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Reduction in Serum LDL Cholesterol Using a Nutrient Compendium in Hyperlipidemic Adults Unable or Unwilling to Use Statin Therapy: A Double-Blind Randomized Crossover Clinical Trial.

Stephen L Kopecky, Soumya Alias, Elizabeth Klodas, Peter J H Jones,

<h4>Background</h4>Many hyperlipidemic patients prescribed β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitors (statins) are unable or unwilling to take them. A hedonically acceptable snack-based solution formulated from cholesterol-lowering food ingredients could represent a therapeutic alternative but has not been tested in this population.<h4>Objectives</h4>To evaluate the effect of snacks containing a compendium of functional ... Read more >>

J Nutr (The Journal of nutrition)
[2022, :]

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Using Double-Fortified Salt to Reduce Iron Deficiency Anemia in India.

Jan Werner Schultink,

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[2022, :]

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Protein-energy Supplementation in Early-life Decreases the Odds of Mental Distress in Later Adulthood in Guatemala.

Ann M DiGirolamo, Jithin Sam Varghese, Maria F Kroker-Lobos, Mónica Mazariegos, Manuel Ramirez-Zea, Reynaldo Martorell, Aryeh D Stein,

<h4>Background</h4>Prevalence of mental health concerns is growing worldwide, along with lack of access to and receipt of needed treatment. Current gaps in treatment provision have led to exploring alternative methods of prevention, with research linking nutrition and mental health, of particular relevance in low- and middle- income countries with high ... Read more >>

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[2022, :]

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Changes in Visceral and Ectopic Adipose Tissue Stores Across Pregnancy and their Relationship to Gestational Weight Gain.

Kimberly K Vesco, Nicole E Marshall, Eric Baetscher, Michael C Leo, William Rooney, Melanie Francisco, Eric Baker, Janet C King, Patrick Catalano, Antonio E Frias, Jonathan Q Purnell,

<h4>Background</h4>Excessive gestational weight gain has been associated with increased total body fat (TBF), metabolic syndrome and abdominal obesity. However, little is known about the relationship of gestational weight gain with changes in metabolically active visceral or ectopic (hepatic and skeletal muscle) lipid stores.<h4>Objectives</h4>In a prospective study of 50 healthy pregnant ... Read more >>

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[2022, :]

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Human Gastrointestinal Transit and Hormonal Response to Different Meal Types: A Randomized Crossover Study.

Marie Møller Jensen, Hanne Pedersen, Kim Katrine Bjerring Clemmensen, Anne-Marie Langmach Wegeberg, Nina Wittorff Jensen, Jonas Salling Quist, Kristine Færch, Christina Brock,

<h4>Background</h4>The wireless motility capsule (WMC) is a non-invasive and radiation-free method for measuring regional and whole gut transit in response to ingestion of a granola bar (SmartBar®) or an Eggbeater meal. The WMC has the potential to measure gastrointestinal transit in metabolic research as part of a standardized mixed meal ... Read more >>

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[2022, :]

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Different Isocaloric Meals and Adiposity Modify Energy Expenditure, Clinical and Metabolomic Biomarkers During Resting and Exercise States in a Randomized Cross-over Acute Trial of Normal Weight and Overweight/obese Men.

Quan Xiong, Liang Sun, Yaogan Luo, Huan Yun, Xia Shen, Huiyong Yin, Xiafei Chen, Xu Lin,

<h4>Background</h4>Few studies have assessed the integrative effects of diet, BMI, and exercise on postprandial changes of energy and circulating metabolic profiles.<h4>Objectives</h4>We aimed to assess the collective effects of three isocaloric diets high in carbohydrate (74.2% energy), fat (64.6% energy), or protein (39.5% energy) on energy expenditure, clinical and metabolomic biomarkers ... Read more >>

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[2022, :]

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Cheese Ingestion Increases Muscle Protein Synthesis Rates Both at Rest and During Recovery from Exercise in Healthy, Young Males: A Randomized Parallel-group Trial.

