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Aquagenic wrinkling of the palms and cystic fibrosis diagnosis.

G Grimalt, M Carbonell, R Grimalt,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, 35(8):1608]

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Pioneers in Dermatology and Venereology: an interview with Professor Ricardo Luis Galimberti.

R L Galimberti,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, 35(8):1609-1611]

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Quality of life in patients with Mycosis Fungoides and Sézary Syndrome: a systematic review of the literature.

R Ottevanger, S van Beugen, A W M Evers, R Willemze, M H Vermeer, K D Quint,

Cutaneous T-cell Lymphoma's (CTCL) are a rare, heterogenous group of T-cell lymphomas that primarily manifest in the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are considered the claswsic types of CTCL. The diverse manifestation of CTCL results in a wide range of symptoms with a possible mild to severe ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Raman spectroscopy reveals collagen and phospholipids as major components of hyalinosis in the arteriolosclerotic ulcer of Martorell.

J Deinsberger, M Felhofer, J P Kläger, P Petzelbauer, N Gierlinger, B Weber,

<h4>Background</h4>Arteriolosclerotic ulcers of Martorell are histologically characterized by hyaline arteriolosclerosis resulting in concentric occlusion of the arteriolar lumina. Although several authors have previously reported on hyaline changes in hypertensive arteriolopathies, so far, little information is available on the molecular composition of hyaline wall depositions.<h4>Objectives</h4>This study aimed at the molecular characterization ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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An innovative application of follicular unit extraction technique in the treatment of bromhidrosis.

Haihong Li, Xiang Zhang, Wei Wei, Lei Zhang, Zixiu Chen, ManXiu Cao, Jiaqi Cheng, Lijie Du, Junhong Zhao, Zheng Fang, Xiangjun Li, Pingxiang Chen,

<h4>Background</h4>Surgery is the most effective way to treat bromhidrosis, but postoperative complications are still the biggest obstacles for patients to choose surgical treatment.<h4>Objectives</h4>To introduce an innovative application of follicular unit extraction (FUE) in the treatment of bromhidrosis.<h4>Methods</h4>We conducted a case series study on 20 patients who received FUE technique for the ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Editor's picks.

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, 35(8):1605]

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Updates on lymphogranuloma venereum.

G Ciccarese, F Drago, A Rebora, A Parodi,

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, 35(8):1606-1607]

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Concordance Between a Mohs Surgeon and a Dermatopathologist in Evaluating Mohs Cryosections.

S Atilla, Ö Gököz, S Özer, G Elçin,

<h4>Background</h4>Mohs micrographic surgery is the gold standard treatment for high-risk non-melanoma skin cancers. The success of Mohs relies on accurate histopathologic evaluation. Due to law restrictions in some European countries Mohs surgeons are not permitted to report on histopathology, therefore a pathologist evaluates the frozen sections.<h4>Objective</h4>To retrospectively assess the concordance ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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High prevalence of syphilis in women, minors, and precarious patients: a cross-sectional study in a Reunion Island sexually transmitted infection clinic, 2017-2020.

A Delfosse, N Bouscaren, N Dupin, J Jaubert, P L Tran, C Saint Pastou, R Manaquin, P Poubeau, P Gerardin, A Bertolotti,

<h4>Background</h4>Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012. Syphilis has been on the rise among men who have sex with men (MSM) in high-income countries and remains at endemic levels in low- and middle-income countries. This trend, however, has not been observed ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Fluorescence-Advanced Videodermoscopy (FAV) - a new method of hairs and scalp evaluation. Comparison with trichoscopy.

A Rossi, F Magri, G Caro, S Michelini, M Di Fraia, M C Fortuna, G Pellacani, M Carlesimo,

<h4>Introduction</h4>Non-invasive diagnostic methods in clinical dermatology are widely used to reduce the need for invasive techniques, with great advantages in terms of cost and time. Dermoscopy is the reference test for the in vivo diagnosis of cutaneous lesions, and when it is performed on the scalp region it is named ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Efficacy of ixekizumab on nail psoriasis in pediatric patients with moderate-to-severe psoriasis: a post-hoc analysis from IXORA-PEDS.

