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LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis.

Junfeng Ye, Yuanqiang Lin, Ying Yu, Di Sun,

BACKGROUND:Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) has been reported to play an essential role in non-alcoholic fatty liver disease. However, the role of NEAT1 in regulation of alcoholic steatohepatitis (ASH) remains largely unknown. This study aims to explore the role of NEAT1 in ASH by mediating microRNA-129-5p ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):445]

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Tespa1 plays a role in the modulation of airway hyperreactivity through the IL-4/STAT6 pathway.

Ruhui Yang, Guangli Wang, Lingyun Li, Hanjiang He, Mingzhu Zheng, Linrong Lu, Songquan Wu,

BACKGROUND:Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells in the pathogenesis of asthma and its relationship with the interleukin (IL)-4/signal transducers and activators of transcription 6 (STAT6) signaling pathway. METHODS:Tespa1 mRNA expression ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):444]

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Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature.

Wei Ma, Fangkun Zhao, Xinmiao Yu, Shu Guan, Huandan Suo, Zuo Tao, Yue Qiu, Yunfei Wu, Yu Cao, Feng Jin,

BACKGROUND:Breast cancer is a highly heterogeneous disease, this poses challenges for classification and management. Long non-coding RNAs play acrucial role in the breast cancersdevelopment and progression, especially in tumor-related immune processes which have become the most rapidly investigated area. Therefore, we aimed at developing an immune-related lncRNA signature to improve ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):442]

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Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients.

Ilseon Hwang, Jeong Won Kim, Kris Ylaya, Eun Joo Chung, Haruhisa Kitano, Candice Perry, Jun Hanaoka, Junya Fukuoka, Joon-Yong Chung, Stephen M Hewitt,

BACKGROUND:The tumor microenvironment (TME) is a critical player in tumor progression, metastasis and therapy outcomes. Tumor-associated macrophages (TAMs) are a well-recognized core element of the TME and generally characterized as M2-like macrophages. TAMs are believed to contribute to tumor progression, but the mechanism behind this remains unclear. We aimed to ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):443]

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Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy.

Razan Sheta, Magdalena Bachvarova, Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire, Jamilet Miranda Navarro, Ricardo Bringas Perez, Jean-Yves Masson, Dimcho Bachvarov,

BACKGROUND:Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and epithelial ovarian cancer (EOC). However, about 50% of high grade serous ovarian cancers (HGSOC) present with HRD due to epigenetic BRCA1 inactivation, as well as genetic/epigenetic inactivation(s) ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):439]

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Dysregulated PDGFR alpha expression and novel somatic mutations in colorectal cancer: association to RAS wild type status and tumor size.

Nadia Ben Jemii, Haifa Tounsi-Kettiti, Hamza Yaiche, Najla Mezghanni, Amira Jaballah Gabteni, Emna Fehri, Chayma Ben Fayala, Sonia Abdelhak, Samir Boubaker,

BACKGROUND:Platelet derived growth factor receptor alpha (PDGFRα) has been considered as a relevant factor in tumor proliferation, angiogenesis and metastatic dissemination. It was a target of tyrosine kinase (TK) inhibitors emerged in the therapy of diverse cancers. In colorectal cancer, the commonly used therapy is anti-epithelial growth factor receptor (EGFR). However, ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):440]

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Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis related immune analysis and visualization.

Xiaoqi Zhang, Qingxuan Wang, Xinyu Yan, Yue Shan, Lu Xing, Minqi Li, Hu Long, Wenli Lai,

BACKGROUND:Immunity reaction plays an essential role in periodontitis progress and we aim to investigate the underlying regulatory network of immune reactions in periodontitis. METHODS:CIBERSORT was used to estimate immunocyte fractions in different clinical statuses. Logistic regression was used to assess the immunocyte weight in periodontitis. Immune-related periodontitis subtypes were identified ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):438]

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Putative positive role of inflammatory genes in fat deposition supported by altered gene expression in purified human adipocytes and preadipocytes from lean and obese adipose tissues.

Sang-Hyeop Lee, Nak-Hyeon Choi, In-Uk Koh, Bong-Jo Kim, Song Lee, Song-Cheol Kim, Sun Shim Choi,

BACKGROUND:Obesity is a chronic low-grade inflammatory disease that is generally characterized by enhanced inflammation in obese adipose tissue (AT). Here, we investigated alterations in gene expression between lean and obese conditions using mRNA-Seq data derived from human purified adipocytes (ACs) and preadipocytes (preACs). RESULTS:Total mRNA-seq data were generated with 27 ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):433]

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DLDTI: a learning-based framework for drug-target interaction identification using neural networks and network representation.

