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State of the Science and Paths to Effective Treatments for Traumatic Brain Injury.

David L Brody,

J Neurotrauma (Journal of neurotrauma)
[2021, 38(23):3185]

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Development and Validation of a Functionally Relevant Comorbid Health Index in Adults Admitted to Inpatient Rehabilitation for Traumatic Brain Injury.

Raj G Kumar, Xiaobo Zhong, Gale G Whitenack, Madhu Mazumdar, Flora M Hammond, Natalia Egorova, Kirk Lercher, Kristen Dams-O'Connor,

Several studies have characterized comorbidities among individuals with traumatic brain injury (TBI); however, there are few validated TBI comorbidity indices. Widely used indices (e.g., Elixhauser Comorbidity Index [ECI]) were developed in other patient populations and anchor to mortality or healthcare utilization, not functioning, and notably exclude conditions known to co-occur ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :1-9]

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Fetal and Perinatal Expression Profiles of Proinflammatory Cytokines in the Neuroplacodes of Rats with Myelomeningoceles: A Contribution to the Understanding of Secondary Spinal Cord Injury in Open Spinal Dysraphism.

Gesa Cohrs, Ann-Kathrin Blumenröther, Jan-Philip Sürie, Michael Synowitz, Janka Held-Feindt, Friederike Knerlich-Lukoschus,

The cellular and molecular mechanisms that presumably underlie the progressive functional decline of the myelomeningocele (MMC) placode are not well understood. We previously identified key players in post-traumatic spinal cord injury cascades in human MMC tissues obtained during postnatal repair. In this study, we conducted experiments to further investigate these ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Identifying discomplete spinal lesions: New evidence from pain-autonomic interaction in spinal cord injury.

Robin Lütolf, Jan Rosner, Armin Curt, Michèle Hubli,

The clinical evaluation of spinal afferents is an important diagnostic and prognostic marker for neurological and functional recovery after spinal cord injury (SCI). Particularly important regarding neuropathic pain following SCI is the function of the spinothalamic tract (STT) conveying nociceptive and temperature information. Here, we investigated the added value of ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Intraoperative monitoring of CSF pressure in patients with degenerative cervical myelopathy (COMP-CORD Study): a prospective cohort study.

Carl Zipser, Nikolai Pfender, Najmeh Kheram, Andrea Boraschi, Jose Aguirre, Nils Ulrich, Jose Spirig, Alexandre Ansorge, Michael Betz, Florian Wanivenhaus, Markus Hupp, Vartan Kurtcuoglu, Mazda Farshad, Armin Curt, Martin Schubert,

Degenerative cervical myelopathy (DCM) is hallmarked by spinal canal narrowing and related cord compression and myelopathy. CSF pressure dynamics are likely disturbed due to spinal canal stenosis. The study aims to investigate the diagnostic value of continuous intraoperative CSF pressure monitoring during surgical decompression. Prospective single center study (NCT02170155) with ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Ampakines stimulate diaphragm activity after spinal cord injury.

Sabhya Rana, Michael D Sunshine, John J Greer, David D Fuller,

Respiratory compromise after cervical spinal cord injury (SCI) is a leading cause of mortality and morbidity. Most SCIs are incomplete and spinal respiratory motoneurons as well as proprio- and bulbospinal synaptic pathways provide a neurological substrate to enhance respiratory output. Ampakines are allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors which ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Extended analysis of axonal injuries detected using magnetic resonance imaging in critically ill traumatic brain injury patients.

Jonathan Tjerkaski, Harriet Nyström, Rahul Raj, Caroline Lindblad, Bo-Michael Bellander, David W Nelson, Eric Peter Thelin,

Studies show conflicting results regarding the prognostic significance of traumatic axonal injuries (TAI) in traumatic brain injury (TBI) patients. Therefore, we documented the presence of TAI in several brain regions, using different MRI sequences, and assessed their association to patient outcomes using machine learning. Furthermore, we created a novel MRI-based ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Characterizing Sleep and Wakefulness in the Acute Phase of Concussion in the General Population: A Naturalistic Cohort from the Toronto Concussion Study.

Catherine Wiseman-Hakes, Evan Foster, Laura Langer, Tharshini Chandra, Mark Bayley, Paul Comper,

Growing literature links concussion to changes in sleep and wakefulness in humans and in rodent models. Sleep has been linked with synaptic reorganization under other conditions; however, the characterization and role of sleep after acute concussion remains poorly understood. While much research has focused on insomnia among patients with chronic ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Mild traumatic brain injury/ concussion initiates an atypical astrocyte response caused by blood-brain barrier dysfunction.

Kijana Kaaria George, Benjamin Patrick Heithoff, Oleksii Shandra, Stefanie Robel,

Mild traumatic brain injury/ concussion (mTBI) accounts for 70-90% of all reported TBI cases and causes long-lasting neurological consequences in 10 to 40% of patients. Recent clinical studies revealed increased blood-brain barrier (BBB) permeability in mTBI patients, which correlated with secondary damage after mTBI. However, the cascade of cellular events ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Selective Myostatin Inhibition Spares Sublesional Muscle Mass and Myopenia-Related Dysfunction after Severe Spinal Cord Contusion in Mice.

