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Journal J. Allergy Clin. Immunol.

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Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective.

Koa Hosoki, Abhijit Chakraborty, Sanjiv Sur,

The global pandemic caused by the newly described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused worldwide suffering and death of unimaginable magnitude from coronavirus disease 2019 (COVID-19). The virus is transmitted through aerosol droplets, and causes severe acute respiratory syndrome. SARS-CoV-2 uses the receptor-binding domain of its spike ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
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Patterns of Farm Exposure are Associated with Reduced Incidence of Atopic Dermatitis in Early Life.

Cheryl A Steiman, Michael D Evans, Kristine E Lee, Michael R Lasarev, Ronald E Gangnon, Brent F Olson, Kathrine L Barnes, Casper G Bendixsen, Christine M Seroogy, James E Gern,

BACKGROUND:Farm exposures may reduce the risk of atopic dermatitis (AD) in children, but this is controversial and US data are limited. OBJECTIVE:This study was conducted to identify patterns of farm exposure in Wisconsin family farms that modify AD incidence and prevalence in early childhood. METHODS:Environmental exposures, health history and clinical ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Human Milk Oligosaccharide profiles and allergic disease up to 18 years.

Caroline J Lodge, Adrian J Lowe, Elasma Milanzi, Gayan Bowatte, Michael J Abramson, Helen Tsimiklis, Christine Axelrad, Bianca Robertson, Aaron E Darling, Cecilie Svanes, Matthias Wjst, Shyamali C Dharmage, Lars Bode,

BACKGROUND:Human Milk Oligosaccharides (HMO) are a diverse range of sugars secreted in breast milk that have direct and indirect effects on immunity. The profiles of HMOs produced differ between mothers. OBJECTIVE:To determine the relationship between maternal HMO profiles and offspring allergic diseases up to 18 years METHODS: Colostrum and early ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Nasopharyngeal Haemophilus and Local Immune Response during Infant Respiratory Syncytial Virus Infection.

Meghan H. Shilts, Christian Rosas-Salazar, Kedir N. Turi, Devi Rajan, Seesandra V. Rajagopala, Megan F. Patterson, Tebeb Gebretsadik, Larry J. Anderson, R. Stokes Peebles, Tina V. Hartert, Suman R. Das,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
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Unsupervised Modeling and Genome-Wide Association Identify Novel Features of Allergic March Trajectories.

Stanislaw J Gabryszewski, Xiao Chang, Jesse W Dudley, Frank Mentch, Michael March, John H Holmes, Jason Moore, Robert W Grundmeier, Hakon Hakonarson, David A Hill,

BACKGROUND:The allergic march refers to the natural history of allergic conditions during infancy and childhood. However, population-level disease incidence patterns do not necessarily reflect the development of allergic disease in individuals. A better understanding of the factors that predispose to different allergic trajectories is needed. OBJECTIVE:Determine the demographic and genetic ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Staphylococcus epidermidis protease EcpA can be a deleterious component of the skin microbiome in atopic dermatitis.

Laura Cau, Michael R Williams, Anna M Butcher, Teruaki Nakatsuji, Jeffrey S Kavanaugh, Joyce Y Cheng, Faiza Shafiq, Kyle Higbee, Tissa R Hata, Alexander R Horswill, Richard L Gallo,

BACKGROUND:S. aureus and S. epidermidis are the most abundant bacteria found on the skin of patients with atopic dermatitis (AD). S. aureus is known to exacerbate AD while S. epidermidis was considered as a beneficial commensal organism. OBJECTIVE:In this study, we hypothesized that S. epidermidis could promote skin damage in ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Gene Therapy for Wiskott-Aldrich Syndrome: History, New Vectors, Future Directions.

Francesca Ferrua, Francesco Marangoni, Alessandro Aiuti, Maria Grazia Roncarolo,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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News Beyond Our Pages.

Marc E. Rothenberg, Jean Bousquet,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):50-51]

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ITK deficiency presenting as Autoimmune Lymphoproliferative Syndrome.

Jacqueline G Wallace, Mohammed Alosaimi, Claudia Djambas Khayat, Faris Jaber, Abduarahman Almutairi, Sarah Beaussant-Cohen, Geraldine Pinkus, Mark Fleming, Cybel Mehawej, Janet Chou, Raif S Geha,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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The Editors’ Choice.

Zuhair K. Ballas,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):44-49]

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Nasopharyngeal Haemophilus and Local Immune Response during Infant Respiratory Syncytial Virus Infection.

