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Genome-wide epigenomic analyses in patients with nociceptive and neuropathic chronic pain subtypes reveals alterations in methylation of genes involved in the neuro-musculoskeletal system.

Ludwig Stenz, Joane Le Carré, François Luthi, Philippe Vuistiner, Cyrille Burrus, Ariane Paoloni-Giacobino, Bertrand Léger,

Nociceptive pain involves the activation of nociceptors without damage to the nervous system, whereas neuropathic pain is related to an alteration in the central or peripheral nervous system. Chronic pain itself and the transition from acute to chronic pain may be epigenetically controlled. In this cross-sectional study, a genome-wide DNA ... Read more >>

J Pain (The journal of pain)
[2021, :]

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A clinical description of chronic pain in a general population using ICD-10 and ICD-11 (The HUNT pain examination study).

Petter C Borchgrevink, Mari Glette, Astrid Woodhouse, Stephen Butler, Tormod Landmark, Pål Romundstad, Ola Dale, Tore C Stiles, Kaare H Bonaa, Dagfinn Thorsvik, Sabina Thünte, Stein Kaasa,

The purpose was to present a total description, distribution, and ranking of chronic pain conditions in the general population. This was based on structured clinical examinations of a random sample from a population-based survey (HUNT3) with a calculated oversampling of participants with chronic pain. Supplemented with access to hospital reports, ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Reduced gut microbiome diversity in people with HIV who have distal neuropathic pain.

Ronald J Ellis, Robert K Heaton, Sara Gianella, Gibraan Rahman, Rob Knight,

<h4>Objective</h4>. Gut dysbiosis, defined as pathogenic alterations in the distribution and abundance of different microbial species, is associated with neuropathic pain in a variety of clinical conditions, but this has not been explored in the context of neuropathy in people with HIV (PWH).<h4>Methods</h4>. We assessed gut microbial diversity and dysbiosis ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Anodal transcranial direct current stimulation reduces secondary hyperalgesia induced by low frequency electrical stimulation in healthy volunteers.

Lechi Vo, Nicole Ilich, Hakuei Fujiyama, Peter D Drummond,

The aim of the study was to determine whether transcranial direct current stimulation (tDCS) reduced pain and signs of central sensitisation induced by low frequency electrical stimulation in healthy volunteers. Thirty-nine participants received tDCS stimulation under four different conditions: anodal tDCS of the primary motor cortex (M1), anodal tDCS of ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Low somatosensory cortex excitability in the acute stage of low back pain causes chronic pain.

Luke C Jenkins, Wei-Ju Chang, Valentina Buscemi, Matthew Liston, Patrick Skippen, Aidan G Cashin, James H McAuley, Siobhan M Schabrun,

Determining the mechanistic causes of complex biopsychosocial health conditions such as low back pain (LBP) is challenging, and research is scarce. Cross-sectional studies demonstrate altered excitability and organisation of the somatosensory and motor cortex in people with acute and chronic LBP, however, no study has explored these mechanisms longitudinally or ... Read more >>

J Pain (The journal of pain)
[2021, :]

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NIH's Helping to End Addiction Long-termSM Initiative (NIH HEAL Initiative) Clinical Pain Management Common Data Element Program.

Laura Dover Wandner, Anthony F Domenichiello, Jennifer Beierlein, Leah Pogorzala, Guadalupe Aquino, Andrew Siddons, Linda Porter, Jane Atkinson, ,

The Helping to End Addiction Long-term<sup>SM</sup> Initiative (NIH HEAL Initiative<sup>SM</sup>) is an aggressive trans-NIH effort to speed solutions to stem the national opioid public health crisis, including through improved pain management. Toward this end, the NIH HEAL Initiative launched a common data element (CDE) program to ensure that NIH-funded clinical ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Assessing Multisensory Sensitivity Across Scales: Using the Resulting Core Factors to Create the Multisensory Amplification Scale.