Gregory E Bigford, Adriana Donovan, Micah T Webster, W Dalton Dietrich, Mark S Nash,

Clinically relevant myopenia accompanies spinal cord injury (SCI), and compromises function, metabolism, body composition, and health. Myostatin, a transforming growth factor (TGF)β family member, is a key negative regulator of skeletal muscle mass. We investigated inhibition of myostatin signaling using systemic delivery of a highly selective monoclonal antibody - muSRK-015P ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics.

Misty M Strain, David T Johnston, Rachel E Baine, Joshua A Reynolds, Yung-Jen Huang, Melissa K Henwood, Gizelle N Fauss, Jacob A Davis, Rajesh C Miranda, Christopher R West, James W Grau,

Nociceptive input diminishes recovery and increases lesion area after a spinal cord injury (SCI). Recent work has linked these effects to the expansion of hemorrhage at the site of injury. The current article examines whether these adverse effects are linked to a pain-induced rise in blood pressure (BP) and/or flow. ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Toward a Comprehensive Delineation of White Matter Tract-Related Deformation.

Zhou Zhou, Xiaogai Li, Yuzhe Liu, Madelen Fahlstedt, Marios Georgiadis, Xianghao Zhan, Samuel J Raymond, Gerald Grant, Svein Kleiven, David Camarillo, Michael Zeineh,

Finite element (FE) models of the human head are valuable instruments to explore the mechanobiological pathway from external loading, localized brain response, and resultant injury risks. The injury predictability of these models depends on the use of effective criteria as injury predictors. The FE-derived normal deformation along white matter (WM) ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Association of Prehospital Helicopter Transport With Reduced Mortality in Traumatic Brain Injury in Japan: A Nationwide Retrospective Cohort Study.

Sanae Hosomi, Tetsuhisa Kitamura, Tomotaka Sobue, Yuko Nakagawa, Hiroshi Ogura, Takeshi Shimazu,

Patients with traumatic brain injury (TBI) are severely injured patients who require timely, efficient, and specialized care. The effectiveness of helicopter emergency medical services (HEMS) for patients with TBI remains unclear. This study aimed to compare the mortality of patients with TBI transported by HEMS and ground ambulance using propensity ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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The effect of subconcussive head impact exposure and jugular vein compression on behavioral and cognitive outcomes after a single season of high-school football: A prospective longitudinal trial.

Megan E Narad, Jeffery Epstein, James Peugh, Kim D Barber Foss, Jed A Diekfuss, Scott Bonnette, Sarah Orban, Weihong Yuan, Jonathan Dudley, Christopher A DiCesare, Danielle L Reddington, Wen Zhong, Katharine Schuyler Nissen, Jessica Shafer, Jason M Avedesian, Alexis B Slutsky-Ganesh, Rhodri S Lloyd, David Howell, Greg D Myer,

This prospective longitudinal trial aimed to 1) determine the role of head impact exposure on behavioral/cognitive outcomes, and 2) assess the protective effect(s) of a jugular vein compression (JVC) collar on behavioral/cognitive outcomes following one season of high-school football. Participants included 284 male high-school football players aged 13-18 years enrolled ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Endogenous opioid dynorphin is a potential link between traumatic brain injury, chronic pain and substance use disorder.

Kaitlin Marie Best, Marissa M Mojena, Gordon A Barr, Heath D Schmidt, Akiva S Cohen,

Traumatic brain injury (TBI) is a serious public health problem associated with numerous physical and neuropsychiatric comorbidities. Chronic pain is prevalent and interferes with post-injury functioning and quality of life, whereas substance use disorder (SUD) is the third most common neuropsychiatric diagnosis after TBI. Neither of these conditions has a ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Cytotoxic Edema Associated with Hemorrhage Predicts Poor Outcome after Traumatic Brain Injury.

L Christine Turtzo, Marie Luby, Neekita Jikaria, Allison Diane Griffin, Danielle Greenman, Reinoud P H Bokkers, Gunjan Parikh, Nicole Peterkin, Mark Whiting, Lawrence L Latour,

Magnetic resonance imaging (MRI) is used rarely in the acute evaluation of traumatic brain injury (TBI) but may identify findings of clinical importance not detected by computed tomography (CT). We aimed to characterize the association of cytotoxic edema and hemorrhage, including traumatic microbleeds, on MRI obtained within hours of acute ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(22):3107-3118]

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Agitated Behaviors following Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prevalence by Post-Traumatic Amnesia Status, Hospital Setting, and Agitated Behavior Type.

