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An integrated approach to improve clinical trial efficiency: Linking a clinical trial management system into the Research Integrated Network of Systems

Royce Sampson, Steve Shapiro, Wenjun He, Signe Denmark, Katie Kirchoff, Kyle Hutson, Rechelle Paranal, Leila Forney, Kimberly McGhee, Jillian Harvey,

Low-accruing clinical trials delay translation of research breakthroughs into the clinic, expose participants to risk without providing meaningful clinical insight, increase the cost of therapies, and waste limited resources. By tracking patient accrual, Clinical and Translational Science Awards hubs can identify at-risk studies and provide them the support needed to ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
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Modeling clinical trajectory status of critically ill COVID-19 patients over time: A method for analyzing discrete longitudinal and ordinal outcomes

Michael J. Ward, David J. Douin, Wu Gong, Adit A. Ginde, Catherine L. Hough, Matthew C. Exline, Mark W. Tenforde, William B. Stubblefield, Jay S. Steingrub, Matthew E. Prekker, Akram Khan, D. Clark Files, Kevin W. Gibbs, Todd W. Rice, Jonathan D. Casey, Daniel J. Henning, Jennifer G. Wilson, Samuel M. Brown, Manish M. Patel, Wesley H. Self, Christopher J. Lindsell, for the Influenza and Other Viruses in the Acutely Ill (IVY) Network,

Early in the COVID-19 pandemic, the World Health Organization stressed the importance of daily clinical assessments of infected patients, yet current approaches frequently consider cross-sectional timepoints, cumulative summary measures, or time-to-event analyses. Statistical methods are available that make use of the rich information content of longitudinal assessments. We demonstrate the ... Read more >>

J Clin Transl Sci (Journal of clinical and translational science)
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Cited: 0 times

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