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Knowledge of iatrogenic premature ovarian insufficiency among Chinese obstetricians and gynaecologists: a national questionnaire survey.

Yanfang Wang, Ying Zou, Wei Wang, Qingmei Zheng, Ying Feng, Han Dong, Zhangyun Tan, Xiaoqin Zeng, Yinqing Zhao, Danhong Peng, Xiaomin Yang, Aijun Sun,

BACKGROUND:With increasing cases of iatrogenic premature ovarian insufficiency (POI), more clinicians are required to counsel patients regarding the gonadotoxic effects of iatrogenic treatments. This survey aimed to explore obstetricians and gynaecologists' knowledge regarding iatrogenic POI. A national online questionnaire survey was conducted across China. Respondents were asked to select the ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):134]

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Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age.

Jacob O'Brien, Kevin Y Du, Chun Peng,

Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a treatment option for COVID-19 patients. However, more female cases and deaths from COVID-19 ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):137]

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Depletion of GPSM1 enhances ovarian granulosa cell apoptosis via cAMP-PKA-CREB pathway in vitro.

Xuzi Cai, Huijiao Fu, Yan Wang, Qiwen Liu, Xuefeng Wang,

BACKGROUND:Genetic causes of premature ovarian insufficiency (POI) account for approximately 20 ~ 25% of patients. So far, only a few genes have been identified. RESULTS:Here, we first identified the c.1840C > A on G-protein signaling modulator 1 (GPSM1) as a susceptibility locus for POI in 10 sporadic POI patients by whole-exome sequencing. The frequency ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):136]

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STAT4 targets KISS1 to promote the apoptosis of ovarian granulosa cells.

Yao Jiang, Xiaoping Xin, Xiangchun Pan, Ailing Zhang, Zhe Zhang, Jiaqi Li, Xiaolong Yuan,

BACKGROUND:In mammals, it is known that the estradiol-17β (E2) is mainly synthetized in ovarian granulosa cells (GCs), and the excessive apoptosis of GCs induces the follicular atresia. Many studies have implicated the essential role of KISS1, with the pro-synthetic effect of E2 and the anti-apoptotic effect on GCs, in the ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):135]

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Possibility of live birth in patients with low serum β-hCG 14 days after blastocyst transfer.

Yixuan Wu, Haiying Liu,

BACKGROUND:Although prior work has attempted to predict pregnancy outcomes by assaying serum β-hCG levels after blastocyst transfer, no study has focused on pregnancy outcomes in those with initially low serum β-hCG levels. This study sought to investigate pregnancy outcomes of patients with low serum β-hCG levels 14 days after blastocyst transfer. ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):132]

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Correction to: Troxerutin protects against DHT-induced polycystic ovary syndrome in rats.

Zixuan Gao, Xiaochen Ma, Jing Liu, Yuhang Ge, Lei Wang, Ping Fu, Zhian Liu, Ruiqin Yao, Xiaonan Yan,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):133]

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Therapeutic role of curcumin and its novel formulations in gynecological cancers.

Mohammad Hossein Pourhanifeh, Maryam Darvish, Javad Tabatabaeian, Mahboobeh Rabbani Fard, Reza Mottaghi, Mohammad Javad Azadchehr, Moghaddaseh Jahanshahi, Amirhossein Sahebkar, Hamed Mirzaei,

Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):130]

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Identification of an autophagy-related gene signature for survival prediction in patients with cervical cancer.

Hengyu Chen, Qingchun Deng, Wenwen Wang, Huishan Tao, Ying Gao,

Cervical cancer is one of the most common female malignancy that occurs worldwide and is reported to cause over 300,000 deaths in 2018. Autophagy controls the survival and death of cancerous cells by regulating the degradation process of cytoplasm and cellular organelle. In the present study, the differentially expressed autophagy-related ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):131]

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Primitive ovarian carcinosarcoma: a clinical and radiological analysis of five cases.

Qiong Xu, Xiaofei Zhang, Yu Zou,

BACKGROUND:Ovarian carcinosarcomas (OCS) are very rare tumors composed of a mixture of carcinomatous and sarcomatous elements. There have been only scattered case studies that have described the imaging findings. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinical and imaging features of ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):129]

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Effects of activating GABAB1 receptor on proliferation, migration, invasion and epithelial-mesenchymal transition of ovarian cancer cells.

