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Neuroimaging risk factors for participation restriction after acute ischemic stroke: 1-year follow-up study.

Jian-Feng Qu, Huo-Hua Zhong, Wen-Cong Liang, Yang-Kun Chen, Yong-Lin Liu, Wei Li,

The aim of the present study was to determine the neuroimaging predictors of poor participation after acute ischemic stroke. A total of 443 patients who had acute ischemic stroke were assessed. At 1-year recovery, the Reintegration to Normal Living Index was used to assess participation restriction. We also assessed the ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Prospective predictive performance comparison between clinical gestalt and validated COVID-19 mortality scores.

Adrian Soto-Mota, Braulio Alejandro Marfil-Garza, Santiago Castiello-de Obeso, Erick Jose Martinez Rodriguez, Daniel Alberto Carrillo Vazquez, Hiram Tadeo-Espinoza, Jessica Paola Guerrero Cabrera, Francisco Eduardo Dardon-Fierro, Juan Manuel Escobar-Valderrama, Jorge Alanis-Mendizabal, Juan Gutierrez-Mejia,

Most COVID-19 mortality scores were developed at the beginning of the pandemic and clinicians now have more experience and evidence-based interventions. Therefore, we hypothesized that the predictive performance of COVID-19 mortality scores is now lower than originally reported. We aimed to prospectively evaluate the current predictive accuracy of six COVID-19 ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Pulmonary arterial hypertension: promising advances and remaining challenges.

Karim El-Kersh, John D Dickinson,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, 69(7):1268-1269]

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Good news continues for JIM in 2021.

Richard McCallum,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, 69(7):1263-1264]

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Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines.

Paul Glynne, Natasha Tahmasebi, Vanya Gant, Rajeev Gupta,

Long COVID is characterized by the emergence of multiple debilitating symptoms following SARS-CoV-2 infection. Its etiology is unclear and it often follows a mild acute illness. Anecdotal reports of gradual clinical responses to histamine receptor antagonists (HRAs) suggest a histamine-dependent mechanism that is distinct from anaphylaxis, possibly mediated by T ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Venous capacitance and venous return in young adults with typical vasovagal syncope: a cross-sectional study.

Ely Fish, Sapir Barak Lanciano, Itay Shavit, Hagar Palacci, Chen Chaiat, Ishay Avivi, Ella Haber Kaptsenel, Udi Nussinovitch,

Vasovagal syncope (VVS) has a high prevalence in the general population and is associated with potential complications. There is limited information on the possible association between venous capacitance (VC) and venous return (VR), important determinants of preload and VVS. Since the tilt test was reported to yield a high rate ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Advances in the management of pulmonary arterial hypertension.

Himanshu Deshwal, Tatiana Weinstein, Roxana Sulica,

The management of pulmonary arterial hypertension (PAH) has significantly evolved over the last decades in the wake of more sensitive diagnostics and specialized clinical programs that can provide focused medical care. In the current era of PAH care, 1-year survival rates have increased to 86%-90% from 65% in the 1980s, ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, 69(7):1270-1280]

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Serum magnesium levels in hospitalized patients with SARS-CoV-2.

Rupam Sharma, Arash Heidari, Royce H Johnson, Shailesh Advani, Greti Petersen,

Early studies have reported various electrolyte abnormalities at admission in patients with severe COVID-19. 104 out of 193 patients admitted to our institution presented with hypermagnesemia at presentation. It is believed this may be important in the evaluation of severe SARS-CoV-2 infections. This study evaluated the outcomes of hypermagnesemia in ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Tocilizumab in patients hospitalized with COVID-19 pneumonia: systematic review and meta-analysis of randomized controlled trials.

Samiksha Gupta, Rana Prathap Padappayil, Agam Bansal, Salim Daouk, Brent Brown,

Tocilizumab is an interleukin receptor inhibitor that has been used in patients with COVID-19 pneumonia. There are recent randomized controlled trials (RCTs) that evaluated the efficacy and safety of tocilizumab in hospitalized patients with COVID-19 pneumonia. We performed a systematic review and meta-analysis of RCTs that evaluated the effectiveness of ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Critical illness in patients with metastatic cancer: a population-based cohort study of epidemiology and outcomes.

