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Thiol-disulphide Homeostasis in Essential Thrombocythemia Patients.

Aysun Şentürk Yıkılmaz, Şule Mine Bakanay, Sema Akinci, Murat Alisik, Özcan Erel, İmdat Dilek,

Background:This study aimed to show the status of thioldisulphide homeostasis in essential thrombocytosis patients, which is known to play a role in platelet function. Methods:The study included 27 ET patients and a control group of 36 healthy subjects. Serum total (-SH + -S-S-) and native (-SH) thiol levels were measured ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):475-480]

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Project Management in Laboratory Medicine.

Giuseppe Lippi, Camilla Mattiuzzi,

The role and responsibilities of laboratory managers have considerably evolved during the past decades. This revolution has been mostly driven by biological, technical, economic and social factors, such as deepened understanding of the pathophysiology of human diseases, technical innovations, renewed focus on patient safety, cost-containment strategies and patient empowerment. One ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):401-406]

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Evaluation of Neutrophil-lymphocyte and Platelet-lymphocyte Ratios as Predictors of 30-day Mortality in Patients Hospitalized for an Episode of Acute Decompensated Heart Failure.

Gianni Turcato, Fabian Sanchis-Gomar, Gianfranco Cervellin, Elisabetta Zorzi, Valentina Sivero, Gian Luca Salvagno, Andrea Tenci, Giuseppe Lippi,

Background:To investigate the association between both neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and 30-day mortality in patients hospitalized for an episode of acute decompensated heart failure (ADHF). Methods:439 patients admitted to emergency department (ED) for an episode of ADHF. Clinical history, demographic, clinical and laboratory ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):452-460]

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Red Blood Cell Distribution Width Predicts 1-month Complications after Percutaneous Transluminal Angioplasty.

Gian Franco Veraldi, Luca Mezzetto, Lorenzo Scorsone, Marco Macrì, Fabio Simoncini, Giuseppe Lippi,

Background:The identification of patients at higher risk of developing percutaneous transluminal angioplasty (PTA)-related complications is pivotal for achieving better clinical outcomes. We carried out a single-center, observational, retrospective study to explore whether in-hospital changes of red blood cell distribution width (RDW) may help predicting early development of PTA-related complications. Methods:The ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):468-474]

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Association of Serum Paraoxonase 1 Activities, Polymorphisms and Oxidative Stress in Breast Cancer Patients with Type 2 Diabetes Mellitus.

Fatma Ceyla Eraldemir, Nihal Üren, Tuğba Kum, Burcu Erbay, Deniz Şahin, Emel Ergül, Esra Acar, Doğa Özsoy, Mustafa Çekmen, Hale Kır, Zafer Utkan,

Background:The aim of the study was to investigate the association of paraoxonase 1 (PON1) polymorphism, PON1/arylesterase (ARE) activity and oxidative stress index (OSI) in breast cancer (BC) patients with type 2 diabetes (DM). Methods:Our study group consisted of 30 healthy women (HV group) and 66 female BC patients. The BC ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):368-375]

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Exploring Sirolimus Pharmacokinetic Variability Using Data Available from the Routine Clinical Care of Renal Transplant Patients - Population Pharmacokinetic Approach.

Bojana Golubović, Katarina Vučićević, Dragana Radivojević, Sandra Vezmar Kovačević, Milica Prostran, Branislava Miljković,

Background:Due to wide intra- and inter-individual pharmacokinetic variability and narrow therapeutic index of sirolimus, the therapeutic drug monitoring (TDM) of sirolimus with detailed biochemical and clinical monitoring is necessary for dose individualization in kidney transplant patients. The purpose of the study was to explore and identify factors that contribute to ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):323-331]

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Superoxide Dismutase Isoenzymes Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Coronary Artery Disease.

Ana Ninić, Nataša Bogavac-Stanojević, Miron Sopić, Jelena Munjas, Jelena Kotur-Stevuljević, Milica Miljković, Tamara Gojković, Dimitra Kalimanovska-Oštrić, Vesna Spasojević-Kalimanovska,

Background:Coronary artery disease (CAD) is one of the most important causes of mortality and morbidity in wide world population. Dyslipidemia, inflammation and oxidative stress may contribute to disruption of endothelium structure and function, atherosclerosis and CAD. Our study was aimed to determine whether Cu/Zn superoxide dismutase (Cu/Zn SOD) and Mn ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):284-291]

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Nitric Oxide Products are not Associated with Metabolic Syndrome.

Aleksandra Klisic, Gordana Kocic, Nebojsa Kavaric, Radmila Pavlovic, Ivan Soldatovic, Ana Ninic,

Background:Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):361-367]

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TNF-α and IL-6 as Biomarkers of Impaired Lung Functions in Dimethylacetamide Exposure.