Wesley J H Hermans, Cas J Fuchs, Floris K Hendriks, Lisanne H P Houben, Joan M Senden, Lex B Verdijk, Luc J C van Loon,

<h4>Background</h4>Protein ingestion increases muscle protein synthesis rates. The food matrix in which protein is provided can strongly modulate the postprandial muscle protein synthetic response. So far, the muscle protein synthetic response to the ingestion of whole foods remains largely unexplored.<h4>Objectives</h4>To compare the impact of ingesting 30g protein provided as milk protein ... Read more >>

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[2022, :]

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Biography of John W. Suttie, PhD.

Richard S Eisenstein, Sarah L Booth,

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[2022, :]

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Prebiotic Galacto-oligosaccharides and Fructo-oligosaccharides, but not Acacia Gum, Increase Iron Absorption from a Single High-dose Ferrous Fumarate Supplement in Iron-depleted Women.

Ambra Giorgetti, Frederike M D Hussman, Christophe Zeder, Isabelle Herter-Aeberli, Michael B Zimmermann,

<h4>Background</h4>Prebiotic galacto-oligosaccharides (GOS) increase iron absorption from fortification-level iron doses given as ferrous fumarate (FeFum) in women and children. Whether GOS or other fibers, such as prebiotic fructo-oligosaccharides (FOS) and acacia gum, increase iron absorption from higher supplemental doses of FeFum is unclear.<h4>Objectives</h4>In iron-depleted [serum ferritin (SF)< 25μg/L] women,  we tested ... Read more >>

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[2022, :]

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Breastfeeding Interpersonal Communication, Mobile Phone Support, and Mass Media Messaging Increase Exclusive Breastfeeding at 6 and 24 Weeks Among Clients of Private Health Facilities in Lagos, Nigeria.

Valerie L Flax, Abiodun Ipadeola, Courtney H Schnefke, Uche Ralph-Opara, Olatoun Adeola, Susan Edwards, Sujata Bose, Alice O Brower,

<h4>Background</h4>Although most health facilities in urban Nigeria are privately-owned, interventions to promote optimal breastfeeding practices in private facilities have not previously been implemented.<h4>Objectives</h4>We tested the impact of a breastfeeding promotion intervention on early initiation of breastfeeding and exclusive breastfeeding among clients in private facilities in Lagos, Nigeria.<h4>Methods</h4>The intervention included training ... Read more >>

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The Effects of Physical Activity and Sedentary Behaviors on Overweight and Obesity among Boys may Differ from those among Girls in China: An Open Cohort Study.

Zhe Mo, Huijun Wang, Bing Zhang, Gangqiang Ding, Barry M Popkin, Shufa Du,

<h4>Background</h4>Childhood overweight and obesity are increasing steadily in China, yet few studies have explored the risk factors, focusing on sex differences.<h4>Objectives</h4>We tested the hypothesis that the effects of physical activity and sedentary behaviors on overweight and obesity differ between boys and girls.<h4>Methods</h4>We used data collected from 4,520 children and adolescents ... Read more >>

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[2022, :]

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Different Doses, Forms, and Frequencies of Zinc Supplementation for the Prevention of Diarrhea and Promotion of Linear Growth among Young Bangladeshi Children: A Six-arm, Randomized, Community-based Efficacy Trial.

M Munirul Islam, Robert E Black, Nancy F Krebs, Jamie Westcott, Julie Long, Kazi Munisul Islam, Janet M Peerson, Rahvia Alam Sthity, Afsana Mim Khandaker, Mehedi Hasan, Shams E L Arifeen, Tahmeed Ahmed, Janet C King, Christine M McDonald,

<h4>Background</h4>Children in resource-limited settings remain vulnerable to zinc deficiency and its consequences.<h4>Objectives</h4>To evaluate the effects of different doses, durations, and frequencies of zinc supplementation on the incidence of diarrhea and change in linear growth among young children.<h4>Design</h4>We conducted a randomized, partially double-blind, controlled, six-arm, community-based efficacy trial in Dhaka, Bangladesh. ... Read more >>

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[2022, :]

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Biomarkers for Components of Dietary Protein and Carbohydrate with Application to Chronic Disease Risk Among Postmenopausal Women.

