Full Text Journal Articles in
Journal J. Biol. Chem.

Advertisement

Find full text journal articles






The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.

Seita Tomida, Misaki Takata, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Yasuhiko Kizuka,

Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear. At the luminal side and uncommon for Golgi proteins, FUT8 has an Src homology 3 ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2020, 295(23):7992-8004]

Cited: 0 times

View full text PDF listing >>



CD44 Transmembrane Receptor and Hyaluronan Regulate Adult Hippocampal Neural Stem Cell Quiescence and Differentiation.

Weiping Su, Scott C Foster, Rubing Xing, Kerstin Feistel, Reid H J Olsen, Summer F Acevedo, Jacob Raber, Larry S Sherman,

Adult neurogenesis in the hippocampal subgranular zone (SGZ) is involved in learning and memory throughout life but declines with aging. Mice lacking the CD44 transmembrane receptor for the glycosaminoglycan hyaluronan (HA) demonstrate a number of neurological disturbances including hippocampal memory deficits, implicating CD44 in the processes underlying hippocampal memory encoding, ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2017, 292(11):4434-4445]

Cited: 11 times

View full text PDF listing >>



Advertisement

Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.

Jingjing Gong, Glenn Belinsky, Usman Sagheer, Xuchen Zhang, Paul J Grippo, Chuhan Chung,

An increase in autophagy characterizes pancreatic carcinogenesis, but the signals that regulate this process are incompletely understood. Because canonical Wnt/β-catenin signaling is necessary for the transition from early to advanced pancreatic intraepithelial neoplasia (PanIN) lesions, we assessed whether Wnt ligands and endogenous inhibitors of Wnt signaling modulate autophagy. In this ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(42):22074-22085]

Cited: 2 times

View full text PDF listing >>



Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.

Valerie N Babinsky, Fadil M Hannan, Caroline M Gorvin, Sarah A Howles, M Andrew Nesbit, Nigel Rust, Aylin C Hanyaloglu, Jianxin Hu, Allen M Spiegel, Rajesh V Thakker,

Germline loss- and gain-of-function mutations of G-protein α-11 (Gα11), which couples the calcium-sensing receptor (CaSR) to intracellular calcium (Ca(2+) i) signaling, lead to familial hypocalciuric hypercalcemia type 2 (FHH2) and autosomal dominant hypocalcemia type 2 (ADH2), respectively, whereas somatic Gα11 mutations mediate uveal melanoma development by constitutively up-regulating MAPK signaling. ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(20):10876-10885]

Cited: 17 times

View full text PDF listing >>



Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein.

Irida Kastrati, Marton I Siklos, Esther L Calderon-Gierszal, Lamiaa El-Shennawy, Gergana Georgieva, Emily N Thayer, Gregory R J Thatcher, Jonna Frasor,

In breast tumors, activation of the nuclear factor κB (NFκB) pathway promotes survival, migration, invasion, angiogenesis, stem cell-like properties, and resistance to therapy--all phenotypes of aggressive disease where therapy options remain limited. Adding an anti-inflammatory/anti-NFκB agent to breast cancer treatment would be beneficial, but no such drug is approved as ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(7):3639-3647]

Cited: 26 times

View full text PDF listing >>



Hierarchal Autophagic Divergence of Hematopoietic System.

Yan Cao, Suping Zhang, Na Yuan, Jian Wang, Xin Li, Fei Xu, Weiwei Lin, Lin Song, Yixuan Fang, Zhijian Wang, Zhen Wang, Han Zhang, Yi Zhang, Wenli Zhao, Shaoyan Hu, Xueguang Zhang, Jianrong Wang,

Autophagy is integral to hematopoiesis and protects against leukemogenesis. However, the fundamentals of the required molecular machinery have yet to be fully explored. Using conditional mouse models to create strategic defects in the hematopoietic hierarchy, we have shown that recovery capacities in stem cells and somatic cells differ if autophagy ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(38):23050-23063]

Cited: 11 times

View full text PDF listing >>



Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.

