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Journal J Chem Neuroanat

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Neurodevelopmental disorders and neurotoxicity: MicroRNA in focus.

Abhishek Jauhari, Tanisha Singh, Sanjay Yadav,

Controlled protein synthesis in different cell types is a prerequisite for the proper development and functioning of organs. Alterations in proteostasis either due to neurotoxicants (biological, chemical, or genetic) or aging promotes neuronal degeneration and result in the development of neurological disorders. Gene expression is controlled at the transcriptional, post-transcriptional, ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 120:102072]

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Human olfactory epithelium-derived stem cells ameliorate histopathological deficits and improve behavioral functions in a rat model of cerebellar ataxia.

Meysam Hassani Moghaddam, Saba Hatari, Amir Mahdi Emam Jome Shahidi, Fatemeh Nikpour, Hossein Salehi Omran, Mobina Fathi, Kimia Vakili, Mohammad Amin Abdollahifar, Mahdi Tizro, Neda Eskandari, Amir Raoofi, Vahid Ebrahimi, Abbas Aliaghaei,

Cell replacement therapy (CRT) is one of the most effective approaches used to alleviate symptoms of neurodegenerative syndromes such as cerebellar ataxia (CA). Human olfactory epithelium mesenchymal stem cells (OE-MSCs) have been recognized as a promising candidate for CRT, due to their distinctive features including immunomodulatory properties and ease of ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 120:102071]

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Reverse relationship between autophagy and apoptosis in an in vitro model of cortical neuronal injury.

Lei Zhang, Rong-Ling Pan, Yang Li, Yu-Qi Hu, Hui Xv, Chao Zhu, Xv Wang, Ke-Tao Ma, Dong Zhao,

Autophagy and apoptosis are intertwined, and their relationship involves complex cross-talk. Whether the activation and inhibition of autophagy protect or damage neurons in the central nervous system has been a matter of longstanding controversy. We investigated the effect of autophagy on the apoptosis of cortical neurons after oxygen- and glucose-deprivation/reoxygenation ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 120:102070]

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Combination of Ocimum sanctum extract and Levetiracetam ameliorates cognitive dysfunction and hippocampal architecture in rat model of Alzheimer's disease.

H S Nandini, K L Krishna, Chinnappa Apattira,

Alzheimer's disease (AD) is the most common neurodegenerative disease which affects more than 40 million people worldwide with progressive loss of memory and cognitive functions. It is reported, persistent AD is also one of the main causes of epilepsy in elders and comorbidity of both these will contribute to worsening ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 120:102069]

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The association of Edaravone with shunt surgery improves behavioral performance, reduces astrocyte reaction and apoptosis, and promotes neuroprotection in young hydrocephalic rats.

Thaís Helena Romeiro, Stephanya Covas Da Silva, Pâmella da Silva Beggiora, Gustavo Botelho Sampaio, Ricardo Andrade Brandão, Marcelo Volpon Santos, Hélio Rubens Machado, Luiza da Silva Lopes,

The neuroprotective effect of Edaravone in young hydrocephalic rats associated with a CSF derivation system was evaluated. The drug has already been shown to be beneficial in experimental hydrocephalus, but the combination of this drug with shunt surgery has not yet been investigated. Fifty-seven-day-old Wistar rats submitted to hydrocephalus by ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102059]

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Losartan enhances cognitive and structural neuroplasticity impairments in spontaneously hypertensive rats.

Heriberto Coatl-Cuaya, Hiram Tendilla-Beltrán, Luis Manuel de Jesús-Vásquez, Linda Garcés-Ramírez, María de Jesús Gómez-Villalobos, Gonzalo Flores,

Hypertension is a risk factor for vascular dementia, which is the second most prevalent type of dementia, just behind Alzheimer's disease. This highlights the brain vulnerability due to hypertension, which may increase with aging. Thus, studying how hypertension affects neural cells and behavior, as well as the effects of antihypertensives ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 120:102061]

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The effects of Gum Arabic, curcumin (Curcuma longa) and Garcinia kola on the rat hippocampus after electromagnetic field exposure: A stereological and histological study.

Abdalla Ahmed Eldaw Elamin, Omur Gulsum Deniz, Suleyman Kaplan,

The present study was designed to focus on the potential effects of the electromagnetic field (EMF) emitted by mobile phones on hippocampal pyramidal neurons and to investigate the role of curcumin (Cur), Garcinia kola (GK) and Gum Arabic (GA) in reducing these adverse effects. Fifty-four 12-week-old male Wistar albino rats ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 120:102060]

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Schisandrin A and B affect the proliferation and differentiation of neural stem cells.

Ning-Ning Cai, Qi Geng, Yu Jiang, Wen-Qian Zhu, Rui Yang, Bo-Yang Zhang, Yu-Feng Xiao, Bo Tang, Xue-Ming Zhang,

Schisandrin A and B (Sch A and B) are the important components of Asian dietary supplement and phytomedicine Schisandra chinensis (S. chinensis). They can enhance adult neurogenesis in vivo; however, these effects still need to be verified. Here NE-4 C neural stem cells (NSCs) were employed as the in vitro model ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102058]

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Immunohistochemical expression of HIF-1α, IDH1 and TP53: Prognostic profile of Moroccan patients with diffuse glioma.

