Full Text Journal Articles in
Journal J Pharm Biomed Anal

Advertisement

Find full text journal articles






Determination of clozapine and norclozapine in dried plasma spot and dried blood spot by liquid chromatography-tandem mass spectrometry.

Eliana Carniel, Karen Adams Dos Santos, Lucas de Andrade de Lima, Ramona Kohlrausch, Rafael Linden, Marina Venzon Antunes,

The use of alternative blood sampling strategies in clozapine (CLZ) therapeutic drug monitoring (TDM) aims to facilitate collection and improve drug therapy and adherence. This study aimed to develop and validate two methods for the determination CLZ and norclozapine (NOR) in dried blood spots (DBS) and dried plasma spots (DPS) ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114591]

Cited: 0 times

View full text PDF listing >>



2D NMR peak profiling to compare chemical differences between batches of pentosan polysulfate sodium.

Kang Chen,

Pentosan Polysulfate Sodium (PPS) is a semi-synthetic polysulfated xylan sourced from beechwood tree barks. PPS, which is mainly composed of a xylose chain with branched O-methyl-glucuronate (MGA), can have heterogeneity in monosaccharide species, sequence and chemical modifications including sulfation and acetylation. The monosaccharide composition in polysaccharide therapeutics is a frequently ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 211:114589]

Cited: 0 times

View full text PDF listing >>



Advertisement

Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics.

Chunyan Zhu, Guoyin Lai, Ying Jin, Dunming Xu, Jiayun Chen, Xiaojuan Jiang, Suping Wang, Guoqiang Liu, Niusheng Xu, Rong Shen, Luxiao Wang, Mingshe Zhu, Caisheng Wu,

The presence of veterinary drug and pesticide residues in food products pose considerable threats to human health. Monitoring of these residues in food is mainly carried out using targeted analysis by triple quadrupole mass spectrometry. However, these methods are not suitable for suspect screening and untargeted analysis of unknowns. The ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114583]

Cited: 0 times

View full text PDF listing >>



Isolation and structural characterization of eight impurities in aztreonam.

Yahui Li, Minghua Yuan, Dong Ding, Xiong Jiang, Qing Ye, Fujiang Guo,

To comply with regulatory requirements, it is necessary to detect and separate the impurities generated during aztreonam synthesis or storage. The chromatogram of aztreonam revealed eight major impurities, which were purified through medium-pressure reversed-phase column and preparative High Performance Liquid Chromatography (HPLC). Through high resolution electrospray ionization mass spectroscopy (HRESIMS), ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114587]

Cited: 0 times

View full text PDF listing >>



Experimental mixture design as a tool to evaluate coumarin (1,2-benzopyrone) extraction from Dipteryx odorata seeds.

Maria Lourdes Leite Moraes, Sabrina Aparecida Silva, Heron Dominguez Torres Silva,

Experimental mixture design was drawn to evaluated the effects of the interactions between water, methanol and ethyl acetate mixtures on the extraction efficiency of coumarin (1,2-benzopyrone) from Dipteryx odorata seeds. Solvents were defined considering those preferred as green solvents for natural products extraction. Ultrasonic-assisted extraction method developed was simple, fast, ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114586]

Cited: 0 times

View full text PDF listing >>



Analysis of polymerized impurities in mezlocillin sodium and sulbenicillin sodium using two chromatographic separation mechanisms coupled to tandem mass spectrometry.

Xiaojuan Ren, Kaixian Tang, Ping Zhou, Jian Wang,

To effectively control the polymerized impurities in mezlocillin sodium and sulbenicillin sodium, a HPSEC method with TSK-gel G2000SWxl column and a RP-HPLC method with C18 analytical column were established to replace the classical gel filtration chromatography with Sephadex G-10 gel as stationary phase. By studying the chromatographic behavior of polymerized ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114584]

Cited: 0 times

View full text PDF listing >>



Correlation analysis of physicochemical properties with anti-inflammatory activity of Andrographis paniculata (Burm.f.) Nees based on HPLC-DAD, colorimeter and multivariate statistics: A comprehensive quality evaluation strategy.

