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Journal J. Alzheimers Dis.

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A New Discovery of MicroRNA-455-3p in Alzheimer's Disease.

Subodh Kumar, P Hemachandra Reddy,

MicroRNA-455-3p (miR-455-3p) is identify as a member of broadly conserved miRNA family expressed in most of the phylum and species. In humans, miR-455 is present on the human chromosome 9 at locus 9q32 and encoded by the human COL27A1 gene (collagen type XXVII alpha 1 chain). The role of miR-455 ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2019, 72(s1):S117-S130]

Cited: 1 time

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A Long Journey into Aging, Brain Aging, and Alzheimer's Disease Following the Oxidative Stress Tracks.

Patrizia Mecocci, Virginia Boccardi, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Carmelinda Ruggiero, Marta Baroni,

The Editors of the Journal of Alzheimer's Disease invited Professor Patrizia Mecocci to contribute a review article focused on the importance and implications of her research on aging, brain aging, and senile dementias over the last years. This invitation was based on an assessment that she was one of the ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2018, 62(3):1319-1335]

Cited: 14 times

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Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment.

Francis T Hane, Morgan Robinson, Brenda Y Lee, Owen Bai, Zoya Leonenko, Mitchell S Albert,

The field of Alzheimer's disease (AD) research has grown exponentially over the past few decades, especially since the isolation and identification of amyloid-β from postmortem examination of the brains of AD patients. Recently, the Journal of Alzheimer's Disease (JAD) put forth approximately 300 research reports which were deemed to be ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2017, 57(3):645-665]

Cited: 13 times

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Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice.

Siân Baker, Juan Carlos Polanco, Jϋrgen Götz,

In Alzheimer's disease, the distribution of neurofibrillary tangles, a histological hallmark comprised of phosphorylated forms of the protein tau, follows a distinct pattern through anatomically connected brain regions. The well-documented correlation between the severity of tau pathology and disease progression implies a prion-like seeding and spreading mechanism for tau. Experimentally, ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2016, 54(3):1207-1217]

Cited: 11 times

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Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails.

Véréna Landel, Cédric Annweiler, Pascal Millet, Maria Morello, François Féron,

Since its discovery during the epidemic of rickets in the early 1920s, the physiological effects of vitamin D on calcium/phosphorus homeostasis have been thoroughly studied. Along with the understanding of its actions on skeletal diseases and advances in cellular and molecular biology, this misnamed vitamin has gained attention as a ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2016, 53(2):419-444]

Cited: 26 times

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Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo.

Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avila,

The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of tauopathies. Excess tau can be released into the extracellular medium in a physiological or pathological manner to be internalized by surrounding neurons-a process that contributes to the spread of this protein throughout the brain. Such spreading may ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2016, 50(1):77-87]

Cited: 39 times

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Neurophysiological assessment of Alzheimer's disease individuals by a single electroencephalographic marker.

Roberta Lizio, Claudio Del Percio, Nicola Marzano, Andrea Soricelli, Görsev G Yener, Erol Başar, Ciro Mundi, Salvatore De Rosa, Antonio Ivano Triggiani, Raffaele Ferri, Dario Arnaldi, Flavio Mariano Nobili, Susanna Cordone, Susanna Lopez, Filippo Carducci, Giulia Santi, Loreto Gesualdo, Paolo M Rossini, Enrica Cavedo, Margherita Mauri, Giovanni B Frisoni, Claudio Babiloni,

Here we presented a single electroencephalographic (EEG) marker for a neurophysiological assessment of Alzheimer's disease (AD) patients already diagnosed by current guidelines. The ability of the EEG marker to classify 127 AD individuals and 121 matched cognitively intact normal elderly (Nold) individuals was tested. Furthermore, its relationship to AD patients' ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2016, 49(1):159-177]

Cited: 7 times

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General public perceptions and attitudes toward Alzheimer's disease from five cities in China.

Fan Zeng, Wan-Ting Xie, Yan-Jiang Wang, Hong-Bo Luo, Xiang-Qun Shi, Hai-Qiang Zou, Yue-Qing Zeng, Ya-Fei Li, Shao-Rong Zhang, Yan Lian,

Alzheimer's disease (AD) is the most common type of dementia affecting the aged population worldwide, yet its social perceptions have been less studied. To investigate the perceptions and attitudes toward AD in the Chinese population, a cross-sectional face-to-face survey of 2,000 randomly selected adults was conducted in five representative cities ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2015, 43(2):511-518]

Cited: 11 times

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PKCε deficits in Alzheimer's disease brains and skin fibroblasts.

Tapan K Khan, Abhik Sen, Jarin Hongpaisan, Chol S Lim, Thomas J Nelson, Daniel L Alkon,

In Alzheimer's disease (AD) transgenic mice, activation of synaptogenic protein kinase C ε (PKCε) was found to prevent synaptotoxic amyloid-β (Aβ)-oligomer elevation, PKCε deficits, early synaptic loss, cognitive deficits, and amyloid plaque formation. In humans, to study the role of PKCε in the pathophysiology of AD and to evaluate its ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2015, 43(2):491-509]

Cited: 11 times

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Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.

Carol Yim-lui Cheung, Yi Ting Ong, Saima Hilal, M Kamran Ikram, Sally Low, Yi Lin Ong, N Venketasubramanian, Philip Yap, Dennis Seow, Christopher Li Hsian Chen, Tien Yin Wong,

Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it is associated with retinal ganglion cell loss; however, few data exist to establish this association.To determine whether macular ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL), as quantitatively measured by non-invasive in vivo spectral-domain optical ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2015, 45(1):45-56]

Cited: 82 times

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Cerebrospinal fluid biomarkers and memory present distinct associations along the continuum from healthy subjects to AD patients.

Lorena Rami, Juan Fortea, Beatriz Bosch, Cristina Solé-Padullés, Albert Lladó, Alex Iranzo, Raquel Sánchez-Valle, Jose Luis Molinuevo,

The objective was to study the association between cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)(1-42), t-tau, and p-tau and cognitive performance along the Alzheimer's disease (AD) continuum from healthy subjects to AD patients and, specifically, among patients in the pre-dementia stage of the disease. A total of 101 subjects were ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2011, 23(2):319-326]

Cited: 32 times

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Grey and white matter changes at different stages of Alzheimer's disease.

Laura Serra, Mara Cercignani, Delia Lenzi, Roberta Perri, Lucia Fadda, Carlo Caltagirone, Emiliano Macaluso, Marco Bozzali,

This study investigates abnormalities of grey (GM) and white matter (WM) in Alzheimer's disease (AD), by modeling the AD pathological process as a continuous course between normal aging and fully developed dementia, with amnesic mild cognitive impairment (aMCI) as an intermediate stage. All subjects (9 AD, 16 aMCI patients, and ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2010, 19(1):147-159]

Cited: 47 times

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