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Amniodrainage-Induced Circulatory Dysfunction in Women Treated for Twin-To-Twin Transfusion Syndrome.

Patrick Greimel, Philipp Klaritsch, Holger Simonis, Bence Csapó, Maximilian Pohl, Daniel Schneditz,

Twin-to-twin transfusion syndrome (TTTS) in monochorionic-diamniotic twin pregnancies usually requires fetoscopic laser ablation (FLA) followed by amniodrainage (AD). Perioperative maternal hemodynamic changes and hemodilution have been observed. Little is known about the underlying pathophysiology. We aimed to evaluate the impact of high volume amniodrainage on intrauterine pressure, placental thickness and ... Read more >>

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The Inflammatory Response to Alcohol Consumption and Its Role in the Pathology of Alcohol Hangover.

Aurora J A E van de Loo, Marlou Mackus, Oran Kwon, Illathu Madhavamenon Krishnakumar, Johan Garssen, Aletta D Kraneveld, Andrew Scholey, Joris C Verster,

An increasing number of studies are focusing on the inflammatory response to alcohol as a potentially important determinant of hangover severity. In this article, data from two studies were re-evaluated to investigate the relationship between hangover severity and relevant biomarkers of alcohol metabolism, oxidative stress and the inflammatory response to ... Read more >>

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Intensive Motion Style Acupuncture Treatment (MSAT) Is Effective for Patients with Acute Whiplash Injury: A Randomized Controlled Trial.

Doori Kim, Kyoung-Sun Park, Jin-Ho Lee, Won-Hyung Ryu, Heeyoung Moon, Jiwon Park, Yong-Hyun Jeon, Ji-Yeon Seo, Young-Joo Moon, Jin Namgoong, Byung-Cheul Shin, In-Hyuk Ha,

In this single-center, parallel, randomized controlled trial, we aim to examine the effects and safety of motion style acupuncture treatment (MSAT; a combination of acupuncture and Doin therapy) on pain reduction and functional improvement in patients with whiplash-associated disorders (WADs). Ninety-seven patients with cervical pain admitted to the Bucheon Jaseng ... Read more >>

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A Potential Mechanism of Tumor Progression during Systemic Infections Via the Hepatocyte Growth Factor (HGF)/c-Met Signaling Pathway.

Hironori Tsujimoto, Hiroyuki Horiguchi, Yusuke Matsumoto, Risa Takahata, Nariyoshi Shinomiya, Takao Yamori, Hiromi Miyazaki, Satoshi Ono, Daizoh Saitoh, Yoji Kishi, Hideki Ueno,

BACKGROUND:Increasing evidence has demonstrated that postoperative infectious complications (PICs) after digestive surgery are significantly associated with negative long-term outcomes; however, precise mechanisms of how PICs affect the poor long-term survival remain unclear. Here, we focused on the hepatocyte growth factor (HGF)/c-Met signaling pathway as one of those mechanisms. Methods: In ... Read more >>

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Baseline Cognitive Performance Moderates the Effects of Physical Activity on Executive Functions in Children.

Toru Ishihara, Eric S Drollette, Sebastian Ludyga, Charles H Hillman, Keita Kamijo,

Findings regarding the effects of regular physical activity on cognition in children have been inconsistent due to a number of demographic factors and experimental considerations. The present study was designed to examine baseline cognitive performance and executive function demands, as possible factors underlying the lack of consensus in the literature, ... Read more >>

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Home Respiratory Polygraphy is Useful in the Diagnosis of Childhood Obstructive Sleep Apnea Syndrome.

Eusebi Chiner, Cristina Cánovas, Virginia Molina, Jose N Sancho-Chust, Sandra Vañes, Esther Pastor, Miguel Angel Martinez-Garcia,

The utility of home respiratory polygraphy (HRP) was assessed as an alternative to polysomnography (PSG) in the diagnosis of childhood obstructive sleep apnea syndrome (OSAS). PSG was indicated only in patients with concomitant disease or where HRP results were questionable. The follow-up period was 1 year. We recorded clinical and ... Read more >>

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Acute Coronary Syndrome, Antiplatelet Therapy, and Bleeding: A Clinical Perspective.