Lavi Oud,

The appropriateness of intensive care unit (ICU) admission of patients with metastatic cancer remains debated. We aimed to examine the short-term outcomes and their temporal pattern in critically ill patients with metastatic disease. We used state-wide data to identify hospitalizations aged ≥18 years with metastatic cancer admitted to ICU in ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Exploring the appropriate dose of nebulized hypertonic saline for bronchiolitis: a dose-response meta-analysis.

Jilei Lin, Yin Zhang, Anchao Song, Linyan Ying, Jihong Dai,

Nebulized hypertonic saline (HS) has gathered increasing attention in bronchiolitis. This study aims to evaluate the relationship between the dose of nebulized HS and the effects on bronchiolitis. Five electronic databases-PubMed, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and ISRCTN-were searched until May 2021. Randomized controlled trials (RCTs) that ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Artificial intelligence to diagnose ear disease using otoscopic image analysis: a review.

Therese L Canares, Weiyao Wang, Mathias Unberath, James H Clark,

AI relates broadly to the science of developing computer systems to imitate human intelligence, thus allowing for the automation of tasks that would otherwise necessitate human cognition. Such technology has increasingly demonstrated capacity to outperform humans for functions relating to image recognition. Given the current lack of cost-effective confirmatory testing, ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Protective effects of sunscreen (50+) and octatrienoic acid 0.1% in actinic keratosis and UV damages.

Daniela Pinto, Anna Trink, Giammaria Giuliani, Fabio Rinaldi,

Actinic keratosis is a form of dysplastic epidermal lesion resulting from chronic and excessive UV exposure with a certain risk of becoming cancerous. Current guidelines advocated the use of sunscreens to prevent photodamage. An efficient photoprotection must involve both primary protective factors such as UV filters and secondary factors (eg, ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Septic arthritis in the end-stage renal disease population.

Lorry Aitkens, Matthew Winn, Jennifer L Waller, Lu Huber, Stephanie L Baer, Azeem Mohammed, Mufaddal Kheda, Sarah Tran, Budder Siddiqui, Sandeep Padala, Rhonda E Colombo, Wendy B Bollag,

Septic arthritis is important to consider in any patient who presents with joint pain because it is a medical emergency with an 11% fatality rate. Diagnosis and treatment may improve prognosis; however, many patients do not regain full joint function. In patients with end-stage renal disease (ESRD), immune dysfunction due ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Variation in clinical characteristics, outcomes, and mortality of hospitalized patients with COVID-19 during the second wave of the pandemic: a single-center experience.

Mohsin Sheraz Mughal, Ikwinder Preet Kaur, Chang Wang, Reem Alhashemi, Alvin Buemio, Chandler D Patton, Kenneth M Granet,

As of February 2, 2021, the USA has 26,431,799 reported COVID-19 cases with 446,744 deaths. A high mortality rate (15%-40%) was reported among hospitalized patients with COVID-19 during the first wave of the pandemic. However, data regarding variation in COVID-19-related mortality and severity of illness among hospitalized patients with COVID-19 ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Impact on the fitness of N95 masks with extended use/limited reuse and dry heat decontamination.

Mengyi Zha, Jude Alsarraj, Brandon Bunch, David Venzon,

Substandard use of N95 masks, sometimes combined with dry heat decontamination, lacks safety data. We evaluated the impact of these practices on the fitness of N95 masks. This is a non-human subject research conducted from July to October 2020. 155 masks were used by 12 healthcare workers during 10-hour shifts. ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Correspondence on 'Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma' by Radovanovic et al.

Shahrokh Lorzadeh, Saeid Ghavami,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Predictive role of ultrasound remission for progressive ultrasonography-detected structural damage in patients with rheumatoid arthritis.