Lütfiye Tutkun, Servet Birgin İritaş, Serdar Deniz, Özgür Öztan, Sedat Abuşoğlu, Ali Ünlü, Vugar Ali Türksoy, Sultan Pınar Çetintepe,

Background:Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) are well-known biomarkers of systemic inflammation that have been associated with many diseases in the past. In this study, we aimed to determine the relationship between impaired lung functions and the levels of these biomarkers in DMAc exposed people. Methods:101 non-exposed control subjects ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):276-283]

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Serum C-C Motif Ligand 11/eotaxin-1 May Serve as a Candidate Biomarker for Postmenopausal Osteoporosis.

Wen Wang, Ci-You Huang, Zhuo-Ping Wang, Shan-Shan Xu, Tie-Yong Qian, Yi-Ding Chen, Wei-Guo Wu,

Background:The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. Objective:The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):353-360]

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Effects of Timolol Treatment on Pancreatic Antioxidant Enzymes in Streptozotocin-induced Diabetic Rats: An Experimental and Computational Study.

Nuriye Nuray Ulusu, Muslum Gok, Burak Erman, Belma Turan,

Background:The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGDH) enzyme activities and cAMP level in streptozotocin-induced diabetic rats in pancreatic tissues. Methods:Diabetes was induced by streptozotocin (STZ) in 3-month old male Wistar rats. The ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):306-316]

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Plasma Cathepsin S is Associated with High-density Lipoprotein Cholesterol and Bilirubin in Patients with Abdominal Aortic Aneurysms.

Bosa Mirjanic-Azaric, Novak Vasic, Darko Cerne, Janko Kos, Natasa Bogavac-Stanojevic,

Background:Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):268-275]

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Soluble sPD-L1 and Serum Amyloid A1 as Potential Biomarkers for Lung Cancer.

Dragana Jovanović, Marina Roksandić-Milenković, Jelena Kotur-Stevuljević, Vesna Ćeriman, Ivana Vukanić, Natalija Samardžić, Spasoje Popević, Branislav Ilić, Milija Gajić, Marioara Simon, Ioan Simon, Vesna Spasojević-Kalimanovska, Milica Belić, Damjan Mirkov, Zorica Šumarac, Vladislav Milenković,

Background:The objective of this prospective study was to evaluate whether soluble programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) and serum amyloid A1 (SAA1) are potential diagnostic, predictive or prognostic biomarkers in lung cancer. Methods:Lung cancer patients (n=115) with advanced metastatic disease, 101 with non-small cell lung cancer, NSCLC (77 EGFR ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):332-341]

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Expression Pattern of Long Non-coding RNA Growth Arrest-specific 5 in the Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia.

Vladimir Gasic, Biljana Stankovic, Branka Zukic, Dragana Janic, Lidija Dokmanovic, Nada Krstovski, Jelena Lazic, Goran Milosevic, Marianna Lucafò, Gabriele Stocco, Giuliana Decorti, Sonja Pavlovic, Nikola Kotur,

Background:Long non-coding RNA growth arrest-specific 5 (GAS5) is deregulated in many cancers because of its role in cell growth arrest and apoptosis. Additionally, GAS5 interacts with glucocorticoid receptor, making it a potential pharmacotranscription marker of glucocorticoid (GC) therapy. In this study, we aimed at analysing GAS5 expression in the remission ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):292-298]

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The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β , 5α , 6β -triol and their Role in the Diagnosis of Coronary Artery Disease.

Muhammed Emin Keles, Afshin Samadi, Selen Yilmaz Isikhan, Yusuf Ziya Sener, Ali Sezgin, Emine Keles, Incilay Lay, Uğur Canpolat,

Background:Oxysterols have been shown to play a role in plaque formation while ischemia modified albumin (IMA) is widely accepted as an acute marker for ischemia. The effort test is one of the methods used to identify the presence of coronary artery disease. Thus, there may be a relationship between effort ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):249-255]

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T Cell Subsets' Distribution in Elite Karate Athletes as a Response to Physical Effort.

Dorota Kostrzewa-Nowak, Rafał Buryta, Robert Nowak,

Background:During karate fight muscles work at a very high intensity, and their contractions are extremely strong. The movement pattern contains a great number of feints, dodges, frequent changes in movements' tempo and direction, hits and kicks, all of which is highly stressful for athlete's organism, including the immune system. Methods:T ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):342-352]

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A Novel Biomarker Renalase and Its Relationship with its Substrates in Schizophrenia.

Zekiye Catak, Esra Kocdemir, Kader Ugur, Meltem Yardim, İbrahim Sahin, Hilal Kaya, Suleyman Aydin,

Background:Schizophrenia, particularly the form related to excessive dopamine (DA), is a chronic psychotic disorder affecting millions of people worldwide. Renalase metabolizes its catecholamine (CA) substrates, including DA, suggesting that there might be an association between renalase levels and schizophrenia occurrence. Therefore, the current study aimed to evaluate the renalase and ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):299-305]

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Comparison of Selected CD45+ Cell Subsets' Response and Cytokine Levels on Exhaustive Effort Among Soccer Players.