Meng Xia, Yan Guo, Jia Li, Han Ma, Wei Gao, Xiaoyi Wu,

Andrographis paniculata (Burm.f.) Nees is an essential traditional herbal medicine with various bioactivities in Asian countries. The quality of herbal medicines directly affects its clinical efficacy, so a comprehensive strategy, including color assay, chemical profiles, quantitative analysis, and anti-inflammatory activity assay, is constructed to evaluate the quality of A. paniculata ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114565]

Cited: 0 times

View full text PDF listing >>



In memory of Professor Sergio Pinzauti.

Coral Barbas, Bezhan Chankvetadze, Markus Ganzera, Jun Haginaka, Shaoping Li, Michal Markuszewski, Ruin Moaddel, Zhengjin Jiang, Sibel Ozkan,

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114567]

Cited: 0 times

View full text PDF listing >>



A novel method for multiplex protein biomarker analysis of human serum using quantitative MALDI mass spectrometry.

Aleksandr S Taraskin, Konstantin K Semenov, Alexey A Lozhkov, Irina L Baranovskaya, Aleksandr V Protasov, Edward S Ramsay, Alexandr A Tyulin, Olga A Mirgorodskaya, Andrey V Vasin, Sergey A Klotchenko, Yana A Zabrodskaya,

In this work, we have extended our previously proposed approach for determining protein concentrations in human serum (using MALDI-TOF mass spectrometry) to include simultaneous analysis of several proteins associated with acute inflammation (alpha-2-macroglobulin, fetuin-A, serum amyloid A1). This technique can be used to diagnose systemic inflammation and provides results in ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114575]

Cited: 0 times

View full text PDF listing >>



High level nitrosamines in rat faeces with colorectal cancer determined by a sensitive GC-MS method.

Zhen Xiong Zhao, Sai Zhen Chen, Zhe Lin Xia, Yu Bin Xu, Ling Ling Zhang, Shan Ming Tian, Qing Fan,

N-nitrosamines (NAs) are common toxic substances that have a strong correlation with many human diseases, such as liver damage and cancer. However, there is a lack of studies on methods involving the detection of NAs in biological samples, possibly owing to the interference of complex biological matrices and the influence ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114576]

Cited: 0 times

View full text PDF listing >>



Blood pressure and urine metabolite changes in spontaneously hypertensive rats treated with leaf extract of Ficus deltoidea var angustifolia.

Mohd Saleh Ahmad Kamal, Ahmed Mediani, Noraini Kasim, Nor Hadiani Ismail, Nuraliza Abdul Satar, Norasikin Ab Azis, Zurain Radjeni, Harbindar Jeet Singh,

Ficus deltoidea var angustifolia (FD-A) reduces blood pressure in spontaneously hypertensive rats (SHR) but the mechanism remains unknown. Changes in urine metabolites following FD-A treatment in SHR were, therefore, examined to identify the mechanism of its antihypertensive action. Male SHR were given either FD-A (1000 mg kg<sup>-1</sup> day<sup>-1</sup>) or losartan (10 mg kg<sup>-1</sup> day<sup>-1</sup>) ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114579]

Cited: 0 times

View full text PDF listing >>



Holistic quality evaluation of commercial Agastache rugosa by multiple chromatographic and chemometric analysis.

Hui-Dan Hou, Cheng-Ying Wu, Jing Zhou, Jin-Di Xu, Fang Long, Jin-Hao Zhu, Shan-Shan Zhou, Wei Zhang, Qian Mao, Hong Shen, Zi-Qi Shi, Ying-Jie Wei, Song-Lin Li,

In present study, a comprehensive strategy integrating multiple chromatographic and chemometric methods to simultaneously characterize the volatile and non-volatile components was developed for the holistic quality evaluation of commercial Agastache rugosa (AR), a common edible and medicinal herb, collected in China. The volatile components and the non-volatile components were characterized ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2022, 210:114574]

Cited: 0 times

View full text PDF listing >>



Development of an in-syringe gas-assisted density tunable solidification of floating organic droplet-based dispersive liquid phase microextraction method coupled with HPLC-MS/MS for monitoring amikacin in biological fluids.