Jun Gao, Yao Gao, Shixin Lin, Xia Zou, Yukai Zhu, Xintong Chen, Hong Wan, Hong Zhu,

OBJECTIVE:This study aimed to explore the effects of activating GABAB1 receptor by baclofen on proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of ovarian cancer cells. RESULTS:One hundred μmol/L, 200 μmol/L and 300 μmol/L were selected as low, medium and high baclofen concentrations respectively. Cells were divided into four groups: Control, 100 μmol/L, 200 μmol/L and ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):126]

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Ovarian metastasis from nongynecologic primary sites: a retrospective analysis of 177 cases and 13-year experience.

Jing-Jing Zhang, Dong-Yan Cao, Jia-Xin Yang, Keng Shen,

BACKGROUND:Metastasis to the ovary from nongynecologic organs accounts for 9% of all ovarian malignancies. Although the most common nongynecologic primary site of ovarian metastasis is the gastrointestinal tract, metastasis from other sites to the ovary is not uncommon. Differential diagnosis of primary and metastatic ovarian tumors is important; otherwise, appropriate ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):128]

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Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer.

Weiwei Gong, Yueyang Liu, Eleftherios P Diamandis, Marion Kiechle, Holger Bronger, Julia Dorn, Tobias Dreyer, Viktor Magdolen,

BACKGROUND:High-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests tumor-supporting roles of several members of the kallikrein-related peptidase (KLK) family, including KLK5 and KLK7, in this cancer subtype. In normal physiology, KLK5 and KLK7 are the major proteases ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):125]

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Long non-coding RNA PTPRG-AS1 promotes cell tumorigenicity in epithelial ovarian cancer by decoying microRNA-545-3p and consequently enhancing HDAC4 expression.

Juanjuan Shi, Xijian Xu, Dan Zhang, Jiuyan Zhang, Hui Yang, Chang Li, Rui Li, Xuan Wei, Wenqing Luan, Peishu Liu,

BACKGROUND:Long non-coding RNA PTPRG antisense RNA 1 (PTPRG-AS1) deregulation has been reported in various human malignancies and identified as an important modulator of cancer development. Few reports have focused on the detailed role of PTPRG-AS1 in epithelial ovarian cancer (EOC) and its underlying mechanism. This study aimed to determine the ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):127]

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Development and validation of Nomograms for predicting overall survival and Cancer-specific survival in patients with ovarian clear cell carcinoma.

Qian Chen, Shu Wang, Jing-He Lang,

BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a rare histologic type of ovarian cancer. There is a lack of an efficient prognostic predictive tool for OCCC in clinical work. This study aimed to construct and validate nomograms for predicting the overall survival (OS) and cancer-specific survival (CSS) in patients with OCCC. ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):123]

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LINC01094/miR-577 axis regulates the progression of ovarian cancer.

Jing Xu, Ping Zhang, Huajun Sun, Yang Liu,

BACKGROUND:Long intergenic non-coding RNA 01094 (LINC01094) is probably a novel regulator in cancer biology. This study aimed to probe into the function and mechanism of LINC01094 in ovarian cancer (OC). METHODS:Quantitative real-time polymerase chain reaction (qRT-PCR) assay was utilized to measure LINC01094 and miR-577 expressions in OC tissues and cell ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):122]

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Prediction of the treatment response in ovarian cancer: a ctDNA approach.

Mina Sharbatoghli, Somayeh Vafaei, Hamidreza Aboulkheyr Es, Mohsen Asadi-Lari, Mehdi Totonchi, Zahra Madjd,

Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular markers toward prediction of treatment response. Recently, analysis of liquid biopsies including circulating tumor DNA (ctDNA) open new way toward cancer diagnosis ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):124]

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Comparison of methods for quantifying primordial follicles in the mouse ovary.

Urooza C Sarma, Amy L Winship, Karla J Hutt,

BACKGROUND:Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ovarian reserve. In this study, we compared and contrasted two methods for counting healthy primordial follicles following exposure to cyclophosphamide (75 mg/kg), ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):121]

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Patient with ovarian insufficiency: baby born after anticancer therapy and re-transplantation of cryopreserved ovarian tissue.

Vladimir Isachenko, Bernd Morgenstern, Plamen Todorov, Evgenia Isachenko, Peter Mallmann, Bettina Hanstein, Gohar Rahimi,

BACKGROUND:The second major cause of death is cancer. In fact, the effectiveness of anticancer treatments and positive long-term prognosis for young women has increased. However, the problem of post-cancer infertility plays a significant role, because chemotherapy can be gonadotoxic and lead to the functional death of ovaries. There is potential ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):118]

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Predicting complete cytoreduction for advanced ovarian cancer patients using nearest-neighbor models.

