu, Jing Zhang, Qiuchen Chen, Minjie Wei, Lin Zhao, Huizhe Wu,

Circular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs in CRC is still in its infancy. Herein, we discovered the differential expressed circRNAs (DECs) between CRC tissues and matched adjacent using ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, :]

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MeCP2 epigenetically regulates alpha-smooth muscle actin in human lung fibroblasts.

Zheyi Xiang, Qingxian Zhou, Min Hu, Yan Y Sanders,

BACKGROUND:A critical feature for fibroblasts differentiation into myofibroblasts is the expression of alpha-smooth muscle actin (α-SMA) during the tissue injury and repair process. The epigenetic mechanism, DNA methylation, is involved in regulating α-SMA expression. It is not clear how methyl-CpG-binding protein 2 (MeCP2) interacts with CpG-rich region in α-SMA, and ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, 121(7):3616-3625]

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Transcriptome-wide study of the response of human trabecular meshwork cells to the substrate stiffness increase.

Jinjun Tie, Dong Chen, Junhong Guo, Shengjie Liao, Xiaotian Luo, Yu Zhang, Ruru Guo, Chenjia Xu, Dandan Huang, Yi Zhang, Jiantao Wang,

Elevated intraocular pressure, a major risk factor of glaucoma, is caused by the abnormal function of trabecular outflow pathways. Human trabecular meshwork (HTM) tissue plays an important role in the outflow pathways. However, the molecular mechanisms that how TM cells respond to the elevated IOP are largely unknown. We cultured ... Read more >>

J. Cell. Biochem. (Journal of cellular biochemistry)
[2020, 121(5-6):3112-3123]

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