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Journal J Rheumatol

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ASAS Health Index as an Addition to Routine Clinical Practice.

Rubén Queiro, Sara Alonso-Castro, Mercedes Alperi,

We have read with great interest the recent editorial published in <i>The Journal</i> by Dr. Kiltz, <i>et al</i>, referring to the possibility of using the Spondyloarthritis international Society Health Index (ASAS HI) as an all-in-one in the assessment of axial spondyloarthritis (axSpA)<sup>1</sup> AxSpA has been evaluated over the years with ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Use of Hydroxychloroquine And Risk of Heart Failure in Patients With Rheumatoid Arthritis.

Ahmed A Sorour, Reto D Kurmann, Youssef E Shahin, Cynthia S Crowson, Sara J Achenbach, Rekha Mankad, Elena Myasoedova,

<h4>Objective</h4>To examine the relationship between the use of Hydroxychloroquine (HCQ) and risk of developing Heart Failure (HF) in Rheumatoid Arthritis (RA).<h4>Methods</h4>In this nested case-control study, cases were Olmsted county, Minnesota residents with incident RA (based on 1987 ACR criteria) from 1980-2013 who developed HF after RA incidence. Each case was ... Read more >>

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[2021, :]

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Erectile Dysfunction and Cardiovascular Risk in Men with Rheumatoid Arthritis: A Population- Based Cohort Study.

Katelynn M Wilton, Sara J Achenbach, John M Davis, Elena Myasoedova, Eric L Matteson, Cynthia S Crowson,

<h4>Objective</h4>Both erectile dysfunction (ED) and rheumatoid arthritis (RA) are associated with increased cardiovascular risk. It is unknown if these diagnoses are associated or if their combination confers additional cardiovascular risk. We aim to define the incidence of ED in RA, and determine if ED correlates with increased cardiovascular risk in ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Essential hypertension worsens left ventricular contractility in systemic sclerosis.

Valentina Mercurio, Alicia M Hinze, Laura K Hummers, Fredrick M Wigley, Ami A Shah, Monica Mukherjee,

<h4>Objective</h4>Primary cardiac involvement in systemic sclerosis (SSc) is prevalent and morbid, however the influence of traditional cardiovascular risk factors such as essential hypertension (HTN) are unclear. In the present study, we sought to understand the effects of HTN on left ventricular (LV) contractility in SSc patients using echocardiographic speckle-derived global ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Assessment of widespread and extra-articular pain in psoriatic arthritis: a case-control study.

Ennio Lubrano, Silvia Scriffignano, Romeo Morelli, Fabio Massimo Perrotta,

<h4>Objective</h4>A remarkable lack of detailed knowledge on pain areas in Psoriatic Arthritis (PsA) is present, and their clinical relevance is quite unknown. The main aim of the study was to explore pain areas in PsA, comparing them with those involved in Fibromyalgia (FM) patients. In addition, to investigate any possible ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Dr. Kiltz, et al reply.

Uta Kiltz, Daniel Wendling, Juergen Braun,

We thank Dr. Queiro and colleagues for their interest in our editorial review and the fascinating field of axial spondyloarthritis (axSpA)<sup>1</sup> Queiro and colleagues point out that disease-specific assessments used in routine care for patients with axSpA focus on assessment of disease activity and physical function but do not look ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Association of patients' familiarity and perceptions of efficacy and risks with the use of opioid medications in the management of osteoarthritis.

Ernest R Vina, Cristian Quinones, Leslie R M Hausmann, Said A Ibrahim, C Kent Kwoh,

<h4>Objective</h4>While opioids are known to cause unintended adverse effects, they are being utilized by a number of patients with osteoarthritis (OA). The aim of this study was to evaluate the association of patient familiarity and perceptions regarding efficacy and risks with opioid medication use for OA.<h4>Methods</h4>A total of 362 adults ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Prevalence of non-radiographic sacroiliitis in patients with psoriatic arthritis: a real-life observational study.

Victoria Furer, David Levartovsky, Jonathan Wollman, Irena Wigler, Daphna Paran, Ilana Kaufman, Ofir Elalouf, Sara Borok, Marina Anouk, Hagit Sarbagil-Maman, Mark Berman, Ari Polachek, Hagit Matz, Gideon Flusser, Ido Druckmann, Iris Eshed, Ori Elkayam,

<h4>Objective</h4>To establish the prevalence of non-radiographic sacroiliitis within a real-life sample of patients with psoriatic arthritis (PsA), using pelvic radiographs and magnetic resonance imaging (MRI) of sacroiliac joints (SIJ).<h4>Methods</h4>This cross-sectional study included 107 consecutive adults with PsA (CASPAR criteria). Participants completed clinical and laboratory evaluation, pelvic radiographs scored for radiographic ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Hyperviscosity Syndrome in Rheumatoid Arthritis.