Gregorio Tersalvi, Luigi Biasco, Giacomo Maria Cioffi, Giovanni Pedrazzini,

Inhibition of platelet function by means of dual antiplatelet therapy (DAPT) is the cornerstone of treatment of acute coronary syndrome (ACS). While preventing ischemic recurrences, inhibition of platelet function is clearly associated with an increased bleeding risk, a feared complication that may lead to significant morbidity and mortality. Since bleeding ... Read more >>

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Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic.

Carmen Frontela-Saseta, Carlos A González-Bermúdez, Luis García-Marcos,

The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich ... Read more >>

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Childhood Trauma Predicts Less Remission from PTSD among Patients with Co-Occurring Alcohol Use Disorder and PTSD.

Paul Brunault, Kevin Lebigre, Fatima Idbrik, Damien Maugé, Philippe Adam, Servane Barrault, Grégoire Baudin, Robert Courtois, Hussein El Ayoubi, Marie Grall-Bronnec, Coraline Hingray, Nicolas Ballon, Wissam El-Hage,

Post-traumatic stress disorder (PTSD) is highly prevalent among patients hospitalized for an alcohol use disorder (AUD). Hospitalization can improve PTSD and AUD outcomes in some but not all patients, but we lack data on the baseline predictors of PTSD non-remission. This study aimed to determine the baseline risk factors for ... Read more >>

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Systematic Kleihauer-Betke Test after External Cephalic Version for Breech Presentation: Is It Useful?

Johanna Lemaitre, Lucie Planche, Guillaume Ducarme,

The incidence of fetomaternal hemorrhage (FMH) after external cephalic version (ECV) has been poorly reported. In this study, we evaluated the frequency of FMH, diagnosed by positive Kleihauer-Betke test (KBT), after ECV attempt and then evaluate the relevance of its routine use after procedure. A total of 282 women with ... Read more >>

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Vasopressors and Inotropes in Acute Myocardial Infarction Related Cardiogenic Shock: A Systematic Review and Meta-Analysis.

Mina Karami, Veemal V Hemradj, Dagmar M Ouweneel, Corstiaan A den Uil, Jacqueline Limpens, Luuk C Otterspoor, Alexander P Vlaar, Wim K Lagrand, José P S Henriques,

Vasopressors and inotropes are routinely used in acute myocardial infarction (AMI) related cardiogenic shock (CS) to improve hemodynamics. We aimed to investigate the effect of routinely used vasopressor and inotropes on mortality in AMI related CS. A systematic search of MEDLINE, EMBASE and CENTRAL was performed up to 20 February ... Read more >>

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Peptidyl Arginine Deiminase Type 4 Gene Promoter Hypo-Methylation in Rheumatoid Arthritis.

Bogdan Kolarz, Marek Ciesla, Magdalena Dryglewska, Maria Majdan,

Protein citrullination is carried out by peptidylarginine deiminase type 4 (PAD4) enzyme. As a consequence of this process, post-translationally modified proteins are formed that become antigens for anti-citrullinated protein antibodies (ACPA). The study aimed at identifying whether the PADI4 gene is subject to epigenetic regulation through methylation of its promoter ... Read more >>

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[2020, 9(7):]

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Slug Is A Surrogate Marker of Epithelial to Mesenchymal Transition (EMT) in Head and Neck Cancer.

T B Steinbichler, J Dudas, J Ingruber, R Glueckert, S Sprung, F Fleischer, N Cidlinsky, D Dejaco, B Kofler, A I Giotakis, I I Skvortsova, H Riechelmann,

BACKGROUND:Epithelial to mesenchymal transition (EMT) promotes therapy resistance in head and neck cancer (HNC) cells. In this study, EMT was quantified in HNC tumor samples by the cellular co-localization of cytokeratin/vimentin, E‑cadherin/β‑catenin and by Slug expression. METHODS:Tissue samples from HNC patients were stained with antibody pairs against cytokeratin/vimentin and E-cadherin/β-catenin. ... Read more >>

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ECG Changes in Melanoma Patients Undergoing Cancer Therapy-Data From the ECoR Registry.

