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Pediatric Acute B-Cell Lymphoblastic Leukemia Developing Following Recent SARS-CoV-2 Infection.

Charlotte Leclercq, Fabienne Toutain, Frederic Baleydier, Arnaud G L'Huillier, Noemie Wagner, Céline Lironi, Anne-Marie Calza, Marc Ansari, Geraldine Blanchard-Rohner,

Coronavirus disease-2019 in children has been linked to various clinical presentation, from paucisymptomatic cutaneous eruptions, to multisystemic inflammatory syndrome. We report the case of an 8-year-old boy who presented with persistent fever and pancytopenia, associated to a skin rash. An extensive etiological workup showed a positive serology for severe acute ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Graft-Versus-Host-Disease of the Central Nervous System and Lung in a Patient With Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report.

Zhihui Li, Xiaopei Wen, Yanping Geng, Tong Wu,

<h4>Introduction</h4>The common etiology of central nervous system (CNS) complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT) includes CNS infection, metabolic abnormalities, drug toxicity, cerebrovascular events, Epstein-Barr virus-associated posttransplant lymphoproliferative diseases, and hematologic CNS relapse of leukemia. Although graft-versus-host disease (GVHD) is a major complication of allo-HSCT, its CNS involvement is ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Primary Primitive Neuroectodermal Tumor (PNET) of the Spine With t(11;22): Report of 3 Cases and Review of Literature.

Ashley Margol, Chenue Abongwa, Girish Dhall,

Intradural extramedullary peripheral primitive neuroectodermal tumor (pPNET) with t(11;22) is a rare clinical finding in the pediatric population with few published cases in the literature. The authors report 3 cases of intradural primary pPNET and discuss the clinical presentation, treatment, and survival of the patients. Clinicians should be vigilant in ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Decision-Making in the Era of New Medical Technologies in Pediatric Hematology-Oncology: The Death of Palliative Care?

Sylvie Fortin, Josiane Le Gall, Johanne Richer, Antoine Payot, Michel Duval,

<h4>Background</h4>Recent advances in immunology, genomics, and cellular therapy have opened numerous therapeutic possibilities in pediatric hematology-oncology, generating new hope in poor prognosis situations. How decisions are made when it comes to treatments and aims needs to be explored in this new technological context. In particular, their impact on the gold ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Venetoclax and Decitabine in Pediatric Refractory T-cell Lymphoblastic Lymphoma.

Muhammad U Baig, Michael Rytting, Michael Roth, Ajaykumar C Morani, Cesar Nunez, Pei Lin, Branko Cuglievan,

<h4>Background</h4>Overall survival of adolescents with relapsed T-cell lymphoblastic lymphoma (T-LL) remains poor with limited options for salvage therapy. The BCL-2 inhibitor venetoclax combined with hypomethylating agents like decitabine, has shown favorable responses in elderly patients with acute myeloid leukemia.<h4>Observation</h4>We present the case of a 19-year-old adolescent with stage III relapsed ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Tissue Plasminogen Activator Use in Pediatric Patients: A Single Center Experience.

Esra Pekpak, Elif İnce, Mehmet Ertem, Ercan Tutar, Talia İleri, Tayfun Ucar, Serap T Tiras, Hasan F Cakmakli, Zümrüt Uysal,

<h4>Introduction</h4>Thrombosis is rare in children and antithrombolytic treatment is controversial. Most commonly used thrombolytic agent is tissue plasminogen activator (t-PA) in pediatrics. In this study, we report our experience in the use of thrombolytic treatment.<h4>Methods</h4>Eighteen patients who had received systemic t-PA between January 2006 and December 2013 were recorded. The ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Vision Outcomes for Pediatric Patients With Optic Pathway Gliomas Associated With Neurofibromatosis Type I: A Systematic Review of the Clinical Evidence.

Vineeth M Thirunavu, Laila M Mohammad, Viswajit Kandula, Molly Beestrum, Sandi K Lam,

Children with neurofibromatosis type I (NF1) have a higher predisposition for low-grade astrocytomas of the optic pathway, commonly referred to as optic pathway gliomas (OPGs). OPGs can result in visual deterioration. Treatment outcomes in OPG-NF1 management are often reported around tumor stabilization. We sought to compare vision outcomes associated with ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Compound Heterozygous Mutations in the F7 Gene in 2 Unrelated Families With Congenital Factor VII Deficiency.