Feifei Liu, Wenxue Li, Jiaan Zhu, Fang Liu, Wenting Fan, Zheng Chen,

Regarding the persistence of subclinical synovitis, the concept of ultrasound remission has been proposed in addition to clinical remission. However, there have been no studies that explored the different time points of ultrasound remission to predict non-progressive structural damage. Given this, the aim of our study is to explore whether ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Association between blood carboxyhemoglobin level and bronchopulmonary dysplasia in extremely low birthweight infants.

Thea Tagliaferro, Rowena Cayabyab, Rangasamy Ramanathan,

Carboxyhemoglobin (CO-Hb) can be endogenously formed in the presence of oxidative stress and may be elevated in inflammatory lung disease. There is lack of evidence of its relationship with the development of bronchopulmonary dysplasia (BPD) in extremely low birthweight (ELBW) infants. The objective of the study is to evaluate the ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Response to: Correspondence on 'Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma' by Lorzadeh et al.

Milan Radovanovic, Sasenka Vidicevic, Jelena Tasic, Nina Tomonjic, Zeljka Stanojevic, Predrag Nikic, Aleksandar Vuksanovic, Zoran Dzamic, Uros Bumbasirevic, Aleksandra Isakovic, Vladimir Trajkovic,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Call for emergency action to limit global temperature increases, restore biodiversity and protect health.

Lukoye Atwoli, Abdullah H Baqui, Thomas Benfield, Raffaella Bosurgi, Fiona Godlee, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Carlos Augusto Monteiro, Ian Norman, Kirsten Patrick, Nigel Praities, Marcel Gm Olde Rikkert, Eric J Rubin, Peush Sahni, Richard Smith, Nicholas J Talley, Sue Turale, Damián Vázquez,

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, 69(7):1265-1267]

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In-vivo skeletal muscle mitochondrial function in Klinefelter syndrome.

Stephanie Cung, Laura Pyle, Kristin Nadeau, Dana Dabelea, Melanie Cree-Green, Shanlee M Davis,

Klinefelter syndrome (XXY) occurs in 1 in 600 males, resulting in testosterone deficiency and a high prevalence of insulin resistance. Testosterone deficiency in men is a known cause of insulin resistance, and mitochondrial dysfunction is hypothesized to mediate this relationship. The aim of this cross-sectional study was to evaluate muscle ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Quantitative increase in short-chain fatty acids, especially butyrate protects kidney from ischemia/reperfusion injury.

Yangyang Sun, Cuixing Zhou, Yimeng Chen, Xiaozhou He, Fang Gao, Dong Xue,

Short-chain fatty acids (SCFAs), the end products of fermentation carried out by the intestinal microbiota, were demonstrated to produce anti-oxidant and anti-inflammatory effects. Butyrate, part of the SCFAs, also shows the same effect. Renal ischemia/reperfusion (I/R) injury commonly occurs in renal transplantation and is often accompanied by oxidative stresses and ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Nocardiosis in renal transplant patients.

Maya Gibson, Nianlan Yang, Jennifer L Waller, Lufei Young, Wendy B Bollag, Mufaddal Kheda, Azeem Mohammed, Stephanie L Baer,

Renal transplant patients are immunosuppressed and are at increased risk of opportunistic infections, including <i>Nocardia</i> infection. In renal transplant patients, information on the incidence and risk factors associated with nocardiosis is limited. To address the incidence and risk factors associated with nocardiosis in a large renal transplant population, we used ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Predictors of misperceptions, risk perceptions, and personal risk perceptions about COVID-19 by country, education and income.

Tanzim Bhuiya, Richard Klares Iii, Madellena A Conte, Joseph Steven Cervia,

Government interventions, such as mandating the use of masks and social distancing, play crucial roles in controlling the spread of pandemic infection. Adherence depends on public perceptions about pandemic risk. The goal was to explore the roles of education, income, and country on misperceptions, risk perceptions and personal risk perceptions ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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