Ali Mohebbi, Abolghasem Jouyban, Mir Ali Farajzadeh, Mohammad Reza Afshar Mogaddam, Mahboob Nemati,

A new sample preparation method named in-syringe gas-assisted density tunable dispersive liquid phase microextraction based on solidification of floating organic droplet has been introduced. This method was coupled with high-performance liquid chromatography-tandem mass spectrometry and used for the extraction and quantification of amikacin in plasma and exhaled breath condensate (EBC) ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114552]

Cited: 0 times

View full text PDF listing >>



Subcellular metabolomics: Isolation, measurement, and applications.

Siyuan Qin, Yuxin Zhang, Yuan Tian, Fengguo Xu, Pei Zhang,

Metabolomics, a technique that profiles global small molecules in biological samples, has been a pivotal tool for disease diagnosis and mechanism research. The sample type in metabolomics covers a wide range, including a variety of body fluids, tissues, and cells. However, little attention was paid to the smaller, relatively independent ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114557]

Cited: 0 times

View full text PDF listing >>



An UPLC-PDA assay for simultaneous determination of seven antibiotics in human plasma.

Feifan Xie, Lanyu Liu, Yan Wang, Yaru Peng, Sanwang Li,

Appropriate antibiotic dosing in critically ill patients requires concentration monitoring due to the occurrence of pathophysiological changes and frequent extracorporeal therapy that could significantly alter the normal pharmacokinetics of drugs. Herein, we describe an ultra-performance liquid chromatography with photodiode array (UPLC-PDA) for the simultaneous concentration determination of seven frequently used ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114558]

Cited: 0 times

View full text PDF listing >>



Isolation of N-nitrosodimethylamine from drug substances using solid-phase extraction-liquid chromatography-tandem mass spectrometry.

Eiichi Yamamoto, Hitomi Kan-No, Naomi Tomita, Daisuke Ando, Tamaki Miyazaki, Ken-Ichi Izutsu,

N-Nitrosodimethylamine (NDMA) has been detected in some drug substances and pharmaceutical products containing sartans, ranitidine and metformin, and a potential risk of NDMA contamination exists in other drug substances and their pharmaceutical products. To quantitate NDMA in various drugs having diverse physicochemical properties, a specific, sensitive, and reliable analytical method ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114561]

Cited: 0 times

View full text PDF listing >>



Rapid and non-invasive discrimination of acute leukemia bone marrow supernatants by Raman spectroscopy and multivariate statistical analysis.

Haoyue Liang, Xuelian Cheng, Shuxu Dong, Haoyu Wang, Ertao Liu, Yongxin Ru, Yinghui Li, Xiaodong Kong, Yingdai Gao,

A simple and non-invasive detection method for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) was established by systematically investigating the characteristics of bone marrow supernatants from 61 AML patients, 22 ALL patients, and 5 volunteers without hematological tumors by Raman spectroscopy and orthogonal partial least squares discriminant analysis ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114560]

Cited: 0 times

View full text PDF listing >>



A comprehensive strategy for quality evaluation of Wushe Zhiyang Pills by integrating UPLC-DAD fingerprint and multi-ingredients rapid quantitation with UPLC-MS/MS technology.

Maoyuan Jiang, Jiliang Cao, Chunbo Zhang, Biru Su, Shengpeng Wang, Na Ning, Ting Lei, Peng Li,

Wushe Zhiyang Pills (WZP), a classical traditional Chinese medicine (TCM) formula, has been extensively used for the treatment of chronic urticaria and other relevant dermatologic diseases. In this study, a holistic method combining ultra-performance liquid chromatography coupled with diode array detector (UPLC-DAD) fingerprint and multi-components quantitative analysis was developed and ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114556]

Cited: 0 times

View full text PDF listing >>



BH+/MH+-matching method for discovery of cis-diol-containing modified nucleosides in urine by ribose-targeted solid phase extraction followed by dual-mass spectrometry platform identification.

