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Agreement Among International Periodontal Experts Using the 2017 World Workshop Classification of Periodontitis.

Andrea Ravidà, Suncica Travan, Muhammad H A Saleh, Henry Greenwell, Panos N Papapanou, Mariano Sanz, Maurizio Tonetti, Hom-Lay Wang, Kenneth Kornman,

<h4>Background</h4>A new periodontitis classification was recently introduced involving multidimensional staging and grading. The Study's aim was to assess if individuals well-trained in periodontics consistently used the new classification for patients with severe periodontitis. The secondary goal was to identify "gray zones" related to classifications.<h4>Methods</h4>Participants (raters) individually classified 10 pre-selected severe ... Read more >>

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Synergistic antimicrobial effect of photodynamic therapy and chitosan on the titanium-adherent biofilms of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa: an in vitro study.

Fabio Camacho-Alonso, Jesús Salinas, Mariano Sánchez-Siles, Jesús Pato-Mourelo, Brian Davis Cotrina-Veizaga, Nieves Ortega,

<h4>Background</h4>To date, no studies on the combined use of photodynamic therapy (PDT) and chitosan against peri-implantitis have been published. The aim of this study was to evaluate the possible synergistic antimicrobial effect of PDT and chitosan on the titanium-adherent biofilms of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.<h4>Methods</h4>A total of ... Read more >>

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[2021, :]

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Fibromyalgia and periodontitis: bidirectional associations in population-based 15-year retrospective cohorts.

Kevin Sheng-Kai Ma, Jung-Nien Lai, John Jims Veeravalli, Lu-Ting Chiu, Thomas E Van Dyke, James Cheng-Chung Wei,

<h4>Aim</h4>To determine the bidirectional link between periodontitis and fibromyalgia.<h4>Materials and methods</h4>In this cohort study, 196,428 periodontitis patients and 196,428 propensity score-matched non-periodontitis controls were enrolled. A Cox proportional hazard model was utilized to estimate the risk of fibromyalgia and survival analysis was adopted to assess the time-dependent effect of periodontitis ... Read more >>

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A Clinico-radiographic comparative evaluation of 1% Metformin gel plus Platelet Rich Fibrin over Platelet Rich Fibrin alone in Treatment of Grade II Furcation Defects: A Randomized Controlled Double-blind Clinical Trial.

Renuka K Swami, Abhay P Kolte, Rajashri A Kolte,

<h4>Background</h4>The present study was aimed to evaluate and compare the effects of 1%MF plus PRF over PRF alone in treatment of Grade II furcation defects, clinically and radiographically by using CBCT.<h4>Material and methods</h4>This split-mouth clinical trial randomly allotted 21 patients with 42 bilateral Grade II furcation defects into two groups. ... Read more >>

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[2021, :]

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CTGF promotes cell-to-cell communication in human periodontal ligament stem cells via MAPK and PI3K pathway.

Zuping Wu, Sirui Chen, Yuying He, Demao Zhang, Shujuan Zou, Jing Xie, Chenchen Zhou,

<h4>Purposes</h4>Cell-cell communication is an essential process to respond to biological stimuli and sustain the microenvironmental homeostasis of human periodontal ligament stem cells (hPDLSCs). Connective tissue growth factor (CTGF), a critical secreted matrix protein, exhibits significant tasks in regulating the cell-cell and cell-matrix interactions. This study aimed to explore the relationship ... Read more >>

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[2021, :]

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Combined association of cognitive impairment and poor oral health on mortality risk in older adults: results from the NHANES with 15 years of follow-up.

An Li, Yuntao Chen, Anita Visser, Luc A M Marks, Geerten-Has E Tjakkes,

<h4>Background</h4>Cognitive impairment and poor oral health are frequently seen among older adults. Both conditions have been identified as risk factors for mortality. However, the combined associations of cognitive impairment and poor oral health with mortality have not been well studied and are therefore the aim of this cohort study.<h4>Methods</h4>We analyzed ... Read more >>

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Reporting quality of abstracts of randomized controlled trials related to implant dentistry.

Max C Menne, Nikolaos Pandis, Clovis M Faggion,

<h4>Background</h4>Abstracts of scientific articles should be accurate and detailed in summarizing the information in the full-text because they are the first article section the reader examines. This study assessed the reporting quality of randomized controlled trials (RCTs) abstracts related to implant dentistry and examined associations between reporting quality and study ... Read more >>

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Therapeutic effect of fluvastatin on medication-related osteonecrosis of the jaw.

Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano,

<h4>Background</h4>Refractory jaw osteonecrosis that occurs in osteoporotic or cancer patients treated with bisphosphonates is called medication-related osteonecrosis of the jaw but its underlying mechanism is unclear. Statins, therapeutic agents for dyslipidemia, lower blood low-density lipoprotein cholesterol. Fluvastatin promotes the healing of tooth extraction sockets and reduces the risk of developing ... Read more >>

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[2021, :]

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Diagnostic accuracy of severe periodontitis case definitions: comparison of the CDC/AAP, EFP/AAP and CPI criteria.

