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Journal J Urol

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Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.

Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen,

<h4>Purpose</h4>Next-generation sequencing (NGS)-based profiling of both urinary tumor DNA (utDNA) and circulating tumor DNA (ctDNA) shows promise for noninvasive detection and surveillance of urothelial bladder cancer (UBC). However, the analytic performance of these assays remains undefined in the real-world setting. Here, we sought to evaluate the concordance between tumor DNA ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001878]

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Editorial Comment.

Caroline Kang, James A Kashanian,

J Urol (The Journal of urology)
[2021, :101097JU000000000000179202]

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Efficacy of a Novel Penile Traction Device in Improving Penile Length and Erectile Function Post Prostatectomy: Results from a Single-Center Randomized, Controlled Trial.

Amir Toussi, Matthew Ziegelmann, David Yang, Madeleine Manka, Igor Frank, Stephen A Boorjian, Matthew Tollefson, Tobias Köhler, Landon Trost,

<h4>Purpose</h4>RestoreX is a novel penile traction therapy device, with randomized, controlled data demonstrating improvements in penile length and erectile function after 30 to 90 minutes of daily use in men with Peyronie's disease. We sought to determine if similar improvements could be achieved post prostatectomy.<h4>Materials and methods</h4>Men post prostatectomy were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001792]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J Manley, Roger Li, Wade Sexton, Scott M Gilbert,

<h4>Purpose</h4>Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or improved overall survival (OS) for patients with variant histology. Our objective was to assess for associations between receipt of neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001855]

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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Disparate Practice Patterns and Survival Outcomes: The Impact of Centralization of Cancer Care for Adrenocortical Carcinoma in the United States.

Benjamin V Stone, Jacob E Tallman, Kelvin A Moses,

<h4>Purpose</h4>Adrenocortical carcinoma is a rare but aggressive malignancy. While centralization of care to referral centers improves outcomes across common urologic malignancies, there exists a paucity of data for low-incidence cancers. We sought to evaluate differences in practice patterns and overall survival in patients with adrenocortical carcinoma across types of treating ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001871]

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Editorial Comment.

Woodson W Smelser,

J Urol (The Journal of urology)
[2021, :101097JU000000000000183701]

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Testicular Temperature and the Effects of Orchiopexy in Infants With Cryptorchidism.

Koji Shiraishi, Hiroshi Takihara, Hideyasu Matsuyama,

<h4>Introduction and objective</h4>Testicular temperature should remain low to maintain optimal function of germ cells; however, information regarding testicular temperature in infants and the effect of cryptorchidism and its correction, including laparoscopic staged Fowler-Stephens orchiopexy (LSFSO), are limited.<h4>Methods</h4>Eighty-two infants with unilateral palpable cryptorchidism, 24 with nonpalpable testes who underwent unilateral LSFSO ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001896]

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A Contemporary Analysis of Urethral Recurrence following Radical Cystectomy.

Abhinav Khanna, Andrew Zganjar, Timothy Lyon, Paras Shah, Matthew K Tollefson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, R Houston Thompson, Igor Frank, Stephen A Boorjian,

<h4>Introduction</h4>Oncologic outcomes following UR remain incompletely described, with reports limited by small cohort sizes. We evaluated risk factors for UR as well as cancer-specific survival (CSS) and overall survival (OS) among patients with UR.<h4>Methods</h4>We reviewed our institutional RC registry to identify patients with UR. Cox proportional hazards regression was used ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001842]

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Sarcopenic Obesity and Its Prognostic Impact on Urologic Cancers: A Systematic Review.

J Stangl-Kremser, A Mari, L Y Lai, C T Lee, R Vince, A Zaslavsky, S S Salami, H Fajkovic, S F Shariat, G S Palapattu,

<h4>Purpose</h4>Sarcopenia, an age-related loss of muscle mass and function, may predict adverse outcomes for patients with urologic cancers. However, the clinical implication and significance of sarcopenic obesity are not well understood. We systematically reviewed data on the prevalence and prognostic impact of sarcopenic obesity for patients with renal cell carcinoma, ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001873]

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Apalutamide Plus Androgen Deprivation Therapy for Metastatic Castration-Sensitive Prostate Cancer: Analysis of Pain and Fatigue in the Phase 3 TITAN Study.

