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Synchronous thoracic and head-and-neck malignancies-double trouble-challenges, pitfalls, and lessons learnt.

Kanika Sharma Sood, Manisha Himthani, Aditi Tanwar, S Lakshmana Perumal,

Synchronous malignancies arising from head and neck and thorax are rare presentation, and only few cases are reported in the scientific literature. We report three cases of double primary malignancies treated at our hospital. ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):946-949]

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Calvarial metastasis from adenocarcinoma of lung: An uncommon initial presentation diagnosed by cytology.

Subrata Pal, Biswajit Biswas, Ranu Roy Biswas, Rajashree Pradhan, Abhishek Sharma,

Bone metastasis from lung primary is not uncommon and about one-third of bone metastases originate from lung. However, skull bone metastasis is uncommon from lung carcinoma. Metastasis to skull bone and scalp as an initial presentation of lung carcinoma is a very rare phenomenon. We have diagnosed a case of ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):935-937]

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A cutaneous metastasis of bronchogenic carcinoma: Milia-like lesions with dermatomal pattern.

Esra Varnali, Ayse Kavak, Yasemin Özkan, Fatma Büsra Karahacioglu,

Clinical presentation of cutaneous metastases is often variable. Presented case had an intriguing cutaneous metastasis of bronchogenic squamous cell carcinoma. Lesions were characterized by dermatomal pattern with milia-like papules, plaques, and nodules. ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):917-918]

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Q192R variant in paraoxonase 1 gene confers susceptibility to leiomyoma.

Shirin Shahbazi, Soghra Zarei, Mahnaz Torfeh, Neda Fatahi,

Objective:Paraoxonase 1 (PON1) plays a defensive role against oxidative stress by destroying oxidized lipids. Q192R single nucleotide polymorphism of PON1 gene alters the enzyme's activity. Several investigations reported a link between Q192R and an increased risk of developing tumors including uterine leiomyomas. We assessed the antioxidant effects of Q192R on ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):884-887]

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Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy.

Pelin Uysal, Cigdem Usul Afsar, Volkan Sozer, Berrin Inanc, Fulya Agaoglu, Zeynep Gural, Nevin Yaman Fazlıoglu, Caglar Cuhadaroglu, Hafize Uzun,

Background:Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):855-859]

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Evaluation of antioxidant and anticancer effects of Thymbra sintenisii subsp. isaurica extract.

Ceylan Hepokur, Sema Misir, Mehmet Çiçek, Ilhan Yaylim, Umit Zeybek,

Background:The purpose of this study was to investigate the phenolic composition and antioxidant activity of Thymbra sintenisii subsp. isaurica extract (TSIE) and, to evaluate, for the first time, anticancer effect on human MCF-7 (breast carcinoma) cells. Materials and Methods:The antioxidant capacity of TSIE was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and total ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):822-827]

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Identification of activated pathways in lung adenocarcinoma based on network strategy.

Bo Yu, Tao Li, Juan Chen, Feng-Qiang Wang, Jian-Hua Fu, Shu-Mei Liu, Yan Wang, Xin Zhang, Hai-Tao Yang,

Background:Lung adenocarcinoma has increased incidence over the past years and is the cause for almost 50% of deaths attributable to lung cancer. The objective of this paper is to identify activated pathways associated with lung adenocarcinoma based on gene co-expression network analysis. Materials and Methods:Kyoto Encyclopedia of Genes and Genomes ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):793-799]

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Definitive concurrent chemoradiotherapy outcomes in Stage IIIB nonsmall cell lung cancer patients younger than 45 years: A retrospective analysis of 145 patients.

Erkan Topkan, Ozan Cem Guler, Yurday Ozdemir,

Purpose:To assess the survival outcomes and prognostic factors of young (≤45 years) Stage IIIB nonsmall cell lung cancer (NSCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Materials and Methods:Medical records of 145 Stage IIIB NSCLC patients (≤45 years) who received 60-66 Gy thoracic radiotherapy and concurrent 1-3 cycles of cisplatin-based ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):757-763]

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Evaluation of the organs at risk doses for lung tumors in gated and conventional radiotherapy.

