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Emerging Comorbidities in Inflammatory Bowel Disease: Eating Disorders, Alcohol and Narcotics Misuse.

Paweł Kuźnicki, Katarzyna Neubauer,

Inflammatory bowel disease (IBD) is a chronic and potentially devastating condition of the digestive tract which is exemplified by increasing prevalence worldwide, byzantine pathogenesis with a poorly defined role of the environmental factors, and complex clinical demonstration. As a systemic disease, IBD may progress with a wide spectrum of extraintestinal ... Read more >>

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Diabetes, Vascular Aging and Stroke: Old Dogs, New Tricks?

Theano Penlioglou, Anca Pantea Stoian, Nikolaos Papanas,

<h4>Background</h4>Stroke remains a leading cause of death and disability throughout the world. It is well established that Diabetes Mellitus (DM) is a risk factor for stroke, while other risk factors include dyslipidaemia and hypertension. Given that the global prevalence of diabetes steadily increases, the need for adequate glycaemic control and ... Read more >>

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The Impact of Infectious Complications after Esophagectomy for Esophageal Cancer on Cancer Prognosis and Treatment Strategy.

Eisuke Booka, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Hiroya Takeuchi,

Despite advances in the perioperative management of esophagectomy, it is still a highly invasive procedure for esophageal cancer and is associated with severe postoperative complications. The two major postoperative infectious complications after esophagectomy are pulmonary complications and anastomotic leakage. We previously reported that postoperative infectious complications after esophagectomy adversely affect ... Read more >>

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A Retrospective Cohort Study of Clinical Factors Associated with Transitions of Care among COVID-19 Patients.

Dennis Swearingen, Gregory Boverman, Kristen Tgavalekos, David P Noren, Shreyas Ravindranath, Erina Ghosh, Minnan Xu, Lisa Wondrely, Pam Thompson, J David Cowden, Corneliu Antonescu,

Coronavirus Disease 2019 (COVID-19) is an international health crisis. In this article, we report on patient characteristics associated with care transitions of: 1) hospital admission from the emergency department (ED) and 2) escalation to the intensive care unit (ICU). Analysis of data from the electronic medical record (EMR) was performed ... Read more >>

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Needling Interventions for the Management of Musculoskeletal Pain Syndromes.

César Fernández-de-Las-Peñas,

Needling interventions consist of the use of filiform needles for the management of different conditions of the neuromusculoskeletal system [...]. ... Read more >>

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MRI Protocol for Pituitary Assessment in Children with Growth or Puberty Disorders-Is Gadolinium Contrast Administration Actually Needed?

Marta Michali-Stolarska, Andrzej Tukiendorf, Anna Zacharzewska-Gondek, Jagoda Jacków-Nowicka, Joanna Chrzanowska, Grzegorz Trybek, Joanna Bladowska,

The aim of this study was to assess the diagnostic value of non-contrast pituitary MRI in children with growth or puberty disorders (GPDs) and to determine the criteria indicating the necessity to perform post-contrast examination. A retrospective study included re-analysis of 567 contrast-enhanced pituitary MRIs of children treated in a ... Read more >>

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Current State of the Art and Prospects of T Cell-Redirecting Bispecific Antibodies in Multiple Myeloma.

Mashhour Hosny, Christie P M Verkleij, Jort van der Schans, Kristine A Frerichs, Tuna Mutis, Sonja Zweegman, Niels W C J van de Donk,

Multiple myeloma (MM) patients eventually develop multi-drug-resistant disease with poor survival. Hence, the development of novel treatment strategies is of great importance. Recently, different classes of immunotherapeutic agents have shown great promise in heavily pre-treated MM, including T cell-redirecting bispecific antibodies (BsAbs). These BsAbs simultaneously interact with CD3 on effector ... Read more >>

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Regulatory T-Cells and Multiple Myeloma: Implications in Tumor Immune Biology and Treatment.