Maria C Franco, Karina C Ricart, Analía S Gonzalez, Cassandra N Dennys, Pascal A Nelson, Michael S Janes, Ryan A Mehl, Aimee Landar, Alvaro G Estévez,

Peroxynitrite production and tyrosine nitration are present in several pathological conditions, including neurodegeneration, stroke, aging, and cancer. Nitration of the pro-survival chaperone heat shock protein 90 (Hsp90) in position 33 and 56 induces motor neuron death through a toxic gain-of-function. Here we show that nitrated Hsp90 regulates mitochondrial metabolism independently ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(31):19055-19066]

Cited: 13 times

View full text PDF listing >>



Writing and Reading the Tubulin Code.

Ian Yu, Christopher P Garnham, Antonina Roll-Mecak,

Microtubules give rise to intracellular structures with diverse morphologies and dynamics that are crucial for cell division, motility, and differentiation. They are decorated with abundant and chemically diverse posttranslational modifications that modulate their stability and interactions with cellular regulators. These modifications are important for the biogenesis and maintenance of complex ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(28):17163-17172]

Cited: 73 times

View full text PDF listing >>



Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.

Noriko Ishida, Taichi Hara, Takumi Kamura, Minoru Yoshida, Keiko Nakayama, Keiichi I Nakayama,

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(11):6754]

Cited: 5 times

View full text PDF listing >>



Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy.

Ji-Young Han, Min-Ji Kang, Kyung-Hee Kim, Pyung-Lim Han, Hyun-Seok Kim, Ji-Young Ha, Jin H Son,

The failure to trigger mitophagy is implicated in the pathogenesis of familial Parkinson disease that is caused by PINK1 or Parkin mutations. According to the prevailing PINK1-Parkin signaling model, mitophagy is promoted by the mitochondrial translocation of Parkin, an essential PINK1-dependent step that occurs via a previously unknown mechanism. Here ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2015, 290(16):10325-10335]

Cited: 16 times

View full text PDF listing >>



The role of autophagy during group B Streptococcus infection of blood-brain barrier endothelium.

Andrew S Cutting, Yvette Del Rosario, Rong Mu, Anthony Rodriguez, Andreas Till, Suresh Subramani, Roberta A Gottlieb, Kelly S Doran,

Bacterial meningitis occurs when bloodborne pathogens invade and penetrate the blood-brain barrier (BBB), provoking inflammation and disease. Group B Streptococcus (GBS), the leading cause of neonatal meningitis, can enter human brain microvascular endothelial cells (hBMECs), but the host response to intracellular GBS has not been characterized. Here we sought to ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2014, 289(52):35711-35723]

Cited: 20 times

View full text PDF listing >>



Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.

Hong Qu, Yizeng Tu, Jun-Lin Guan, Guozhi Xiao, Chuanyue Wu,

Integrin-mediated cell-extracellular matrix (ECM) adhesion is critical for control of intracellular signaling; however, the mechanisms underlying this "outside-in" signaling are incompletely understood. Here we show that depletion of kindlin-2 impairs integrin outside-in signaling. Kindlin-2 is tyrosine-phosphorylated upon cell-ECM adhesion. Furthermore, kindlin-2 binds Src in a cell-ECM adhesion-regulatable fashion. At the ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2014, 289(45):31001-31013]

Cited: 15 times

View full text PDF listing >>



Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

Yoshimi Arima, Hidemi Hayashi, Mikako Sasaki, Mari Hosonaga, Takaaki M Goto, Tatsuyuki Chiyoda, Shinji Kuninaka, Tatsuhiro Shibata, Hirokazu Ohata, Hitoshi Nakagama, Yoichi Taya, Hideyuki Saya,

We previously showed that depletion of the retinoblastoma protein (RB) induces down-regulation of the adhesion molecule E-cadherin and thereby triggers the epithelial-mesenchymal transition. To further characterize the effect of RB inactivation on the phenotype of cancer cells, we have now examined RB expression in human breast cancer cell lines and ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2012, 287(11):7896-7906]

Cited: 46 times

View full text PDF listing >>



Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids.