Ross L Prentice, Mary Pettinger, Cheng Zheng, Marian L Neuhouser, Daniel Raftery, G A Nagana Gowda, Ying Huang, Lesley F Tinker, Barbara V Howard, JoAnn E Manson, Linda Van Horn, Robert Wallace, Yasmin Mossavar-Rahmani, Karen C Johnson, Linda Snetselaar, Johanna W Lampe,

<h4>Background</h4>We recently developed protein and carbohydrate intake biomarkers using metabolomics profiles in serum and urine, and used them to correct self-reported dietary data for measurement error. Biomarker-calibrated carbohydrate density was inversely associated with chronic disease risk, while protein density associations were mixed.<h4>Objective</h4>To elucidate and extend this earlier work through biomarker ... Read more >>

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[2022, :]

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Body Composition and Cardiometabolic Risk Markers in Children of Women who Took Part in a Randomized Controlled Trial of a Pre-conceptional Nutritional Intervention in Mumbai, India.

Sirazul Ameen Sahariah, Meera Gandhi, Harsha Chopra, Sarah H Kehoe, Matthew J Johnson, Chiara di Gravio, Deepak Patkar, Harshad Sane, Patsy J Coakley, Aarti H Karkera, Dattatray S Bhat, Nick Brown, Barrie M Margetts, Alan A Jackson, Kumaran K, Ramesh D Potdar, Caroline H D Fall,

<h4>Background</h4>Maternal nutrition influences fetal development and may permanently alter ('program') offspring body composition and metabolism, thereby influencing later risk of diabetes and cardiovascular (cardiometabolic) disease. The prevalence of cardiometabolic disease is rising rapidly in India.<h4>Objectives</h4>To test the hypothesis that supplementing low-income Indian women with micronutrient-rich foods pre-conceptionally and during pregnancy ... Read more >>

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[2022, :]

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Evaluation of Increasing Dairy Intake on Bone Density in Post-pubertal Youth: A Randomized Controlled Trial Using Motivational Interviewing.

May Slim, Catherine A Vanstone, Suzanne N Morin, Elham Rahme, Simon L Bacon, Hope A Weiler,

<h4>Background</h4>Adequate nutrition is important for bone health, especially for bone mineral accretion.<h4>Objective</h4>The primary objective tested whether increasing dairy intake using the motivational interviewing technique (MInt) improves lumbar spine (LS) bone mineral density (BMD) after 2 years in post-pubertal adolescents with habitual dairy intake of < 2 dairy servings/day.<h4>Design</h4>Participants (14-18.9 y) ... Read more >>

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Using Commercially Available Measurement Devices for the Intake-Balance Method to Estimate Energy Intake: Work in Progress.

Klaus Gebel, Ding Ding,

J Nutr (The Journal of nutrition)
[2022, :]

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Supplementary Feeding of Moderately Wasted Children in Sierra Leone Reduces Severe Acute Malnutrition and Death When Compared to Nutrition Counseling: a Retrospective Cohort Study.

Tannaz Rajabi, Sam K Schell, Sophia E Agapova, Amir Hassan, Max Zalta, Donna R Wegner, Meghan Callaghan-Gillespie, Aminata Koroma, Mohamed Tabita Kamara, Mark J Manary, Kevin B Stephenson,

<h4>Background</h4>There is uncertainty about whether children with moderate wasting should receive supplementary feeding.<h4>Objectives</h4>We examined whether supplementary feeding compared to counseling alone in children with moderate wasting prevented progression to severe acute malnutrition (SAM) or death.<h4>Methods</h4>This was a retrospective, dual cohort study in which 1,791 children with moderate wasting were drawn ... Read more >>

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[2022, :]

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Ultrasonication of Milk Decreases the Content of Exosomes and MicroRNAs in an Exosome-defined Rodent Diet.

Sonal Sukreet, Camila Pereira Braga, Thuy T An, Jiri Adamec, Juan Cui, Janos Zempleni,

<h4>Background</h4>Bovine milk exosomes (BMEs) harbor regulatory proteins, lipids and microRNAs. Consumption of an exosome and RNA-depleted (ERD) diet elicited phenotypes compared to controls fed an exosome and RNA-sufficient (ERS) diet in mice. All other ingredients were identical in the diets. ERD and ERS diets were prepared by substituting ultrasonicated and ... Read more >>

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[2022, :]

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Accuracy and Practical Considerations for Doubly Labeled Water Analysis in Nutrition Studies Using a Laser-Based Isotope Instrument (Off-Axis Integrated Cavity Output Spectroscopy).