John B Miller, Alan N Baer,

Hyperviscosity syndrome (HVS) is a life-threatening condition often occurring as a complication of Waldenström macroglobulinemia (WM) but rarely in the context of rheumatic disease. Given its rarity, diagnosis can be delayed, leading to greater morbidity. ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Increased Risk of Valvular Heart Disease in Systemic Sclerosis: An Underrecognized Cardiac Complication.

Reto D Kurmann, Edward A El-Am, Yasser A Radwan, Avneek S Sandhu, Cynthia S Crowson, Eric L Matteson, Kenneth J Warrington, Rekha Mankad, Ashima Makol,

<h4>Objective</h4>Cardiac involvement is a poor prognostic marker in systemic sclerosis (SSc). While diastolic dysfunction, myocardial fibrosis, and arrhythmias are traditionally considered features of primary cardiac involvement in SSc, the incidence of valvular heart disease (VHD) is not well reported. Our objective was to examine the prevalence of VHD at time ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Absence of Association Between Abatacept Exposure and Initial Infection in Patients With Juvenile Idiopathic Arthritis.

Nicolino Ruperto, Hermine I Brunner, Nikolay Tzaribachev, Gabriel Vega-Cornejo, Ingrid Louw, Rolando Cimaz, Jason Dare, Graciela Espada, Enrique Faugier, Manuel Ferrandiz, Valeria Gerloni, Pierre Quartier, Clovis Artur Silva, Linda Wagner-Weiner, Yash Gandhi, Julie Passarell, Marleen Nys, Robert Wong, Alberto Martini, Daniel J Lovell, ,

<h4>Objective</h4>To assess the relationship between infection risk and abatacept exposure levels in patients with polyarticular-course juvenile idiopathic arthritis (pJIA) following treatment with subcutaneous and intravenous abatacept.<h4>Methods</h4>Data from two published studies (NCT01844518, NCT00095173) of abatacept treatment in pediatric patients were analyzed. One study treated patients aged 2-17 years with subcutaneous abatacept ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Relation of NSAID, DMARD and TNF-inhibitors for Ankylosing Spondylitis and Psoriatic Arthritis to Risk of Total Hip and Knee Arthroplasty.

Rachael Stovall, Christine Peloquin, David Felson, Tuhina Neogi, Maureen Dubreuil,

<h4>Objective</h4>Ankylosing spondylitis and psoriatic arthritis (AS/PsA) often affect the hip and/or knee. If effective, treatments might reduce risk of total hip or total knee arthroplasty (THA/TKA). We evaluated risk of THA/TKA related to use of medical therapies in AS/PsA.<h4>Methods</h4>We conducted a nested case-control study using 1994-2018 data from the OptumLabs® ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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UCLA Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 Reflux Scale correlates with impaired Esophageal Scintigraphy findings in Systemic Sclerosis.

Giuseppina Abignano, Gianna Angela Mennillo, Giovanni Lettieri, Duygu Temiz Karadag, Antonio Carriero, Angela Anna Padula, Francesco Del Galdo, Dinesh Khanna, Salvatore D'Angelo,

<h4>Objective</h4>The University of California Los Angeles Scleroderma Clinical Trials Consortium gastrointestinal tract 2.0 (UCLA GIT 2.0) questionnaire is a self-reported tool measuring gastrointestinal (GI) quality of life in systemic sclerosis (SSc) patients. Scarce data are available on the correlation between patient reported GI symptoms and motility dysfunction as assessed by ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2021, :]

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Porphyria Cutanea Tarda Masquerading as Systemic Sclerosis: Two Cases Demonstrating an Important Clinical Observation.

Elizabeth Tkachenko, Joseph C Pierson, Ruth Ann Vleugels,

J Rheumatol (The Journal of rheumatology)
[2021, 48(1):145-146]

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Transfer from Pediatric to Adult Care Is Hardly Child's Play.

Amanda Steiman, Zahi Touma,

J Rheumatol (The Journal of rheumatology)
[2021, 48(1):3-5]

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Real-world Evidence Needs Careful Interpretation.

Peter Nash,

J Rheumatol (The Journal of rheumatology)
[2021, 48(1):1-2]

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Severe Hypopyon Uveitis in the Right Eye of Ankylosing Spondylitis.

Fan Wang, Chengde Yang, Junna Ye,

J Rheumatol (The Journal of rheumatology)
[2021, 48(1):147-148]

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Impact of comorbid conditions on health care expenditure and work-related outcomes in patients with rheumatoid arthritis.

Martin Vu, Natalie Carvalho, Philip M Clarke, Rachelle Buchbinder, An Tran-Duy,

<h4>Objective</h4>To evaluate the impact of comorbid conditions on direct health care expenditure and work-related outcomes in patients with rheumatoid arthritis (RA).<h4>Methods</h4>This was a retrospective analysis of the Medical Expenditure Panel Survey from 2006 to 2015 in 4,967 adult RA patients in the USA. Generalised linear models were used for health ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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The Clinical Disease Activity Index (CDAI) and the Routine Assessment of Patient Index Data3 (RAPID3) for Achievement of Treatment Strategies.