Liana F Brito, Zuila A Taboza, Virginia R Silveira, Ana K Teixeira, Rodrigo O Rego,

<h4>Objectives</h4>This cross-sectional study aimed to evaluate the diagnostic accuracy of severe periodontitis by three different case definitions.<h4>Methods</h4>Patients over 35 years (n = 243, mean age = 47.8±9.3 years) were evaluated by periodontal examinations and classified in severe periodontitis patients according to the case definition proposed by the Centers for Disease ... Read more >>

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AAP President's Address.

Bryan J Frantz,

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Sebastian G. Ciancio, DDS.

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Association of enhanced circulating Trimethylamine N-oxide with Vascular Endothelial Dysfunction in periodontitis patients.

Jiamin Zhou, Shan Chen, Jing Ren, Huiqiong Zou, Yafang Liu, Yanbin Chen, Yumin Qiu, Weijie Zhuang, Jun Tao, Junying Yang,

<h4>Background</h4>Accumulating evidences indicate that periodontitis is closely associated with endothelial dysfunction. Trimethylamine-N-oxide (TMAO), a harmful microbiota generated metabolite, has been implicated as a nontraditional risk factor for impaired endothelial function. However, whether increased circulating levels of TMAO in periodontitis patients induces endothelial dysfunction remains unknown.<h4>Methods</h4>Patients with periodontitis and periodontally healthy ... Read more >>

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Proportion and severity of periodontitis and correlation of periodontal inflamed surface area with glycemic status in type 2 diabetic neuropathy patients with and without diabetic foot.

Raji Adhenkavil Radhakrishnan, Rosamma Joseph Vadakkekuttical, Chandni Radhakrishnan,

<h4>Background</h4>The association between diabetic neuropathy with and without diabetic foot and periodontitis remains unaddressed in the literature. The present study was conducted to evaluate the frequency of patients with periodontitis and its severity, and to correlate Clinical Attachment Loss (CAL) and Periodontal Inflamed Surface Area (PISA) with HbA1c in Type ... Read more >>

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[2021, :]

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Impact of interproximal composite restorations on periodontal tissues health. Clinical and cytokine profiles from a pre-post quasi-experimental study.

Discepoli Nicola, Marruganti Crystal, Santoro Francesco, Mirra Raffaele, Fabio Fiorino, Medaglini Donata, Pozzi Gianni, Ferrari Marco, Grandini Simone,

<h4>Background</h4>to clinically and molecularly evaluate the effect of an interproximal iuxta/subgingival direct composite restoration on periodontal tissues healing.<h4>Methods</h4>Individuals in need of a posterior iuxta/subgingival interproximal restoration were consecutively enrolled. After enrollment, a Test (site with tooth decay) and a Control site (intact contralateral tooth) were identified. After a periodontal examination ... Read more >>

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[2021, :]

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Porphyromonas gingivalis outer membrane vesicles inhibit the invasion of Fusobacterium nucleatum into oral epithelial cells by down-regulating FadA and FomA.

Zhiying Zhang, Sai Liu, Shuwei Zhang, Yuchao Li, Xiaoting Shi, Dongjuan Liu, Yaping Pan,

<h4>Background</h4>Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) participate in the formation and progression of periodontitis. They can exert virulence by invading into host cells, but the interaction between them and their specific mechanisms remain unclear. The purpose of this study was to study the effect of P. gingivalis ... Read more >>

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[2021, :]

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Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: estimates of population attributable risk in a Japanese community.

Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Yoshihiro Shimazaki, Jun Hata, Toshiharu Ninomiya, Yoshihisa Yamashita,

<h4>Background</h4>This study aimed to examine whether modifiable risk factors can predict tooth loss over 10 years and estimate population attributable risk (PAR) for a combination of modifiable factors.<h4>Methods</h4>This longitudinal study included 1,466 participants who underwent dental examinations in 2007 and 2017 and were aged 40-79 years at baseline. Periodontal conditions ... Read more >>

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Osteopontin induces osteogenic differentiation by human periodontal ligament cells via calcium binding domain-ALK-1 interaction.

D Chaikiawkeaw, N Khorattanakulchai, K Nammultriputtar, K Rattanapisit, V Everts, A Kubera, W Phoolchareon, P Pavasant,

<h4>Background</h4>Recently we have generated recombinant human osteopontin (rhOPN) using a plant platform (Nicotiana benthamiana) and demonstrated, when coated on culture plates, its osteogenic induction capacity of human periodontal ligament (PDL) cells. The aim of this study is to elucidate the molecular mechanism underlying the rhOPN-induced osteogenic differentiation of human PDL ... Read more >>

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Multivariate Outcome Evaluation of Furcation-Involved Molars Treated with Non-Surgical Mechanical Therapy Alone or Combined with Open Flap Debridement: A Retrospective Study.