Sharon Anavi-Goffer, Gemma Baillie, Andrew J Irving, Jürg Gertsch, Iain R Greig, Roger G Pertwee, Ruth A Ross,

GPR55 is activated by l-α-lysophosphatidylinositol (LPI) but also by certain cannabinoids. In this study, we investigated the GPR55 pharmacology of various cannabinoids, including analogues of the CB1 receptor antagonist Rimonabant®, CB2 receptor agonists, and Cannabis sativa constituents. To test ERK1/2 phosphorylation, a primary downstream signaling pathway that conveys LPI-induced activation ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2012, 287(1):91-104]

Cited: 51 times

View full text PDF listing >>



Glycomic analyses of mouse models of congenital muscular dystrophy.

Stephanie H Stalnaker, Kazuhiro Aoki, Jae-Min Lim, Mindy Porterfield, Mian Liu, Jakob S Satz, Sean Buskirk, Yufang Xiong, Peng Zhang, Kevin P Campbell, Huaiyu Hu, David Live, Michael Tiemeyer, Lance Wells,

Dystroglycanopathies are a subset of congenital muscular dystrophies wherein α-dystroglycan (α-DG) is hypoglycosylated. α-DG is an extensively O-glycosylated extracellular matrix-binding protein and a key component of the dystrophin-glycoprotein complex. Previous studies have shown α-DG to be post-translationally modified by both O-GalNAc- and O-mannose-initiated glycan structures. Mutations in defined or putative ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2011, 286(24):21180-21190]

Cited: 45 times

View full text PDF listing >>



Cysteine is not the sulfur source for iron-sulfur cluster and methionine biosynthesis in the methanogenic archaeon Methanococcus maripaludis.

Yuchen Liu, Magdalena Sieprawska-Lupa, William B Whitman, Robert H White,

Three multiprotein systems are known for iron-sulfur (Fe-S) cluster biogenesis in prokaryotes and eukaryotes as follows: the NIF (nitrogen fixation), the ISC (iron-sulfur cluster), and the SUF (mobilization of sulfur) systems. In all three, cysteine is the physiological sulfur source, and the sulfur is transferred from cysteine desulfurase through a ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(42):31923-31929]

Cited: 36 times

View full text PDF listing >>



Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.

Timothy D Wiltshire, Courtney A Lovejoy, Tong Wang, Fen Xia, Mark J O'Connor, David Cortez,

DNA damage repair and checkpoint responses prevent genome instability and provide a barrier to the development of cancer. Inherited mutations in DNA damage response (DDR) genes such as those that encode the homologous recombination (HR) proteins BRCA1 and BRCA2 cause cancer predisposition syndromes. PARP inhibitors are an exciting new class ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(19):14565-14571]

Cited: 71 times

View full text PDF listing >>



Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum.

Chloe Singleton, Gaye F White, Jonathan D Todd, Sophie J Marritt, Myles R Cheesman, Andrew W B Johnston, Nick E Le Brun,

Heme, a physiologically crucial form of iron, is a cofactor for a very wide range of proteins and enzymes. These include DNA regulatory proteins in which heme is a sensor to which an analyte molecule binds, effecting a change in the DNA binding affinity of the regulator. Given that heme, ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(21):16023-16031]

Cited: 26 times

View full text PDF listing >>



Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1.

Xiaoyan Hui, Huiying Li, Zhiguang Zhou, Karen S L Lam, Yang Xiao, Donghai Wu, Ke Ding, Ke Ding, Yu Wang, Paul M Vanhoutte, Aimin Xu,

Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation remain elusive. Here, we report that A-FABP forms ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(14):10273-10280]

Cited: 70 times

View full text PDF listing >>



Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.