Alexandros Laios, Alexandros Gryparis, Diederick DeJong, Richard Hutson, Georgios Theophilou, Chris Leach,

BACKGROUND:The foundation of modern ovarian cancer care is cytoreductive surgery to remove all macroscopic disease (R0). Identification of R0 resection patients may help individualise treatment. Machine learning and AI have been shown to be effective systems for classification and prediction. For a disease as heterogenous as ovarian cancer, they could ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):117]

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Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer.

Jing Wang, Jing Xu, Ke Li, Yunke Huang, Yilin Dai, Congjian Xu, Yu Kang,

BACKGROUND:Wilms tumor 1 associated protein (WTAP) modulates other genes via transcriptional and post-transcriptional regulation, in particular, by acting as a N6-methyladenosine writer or binding to the 3'UTR of mRNA, and promotes a variety of tumuors. However, the roles and mechanisms of WTAP in ovarian cancer are unknown. RESULTS:In this study, ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):119]

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Bioinformatics analysis of prognostic value and prospective pathway signal of miR-30a in ovarian cancer.

Weijia Lu, Yunyu Wu, Can Xiong Lu, Ting Zhu, Zhong Lu Ren, Zhiwu Yu,

OBJECTIVE:MicroRNAs (MiRNAs) is thought to play a critical role in the initiation and progress of ovarian cancer (OC). Although miRNAs has been widely recognized in ovarian cancer, the role of hsa-miR-30a-5p (miR-30a) in OC has not been fully elucidated. METHODS:Three mRNA datasets of normal ovarian tissue and OC, GSE18520,GSE14407 and ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):120]

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Adipocytes: active facilitators in epithelial ovarian cancer progression?

Lan Dai, Keqi Song, Wen Di,

There is growing evidence that adipocytes play important roles in the progression of multiple cancers. Moreover, in obesity, adipocytes alter their original functions and contribute to the metabolic and inflammatory changes of adipose tissue microenvironment, which can further enhance tumor development. At present, the roles of adipocytes in the pathogenesis ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):115]

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Integrative analysis of the common genetic characteristics in ovarian cancer stem cells sorted by multiple approaches.

Xiaoxiao Zhang, Yue Su, Xue Wu, Rourou Xiao, Yifan Wu, Bin Yang, Zhen Wang, Lili Guo, Xiaoyan Kang, Changyu Wang,

BACKGROUND:Ovarian cancer is the second fatal malignancy of the female reproductive system. Based on the cancer stem cell (CSC) theory, its poor prognosis of ovarian cancer attributed to tumor recurrence caused by CSCs. A variety of cell surface-specific markers have been employed to identify ovarian cancer stem cells (OCSCs). In ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):116]

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A novel signature of two long non-coding RNAs in BRCA mutant ovarian cancer to predict prognosis and efficiency of chemotherapy.

Yinglian Pan, Li Ping Jia, Yuzhu Liu, Yiyu Han, Qian Li, Qin Zou, Zhongpei Zhang, Jin Huang, Qingchun Deng,

BACKGROUND:In this study we aimed to identify a prognostic signature in BRCA1/2 mutations to predict disease progression and the efficiency of chemotherapy ovarian cancer (OV), the second most common cause of death from gynecologic cancer in women worldwide. METHODS:Univariate Cox proportional-hazards and multivariate Cox regression analyses were used to identifying ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):112]

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Whole-exome sequencing in patients with premature ovarian insufficiency: early detection and early intervention.

Hongli Liu, Xiaoli Wei, Yanwei Sha, Wensheng Liu, Haijie Gao, Jin Lin, Youzhu Li, Yaling Tang, Yifeng Wang, Yanlong Wang, Zhiying Su,

BACKGROUND:The loss of ovarian function in women, referred to as premature ovarian insufficiency (POI), is associated with a series of concomitant diseases. POI is genetically heterogeneous, and in most cases, the etiology is unknown. METHODS:Whole-exome sequencing (WES) was performed on DNA samples obtained from patients with POI, and Sanger sequencing ... Read more >>

J Ovarian Res (Journal of ovarian research)
[2020, 13(1):114]

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