Fatima Sfifou, Mounir Ouzir, El Mehdi Hakkou, Majdouline Obtel, Hassan Errihani, Abderrahmane Al Bouzidi, Redouane Abouqal, Abdessamad El Ouahabi, Nadia Cherradi,

Diffuse gliomas are growing brain tumors that occur in adult life. This study was designed to determine whether the immunohistochemical analysis of IDH1, HIF-1alpha, or TP53 can provide useful biomarkers of clinical severity and progression of diffuse gliomas. Also, it is hypothesized that the expression of IDH1 mutant induces HIF-1alpha. ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102056]

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Time dependent alteration of locomotor behavior in rat with acute liver failure induced cerebellar neuroinflammation and neuro-astroglial damage.

Abdelaati El Khiat, Omar El Hiba, Lahcen Tamegart, Hanane Rais, Naima Fdil, Souad Sellami, Mohamed Ait El Mokhtar, Halima Gamrani,

Hepatic encephalopathy (HE) is a neurophysiological syndrome secondary to acute or chronic liver failure. Studies showed that HE patients exhibit a deficit in motor coordination, which may result from cerebellar functional impairment. The aim of this study is to assess the time-dependent alteration of locomotor behavior and the glial and ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102055]

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Dendritic and behavioral changes in rats neonatally treated with homocysteine; A proposal as an animal model to study the attention deficit hyperactivity disorder.

Sandra De la Torre-Iturbe, Rubén Antonio Vázquez-Roque, Fidel De la Cruz-López, Gonzalo Flores, Linda Garcés-Ramírez,

Attention deficit hyperactivity disorder (ADHAD) is a neurobehavioral disorder that affects children and adolescents with a high prevalence. Despite its prevalence and an unclear etiology, previous reports suggest that it is closely related to homocysteine metabolism. Male Sprague Dawley rats were administered with homocysteine from postnatal day (PD) 2 to ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102057]

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Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.

Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Shu,

Chronic spinal cord injury (CSCI) results from progressive compression of the spinal cord over time. A variety of factors cause CSCI, and its exact pathogenesis is unknown. Cyclin-dependent kinase 1 (CDK1) is closely related to the apoptosis pathway, but no CSCI-related studies on CDK1 have been conducted. In this study, ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102053]

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Changes in dendritic arborization related to the estrous cycle in pyramidal neurons of layer V of the motor cortex.

Susana Castillo-Fernández, Adriana Berenice Silva-Gómez,

Many studies on neuronal plasticity have been conducted in the hippocampus and sensory cortices. In female rats in the estrus phase, when there is a low concentration of estradiol in the blood, there is a reduction in the dendritic spine density of CA1 neurons, while an increase in dendritic spines ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102042]

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Long-term effect of neonatal antagonism of ionotropic glutamate receptors on dendritic spines and cognitive function in rats.

Cesar Arturo Pinzón-Parra, Heriberto Coatl-Cuaya, Alfonso Díaz, Jorge Guevara, Antonio Rodríguez-Moreno, Gonzalo Flores,

Glutamate is the most abundant excitatory neurotransmitter in the hippocampus where mediates its actions by activating glutamate receptors. The activation of these receptors is essential for the maintenance and dynamics of dendritic spines and plasticity that correlate with learning and memory processes during neurodevelopment and adulthood. We studied in adults ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102054]

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The effects of different herbals on the rat hippocampus exposed to electromagnetic field for one hour during the prenatal period.

Ömür Gülsüm Deniz, Süleyman Kaplan,

The purpose of this study was to highlight the possible effects on the hippocampus of the electromagnetic field (EMF) emitted by mobile phones, and to investigate whether these potential effects can be reduced using various antioxidant substances. Twenty-seven female Wistar albino rats were divided into nine equal groups, each containing ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2022, 119:102043]

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Expression of matrix metalloproteinases during axonal regeneration in the goldfish spinal cord.

Akihito Takeda, Ami Kanemura, Kengo Funakoshi,

Spinal cord injury in fish produces fibrous scar, but spontaneous axonal regeneration beyond the scar sometimes occurs. A previous study revealed that regenerating axons enter the scar through tubular structures with laminin, and that an increased number of axons within the tube is coincident with enlargement of the tube diameter ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102041]

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Hippocampal chloride transporter KCC2 contributes to excitatory GABA dysregulation in the developmental rat model of schizophrenia.

Pezhman Atefimanash, Mahsa Pourhamzeh, Alireza Susanabadi, Mehrnoosh Arabi, Nida Jamali-Raeufy, Soraya Mehrabi,

Recent studies have revealed an altered expression of NKCC1 and KCC2 in prefrontal cortex (PFC) and hippocampus of schizophrenic patients. Despite extensive considerations, the alteration of NKCC1 and KCC2 co-transporters at different stages of development has not been fully studied. Therefore, we evaluated the expression of these transporters in PFC ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102040]

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Gene expression pattern of Kisspeptin and RFamide-related peptide (Rfrp) in the male Damaraland mole-rat hypothalamus.