Zhiwei Lu, Xinyue Liu, Xuejiao Li, Chuanjia Zhai, Yulian Shi, Xiaoyan Gao,

Profiling of new modified nucleosides from urine plays an important role in exploring biomarkers for cancer. However, limitations from the nature of the compound, bio-sample, instrumentation, and analytical method pose great challenges to achieving a comprehensive analysis of urinary nucleosides. Herein, a method of BH<sup>+</sup>/MH<sup>+</sup>-matching (BH<sup>+</sup>, protonated nucleobase ion; MH<sup>+</sup>, ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114555]

Cited: 0 times

View full text PDF listing >>



Isolation and quantification of diarylheptanoids from European hornbeam (Carpinus betulus L.) and HPLC-ESI-MS/MS characterization of its antioxidative phenolics.

Csenge Anna Felegyi-Tóth, Zsófia Garádi, András Darcsi, Orsolya Csernák, Imre Boldizsár, Szabolcs Béni, Ágnes Alberti,

Detailed polyphenol profiling of European hornbeam (Carpinus betulus L.) bark, leaf, male and female catkin extracts was performed by high-performance liquid chromatography-diode array detection coupled to tandem mass spectrometry (HPLC-DAD-MS/MS). A total of 194 compounds were characterized and tentatively identified. Gallo- and ellagitannins dominated in the methanol extracts, while flavonol ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114554]

Cited: 0 times

View full text PDF listing >>



Stability of a high-concentrated aqueous solution of idarubicin stored in a polypropylene syringe for transarterial chemoembolization.

Blandine Bourcier, Frédéric Lagarce, Vincent Lebreton,

Idarubicin (IDA) is an antineoplasic drug commonly used to treat hematologic diseases. Because of its relative lipophilic properties, this anthracycline is also used in transarterial chemoembolization (TACE) as part of hepatocellular carcinoma (HCC) treatment. But TACE requires injected volume to be reduced to restrict systemic diffusion and side effects. The ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114543]

Cited: 0 times

View full text PDF listing >>



A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications.

Josefine Schulz, Robin Michelet, Jan F Joseph, Markus Zeitlinger, Fabian Schumacher, Gerd Mikus, Charlotte Kloft,

Voriconazole (VRC) pharmacokinetics, in particular its complex metabolism, is still not fully understood which challenges its optimal therapeutic use. To increase knowledge on the pharmacokinetics of this antifungal drug, it is essential to broaden the perspective and expand in vitro and clinical in vivo investigations in particular to aspects such ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114551]

Cited: 0 times

View full text PDF listing >>



Drug discovery from natural products - Old problems and novel solutions for the treatment of neurodegenerative diseases.

Urmila Maitra, Cayman Stephen, Lukasz M Ciesla,

The use of natural products has been shown to be a fruitful approach in the discovery of novel pharmaceuticals. In fact, many currently approved drugs originated from compounds that were first identified in nature. Chemical diversity of natural compounds cannot be matched by man-made libraries of chemically synthesized molecules. Many ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114553]

Cited: 0 times

View full text PDF listing >>



Advanced microextraction techniques for the analysis of amphetamines in human breast milk and their comparison with conventional methods.

Hana Bavlovič Piskáčková, Alžběta Nemeškalová, Radim Kučera, Stig Pedersen-Bjergaard, Věra Najmanová, Petra Štěrbová-Kovaříková, Martin Kuchař, David Sýkora,

Breast milk analysis provides useful information about acute newborn exposure to harmful substances, such as psychoactive drugs abused by a nursing mother. Since breast milk represents a complex matrix with large amounts of interfering compounds, a comprehensive sample pre-treatment is necessary. This work focuses on determination of amphetamines and synthetic ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114549]

Cited: 0 times

View full text PDF listing >>



Pharmacokinetics, oral bioavailability and metabolic analysis of solasodine in mice by dried blood spot LC-MS/MS and UHPLC-Q-Exactive MS.

Mei Qu, Peng Xue, Qi Zhang, Tiantian Lu, Kun Liu, Bingying Hu, Jingjing Pang, Qianqian Xiao, Tongxin Xu, Quande Wang, Zhongzhe Cheng,

Solasodine, a major ingredient in Solanaceae family, has various biological functions such as inducing neurogenesis, anticonvulsant and anti-tumor. Its risk assessment has also drawn public attention. However, little is known about its oral bioavailability and metabolic process. In this study, an liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2021, 210:114542]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

0.9926 s