Linda M Reynard, William W Wong, Noreen Tuross,

<h4>Background</h4>Given the utility of the doubly labeled water (DLW) method for determination of energy expenditure, additional techniques for isotope analysis of the samples are welcome. Laser-based instruments are one such new analytical tool, but their accuracy and feasibility for DLW studies are grossly understudied.<h4>Objectives</h4>We assessed the accuracy of laser-based isotope ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):78-85]

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Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport.

Stefan Bröer, Gregory Gauthier-Coles,

Amino acid homeostasis is maintained by import, export, oxidation, and synthesis of nonessential amino acids, and by the synthesis and breakdown of protein. These processes work in conjunction with regulatory elements that sense amino acids or their metabolites. During and after nutrient intake, amino acid homeostasis is dominated by autoregulatory ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):16-28]

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Disparities in Vitamin D Status of Newborn Infants from a Diverse Sociodemographic Population in Montreal, Canada.

Hope A Weiler, Catherine A Vanstone, Maryam Razaghi, Nathalie Gharibeh, Sharina Patel, Shu Q Wei, Dayre McNally,

<h4>Background</h4>Vitamin D status at birth is reliant on maternal-fetal transfer of vitamin D during gestation.<h4>Objectives</h4>We aimed to examine the vitamin D status of newborn infants in a diverse population and to subsequently identify the modifiable correlates of vitamin D status.<h4>Methods</h4>In this cross-sectional study, healthy mother-infant dyads (n = 1035) were ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):255-268]

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The VitMin Lab Sandwich-ELISA Assays for Iron and Inflammation Markers Compared Well with Clinical Analyzer Reference-Type Assays in Subsamples of the Nepal National Micronutrient Status Survey.

Christina M Fischer, Ming Zhang, Maya R Sternberg, Maria E Jefferds, Ralph D Whitehead, Zuguo Mei, Naveen Paudyal, Nira Joshi, Kedar R Parajuli, Debendra P Adhikari, Donna J LaVoie, Christine M Pfeiffer,

<h4>Background</h4>The low cost and small specimen volume of the VitMin Lab ELISA assays for serum ferritin (Fer), soluble transferrin receptor (sTfR), C-reactive protein (CRP), and α-1-acid glycoprotein (AGP) have allowed their application to micronutrient surveys conducted in low-resource countries for ∼2 decades.<h4>Objectives</h4>We conducted a comparison between the ELISA and reference-type ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):350-359]

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Joint Associations between Plasma 25-Hydroxyvitamin D, Glycemic Status, and First Stroke in General Hypertensive Adults: Results from the China Stroke Primary Prevention Trial (CSPPT).

Yaping Wei, Benjamin Xu, Zhuo Wang, Ziyi Zhou, Lishun Liu, Tengfei Lin, Yun Song, Jianping Li, Yan Zhang, Yong Huo, Guangyun Mao, Binyan Wang, Genfu Tang, Xianhui Qin, Hao Zhang, Xiaobin Wang, Huiyuan Guo, Xiping Xu,

<h4>Background</h4>Associations between vitamin D and stroke remain inconsistent. One major risk factor for stroke is high blood glucose, but the role it plays in this association is not well studied.<h4>Objectives</h4>We aimed to evaluate the individual association between plasma 25-hydroxyvitamin D [25(OH)D] and risk of first stroke stratified by fasting blood ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):246-254]

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Invitation for Nominations and Applications for 2022 Scientific Achievement Awards, the ASN Class of 2022 Fellows, and Other Honors.

J Nutr (The Journal of nutrition)
[2022, 152(1):365-368]

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Drinking Water Source and Intake Are Associated with Distinct Gut Microbiota Signatures in US and UK Populations.

Tiphaine Vanhaecke, Oriane Bretin, Marion Poirel, Julien Tap,

<h4>Background</h4>The microbiome of the digestive tract exerts fundamental roles in host physiology. Extrinsic factors including lifestyle and diet are widely recognized as key drivers of gut and oral microbiome compositions. Although drinking water is among the food items consumed in the largest amount, little is known about its potential impact ... Read more >>

J Nutr (The Journal of nutrition)
[2022, 152(1):171-182]

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