Jad Majzoub, Ali Salami, Shayan Barootchi, Lorenzo Tavelli, Hom-Lay Wang, Hsun-Liang Chan,

<h4>Aim</h4>This retrospective study assessed the effect of non-surgical and surgical mechanical therapy for furcation-involved molars.<h4>Materials and methods</h4>Furcation defects treated and followed for at least one year were selected. Data relative to the clinical outcomes were recorded. The immediate (3-6 month) clinical outcomes and the long-term survival of the treated molars ... Read more >>

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A Commentary on strategic extraction.

Richard T Kao, Guo-Hao Lin, Yvonne Kapila, Steven Sadowsky, Donald A Curtis,

<h4>Background</h4>Advancements in strategies to maintain compromised teeth combined with a greater understanding of risks associated with dental implants invite a reassessment of the benefits of strategic extraction of a tooth with a questionable prognosis or of limited strategic value.<h4>Methods</h4>Evidence of the management of compromised teeth and decision making for strategic ... Read more >>

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[2021, :]

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Metformin accelerate wound healing by Akt phosphorylation of gingival fibroblast in insulin-resistant prediabetes mice.

Hiromi Kominato, Kohei Takeda, Koji Mizutani, Risako Mikami, Daisuke Kido, Prima Buranasin, Natsumi Saito, Shu Takemura, Keita Nakagawa, Toshiyuki Nagasawa, Takanori Iwata,

<h4>Background</h4>This study aimed to investigate the effects of metformin on gingival wound healing in insulin-resistant prediabetes.<h4>Methods</h4>C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for 10 weeks; half of the HFD mice were treated with metformin (HFD+Met) for the last 2 weeks. Insulin and glucose tolerance tests were ... Read more >>

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[2021, :]

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Efficacy of Nd:YAG laser-assisted periodontal therapy for the management of periodontitis: A double-blind split-mouth randomized controlled clinical trial.

Dorara Dortaj, Seyed Hossein Bassir, Neda Hakimiha, Houlin Hong, Hoori Aslroosta, Reza Fekrazad, Neda Moslemi,

<h4>Background</h4>This study aimed to explore the efficacy of Nd:YAG laser-assisted periodontal therapy for management of patients with stage II-IV periodontitis.<h4>Methods</h4>Patients who presented with residual periodontal pockets were enrolled. After non-surgical periodontal therapy (NSPT), test sites received Nd:YAG laser (first entrance to pocket: 3 W, 100 μs, 20 Hz; second entrance: 4 ... Read more >>

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[2021, :]

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Gingival tissue as a reservoir for human immunodeficiency virus type-1: Preliminary results of a cross-sectional observational study.

Youssouf Sereme, Tábata Larissa S Pólvora, Nicolas Rochereau, Rodrigo Carvalho Santana, Stephane Paul, Benedito Antonio Lopes da Fonseca, Thomas Bourlet, Bruno Pozzetto, Alan Grupioni Lourenço, Ana Carolina F Motta,

<h4>Background</h4>Despite combined antiretroviral therapy (cART), total cure of immunodeficiency virus type 1 (HIV-1) infection remains elusive. Chronic periodontitis (CP) is strongly associated with HIV-1 infection. This condition is characterized by an intense inflammatory infiltrate mainly constituted of immune cells which in turn may be a valuable source of HIV-1 reactivation. ... Read more >>

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[2021, :]

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Periodontal disease progression in the second half of live and following a single episode of scaling and root planing - a clinical study in the Sri Lankan tea plantation cohort with documented clinical parameters over more than 40-years.

Ho-Yan Duong, Eric Schmid, Christoph A Ramseier, Jean E Suvan, Bich Hue Lang-Hua, Rino Burkhardt, Marc Schätzle, Niklaus P Lang,

<h4>Background</h4>To evaluate periodontal disease progression (PDP) and potentially detectable effects of a single episode of scaling and root planing (se-SRP) in subjects lacking professional dental care and oral hygiene practices for more than 40 years.<h4>Methods</h4>In 2013, se-SRP was offered to all available subjects from the original cohort of 480 males ... Read more >>

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[2021, :]

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The "oral" history of COVID-19: Primary infection, salivary transmission, and post-acute implications.

Julie Teresa Marchesan, Blake M Warner, Kevin Matthew Byrd,

Severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has led to more than 3.25 million recorded deaths worldwide as of May 2021. COVID-19 is known to be clinically heterogeneous, and whether the reported oral signs and symptoms in COVID-19 are related to the direct infection of oral ... Read more >>

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[2021, :]

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Factors affecting the decision to rehabilitate the posterior maxilla following surgical closure of oroantral communications/fistulae - A cohort study.

Yehonatan Ben-Zvi, Eli Rosenfeld, Daya Masri, Gal Avishai, Adrian Kahn, Liat Chaushu,

<h4>Background</h4>Search of the English literature yielded no studies assessing the chosen dental treatment following surgical closure of oroantral communication/oroantral fistula (OAC/OAF). The purpose of the present study was to assess factors affecting the decision to rehabilitate the posterior maxilla following surgical closure of OAC/OAF.<h4>Methods</h4>Consecutive patients at a single center. A ... Read more >>

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