Joel M Kremer, Dimitrios A Pappas, Kevin Kane, Jeffrey Greenberg, Leslie Harrold, Vivi L Feathers, Nancy Shadick, Michael E Weinblatt, George Reed,

<h4>Objective</h4>To compare the CDAI with the RAPID3 from two large US Registries.<h4>Methods</h4>Using a cross section of clinic visits within two registries we determined if the outcome of each metric would place the patient in remission (R), low (LDA), moderate (MDA), or high disease activity (HDA) using a CDAI with the ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Safety and Efficacy of Poseltinib, Bruton's Tyrosine Kinase-Inhibitor, in Patients With Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled, 2-Part Phase-2 Study.

Mark Genovese, Alberto Spindler, Akira Sagawa, Won Park, Anna Dudek, Alan Kivitz, Jeannie Chao, Melanie Lai Shan Chan, Jennifer Witcher, William Barchuk, Ajay Nirula,

<h4>Objective</h4>To evaluate efficacy and safety of poseltinib (formerly LY3337641/HM71224), an irreversible covalent inhibitor of Bruton's tyrosine kinase from a 2-part, Phase-2 trial (RAjuvenate) in adults with active rheumatoid arthritis (RA).<h4>Methods</h4>In Part A, 36 patients with mildly active RA were randomized 1:1:1:1 to oral poseltinib 5-, 10-, or 30-mg or placebo ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Chronic pain and assessment of pain sensitivity in patients with axial spondyloarthritis: Results from the SPARTAKUS cohort.

Elisabeth Mogard, Tor Olofsson, Stefan Bergman, Ann Bremander, Lars-Erik Kristensen, Jack Kvistgaard Olsen, Johan K Wallman, Elisabet Lindqvist,

<h4>Objective</h4>To study differences in pain reports between patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), and to assess how pain sensitivity measures associate with disease and health outcomes.<h4>Methods</h4>Consecutive patients with axial SpA (axSpA) were enrolled in the populationbased SPARTAKUS cohort (2015‒2017), and classified as AS (n=120) or nr-axSpA ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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The rheumatoid arthritis gene expression signature among women who improve or worsen during pregnancy - a pilot study.

Amogh Pathi, Matthew Wright, Mette Kiel Smed, J Lee Nelson, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Damini Jawaheer,

<h4>Objective</h4>To assess whether gene expression signatures associated with rheumatoid arthritis (RA) before pregnancy differ between women who improve or worsen during pregnancy, and determine whether these expression signatures are altered during pregnancy when RA improves or worsens.<h4>Methods</h4>Clinical data and blood samples were collected before pregnancy (T0) and at the third ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Improving Pneumococcal Vaccination Rates in Rheumatology Patients by Using Best Practice Alerts in the Electronic Health Records.

Heena Sheth, Vera Grimes, Diana Rudge, Brandon Ayers, Larry Moreland, Gary S Fischer, Rohit Aggarwal,

<h4>Objective</h4>To improve pneumococcal vaccination (PV) rates among rheumatology clinic patients on immunosuppressive therapy in the outpatient settings.<h4>Methods</h4>This quality improvement project was based on the pre-post-intervention design. Phase I of the project targeted rheumatoid arthritis patients from thirteen rheumatology clinics (1/2013 to 7/2015) on immunosuppressive therapy to receive pneumococcal polysaccharide vaccine ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Soluble vascular biomarkers in rheumatoid arthritis and ankylosing spondylitis: effects of one-year anti-TNF-α therapy.

Anita Pusztai, Attila Hamar, Ágnes Horváth, Katalin Gulyás, Edit Végh, Nóra Bodnár, György Kerekes, Monika Czókolyová, Levente Bodoki, Katalin Hodosi, Andrea Domján, Gábor Nagy, Ibolya Szöllősi, Luis R Lopez, Eiji Matsuura, Zoltán Prohászka, Sándor Szántó, Gabriella Szűcs, Zoltán Nagy, Yehuda Shoenfeld, Zoltán Szekanecz, Szilvia Szamosi,

<h4>Objective</h4>Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with cardiovascular (CV) disease. The treatment of arthritis by tumour necrosis factor α (TNF- α) inhibitors may decrease the serum concentrations of vascular biomarkers. We determined circulating levels of oxidized LDL (oxLDL)/β2 glycoprotein I (β2GPI) complexes, antibodies to 60 kDa ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Hydroxychloroquine Retinal Toxicity and Its Association with Dosage.

Daniel Martín-Iglesias, Joseba Artaraz, Guillermo Ruiz-Irastorza,

J Rheumatol (The Journal of rheumatology)
[2021, 48(1):150]

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