Dorota Kostrzewa-Nowak, Rafał Buryta, Robert Nowak,

Background:Immunological alterations may led to the reduction in capacity and endurance levels in elite athletes by e.g. increased susceptibility to infections. There is a need to explain the impact of intensive physical effort on the CD4+ memory T cell subsets. Methods:Fourteen participants median aged 19 years old (range 17-21 years) ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(3):256-267]

Cited: 1 time

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Evaluation of Paraoxonase, Arylesterase, and Homocysteine Thiolactonase Activities in Patients with Diabetes and Incipient Diabetes Nephropathy.

Durmuş Ayan, Mehmet Şeneş, Ayşe Banu Çaycı, Sibel Söylemez, Nezaket Eren, Yüksel Altuntaş, Feyza Yener Öztürk,

Background:The aim of this study is to examine the relationship among the changes in activities of paraoxonase (PON), arylesterase (ARE) and homocysteine thiolactonase (HTLase) enzyme having antioxidant properties and the development of diabetic nephropathy (DN), one of the most common complications of diabetes. Methods:Normoalbuminuric type-2 diabetic patients (Group II, n=100), ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):481-488]

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Thiol/Disulphide Homeostasis, Ischemia Modified Albumin, and Ferroxidase as Oxidative Stress Markers in Women with Obesity with Insulin Resistance.

Elif Ates, Turan Set, Süleyman Caner Karahan, Cemile Biçer, Özcan Erel,

Background:The purpose of the study was to determine oxidative stress-related plasma thiol/disulphide, ischemia-modified albumin (IMA) levels and ferroxidase activity among women with obesity in insulin-resistant and non-insulin-resistant groups in comparison with an overweight group. Methods:We compared plasma thiol/disulphide, IMA levels, and ferroxidase activity between the study groups. We analyzed plasma ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):445-451]

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Assessment of Selected Exercise-induced CD3+ Cell Subsets and Cell Death Parameters Among Soccer Players.

Robert Nowak, Dorota Kostrzewa-Nowak,

Background:Molecular mechanisms of biological adaptation to training in professional soccer players are unclear. The aim of this study was to assess the impact of progressive physical effort on peripheral T-cells and their molecular response. Methods:Thirteen soccer players form Pogo Szczecin S.A., a top league soccer club, (median age 21, range ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):437-444]

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Body Mass Index and C-reactive Protein Are Potential Predictors of Asthma Development in Egyptian Polycystic Ovary Syndrome Patients.

Hebatallah Ahmed Nasser, Nermeen Zakaria Abuel Ezz, Heidi Mohamed Abdel-Mageed, Rasha Ali Radwan,

Background:Recent studies suggest asthma prevalence in polycystic ovary syndrome (PCOS) patients. This is the first study to explore asthma prevalence among Egyptian PCOS patients. It highlighted common findings in PCOS and asthma. It investigated whether these findings could serve as potential predictors of asthma. Methods:A hundred PCOS patients, sixty asthmatic ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):427-436]

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Predictive Values of Serum Uric Acid and Alanine-aminotransferase for Fatty Liver Index in Montenegrin Population.

Aleksandra Klisic, Nebojsa Kavaric, Ana Ninic,

Background:Alanine-aminotransferase (ALT) and uric acid cut-off levels used in non-alcoholic fatty liver disease (NAFLD) diagnosis are advised to be lowered. Due to contradictory results on the utility of both these biomarkers for NAFLD screening, we aimed to determine their cut-off levels that can be applied to Montenegrin population with the ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(4):407-417]

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Association of Overexpressed MYC Gene with Altered PHACTR3 and E2F4 Genes Contributes to Non-small Cell Lung Carcinoma Pathogenesis.

Miodrag Dragoj, Jasna Bankovic, Ana Podolski-Renic, Sonja Stojkovic Buric, Milica Pesic, Nikola Tanic, Tijana Stankovic,

Background:C-Myc is one of the major cellular oncogenes overexpressed in non-small cell lung carcinoma (NSCLC). Its deregulated expression is necessary but not sufficient for malignant transformation. We evaluated expression of MYC gene in NSCLC patients and its association with alterations in the genes previously identified to be related to NSCLC ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(2):188-195]

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A Pilot Study to Assess Kidney Functions and Toxic Dimethyl-arginines as Risk Biomarkers in Women with Low Vitamin D Levels.

Samar Damiati,

Background:Although vitamin D in not a traditional marker for cardiovascular and renal diseases, several studies have proposed a correlation between vitamin D deficiency and these diseases due to the effect of vitamin D on endothelial function. Asymmetric and symmetric dimethyl arginine (ADMA and SDMA, respectively) are endogenous markers of endothelial ... Read more >>

J Med Biochem (Journal of medical biochemistry)
[2019, 38(2):145-152]

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