D Wang, S Casares, K Eilers, S Hitchcock, R Iverson, E Lahn, M Loux, C Schnetzer, L A Frey-Law,

Multisensory sensitivity (MSS), observed in some chronic pain patients, may reflect a generalized central nervous system sensitivity. While several surveys measure aspects of MSS, there remains no gold standard. We explored the underlying constructs of four MSS-related surveys (80 items in total) using factor analyses using REDCap surveys (N = 614, 58.7% ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Prevalence, Incidence, and Factors Associated With Non-Specific Chronic Low Back Pain in Community-Dwelling Older Adults Aged 60 Years and Older: A Systematic Review and Meta-Analysis.

Charles Kw Wong, Rebecca Yw Mak, Terence Sy Kwok, Joshua Sh Tsang, Marco Yc Leung, Martha Funabashi, Luciana G Macedo, Liz Dennett, Arnold Yl Wong,

Chronic low back pain (CLBP) is common among older adults. This systematic review aimed to summarize: (1) the prevalence and incidence of CLBP in older adults, and (2) demographic, psychological, and clinical factors positively/negatively associated with prevalence/incidence of CLBP among older adults. Four databases were searched to identify relevant publications. ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Systematic Review of the Effectiveness of Machine Learning Algorithms for Classifying Pain Intensity, Phenotype or Treatment Outcomes Using Electroencephalogram Data.

Tyler Mari, Jessica Henderson, Michelle Maden, Sarah Nevitt, Rui Duarte, Nicholas Fallon,

Recent attempts to utilize machine learning (ML) to predict pain-related outcomes from Electroencephalogram (EEG) data demonstrate promising results. The primary aim of this review was to evaluate the effectiveness of ML algorithms for predicting pain intensity, phenotypes or treatment response from EEG. Electronic databases MEDLINE, EMBASE, Web of Science, PsycINFO ... Read more >>

J Pain (The journal of pain)
[2021, :]

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The Use of Virtual Reality in Back Pain Rehabilitation: A Systematic Review and Meta-Analysis.

Martine Bordeleau, Alexander Stamenkovic, Pier-Alexandre Tardif, James Thomas,

This systematic review aimed to synthesize the existing evidence of extended reality (XR) on pain and motor function outcomes in patients with back pain. Following the Cochrane guidelines, relevant articles of any language were selected by 2 independent reviewers from CINAHL, Cochrane, Embase, Medline and Web of Knowledge databases. Of ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Widespread Pressure Delivered by a Weighted Blanket Reduces Chronic Pain: A Randomized Controlled Trial.

Jennifer N Baumgartner, Desiree Quintana, Linda Leija, Nathaniel M Schuster, Kelly A Bruno, Joel P Castellanos, Laura K Case,

Pleasant sensation is an underexplored avenue for modulation of chronic pain. Deeper pressure is perceived as pleasant and calming, and can improve sleep. Although pressure can reduce acute pain, its effect on chronic pain is poorly characterized. The current remote, double-blind, randomized controlled trial tested the hypothesis that wearing a ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Chronic Pain Severity and Sociodemographics: An Evaluation of the Neurobiological Interface.

Jared J Tanner, Josue Cardoso, Ellen L Terry, Staja Q Booker, Toni L Glover, Cynthia Garvan, Hrishikesh Deshpande, Georg Deutsch, Song Lai, Roland Staud, Adrianna Addison, David Redden, Burel R Goodin, Catherine C Price, Roger B Fillingim, Kimberly T Sibille,

Chronic pain is variably associated with brain structure. Phenotyping based on pain severity may address inconsistencies. Sociodemographic groups also differ in the experience of chronic pain severity. Whether differences by chronic pain severity and/or sociodemographic groups are indicated in pain-related areas of the brain is unknown. Relations between two measures ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Reframe the Pain: A Randomized Controlled Trial of a Parent-Led Memory-Reframing Intervention.