Cornelia Voigt, Nigel C Bennett,

Damaraland mole-rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals, which exhibit high reproductive skew. Reproduction is monopolized by the dominant female of the group, while subordinates are anovulatory. Similarly, male subordinates within the colony show no sexual behaviour although they have functional gonads and do not differ from reproductive males ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102039]

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Tissue processing and optimal visualization of cerebral infarcts following sub-acute focal ischemia in rats.

Vibeke Bay, Nina K Iversen, Seyedeh Marziyeh Jabbari Shiadeh, R Andrew Tasker, Gregers Wegener, Maryam Ardalan,

Transient cerebral ischemia followed by reperfusion in an infarcted brain comes with predictable acute and chronic morphological alterations in neuronal and non-neuronal cells. An accurate delineation of the cerebral infarct is not a simple task due to the complex shapes and indistinct borders of the infarction. Thus, an exact macroscopic ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102034]

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Alpha lipoic acid ameliorates detrimental effects of maternal lipopolysaccharides exposure on prefrontal white matter in adult male offspring rats.

Zahra Namvarpour, Kobra Afsordeh, Abdollah Amini, Fatemeh Fadaei Fathabady,

<h4>Background</h4>Activation of the maternal immune system by lipopolysaccharide (LPS) increases the production of proinflammatory cytokines, free radicals, and reactive oxygen species (ROS), all of which play a significant role in the pathogenesis of many offspring neurodevelopmental disorders. Alpha Lipoic Acid (ALA) is a natural compound that has anti-inflammatory and antioxidant ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102038]

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Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice.

Stefan Schob, Joana Puchta, Karsten Winter, Dominik Michalski, Bianca Mages, Henrik Martens, Alexander Emmer, Karl-Titus Hoffmann, Frank Gaunitz, Anton Meinicke, Matthias Krause, Wolfgang Härtig,

Surfactant protein C (SP-C) modulates cerebrospinal fluid (CSF) rheology. During ageing, its declining levels are accompanied by an increased burden of white matter lesions. Pulmonary SP-C intermediates harbouring the BRICHOS-domain prevent protein misfolding in the lungs. Thus, cerebral SP-C intermediates may counteract cerebral β-amyloidosis, a hallmark of Alzheimer's disease (AD). ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102036]

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Synergistic neuroprotective effects of hyperbaric oxygen and N-acetylcysteine against traumatic spinal cord injury in rat.

Xiaocheng Zhao, Xiaopeng Zhao, Zengguang Wang,

<h4>Background</h4>The mitochondrial dysfunction and following oxidative stress, as well as the spread of inflammation plays major roles in the failure to regenerate following severe spinal cord injury (SCI). In this regard, we investigated the neuroprotective effects of hyperbaric oxygen (HBO), as an anti-apoptotic and anti-inflammatory agent, and N-acetylcysteine (NAC), as ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102037]

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Serotonin (5-hydroxytryptamine)-immunoreactive neurons in the brain of the viviparous fish Gambusia affinis.

Shilpa K Bhat, C B Ganesh,

The monoaminergic neurotransmitter serotonin (5-HT) acts as a neuromodulator and is associated with a wide range of functions in fish. In this investigation, 5-HT immunoreactivity was studied in the central nervous system (CNS) of the viviparous mosquitofish Gambusia affinis. 5-HT-immunoreactive (5-HT-ir) cells/fibres were observed throughout the subdivisions of ventral and ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102033]

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Early life exposure to poly I:C impairs striatal DA-D2 receptor binding, myelination and associated behavioural abilities in rats.

Brijendra Singh, Yogesh Kumar Dhuriya, Nisha Patro, Mahendra Kumar Thakur, Vinay Kumar Khanna, Ishan Kumar Patro,

Early-life viral infections critically influence the brain development and have been variously reported to cause neuropsychiatric diseases such as Schizophrenia, Parkinson's diseases, demyelinating diseases, etc. To investigate the alterations in the dopaminergic system, myelination and associated behavioral impairments following neonatal viral infection, the viral immune activation model was created by ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102035]

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DUSP1 regulates hippocampal damage in epilepsy rats via ERK1/2 pathway.

Li-Li Shao, Miao-Miao Gao, Jing-Xin Gong, Li-Yong Yang,

<h4>Objective</h4>To investigate the effects of DUSP1 on the hippocampal injury of young rats with epilepsy (EP) through mediating ERK1/2 signaling pathway.<h4>Methods</h4>Young SD rats were selected and divided into Control, EP, EP + LV-GFP, EP + LV-DUSP1, EP + LV-siDUSP1, and EP + LV-siDUSP1 + U0126 groups. Morris Water Maze Test ... Read more >>

J Chem Neuroanat (Journal of chemical neuroanatomy)
[2021, 118:102032]

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