Christina Hadjiaggelidou, Eirini Katodritou,

Multiple myeloma (MM) is associated with both cellular and humoral immune deficiencies and, despite significant advances in treatment, remains an incurable disease. Regulatory T-cells (Tregs) represent a critical subset of CD4 T-cells, characterized by CD4 + CD25+ Forkhead box P3+ (FoxP3+) phenotype, able to control peripheral tolerance and responses to ... Read more >>

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PD-L1 Inhibitors as Monotherapy for the First-Line Treatment of Non-Small-Cell Lung Cancer in PD-L1 Positive Patients: A Safety Data Network Meta-Analysis.

María Rosario García Campelo, Edurne Arriola, Begoña Campos Balea, Marta López-Brea, José Fuentes-Pradera, Javier de Castro Carpeno, Carlos Aguado, Diego Pérez Parente, Fidel de Oro Pulido, Pedro Ruiz-Gracia, Delvys Rodríguez-Abreu,

This network meta-analysis (NMA) evaluates the safety of first-line programmed death-ligand 1 (PD-L1) inhibitor monotherapy in advanced NSCLC patients compared to platinum-based chemotherapy. We also compared the risk of adverse events (AEs) according to programmed cell death-1 receptor (PD-1) or PD-L1 inhibitors therapy. To that end, we conducted a series ... Read more >>

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Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth?

Martina Ferrillo, Mario Migliario, Andrea Roccuzzo, Pedro Molinero-Mourelle, Giovanni Falcicchio, Giuseppina Rosaria Umano, Federica Pezzotti, Pier Luigi Foglio Bonda, Dario Calafiore, Alessandro de Sire,

Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and low birth weight (LBW), although the literature still lacks a consensus. This study aimed to investigate this correlation in a cohort of pregnant women over 20 weeks of gestation from the University Hospital "Maggiore ... Read more >>

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Evaluation of Radiographic Contrast-Induced Nephropathy by Functional Diffusion Weighted Imaging.

Thomas Andreas Thiel, Julian Schweitzer, Taogetu Xia, Eric Bechler, Birte Valentin, Andrea Steuwe, Friedrich Boege, Ralf Westenfeld, Hans-Jörg Wittsack, Alexandra Ljimani,

Contrast-induced nephropathy (CIN) resembles an important complication of radiographic contrast medium (XCM) displayed by a rise in creatinine levels 48-72 h after XCM administration. The purpose of the current study was to evaluate microstructural renal changes due to CIN in high-risk patients by diffusion weighted (DWI) and diffusion tensor imaging ... Read more >>

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Impact of Infliximab Biosimilar CT-P13 Dose and Infusion Interval on Real-World Drug Survival and Effectiveness in Patients with Ankylosing Spondylitis.

Shin-Seok Lee, Tae-Hwan Kim, Won Park, Yeong-Wook Song, Chang-Hee Suh, Soo-Kyoung Kim, Dae-Hyun Yoo,

CT-P13 is an infliximab biosimilar approved for indications including ankylosing spondylitis (AS); the approved maintenance regimen is 5 mg/kg infused every 6-8 weeks. In clinical practice, modifications to infliximab dose and/or infusion interval can be beneficial to the patient. For CT-P13, real-world data on dose and/or interval adjustment are lacking. ... Read more >>

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NOTCH3 rs1043996 Polymorphism Is Associated with the Occurrence of Alcoholic Liver Cirrhosis Independently of PNPLA3 and TM6SF2 Polymorphisms.

Ana Bainrauch, Dino Šisl, Antonio Markotić, Ana Ostojić, Slavko Gašparov, Valerija Bralić Lang, Nataša Kovačić, Danka Grčević, Anna Mrzljak, Tomislav Kelava,

Alcoholic liver cirrhosis (ALC) is the most common indication for liver transplantation (LT) in Croatia and presents a risk factor for the development of hepatocellular carcinoma (HCC). However, genetic susceptibility has not yet been systematically studied. We aimed to investigate the contribution of the risk polymorphisms <i>PNPLA3</i> rs738409, <i>EGF</i> rs4444903, ... Read more >>

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Diagnostic Yield of Transabdominal Ultrasonography for Evaluation of Pancreatic Cystic Lesions Compared with Endoscopic Ultrasonography.