Maria Pavlova, Tatiana Lund, Cara Nania, Madison Kennedy, Susan Graham, Melanie Noel,

Negatively-biased pain memories (ie, recalling more pain as compared to earlier reports) are a robust predictor of future pain experiences. This randomized controlled trial examined the efficacy of a memory-reframing intervention to reframe children's pain memories. Sixty-five children (54% girls, M<sub>age</sub>=5.35 years) underwent a tonsillectomy and reported their levels of ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Producing Clinically Meaningful Reductions in Disability: A Causal Mediation Analysis of a Patient Education Intervention.

Aidan G Cashin, Hopin Lee, Adrian C Traeger, G Lorimer Moseley, Markus Hübscher, Steven J Kamper, Ian W Skinner, James H McAuley,

Patient education is recommended as first-line care for low back pain (LBP), although its efficacy for providing clinically meaningful reductions in disability has been questioned. One way to improve treatment effects is to identify and improve targeting of treatment mechanisms. We conducted a pre-planned causal mediation analysis of a randomized, ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Dorsal Root Ganglion Stimulation for Chronic Pain: Hypothesized Mechanisms of Action.

Robert D Graham, Vishwanath Sankarasubramanian, Scott F Lempka,

Dorsal root ganglion stimulation (DRGS) is a neuromodulation therapy for chronic pain that is refractory to conventional medical management. Currently, the mechanisms of action of DRGS-induced pain relief are unknown, precluding both our understanding of why DRGS fails to provide pain relief to some patients and the design of neurostimulation ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Battle of the Appraisals: Pain-Related Injustice Versus Catastrophizing as Mediators in the Relationship Between Pain Intensity and 3-Month Outcomes in Adolescents with Chronic Pain.

Megan M Miller, Amy E Williams, Eric L Scott, Zina Trost, Adam T Hirsh,

Pain appraisals are closely tied to pain and functional outcomes. Pain-related injustice and pain catastrophizing appraisals have both been identified as important cognitive-emotional factors in the pain experience of youth. Although pain-related injustice and catastrophizing have been linked to worse pain outcomes - as primary predictors and intermediary variables - ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Pain Relief Reverses Hippocampal Abnormalities in Trigeminal Neuralgia.

Alborz Noorani, Peter Shih-Ping Hung, Jia Y Zhang, Kaylee Sohng, Normand Laperriere, Massieh Moayedi, Mojgan Hodaie,

Chronic pain patients frequently report memory and concentration difficulties. Objective testing in this population points to poor performance on memory and cognitive tests, and increased comorbid anxiety and depression. Recent evidence has suggested convergence between chronic pain and memory deficits onto the hippocampus. The hippocampus consists of heterogenous subfields involved ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Anger as a Mechanism of Injustice Appraisals in Pediatric Chronic Pain.

Megan M Miller, Amy E Williams, Eric L Scott, Zina Trost, Adam T Hirsh,

Mechanisms explaining the relationship between pain-related injustice appraisals and functional outcomes in youth with chronic pain have yet to be examined. In studies of adults, greater pain-related injustice is associated with worse depressive symptoms and greater pain through greater anger. No study to date has examined anger expression as a ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Pupillary Reflexes in Complex Regional Pain Syndrome: Asymmetry to Arousal Stimuli Suggests an Ipsilateral Locus Coeruleus Deficit.

Peter D Drummond, Philip M Finch,

Converging lines of evidence suggest that autonomic and nociceptive pathways linked with the locus coeruleus are disrupted in complex regional pain syndrome (CRPS). To investigate this, pupillary dilatation to arousal stimuli (which reflects neural activity in the locus coeruleus) and pupillary reflexes to light were assessed in a cross-sectional study ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Cross-National Trends of Chronic Back Pain in Adolescents: Results From the HBSC Study, 2001-2014.