Yihan Zhao, Kai Zheng, Baoyi Guan, Mengmeng Guo, Lei Song, Jie Gao, Hua Qu, Yuhui Wang, Dazhuo Shi, Ying Zhang,

BACKGROUND:Drug repositioning, the strategy of unveiling novel targets of existing drugs could reduce costs and accelerate the pace of drug development. To elucidate the novel molecular mechanism of known drugs, considering the long time and high cost of experimental determination, the efficient and feasible computational methods to predict the potential ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):434]

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Extracellular vesicles as potential biomarkers and therapeutic approaches in autoimmune diseases.

Kaiyuan Xu, Qin Liu, Kaihui Wu, Liu Liu, Maomao Zhao, Hui Yang, Xiang Wang, Wenmei Wang,

Extracellular vesicles are heterogeneous populations of naturally occurring secreted small vesicles. EVs function as signaling platforms to facilitate intracellular communication, which indicates the physiological or pathophysiological conditions of cells or tissues. Considering that EVs can be isolated from most body fluids and that molecular constituents could be reprogrammed according to ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):432]

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Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome.

Dustin L Norton, Agathe Ceppe, Miriya K Tune, Matthew McCravy, Thomas Devlin, M Bradley Drummond, Shannon S Carson, Benjamin G Vincent, Robert S Hagan, Hong Dang, Claire M Doerschuk, Jason R Mock,

BACKGROUND:Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation from mechanical ventilation, have a higher percentage of Tregs amongst CD4+ T cells in either airway, bronchoalveolar lavage ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):427]

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A brief guide to the science and art of writing manuscripts in biomedicine.

Diego A Forero, Sandra Lopez-Leon, George Perry,

Publishing articles in international scientific journals is the primary method for the communication of validated research findings and ideas. Journal articles are commonly used as a major input for evaluations of researchers and institutions. Few articles have been published previously about the different aspects needed for writing high-quality articles. In ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):425]

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Revisiting the association between skin toxicity and better response in advanced cancer patients treated with immune checkpoint inhibitors.

Nicholas Gulati, Douglas Donnelly, Yingzhi Qian, Una Moran, Paul Johannet, Judy Zhong, Iman Osman,

BACKGROUND:Immune checkpoint inhibition (ICI) improves survival outcomes for patients with several types of cancer including metastatic melanoma (MM), but serious immune-related adverse events requiring intervention with immunosuppressive medications occur in a subset of patients. Skin toxicity (ST) has been reported to be associated with better response to ICI. However, understudied ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):430]

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OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma.

Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M Carcaboso, Rheal A Towner,

BACKGROUND:Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year. Despite extensive research, no significant therapeutic advancements have been made to improve overall survival in DIPG patients. METHODS:Here, we used ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):424]

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Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor.

Turner Palombo, Andrea Campos, Suzanne D Vernon, Shad Roundy,

BACKGROUND:Approximately 2.5 million people in the U.S. suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This disease negatively impacts patients' ability to function, often resulting in difficulty maintaining employment, sustaining financial independence, engaging socially with others, and in particularly severe cases, consistently and adequately performing activities of daily living. The focus ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):423]

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Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.

Mohammad Tahseen Al Bataineh, Nihar Ranjan Dash, Mohammed Elkhazendar, Dua'a Mohammad Hasan Alnusairat, Islam Mohammad Ismail Darwish, Mohamed Saleh Al-Hajjaj, Qutayba Hamid,

BACKGROUND:Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral microbiota remain unknown in these populations. METHODS:We evaluated the composition and functional capabilities of oral microbiota with relation to cigarette smoking ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):421]

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Factors influencing cancer genetic somatic mutation test ordering by cancer physician.

Anastassia Demeshko, David J Pennisi, Sushil Narayan, Stacy W Gray, Matthew A Brown, Aideen M McInerney-Leo,

BACKGROUND:Clinical whole exome sequencing was introduced in an Australian centre in 2017, as an alternative to Sanger sequencing. We aimed to identify predictors of cancer physicians' somatic mutation test ordering behaviour. METHODS:A validated instrument assessed somatic mutation test ordering, genomic confidence, perceived utility of tumour molecular profiling, and percent of ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):431]

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COVID-19: Is there a role for immunonutrition in obese patient?

Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli, Antonino De Lorenzo,

On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all the resources available to find any therapy and prevention strategies to defeat COVID-19. In this context, immunonutrition can play a ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):415]

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Investigation of circulating lncRNAs as potential biomarkers in chronic respiratory diseases.

Zsófia Gál, András Gézsi, Ágnes F Semsei, Adrienne Nagy, Monika Sultész, Zsuzsanna Csoma, Lilla Tamási, Gabriella Gálffy, Csaba Szalai,

BACKGROUND:In the present study the blood expression level of inflammatory response and autoimmunity associated long non-coding RNAs (lncRNAs) were compared in patients with different chronic respiratory diseases and investigated whether they could be used as biomarkers in these diseases. METHODS:In the discovery cohort, the gene expression level of 84 lncRNAs ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):422]

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Identification of cancer stem cell-related biomarkers in intestinal-type and diffuse-type gastric cancer by stemness index and weighted correlation network analysis.

Rui Guo, Aining Chu, Yuehua Gong,

BACKGROUND:Cancer stem cells (CSCs) play an important role in drug resistance, recurrence, and metastasis of tumors. Considering the heterogeneity of tumors, this study aimed to explore the key genes regulating stem cells in intestinal-type and diffuse-type gastric cancer. METHODS:RNA-seq data and related clinical information were downloaded from The Cancer Genome ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):418]

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Low-volume high-intensity interval training improves cardiometabolic health, work ability and well-being in severely obese individuals: a randomized-controlled trial sub-study.

Dejan Reljic, Fabienne Frenk, Hans J Herrmann, Markus F Neurath, Yurdagül Zopf,

BACKGROUND:Obesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training (HIIT) has emerged as a popular exercise option. However, data regarding the effects on cardiometabolic health, perceived work ability and well-being ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):419]

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Transcriptome analysis identifies putative multi-gene signature distinguishing benign and malignant pancreatic head mass.

Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Barsha Saha, Somdatta Lahiri, Sandip Halder, Indranil Ghosh, Sujan Khamrui, Kshaunish Das, Samsiddhi Bhattacharjee, Saroj Kant Mohapatra, Srikanta Goswami,

BACKGROUND:Most often, the patients with pancreatic diseases are presented with a mass in pancreatic head region and existing methods of diagnosis fail to confirm whether the head mass is malignant or benign. As subsequent management of the disease hugely depends on the correct diagnosis, we wanted to explore possible biomarkers ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):420]

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Molecular characterization of breast cancer: a potential novel immune-related lncRNAs signature.

Jianguo Lai, Bo Chen, Guochun Zhang, Xuerui Li, Hsiaopei Mok, Ning Liao,

BACKGROUND:Accumulating evidence has demonstrated that immune-related lncRNAs (IRLs) are commonly aberrantly expressed in breast cancer (BC). Thus, we aimed to establish an IRL-based tool to improve prognosis prediction in BC patients. METHODS:We obtained IRL expression profiles in large BC cohorts (N = 911) from The Cancer Genome Atlas (TCGA) database. Then, in ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):416]

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Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy.

Daniel J Gironda, Daniel L Adams, Jianzhong He, Ting Xu, Hui Gao, Yawei Qiao, Ritsuko Komaki, James M Reuben, Zhongxing Liao, Mariela Blum-Murphy, Wayne L Hofstetter, Cha-Mei Tang, Steven H Lin,

BACKGROUND:Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with poorer progression free survival (PFS) and overall survival (OS) in a variety of cancers; however, no study has evaluated their clinical significance in esophageal ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):413]

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Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study.

Blanca Fuentes, Silvia Pastor-Yborra, Raquel Gutiérrez-Zúñiga, Noemí González-Pérez de Villar, Elena de Celis, Jorge Rodríguez-Pardo, Mari Carmen Gómez-de Frutos, Fernando Laso-García, María Gutiérrez-Fernández, MÁngeles Ortega-Casarrubios, Alfonso Soto, María López-Fernández, María Santamaría, Noemí Díez-González, Mar M Freijo, Beatriz Zandio, Raquel Delgado-Mederos, Ana Calleja, Juan Carlos Portilla-Cuenca, Arturo Lisbona, Laura Otero-Ortega, Exuperio Díez-Tejedor,

INTRODUCTION:Glycemic variability (GV) represents the amplitude of oscillations in glucose levels over time and is associated with higher mortality in critically ill patients. Our aim is to evaluate the impact of GV on acute ischemic stroke (IS) outcomes in humans and explore the impact of two different insulin administration routes ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):414]

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