Yu Ji Li, Gil Ho Lee, Min Jae Yang, Jae Chul Hwang, Byung Moo Yoo, Soon Sun Kim, Sun Gyo Lim, Jin Hong Kim,

Detection rates of pancreatic cystic lesions (PCLs) have increased, resulting in greater requirements for regular monitoring using imaging modalities. We aimed to evaluate the capability of ultrasonography (US) for morphological characterization of PCLs as a reference standard using endoscopic ultrasonography (EUS). A retrospective analysis was conducted of 102 PCLs from ... Read more >>

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Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry.

Anna Szpotowicz, Iwona Gorczyca, Olga Jelonek, Beata Uziębło-Życzkowska, Małgorzata Maciorowska, Maciej Wójcik, Robert Błaszczyk, Agnieszka Kapłon-Cieślicka, Monika Gawałko, Monika Budnik, Tomasz Tokarek, Renata Rajtar-Salwa, Jacek Bil, Michał Wojewódzki, Janusz Bednarski, Elwira Bakuła-Ostalska, Anna Tomaszuk-Kazberuk, Anna Szyszkowska, Marcin Wełnicki, Artur Mamcarz, Małgorzata Krzciuk, Beata Wożakowska-Kapłon,

<h4>Background</h4>Most atrial fibrillation (AF) patients are at high risk of thromboembolic, and the use of oral anticoagulants (OACs) is advised in such cases. The aim of the study was to evaluate the frequency at which OACs were used in patients with AF and high risk thromboembolic complications, and identify factors ... Read more >>

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Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature.

Raúl Antúnez-Conde, Carlos Navarro Cuéllar, José Ignacio Salmerón Escobar, Alberto Díez-Montiel, Ignacio Navarro Cuéllar, Giovanni Dell'Aversana Orabona, José Luis Del Castillo Pardo de Vera, Carlos Navarro Vila, José Luis Cebrián Carretero,

Intraosseous venous malformations affecting the zygomatic bone are infrequent. Primary reconstruction is usually accomplished with calvarial grafts, although the use of virtual surgical planning, cutting guides and patient-specific implants (PSI) have had a major development in recent years. A retrospective study was designed and implemented in patients diagnosed with intraosseous ... Read more >>

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The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030.

Marleen van Dijk, Sylvia M Brakenhoff, Cas J Isfordink, Wei-Han Cheng, Hans Blokzijl, Greet Boland, Anthonius S M Dofferhoff, Bart van Hoek, Cees van Nieuwkoop, Milan J Sonneveld, Marc van der Valk, Joost P H Drenth, Robert J de Knegt,

<h4>Background</h4>The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest detailed data on the Dutch HCV epidemic. ... Read more >>

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Implications for Early Diagnosis and Treatment in Schizophrenia Due to Correlation between Auditory Perceptual Deficits and Cognitive Impairment.

Nikolaos Moschopoulos, Ioannis Nimatoudis, Stergios Kaprinis, Kosmas Boutsikos, Christos Sidiras, Vasiliki Iliadou,

It is indicated that auditory perception deficits are present in schizophrenia and related to formal thought disorder. The purpose of the present study was to investigate the association of auditory deficits with cognitive impairment in schizophrenia. An experimental group of 50 schizophrenia patients completed a battery of auditory processing evaluation ... Read more >>

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Patient-Ventilator Dyssynchrony in Critically Ill Patients.

Bruno De Oliveira, Nahla Aljaberi, Ahmed Taha, Baraa Abduljawad, Fadi Hamed, Nadeem Rahman, Jihad Mallat,

Patient-ventilator dyssynchrony is a mismatch between the patient's respiratory efforts and mechanical ventilator delivery. Dyssynchrony can occur at any phase throughout the respiratory cycle. There are different types of dyssynchrony with different mechanisms and different potential management: trigger dyssynchrony (ineffective efforts, autotriggering, and double triggering); flow dyssynchrony, which happens during ... Read more >>

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Polish Physicians' Perspectives on Medical Cannabis Policy and Educational Needs: Results of An Online Survey.