Rubén Roy, Santiago Galán, Elisabet Sánchez-Rodríguez, Mélanie Racine, Ester Solé, Mark P Jensen, Jordi Miró,

Chronic back pain is a common problem that negatively impacts the wellbeing of many adolescents. Prior research suggests that the prevalence of chronic back pain has increased over the last decades, but research on this issue is scarce, single country-based, and has yielded inconsistent results. This study aimed to examine ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Characterization of Hyperacute Neuropathic Pain after Spinal Cord Injury: A Prospective Study.

Jan Rosner, Michael Negraeff, Lise M Bélanger, Angela Tsang, Leanna Ritchie, Jean-Marc Mac-Thiong, Sean Christie, Jefferson R Wilson, Sanjay Dhall, Raphaële Charest-Morin, John Street, Tamir Ailon, Scott Paquette, Nicolas Dea, Charles G Fisher, Marcel F Dvorak, Nanna B Finnerup, Brian K Kwon, John L K Kramer,

There is currently a lack of information regarding neuropathic pain in the very early stages of spinal cord injury (SCI). In the present study, neuropathic pain was assessed using the Douleur Neuropathique 4 Questions (DN4) for the patient's worst pain within the first 5 days of injury (i.e., hyperacute) and ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Pediatric Pain Screening Tool: A Simple 9-Item Questionnaire Predicts Functional and Chronic Postsurgical Pain Outcomes After Major Musculoskeletal Surgeries.

Suryakumar Narayanasamy, Fang Yang, Lili Ding, Kristie Geisler, Susan Glynn, Arjunan Ganesh, Madhankumar Sathyamoorthy, Victor Garcia, Peter Sturm, Vidya Chidambaran,

Reliable, clinic-friendly screening for Chronic postsurgical pain (CPSP) risk is unavailable. Within a prospective, observational study, we evaluated Pediatric Pain Screening Tool (PPST), a concise 9-item questionnaire, as a preoperative screening tool to identify those at higher risk for CPSP (Numerical Rating Scale > 3/10 beyond 3 months post-surgery) and ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Worst Pain Severity Profiles of Oncology Patients Are Associated With Significant Stress and Multiple Co-Occurring Symptoms.

Joosun Shin, Carolyn Harris, Kate Oppegaard, Kord M Kober, Steven M Paul, Bruce A Cooper, Marilyn Hammer, Yvette Conley, Jon D Levine, Christine Miaskowski,

Little is known about the associations between pain, stress, and co-occurring symptoms in oncology patients. Purpose was to identify subgroups of patients with distinct worst pain profiles and evaluate for differences among the subgroups in demographic and clinical characteristics, as well as stress and symptom scores. Oncology outpatients (n = 1305) completed ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Applying the NIA Health Disparities Research Framework to Identify Needs and Opportunities in Chronic Musculoskeletal Pain Research.

Monika Patel, Alisa J Johnson, Staja Q Booker, Emily J Bartley, Shreela Palit, Keesha Powell-Roach, Ellen L Terry, Dottington Fullwood, Lucas DeMonte, Angela M Mickle, Kimberly T Sibille,

Disparities in the experience of chronic musculoskeletal pain in the United States stem from a confluence of a broad array of factors. Organized within the National Institute on Aging Health Disparity Research Framework, a literature review was completed to evaluate what is known and what is needed to move chronic ... Read more >>

J Pain (The journal of pain)
[2021, :]

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Cognitive Biases in Type 2 Diabetes and Chronic Pain.

Jemma Todd, Daniel Rudaizky, Patrick Clarke, Louise Sharpe,

The aim of the present study was to investigate the role of cognitive processing biases in Type 2 diabetes (T2D) and chronic pain, 2 conditions that are highly co-morbid. The final sample comprised 333 individuals (86 with T2D and chronic pain, 65 with chronic pain, 76 with T2D, 106 without ... Read more >>

J Pain (The journal of pain)
[2021, :]

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