Ruby K Phyland, Jennie L Ponsford, Sarah L Carrier, Amelia J Hicks, Adam McKay,

Agitation is a common behavioral problem following traumatic brain injury (TBI); however, the precise proportion of patients who experience agitation in the early stages of recovery is unknown. The aim of this systematic review and meta-analysis was to evaluate the prevalence of agitation in TBI patients undergoing inpatient care, and ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(22):3047-3067]

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Knockdown of rno_circRNA_009194 Improves Outcomes in Traumatic Brain Injury Rats Through Inhibiting Voltage-gated Sodium Channel Nav1.3.

Xian-Jian Huang, Gao-Jian Su, Chu-Wei Wu, Xiao-Song Sha, Jun-Feng Zou, Xian-Sheng Liu, Min Li, Yun He,

Excessive activation of voltage-gated sodium channel Nav1.3 has been recently reported in secondary traumatic brain injury (TBI). However, the molecular mechanisms underlying regulating voltage-gated sodium channel (Nav1.3) has not been well understood. The present study used a TBI rat model induced by a fluid percussion device and performed a circRNA ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Educating Coaches: The New Frontier in Concussion Care.

David L Brody,

J Neurotrauma (Journal of neurotrauma)
[2021, 38(22):3031]

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Analysis of Brain Natriuretic Peptide Levels after Traumatic Acute Subdural Hematoma and the Risk of Post-Operative Cerebral Infarction.

Mehdi Chihi, Marvin Darkwah Oppong, Daniela Pierscianek, Thiemo Florin Dinger, Yahya Ahmadipour, Oliver Gembruch, Cornelius Deuschl, Yan Li, Börge Schmidt, Karsten H Wrede, Ulrich Sure, Ramazan Jabbarli,

Traumatic acute subdural hematoma (aSDH) is associated with a high mortality rate caused by post-operative cerebral infarction. Recently, brain natriuretic peptide (BNP) was considered a reliable biomarker in the acute phase of traumatic brain injuries. We therefore aimed in this study to analyze BNP levels on admission, identify the predictors ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(22):3068-3076]

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Reality of Accomplishing Surgery within 24 Hours for Complete Cervical Spinal Cord Injury: Clinical Practices and Safety.

Michael Balas, Peter Prömmel, Laura Nguyen, Andrew S Jack, Gerald Lebovic, Jetan H Badhiwala, Leodante da Costa, Avery B Nathens, Michael G Fehlings, Jefferson R Wilson, Christopher D Witiw,

Substantial clinical data support an association between superior neurological outcomes and early (within 24 h) surgical decompression for those with traumatic cervical spinal cord injury (SCI). Despite this, much discussion persists around feasibility and safety of this time threshold, particularly for those with a complete cervical SCI. This study aims to ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(21):3011-3019]

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Optimizing the timing of peripheral nerve transfers for functional re-animation in cervical spinal cord injury: a conceptual framework.

Valera Castanov, Michael James Berger, Benjamin Ritsma, Jessica Trier, J Michael Hendry,

Loss of upper extremity function following spinal cord injury (SCI) can have devastating consequences on quality of life. Peripheral nerve transfer surgery aims to restore motor control of upper extremities following cervical SCI and is poised to revolutionize surgical management in this population. The surgery involves dividing an expendable donor ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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In vivo Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression.

Tomas Horak, Magda Horakova, Alena Svatkova, Zdenek Kadanka, Petr Kudlicka, Jan Valosek, Tomas Rohan, Milos Kerkovsky, Eva Vlckova, Zdenek Kadanka, Dinesh K Deelchand, Pierre-Gilles Henry, Josef Bednarik, Petr Bednarik,

Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study aims to disclose markers of progressive neurochemical alterations in NMDC and DCM by utilizing an approach based on ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(21):2999-3010]

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Three-Month Psychiatric Outcome of Pediatric Mild Traumatic Brain Injury: A Controlled Study.

Jeffrey E Max, Nicholas Judd, Erin D Bigler, Elisabeth A Wilde, Jo Ellen Patterson, Todd Edwards, Ainara Calahorra, Bianca De-la-Garza, Florin Vaida,

The objective was to clarify occurrence, phenomenology, and risk factors for novel psychiatric disorder (NPD) in the first 3-months after mild traumatic brain injury (mTBI) and orthopedic injury (OI). Children aged 8-15 years with mTBI (n=220) and with OI but no TBI (n=110) from consecutive admissions to an emergency department ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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Supraspinal sensorimotor and pain-related reorganization after a hemicontusion rat cervical spinal cord injury.

Basavaraju G Sanganahalli, Jyothsna Chitturi, Peter Herman, Stella Elkabes, Robert Heary, Fahmeed Hyder, Sridhar Kannurpatti,

Since the presence of pain impedes motor recovery in individuals with spinal cord injury (SCI), it is necessary to understand their supraspinal substrates in translational animal models. Using functional magnetic resonance imaging (fMRI) in a rat model of hemicontusion cervical SCI, supraspinal changes were mapped and correlated with sensorimotor behavioral ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, :]

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