Julia Pohl, Raluca-Ileana Mincu, Simone Maria Mrotzek, Lena Hinrichs, Lars Michel, Elisabeth Livingstone, Lisa Zimmer, Reza Wakili, Dirk Schadendorf, Tienush Rassaf, Matthias Totzeck,

We aimed to evaluate whether therapy with immune checkpoint inhibitors (ICI) leads to changes in electrocardiogram (ECG) parameters in melanoma patients. We retrospectively examined 41 patients (46% women, age 61 ± 12years) with advanced melanoma (stage III/IV) before and during ICI treatment from our "Essen Cardio-oncology Registry" (ECoR). ECGs were ... Read more >>

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The Impact of Preoperative Risk on the Association between Hypotension and Mortality after Cardiac Surgery: An Observational Study.

Vanja Ristovic, Sophie de Roock, Thierry G Mesana, Sean van Diepen, Louise Y Sun,

BACKGROUND:Despite steady improvements in cardiac surgery-related outcomes, our understanding of the physiologic mechanisms leading to perioperative mortality remains incomplete. Intraoperative hypotension is an important risk factor for mortality after noncardiac surgery but remains relatively unexplored in the context of cardiac surgery. We examined whether the association between intraoperative hypotension and ... Read more >>

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Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects.

Silvia Valenza, Lucia Paciaroni, Susy Paolini, Anna Rita Bonfigli, Mirko Di Rosa, Rosa Anna Rabini, Elena Tortato, Paolo Pelliccioni, Giuseppe Pelliccioni,

BACKGROUND:Type 2 diabetes (T2D) is correlated to amnestic mild cognitive impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This study evaluated whether the T2D variable characterizes a peculiar cognitive profile in elderly patients. Moreover, it explores the association between glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic ... Read more >>

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A Physiologic Approach to Hemodynamic Monitoring and Optimizing Oxygen Delivery in Shock Resuscitation.

Amy Russell, Emanuel P Rivers, Paresh C Giri, Anja K Jaehne, H Bryant Nguyen,

The approach to shock resuscitation focuses on all components of oxygen delivery, including preload, afterload, contractility, hemoglobin, and oxygen saturation. Resuscitation focused solely on preload and fluid responsiveness minimizes other key elements, resulting in suboptimal patient care. This review will provide a physiologic and practical approach for the optimization of ... Read more >>

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Role of Lopinavir/Ritonavir in the Treatment of Covid-19: A Review of Current Evidence, Guideline Recommendations, and Perspectives.

Simone Meini, Alberto Pagotto, Benedetta Longo, Igor Vendramin, Davide Pecori, Carlo Tascini,

A life-threatening respiratory illness (COVID-19) due to severe acute respiratory syndrome (SARS)-CoV-2 coronavirus was first described in December 2019 in Wuhan (China), rapidly evolving into a pandemic. In the first phase, when the viral replication plays a pivotal pathogenetic role, antiviral drugs could be crucial in limiting viral-induced organ damage. ... Read more >>

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Immunomodulation by an Omega-6 Fatty Acid Reduced Mixed Lipid Emulsion in Murine Acute Respiratory Distress Syndrome.

Matthias Hecker, Matthias Rose, Andreas Hecker, Hartmut Dietrich, Martina B Schaefer, Natascha Sommer, Werner Seeger, Konstantin Mayer,

BACKGROUND:Acute respiratory distress syndrome (ARDS) is associated with both high morbidity and mortality in intensive care units worldwide. Patients with ARDS often require parenteral nutrition with lipid emulsions as essential components. In the present study, we assessed the immunomodulatory and apoptotic effects of a modern, n-6-reduced lipid emulsion mixture in ... Read more >>

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Association of Systemic Comorbidities with Dry Eye Disease.