Cui Ma, Yue Wang, Haidi Gao, Lu Xue, Shuangshuang Wu, Xijing Xu, Huichao Zhang, Chunhuai Li,

Factor VII (FVII) deficiency is a rare bleeding disorder normally caused by homozygous and compound heterozygous mutations in the F7 gene. Whole-exome sequencing was performed to identify F7 mutations in 3 individuals from 2 unrelated families who were diagnosed with FVII deficiency. Four compound heterozygous mutations were identified and validated ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Abnormally Hypersegmented Neutrophilia in Pediatric Acute Myeloid Leukemia Associated With t(2;11)(q31;p15) and NUP98 Rearrangement.

Xuening Hou, Xingzhe Wang, Chen Liu, Futian Ma, Jihong Hao,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Management of Hyperhemolysis in β-thalassemia With Multiple Immunosuppressives, Including Complement Blockade.

Richard C Zanetti, Lauren M Vasta, Kristen Romanelli, Thomas C Newton,

Hyperhemolysis is a life-threatening condition of exaggerated hemolysis of red blood cells which occurs in patients receiving chronic transfusion therapy. We present a 19-year-old male with the β-thalassemia major with an episode of hyperhemolysis. Hemolysis was initially unresponsive to immunosuppression but responded after the addition of eculizumab. Several weeks after ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Augmented Antitumor Activity for Novel Dual PI3K/BDR4 Inhibitors, SF2523 and SF1126 in Ewing Sarcoma.

Amanda N Goldin, Alok Singh, Shweta Joshi, Christina Jamieson, Donald L Durden,

Ewing sarcoma (ES) is the second most common pediatric bone cancer. Despite recent advances in the treatment, patients with metastatic tumors have dismal prognosis and hence novel therapies are urgently needed to combat this cancer. A recent study has shown that phosphoinositide-3 kinase (PI3K) inhibitors can synergistically increase sensitivity to ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Precursor B-Cell Acute Lymphoblastic Leukemia With MYC and BCL2 Rearrangements Presenting as Extensive Extranodal Disease in an Adolescent.

Sapna Oberoi, Angie Dawson, Daniel Marko, Muhamad Almiski, Rick Higgins, Sara J Israels,

Combined rearrangements of MYC and BCL2 are rare in precursor B-cell acute lymphoblastic leukemia (B-ALL). A 14-year-old boy presented with swelling of the knee and face. Imaging revealed diffuse infiltration of lacrimal glands, parotid glands along with the extensive epidural disease. Morphology and immunophenotype of knee joint aspirate were consistent ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Embryonal Tumor With Multilayered Rosettes of the Parietooccipital Region: A Case Report.

Jennifer Horwitz, Annie Huang, David McAuley, Gerard H Jansen, Donna Johnston,

Embryonal tumor with multilayered rosettes is a rare and highly malignant early childhood brain tumor. We report a case of embryonal tumor with multilayered rosettes in the parietooccipital region of a 2-year-old girl. Histopathology of the tumor demonstrated amplification of the 19q13.42 locus and strong positivity for LIN28A. Treatment was ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Copper Deficiency and Cytopenias.

Sonia Morales, Ali Nael, David Buchbinder,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Oral Contraceptive Use in Obese Adolescents: A Cautionary Tale.

Deepti M Warad, Asma J Chattha, Vilmarie Rodriguez,

Venous thromboembolism (VTE) is a life-threatening complication rarely encountered with the use of combined oral contraceptives (COCs). Obesity is an additional thrombosis risk factor that has been shown to further increase the risk of VTE with the use of COCs. We present 5 cases of obese adolescents (body mass index ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Multiple Intraspinal Gangliogliomas in a Child With Neurofibromatosis Type 1: Case Report and Literature Review.

Erin Morales, David Viskochil, Jeffrey Hofmann, Caroline Hagedorn, Luke Linscott, Samuel Cheshier, Carol S Bruggers,

Neurofibromatosis type 1 (NF1)-associated primary intramedullary spinal cord ganglioglioma has only rarely been reported. Because of frequent nonresectability, they pose significant management challenges despite clinical indolence. This report describes a 4-year-old girl with NF1 who was found to have multiple discrete, infiltrative intramedullary cord masses, and biopsy demonstrated World Health ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Two Clonally Distinct B-Cell Lymphomas Reveal the Diagnosis of XLP1 in a Male Child and His Asymptomatic Male Relatives: Case Report and Review of the Literature.