Yihui Fan, Yang Yu, Yi Shi, Wenjing Sun, Min Xie, Ningling Ge, Renfang Mao, Alex Chang, Gufeng Xu, Michael D Schneider, Hong Zhang, Songbin Fu, Jun Qin, Jianhua Yang,

Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-terminal kinase (JNK)/activator protein 1 (AP-1) activation. Here we report that TNFalpha and IL-1beta induce Lys(63)-linked TAK1 polyubiquitination at the Lys(158) residue within ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2010, 285(8):5347-5360]

Cited: 79 times

View full text PDF listing >>



The cholinesterase-like domain, essential in thyroglobulin trafficking for thyroid hormone synthesis, is required for protein dimerization.

Jaemin Lee, Xiaofan Wang, Bruno Di Jeso, Peter Arvan,

The carboxyl-terminal cholinesterase-like (ChEL) domain of thyroglobulin (Tg) has been identified as critically important in Tg export from the endoplasmic reticulum. In a number of human kindreds suffering from congenital hypothyroidism, and in the cog congenital goiter mouse and rdw rat dwarf models, thyroid hormone synthesis is inhibited because of ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2009, 284(19):12752-12761]

Cited: 23 times

View full text PDF listing >>



Isolation of hyperactive mutants of mammalian target of rapamycin.

Yoichiro Ohne, Terunao Takahara, Riko Hatakeyama, Tomoko Matsuzaki, Makoto Noda, Noboru Mizushima, Tatsuya Maeda,

The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that plays essential roles in the regulation of a wide array of growth-related processes such as protein synthesis, cell sizing, and autophagy. mTOR forms two functionally distinct complexes, termed the mTOR complex 1 (mTORC1) and 2 (mTORC2); only the former ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2008, 283(46):31861-31870]

Cited: 41 times

View full text PDF listing >>



Structural basis for sorting mechanism of p62 in selective autophagy.

Yoshinobu Ichimura, Taichi Kumanomidou, Yu-shin Sou, Tsunehiro Mizushima, Junji Ezaki, Takashi Ueno, Eiki Kominami, Takashi Yamane, Keiji Tanaka, Masaaki Komatsu,

Impairment of autophagic degradation of the ubiquitin- and LC3-binding protein "p62" leads to the formation of cytoplasmic inclusion bodies. However, little is known about the sorting mechanism of p62 to autophagic degradation. Here we identified a motif of murine p62 consisting of 11 amino acids (Ser334-Ser344) containing conserved acidic and ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2008, 283(33):22847-22857]

Cited: 385 times

View full text PDF listing >>



Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress.

Anita S Gálvez, Eric W Brunskill, Yehia Marreez, Bonnie J Benner, Kelly M Regula, Lorrie A Kirschenbaum, Gerald W Dorn,

Up-regulation of myocardial Nix and BNip3 is associated with apoptosis in cardiac hypertrophy and ischemia, respectively. To identify mechanisms of gene regulation for these critical cardiac apoptosis effectors, the determinants of Nix and BNip3 promoter activation were elucidated by luciferase reporter gene expression in neonatal rat cardiac myocytes. BNip3 transcription ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2006, 281(3):1442-1448]

Cited: 72 times

View full text PDF listing >>



Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.

Tsuyoshi Tahara, Jiying Sun, Katsuyuki Nakanishi, Masafumi Yamamoto, Hajime Mori, Takeshi Saito, Hiroyoshi Fujita, Kazuhiko Igarashi, Shigeru Taketani,

The transcription factor Bach1 heterodimerizes with small Maf proteins to repress Maf recognition element (MARE)-dependent gene expression. The repressor activity of Bach1 is inhibited by the direct binding of heme. To investigate the involvement of Bach1 in the heme-dependent regulation of the expression of the beta-globin gene, mouse erythroleukemia (MEL) ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2004, 279(7):5480-5487]

Cited: 72 times

View full text PDF listing >>



Advertisement

Disclaimer
1.2114 s