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Therapeutic Advantages of Dual Targeting of PPAR-δ and PPAR-γ in an Experimental Model of Sporadic Alzheimer's Disease.

D Reich, G Gallucci, M Tong, S M de la Monte,

Background:Alzheimer's disease (AD) is associated with progressive impairments in brain responsiveness to insulin and insulin-like growth factor (IGF). Although deficiencies in brain insulin and IGF could be ameliorated with trophic factors such as insulin, impairments in receptor expression, binding, and tyrosine kinase activation require alternative strategies. Peroxisome proliferator-activated receptor (PPAR) ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2018, 5(1):]

Cited: 4 times

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Effects of Non-Pharmacological Treatments on Quality of Life in Parkinson's Disease: A Review.

Sangwoo Ahn, Yan Chen, Tim Bredow, Corjena Cheung, Fang Yu,

Parkinson's disease is a neurodegenerative chronic condition with a declining trajectory and lack of a cure, making quality of life an important aspect of care. The purpose of this literature review was to analyze the state-of-the-science on the effects of non-pharmacological treatments on quality of life in person's with Parkinson's ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2017, 4(1):]

Cited: 1 time

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Alternative Splicing in Alzheimer's Disease.

Julia E Love, Eric J Hayden, Troy T Rohn,

Neurodegenerative diseases have a variety of different genes contributing to their underlying pathology. Unfortunately, for many of these diseases it is not clear how changes in gene expression affect pathology. Transcriptome analysis of neurodegenerative diseases using ribonucleic acid sequencing (RNA Seq) and real time quantitative polymerase chain reaction (RT-qPCR) provides ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2015, 2(2):]

Cited: 18 times

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Lessons from a Rare Familial Dementia: Amyloid and Beyond.

Adam Cantlon, Carlo Sala Frigerio, Dominic M Walsh,

Here we review the similarities between a rare inherited disorder, familial British dementia (FBD), and the most common of all late-life neurological conditions, Alzheimer's diseases (AD). We describe the symptoms, pathology and genetics of FBD, the biology of the BRI2 protein and mouse models of FBD and familial Danish dementia. ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2015, 2(1):]

Cited: 2 times

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Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?

Troy T Rohn, Katie L McCarty, Julia E Love, Elizabeth Head,

Down syndrome is one of the most common genetic causes of intellectual disability and is characterized by a number of behavioral as well as cognitive symptoms. Triplication of all or part of human chromosome 21 has been considered as the main cause of Down syndrome. Due to the location of ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2014, 1(1):]

Cited: 5 times

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The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging.

William K Gottschalk, Michael W Lutz, Yu Ting He, Ann M Saunders, Daniel K Burns, Allen D Roses, Ornit Chiba-Falek,

Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases, including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders. A polymorphism in Translocase of the Outer Mitochondrial Membrane - 40 kD (<i>TOMM40</i>) is associated with risk and age-of onset of late-onset AD, and is the only nuclear- encoded ... Read more >>

J Parkinsons Dis Alzheimers Dis (Journal of Parkinson's disease and Alzheimer's disease)
[2014, 1(1):]

Cited: 27 times

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