Neeraj Agarwal, Kelly McQuarrie, Anders Bjartell, Simon Chowdhury, Andrea J Pereira de Santana Gomes, Byung Ha Chung, Mustafa Özgüroğlu, Álvaro Juárez Soto, Axel S Merseburger, Hirotsugu Uemura, Dingwei Ye, Robert Given, Ethan Basch, Branko Miladinovic, Angela Lopez-Gitlitz, Kim N Chi,

<h4>Purpose</h4>Exploratory analysis of prostate cancer-related pain and fatigue on health-related quality of life in patients with metastatic castration-sensitive prostate cancer (mCSPC) receiving apalutamide (240 mg/day) or placebo, with continuous androgen-deprivation therapy (ADT), in the phase 3, randomized, double-blind placebo-controlled TITAN trial (NCT02489318).<h4>Materials and methods</h4>Patient-reported outcomes for pain and fatigue were ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001841]

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A Year of Change, with More to Come.

Joseph A Smith,

J Urol (The Journal of urology)
[2021, :101097JU0000000000001900]

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Real World Practice Patterns and Predictors of Continuous versus Intermittent ADT Use for Prostate Cancer in Older Men.

D C Cheung, S M H Alibhai, L J Martin, M Komisarenko, C Dharma, P Warde, S S Sridhar, N E Fleshner, G S Kulkarni, A Finelli,

<h4>Purpose</h4>Phase-III RCT evidence suggests intermittent ADT (IADT) is not significantly inferior to continuous ADT for prostate cancer (PC) patients. However, clinical practice and guidelines differ in their recommendations. We evaluate real-world utilization and practice patterns of IADT.<h4>Materials and methods</h4>Ontario men ≥65 years with PC who initiated ADT for ≥3 months ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001876]

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Interstitial Cystitis/Bladder Pain Syndrome's Correlations with Pregnancy and Neonatal Outcomes: A Study of a Population Database.

Mohammad I Khojah, Ahmad M Badeghiesh, Sara Ismail, Haitham A Baghlaf, Noor Almamlouk, Michael H Dahan,

<h4>Purpose</h4>To evaluate the associations with interstitial cystitis during pregnancy using a United States inpatient database.<h4>Material and methods</h4>We conducted a retrospective cohort study utilizing the <i>Nationwide Inpatient Sample</i> database from the <i>Healthcare Cost and Utilization Project</i> (HCUP-NIS). ICD-9 code number 595.1 was used to extract cases of Chronic Interstitial Cystitis and ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001875]

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One-Stage Buccal Mucosal Graft Urethroplasty for Lichen Sclerosus Related Urethral Stricture Disease: A Systematic Review and Pooled Proportional Meta-Analysis.

Jane T Kurtzman, Ruth Blum, Steven B Brandes,

<h4>Purpose</h4>Performing one-stage urethroplasty in patients with urethral strictures caused by lichen sclerosis (LS) is hotly debated among reconstructive urologists due to conflicting reports of success. Therefore, the objective of this study was to determine the pooled incidence of stricture recurrence following one-stage buccal mucosal graft (BMG) urethroplasty in LS patients, ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001870]

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Standing Ultrasound Adds Clinical Utility for the Diagnosis of Varicoceles.

Nahid Punjani, Gal Wald, Omar Al-Hussein Alawamlh, Vanessa Dudley, Marc Goldstein,

<h4>Purpose</h4>To assess the role of standing vs supine scrotal ultrasound (SUS) for varicocele assessment by evaluating differences in clinical outcomes.<h4>Methods</h4>We retrospectively reviewed men from 2008-2020 diagnosed with varicocele who had documented SUS with both supine and standing assessments with and without Valsalva. Clinical outcomes (semen parameters, TUNEL and serum testosterone ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001877]

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In Vitro Fertilization Entails a High Prevalence of Erectile and Male Sexual Dysfunction-A Prospective Case-Control Study.