Martyna Hordowicz, Jerzy Jarosz, Małgorzata Czaplińska, Agnieszka Leonhard, Anna Klimkiewicz,

(1) Background: In November 2017, medical cannabis was legalized in Poland. Until now, there have been no studies conducted to examine the perspectives of Polish physicians about their preferences regarding medical cannabis legal status and educational needs. (2) Methods: The survey was a self-developed online questionnaire with 57 participants. Participation ... Read more >>

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Rupture Rate, Functional Outcome and Patient Satisfaction after Primary Flexor Tendon Repair with the Modified 4-Strand Core Suture Technique by Tsuge and Using the Arthrex FiberLoop® with Early Motion Rehabilitation.

Stephanie Vanessa Koehler, Michael Sauerbier, Athanasios Terzis,

<h4>Purpose</h4>Our hypothesis was that the rupture rate after primary flexor tendon repair in the modified 4-strand core suture technique using the FiberLoop<sup>®</sup> (Arthrex, Munich, Germany) is lower than in other suture materials and functional outcome and patient satisfaction are superior compared to the current literature.<h4>Patients and methods</h4>A 2-stage retrospective, randomized ... Read more >>

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Quantitative Flow Ratio Is Associated with Extent and Severity of Ischemia in Non-Culprit Lesions of Patients with Myocardial Infarction.

Rosalia Dettori, Michael Frick, Kathrin Burgmaier, Richard Karl Lubberich, Martin Hellmich, Nikolaus Marx, Sebastian Reith, Mathias Burgmaier, Andrea Milzi,

Quantitative flow ratio (QFR) is a novel method to assess the relevance of coronary stenoses based only on angiographic projections. We could previously show that QFR is able to predict the hemodynamic relevance of non-culprit lesions in patients with myocardial infarction. However, it is still unclear whether QFR is also ... Read more >>

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Discrepant End-Tidal Concentrations of Sevoflurane at the Same A-Line Autoregressive Index Level during Induction of General Anesthesia: An Observational Study.

Che-Hao Hsu, Shung-Tai Ho, Chih-Cherng Lu, Ju-O Wang, Te-Chun Yeh, Tso-Chou Lin,

<h4>Background</h4>The A-Line Autoregressive Index (AAI), which is derived from auditory evoked potentials, has been used for determining anesthetic depth. This study verified the correlation between AAI values and the corresponding end-tidal concentrations of sevoflurane during general anesthesia induction.<h4>Methods</h4>Thirty young male adults undergoing elective minor orthopedic surgery were sequentially allocated to ... Read more >>

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Caval Valve Implantation (CAVI): An Emerging Therapy for Treating Severe Tricuspid Regurgitation.

Omar Abdul-Jawad Altisent, Rimantas Benetis, Egle Rumbinaite, Vaida Mizarien, Pau Codina, Francisco Gual-Capllonch, Giosafat Spitaleri, Eduard Fernandez-Nofrerias, Antoni Bayes-Genis, Rishi Puri,

Severe tricuspid regurgitation remains a challenging heart-valve disease to effectively treat with high morbidity and mortality at mid-term. Currently guideline-directed medical treatment is limited to escalating dose of diuretics, and the rationale and timing of open-heart surgery remains controversial. Emerging percutaneous therapies for severe tricuspid regurgitation continue to show promising ... Read more >>

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Fibrosis Burden of Missed and Added Populations According to the New Definition of Metabolic Dysfunction-Associated Fatty Liver.

Huiyul Park, Eileen L Yoon, Mimi Kim, Jung-Hwan Kim, Seon Cho, Dae Won Jun, Eun-Hee Nah,

Recently, the classification of fatty liver and the definition for non-alcoholic fatty liver disease (NAFLD) have been challenged. Herein, we aim to evaluate the burden of hepatic fibrosis in the missed and added populations following the proposal of the new definition of metabolic dysfunction-associated fatty liver (MAFLD) in a health ... Read more >>

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