Motoko Kawashima, Masakazu Yamada, Chika Shigeyasu, Kazuhisa Suwaki, Miki Uchino, Yoshimune Hiratsuka, Norihiko Yokoi, Kazuo Tsubota, For The Decs-J For The Decs-J,

We investigated the association between dry eye disease and systemic comorbidities, including dry eye subtype, quality of life (QOL) and health utility among patients with dry eye disease. This cross-sectional, observational study enrolled 449 patients with dry eye disease (386 females; mean age, 62.6 ± 15.7 [range, 21-90] years). Ophthalmic ... Read more >>

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Multimodal Approach to Assessment of Fecal Microbiota Donors based on Three Complementary Methods.

Jaroslaw Bilinski, Mikolaj Dziurzynski, Pawel Grzesiowski, Edyta Podsiadly, Anna Stelmaszczyk-Emmel, Tomasz Dzieciatkowski, Lukasz Dziewit, Grzegorz W Basak,

Methods of stool assessment are mostly focused on next-generation sequencing (NGS) or classical culturing, but only rarely both. We conducted a series of experiments using a multi-method approach to trace the stability of gut microbiota in various donors over time, to find the best method for the proper selection of ... Read more >>

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Endocrinopathies Associated with Immune Checkpoint Inhibitor Cancer Treatment: A Review.

Naoko Okura, Mai Asano, Junji Uchino, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Tadaaki Yamada, Michiaki Fukui, Koichi Takayama,

Treatment with immune checkpoint inhibitors has shown efficacy against a variety of cancer types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and further therapeutic advances are ongoing. The side effects of immune checkpoint inhibitors are very different from those of conventional cytocidal anticancer drugs and ... Read more >>

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Effects of Trigger Point Dry Needling for the Management of Knee Pain Syndromes: A Systematic Review and Meta-Analysis.

Youssef Rahou-El-Bachiri, Marcos J Navarro-Santana, Guido F Gómez-Chiguano, Joshua A Cleland, Ibai López-de-Uralde- Villanueva, César Fernández-de-Las-Peñas, Ricardo Ortega-Santiago, Gustavo Plaza-Manzano,

BACKGROUND:To evaluate the effect of trigger point dry needling alone or as an adjunct with other interventions on pain and related disability in people with knee pain. METHODS:Several electronic databases were searched for randomized controlled trials where at least one group received dry needling for knee pain. Studies had to ... Read more >>

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Burden of Undiagnosed Type 2 Diabetes in Diabetic Kidney Disease: A Japanese Retrospective Cohort Study.

Hayato Tanabe, Haruka Saito, Noritaka Machii, Akihiro Kudo, Kenichi Tanaka, Koichi Asahi, Junichiro James Kazama, Michio Shimabukuro,

The risk of developing diabetic kidney disease (DKD) in patients with undiagnosed diabetes mellitus (UD) has never been evaluated. We studied the burden of UD on the risk of developing DKD in the Japanese population in a single-center retrospective cohort study. The patients with type 2 diabetes mellitus, but without ... Read more >>

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The Complex Relationship Between Serum Uric Acid, Endothelial Function and Small Vessel Remodeling in Humans.

Stefano Masi, Georgios Georgiopoulos, George Alexopoulos, Konstantinos Pateras, Javier Rosada, Gino Seravalle, Carolina De Ciuceis, Stefano Taddei, Claudio Borghi, Guido Grassi, Damiano Rizzoni, Agostino Virdis, The Study Groups On The Uric Acid Right For heArt Health Urrah, Micro-And Macro-Circulation Of The Italian Society Of Hypertension Siia,

AIMS:The relationship between serum uric acid (SUA) and microvascular remodeling in humans remains largely unexplored. We assessed whether SUA provides additional information on the severity of microvascular remodeling than that obtained from the European Heart Score (HS), the patterns of microvascular remodeling associated with changes in SUA levels and the ... Read more >>

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