Roy Lauterbach, Ilan Gruenwald, Revital Linder, Emad Matanes, Ola Gutzeit, Saar Aharoni, Ido Mick, Zeev Weiner, Ofer Fainaru, Lior Lowenstein,

<h4>Purpose</h4>To evaluate the effect of in vitro fertilization (IVF) on sexual function in men, particularly erectile dysfunction.<h4>Materials and methods</h4>A prospective case-control study at a tertiary medical center. The study group comprised men of infertile couples that required IVF to conceive. The control group comprised men of couples who conceived spontaneously. ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001872]

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Patterns of Recurrence Following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Purpose</h4>Our primary objective is to detail the incidence, site, and timing of pSCC recurrence after ILND.<h4>Methods</h4>Retrospective analysis of 551 patients who underwent ILND for pSCC, from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. Recurrences were identified and stratified by site. Timing of recurrence was determined. Multivariable ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001790]

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A Predictive Pre- and Post-operative Nomogram for Post-operative Potency Recovery after Robot-Assisted Radical Prostatectomy.

K R Seetharam Bhat, Marcio Covas Moschovas, Marco Sandri, Paolo Dell'Oglio, Fikret F Onol, Travis Rogers, Sunil Reddy, Jonathan Noel, Shannon Roof, Maria Chiara Sighinolfi, Bernardo Rocco, Vipul R Patel,

<h4>Introduction</h4>Prediction of potency recovery following RARP is useful for better patient counselling and post-operative treatment strategies. In this study we propose a pre-operative and post-operative nomogram to predict post-operative potency recovery following RARP.<h4>Materials and methods</h4>Patients from development set (n=6502) were selected to develop the nomograms, and patients in validation set ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001895]

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Cardiovascular Proteomics: A Post-hoc Analysis from a Phase II Randomized Clinical Trial Comparing GnRH Antagonist Vs GnRH Agonist Among Men with Advanced Prostate Cancer.

Karin Lifshitz, Yaara Ber, Chen Shenhar, Jan Nillson, Avivit Peer, Eli Rosenbaum, Jack Baniel, Daniel Kedar, Osnat Itzhaki Ben Zadok, David Margel,

<h4>Purpose</h4>Recent studies demonstrated reduced cardiovascular risk with GnRH antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established cardiovascular related proteins, among men treated with GnRH agonists Vs. GnRH antagonist.<h4>Materials and methods</h4>We performed a Proteomics analysis of serum samples ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001879]

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SIMPLifying Urology Residency Operative Assessments: A Pilot Study in Urology Training.

Robert S Wang, Stephanie Daignault-Newton, Sapan N Ambani, Khaled Hafez, Brian C George, Kate H Kraft,

<h4>Purpose</h4>The Society for Improving Medical Professional Learning (SIMPL) app is an innovative, convenient, and validated smartphone-based tool to evaluate residents' operative performance. In this study, we describe the initial implementation of SIMPL in our program's pediatric urology rotation - the first among urology residencies - and provide preliminary data on ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001874]

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Urinary Symptom Non-Response ("LUTS-Failure") After Urethroplasty: Incidence and Associations.

David W Chapman, Jordan Bekkema, Keith Rourke,

<h4>Objective</h4>An ill-defined proportion of patients undergoing urethroplasty fail to experience improvement in lower urinary tract symptoms (LUTS) despite being stricture-free. We aim to identify the incidence, associations, and causes of "LUTS failure" after urethroplasty.<h4>Methods</h4>Patients undergoing urethroplasty over a 6-year period were offered enrollment in a prospective study examining urinary function ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001840]

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The Impact of Frailty on Outcomes of Sling Surgery With and without Prolapse Repair. Reply.

Andrew Medendorp, Anne Suskind, Jennifer Anger,

J Urol (The Journal of urology)
[2021, :101097JU0000000000001894]

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Editorial Comment.

Hillary L Copp,

J Urol (The Journal of urology)
[2021, :101097JU000000000000184401]

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Urological Oncology: Prostate Cancer.

Samir S Taneja,

J Urol (The Journal of urology)
[2021, :101097JU0000000000001865]

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