M M B Seyger, A Reich, C El Baou, C Schuster, E Riedl, A S Paller,

Nail psoriasis (NP) has been proposed as a potential clinical predictor for a more severe disease course in children with psoriasis but data regarding NP in children is scarce.<sup>1-3</sup> Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin-(IL)-17A, is an EMA and FDA approved treatment for pediatric (≥6 years ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Improvement in Hidradenitis Suppurativa and Quality of Life in Patients Treated With Adalimumab: Real-World Results From the HARMONY Study.

A Hafner, P-D Ghislain, R Kovács, R Batchelor, A C Katoulis, B Kirby, H Banayan, M Schonbrun,

<h4>Background</h4>Hidradenitis suppurativa (HS), a chronic, recurrent, debilitating skin disease, is characterized by painful, inflammatory, subcutaneous lesions of the axilla, inguinal, and anogenital regions. Overall prevalence of HS is ~1%, and impact of disease on patient quality of life (QoL) and healthcare resource utilization (HRU) is high.<h4>Objectives</h4>To estimate the real-world effectiveness ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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An integrated safety analysis of treatment-emergent fungal infections in patients with psoriasis treated with ixekizumab from 16 clinical studies.

A Blauvelt, M Ramharter, A D Cohen, W Xu, H Patel, C Schuster, E Riedl, L Puig,

Interleukin (IL)-17 plays a role in host defense against common extracellular pathogens, including fungi.<sup>1-3</sup> Biologics that selectively target IL-17 have shown efficacy in the treatment of psoriasis.<sup>4,5</sup>. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Omalizumab prevents anaphylactoid reactions to mRNA COVID-19 vaccine.

A Smola, S Samazadeh, L Müller, O Adams, B Homey, P Albrecht, S Meller,

Within the first days of initiating mass vaccination with the novel Covid-19 vaccines several anaphylactic reactions have been reported<sup>1</sup> . We present two cases experiencing angioedema with or without urticarial rash after the first dose of the mRNA-1273 vaccine. Both patients tolerated the second vaccination after a pre-treatment with the ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Assessing the Responsiveness of Sonographic Biomarkers to Brodalumab Therapy in Hidradenitis Suppurativa.

J W Frew, D Grand, K Navrazhina, S Garcet, J G Krueger,

In Hidradenitis Suppurativa (HS), the identification of disease activity biomarkers is a key priority<sup>1</sup> . Sonographic-based imaging biomarkers have been established as valid measurements of baseline disease activity<sup>2,3</sup> , however the response of epidermal thickness, tunnel diameter and power Doppler intensity<sup>3</sup> in the setting of pharmacologic therapy is unknown. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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New onset of mainly guttate psoriasis after COVID-19 vaccination: a case report.

M Lehmann, P Schorno, R E Hunger, K Heidemeyer, L Feldmeyer, N Yawalkar,

Psoriasis is a chronic, immune-mediated inflammatory disease with heterogeneous clinical manifestations. Various trigger factors like infections and drugs are known to elicit or aggravate psoriasis. Previously, a possible association of vaccination and the new onset (particularly guttate lesions) or exacerbation of psoriasis has been reported. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Cutaneous ulceration as primary presentation of TEMPI syndrome.

Johanna Strobl, Christoph Sinz, Peter M Heil, Georg Stary, Wolfgang Weninger,

TEMPI syndrome is an acquired plasma cell dyscrasia characterised by telangiectasias of the face, elevated erythropoietin and erythrocytosis, monoclonal gammopathy, perinephric fluid collections and intrapulmonary shunting (1). The first case of TEMPI syndrome was described by Bazari at al. in 2010 (2) and currently 23 cases have been identified worldwide ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Small vessel vasculitis related to varicella zoster virus after Pfizer-BioNTech COVID-19 vaccine.