Meghan H Shilts, Christian Rosas-Salazar, Kedir N Turi, Devi Rajan, Seesandra V Rajagopala, Megan F Patterson, Tebeb Gebretsadik, Larry J Anderson, R Stokes Peebles, Tina V Hartert, Suman R Das,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Nucleic Acid Approaches to Antibody-based Therapeutics for COVID-19: A Perspective.

Elizabeth Parzych, David B Weiner,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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News & Notes.

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):A22-A23]

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Brief Overview of This Month's JACI.

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):A5-A6]

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Mechanisms of skin autoimmunity: Cellular and soluble immune components of the skin.

Johann E Gudjonsson, Kenji Kabashima, Kilian Eyerich,

Autoimmune diseases are driven by either T cells or antibodies reacting specifically to 1 or more self-antigens. Although a number of self-antigens associated with skin diseases have been identified, the causative antigen(s) remains unknown in the great majority of skin diseases suspected to be autoimmune driven. Model diseases such as ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):8-16]

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House dust microbiota in relation to adult asthma and atopy in a U.S. farming population.

Mi Kyeong Lee, Annah B Wyss, Megan U Carnes, Marie Richards, Christine G Parks, Laura E Beane Freeman, Peter S Thorne, David M Umbach, M Andrea Azcarate-Peril, Shyamal D Peddada, Stephanie J London,

BACKGROUND:Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear. OBJECTIVE:To examine associations of house dust microbiota with adult asthma, atopy, and hay fever. METHODS:Vacuumed bedroom dust samples from the homes of 879 participants (average age ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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AK2 deficiency: An awkward tale for B cells.

Ana Campos Codo, Pedro Manoel Mendes Moraes-Vieira,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):74-76]

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Corrigendum.

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, 146(1):228]

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Unique skin abnormality in patients with peanut allergy but no atopic dermatitis.

Evgeny Berdyshev, Elena Goleva, Irina Bronova, Anna-Sofia Bronoff, Bryce C Hoffman, Marco A Ramirez-Gama, Shannon L Garcia, Debra Crumrine, Peter M Elias, Christine B Cho, Donald Y M Leung,

BACKGROUND:The nonlesional skin of atopic dermatitis (AD) children with peanut allergy (PA) is associated with increased transepidermal water loss (TEWL), low urocanic (UCA) and pyroglutamic (PCA) acids (filaggrin [FLG] breakdown products), and reduced ratio of esterified ω-hydroxy fatty acid sphingosine ceramides (EOS-CER) to non-hydroxy fatty acid sphingosine ceramides (NS-CER) in ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Atopic dermatitis displays stable and dynamic skin transcriptome signatures.

Lena Möbus, Elke Rodriguez, Inken Harder, Dora Stölzl, Nicole Boraczynski, Sascha Gerdes, Andreas Kleinheinz, Susanne Abraham, Annice Heratizadeh, Christiane Handrick, Eva Haufe, Thomas Werfel, Jochen Schmitt, Stephan Weidinger,

BACKGROUND:Skin transcriptome studies in atopic dermatitis (AD) showed broad dysregulation as well as "improvement" under therapy. These observations were mainly made in trials and based on microarray data. OBJECTIVES:To explore the skin transcriptome and the impact of systemic treatment in patients of the TREATgermany registry. METHODS:Biopsies from 59 patients with ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions.

Janina Petry, Johann Rahmöller, Lara Dühring, Gina-Maria Lilienthal, Selina Lehrian, Jana-Sophia Buhre, Yannic C Bartsch, Alexandra Epp, Hanna B Lunding, Kelley W Moremen, Alexei Leliavski, Marc Ehlers,

Murine blood IgG1, but not IgG2a, sialylation levels attenuate IgG-mediated and IgG-controlled IgE-mediated allergic reactions by enhancing the expression of the IgG inhibitory Fcγ receptor IIB on immune cells, accordingly, human blood IgG sialylation levels correlate with FcγRIIB expression. ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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The scary world of variants of uncertain significance (VUS): A hitchhiker's guide to interpretation.

Kathleen E Sullivan,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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The latest on the role of LAMAs in asthma.

Mario Cazzola, Paola Rogliani, Maria Gabriella Matera,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Reply.

Joaquim Mullol, Franklin Mariño, Meritxell Valls, Isam Alobid, Concepció Marin,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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The clinical relevance of the clinical cytological grading in patients with chronic rhinosinusitis with nasal polyps.

Matteo Gelardi, Michele Cassano, Giorgio Ciprandi,

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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