Fiorella Iglesias Cardenas, Archana M Agarwal, Jennie Vagher, Luke Maese, Mark Fluchel, Zeinab Afify,

X-linked lymphoproliferative disease type 1 (XLP1) is a primary immunodeficiency disorder caused by pathogenic variants in the SH2D1A gene (SH2 domain containing protein 1A). Patients with XLP1 may present acutely with fulminant infectious mononucleosis, hemophagocytic lymphohistiocytosis, and/or B-cell non-Hodgkin lymphoma (B-NHL). We report a boy who developed 2 clonally distinct ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Favorable Response to Interferon-α in Infantile-onset Idiopathic Hypereosinophilic Syndrome Complicated by Status Epilepticus During Treatment.

Watcharoot Kanchongkittiphon, Kornvipa Kittinon, Anyarat Wanitchakorn, Suwat Benjaponpitak, Wiparat Manuyakorn,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, :]

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Outcomes Using Narrowband UVB Phototherapy for Acute Cutaneous Graft Versus Host Disease in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients.

Alan N Snyder, Lara Wine Lee, Jennifer J Jaroscak, Lori B Donahoo, Michelle Hudspeth,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):e151-e153]

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Adiposity in Survivors of Cancer in Childhood: How is it Measured and Why Does it Matter?

Louise Guolla, Katherine M Morrison, Ronald D Barr,

Survival of cancer in childhood is increasingly common with modern therapeutic protocols but leads frequently to adverse long-term impacts on health, including metabolic and cardiovascular disease. Changes in body composition, especially an increase in fat mass and a decrease in muscle mass, are found early in patients with pediatric cancer, ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):1-11]

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AFP-L3 as a Prognostic Predictor of Recurrence in Hepatoblastoma: A Pilot Study.

Insu Kawahara, Hiroaki Fukuzawa, Naoto Urushihara, Yoshiyuki Kosaka, Yasuhiro Kuroda, Yuki Fujieda, Yuki Takeuchi, Kotaro Uemura, Tamaki Iwade, Yoshitomo Samejima, Keiichi Morita, Kosaku Maeda,

The α-fetoprotein (AFP) level is a sensitive biomarker of active hepatoblastoma (HB). This study aimed to clarify whether the Lens culinaris agglutinin A-reactive fraction of AFP (AFP-L3) after complete resection is a prognostic predictor of HB recurrence. Fourteen HB patients who underwent complete resection of HB were divided into the ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):e76-e79]

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Impact of a Best Practice Prevention Bundle on Central Line-associated Bloodstream Infection (CLABSI) Rates and Outcomes in Pediatric Hematology, Oncology, and Hematopoietic Cell Transplantation Patients in Inpatient and Ambulatory Settings.

Monica I Ardura, Mindy J Bibart, Lauren C Mayer, Terri Guinipero, Joseph Stanek, Randal S Olshefski, Jeffery J Auletta,

<h4>Background</h4>Pediatric hematology, oncology, and hematopoietic cell transplantation (HCT) patients are at increased risk for bloodstream infections. The authors sought to evaluate the influence of a standardized best practice central venous catheter (CVC) maintenance bundle on the burden of and risk factors for mucosal barrier injury (MBI) and non-MBI central line-associated ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):e64-e72]

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Horner Syndrome: An Unknown Entity After Tunneled Central Venous Catheter Insertion.

Sohini Chakraborty, Vikas Dua, Mansi Sachdev, Minakshi Bansal, Anand Sinha,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):37-38]

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Sweet Syndrome in Pediatric Acute Myeloid Leukemia.

Vahakn S Keskinyan, David H Noyd, Caroline M Underwood, David Van Mater,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):31-32]

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Nonsurgical Management of Acute Appendicitis in Sickle Cell Disease.

Sarah Sahib, Mark Hanna, Scott T Miller,

A 9-year-old child with sickle cell disease (sickle beta zero thalassemia) was diagnosed to have acute appendicitis during a hospitalization for pain, acute chest syndrome, and exacerbation of asthma. Because of his high surgical risk, his appendicitis was treated nonsurgically, successfully deferring his appendectomy. He remains well after 1 year. ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2021, 43(1):28-30]

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