Francesca Nastro, Gabriella Fabbrocini, Francesca di Vico, Claudio Marasca,

we read with great interest the article by M Ackerman et al. regarding the occurrence of persistent maculopapular rash few hours after receiving the vaccine<sup>1</sup> . We herein report a case of atypical varicella-zoster virus skin infection inducing a small vessel vasculitis after first dose of Pfizer-BioNTech COVID-19 vaccine. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Herpes Zoster following SARS-CoV-2 vaccination - a series of 4 cases.

M Alpalhão, P Filipe,

The SARS-CoV-2 pandemic is a global public health crisis, with significant morbidity, mortality and socioeconomical impacts. Vaccines were developed and granted emergency approvals by most drug agencies to tackle this crisis, but the safety profile of these vaccines is not fully clarified. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Dupilumab in atopic dermatitis: predictors of treatment outcome and time to response.

E Nettis, S M Ferrucci, G Pellacani, E Di Leo, G Argenziano, C Foti, F Rongioletti, C Patruno, M Ortoncelli, L Macchia, S Tavecchio, L Bonzano, D Di Bona, G Calabrese, G Fabbrocini, ,

Recently, dupilumab, an anti-IL-4Rα antibody, has become available for the treatment of moderate-to-severe atopic dermatitis (AD).<sup>1-4</sup> Baseline patient characteristics that can be used as predictors of response to dupilumab treatment in AD patients have not yet been identified. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Cutaneous manifestations of patients hospitalized with coronavirus disease 2019 (COVID-19).

P Ramezani Darmian, Z Memarzadeh, R Aryan, Y Nahidi, Z Mehri, A Taghipour, N Samimi, M Amini, P Layegh,

In December 2019 a new member of the coronavirus family emerged in Wuhan city in Hubei Province of China, and rapidly spread all over the world causing a pandemic.<sup>1, 2</sup> A recent Cochrane review categorized different presentations of COVID-19 into four groups; respiratory, systemic, cardiovascular and gastrointestinal (GI). However, some ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Retiform purpura and extensive skin necrosis as the single manifestation of SARS-CoV-2 infection.

M Brito Caldeira, M Pestana, A Luísa João, C Fernandes, A João, N Cunha,

It is known that dermatological manifestations of SARS-CoV-2 infection are heterogenous and have been a subject of increasing discussion. Most common clinical patterns include maculopapular rash, perniosis, urticaria, vesicular eruption, livedo reticularis and retiform purpura<sup>[1, 2]</sup> . The latter has been exclusively described in critically ill patients, often requiring invasive ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Skin conditions among 20th century politicians and world leaders.

Nicolas Kluger, Antonio Perciaccante, Philippe Charlier, Pierre Vabres,

The health of world leaders is a legitimate source of concern for the global population, and for historians. Cognitive disorders may impact their mandate decisions, particularly when occurring early in office [1]. Cancer and cardio-vascular diseases may lead to disability with impossibility to carry out expected duties or unexpected death ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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A Genome-wide association study identified HLA-C associated with the effectiveness of methotrexate for psoriasis treatment.

Yuanjing Zhang, Ding Xian, Ziyuan Meng, Min Chen, Xiaodong Zheng, Minglong Cai, Juan Wu, YuLing Chang, Qun Zhang, Ling Jin, DanFeng Qian, XueYing Li, MingShun Wu, Kexiang Yan, Yonghong Lu, Xuejun Zhang,

Methotrexate (MTX), a folic acid reductase inhibitor, is prescribed as the first-line systemic treatment for patients with psoriasis.<sup>1-2</sup> Although the therapeutic efficacy of MTX has been well demonstrated, patients show substantial heterogeneity in their response to MTX therapies, and the efficacy of MTX in a given patient is unpredictable. ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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Merkel cell carcinoma is still an unexpected diagnosis.

Helena Svensson, John Paoli,

To the editor: Merkel cell carcinoma (MCC) is a rare, but highly aggressive cutaneous neuroendocrine skin cancer that generally occurs in elderly Caucasian people, on sun-exposed areas (1). In Sweden, the incidence of MCC, adjusted to the European standard population, increased from 0.11 to 0.19 per 100 000 individuals between ... Read more >>

J Eur Acad Dermatol Venereol (Journal of the European Academy of Dermatology and Venereology : JEADV)
[2021, :]

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