Sara Shahzadeh, Somayeh Gholami, Seyed Mahmood Reza Aghamiri, Hojjat Mahani, Mansoure Nabavi,

Purpose:The purpose of this study was to evaluate the organs at risk (OARs) doses for lung tumors in gated radiotherapy (RT) compared to conventional RT using the four-dimensional extended cardiac-torso (4D-XCAT) digital phantom in a simulation study. Materials and Methods:4D-XCAT digital phantom was used to create 32 digital phantom datasets ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):726-730]

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"Choosing Wisely" for cancer care in India.

C S Pramesh, Harit Chaturvedi, Vijay Anand Reddy, Tapan Saikia, Sushmita Ghoshal, Mrinalini Pandit, K Govind Babu, K V Ganpathy, Dhairyasheel Savant, Gunita Mitera, Richard Sullivan, Christopher M Booth, ,

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):955-956]

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Successful treatment of nonsmall cell lung cancer patients with leptomeningeal metastases using whole brain radiotherapy and tyrosine kinase inhibitors.

Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Tsutomu Saito,

The efficacy of treatments in patients with nonsmall cell lung cancer (NSCLC) with leptomeningeal metastases (LMs) remains unclear. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) play an important role in the treatment of patients with NSCLC. However, few studies have investigated the efficacy of combination therapy with TKIs and ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):930-932]

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Prognostic value of the neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 in estimating survival in patients with metastatic pancreatic cancer.

Sirin Cetin, Isa Dede,

Background:The predictive value of different prognostic biomarkers has been studied in various cancer types. Aims and Objectives:The purpose of this study was to examine the degree of risk and prognostic significance of pretreatment neutrophil-to-lymphocyte ratio (NLR) and carbohydrate antigen (CA) 19-9 levels in patients with metastatic pancreatic cancer (PC) and ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):909-916]

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Improvement of metallic artifacts in computed tomography in the absence of artifact reduction algorithms for spinal treatment planning applications.

Marjan Alinejad, Amir Pourmoghaddas, Alireza Amouheidari, Parvaneh Shokrani,

Aim of Study:The goal of this research was to investigate if application of optimized imaging parameters, recommended in literature, would be effective in producing the image quality required for treatment planning of spinal radiation fields with metallic implants. Materials and Methods:CT images from an anthropomorphic torso phantom with and without ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):878-883]

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Concomitant echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation in non-small cell lung cancer patients from eastern India.

Prasanta Raghab Mohapatra, Satyajeet Sahoo, Sourin Bhuniya, Manoj Kumar Panigrahi, Saroj Kumar Das Majumdar, Pritinanda Mishra, Susama Patra,

Background:In non-small cell lung cancer common driver mutations such as epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) are usually mutually exclusive. This study aimed to elucidate the concurrence of EGFR mutation and ALK rearrangement in eastern India patients with primary lung adenocarcinoma and assess the response of ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):850-854]

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The prognostic significance of the 18F-fluorodeoxyglucose positron emission tomography/computed tomography in early-stage nonsmall cell lung cancer.

Caglayan Geredeli, Mehmet Artac, Ismail Kocak, Lokman Koral, Abdullah Sakin, Tamer Altinok, Bugra Kaya, Mustafa Karaagac,

Context:The prognostic criteria for early-stage nonsmall cell lung cancer (NSCLC) wait to be explored. Aim:In this study, our aim was to evaluate the prognostic significance of the positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) value of the primary tumor in patients with a diagnosis of early-stage NSCLC ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):816-821]

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Evaluation of spirometry as a parameter of response to chemotherapy in advanced lung cancer patients: A pilot study.

Deepak Aggarwal, Prasanta R Mohapatra, Ashok K Janmeja, Varinder Saini,

Context:Spirometry is an important tool to monitor treatment response in diseases such as chronic obstructive pulmonary disease and asthma. However, there is lack of evidence to support its application to evaluate response to chemotherapy in advanced lung cancer. It might be a useful adjunct to the imaging-based response evaluation which ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):788-792]

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Can consolidative thoracic radiotherapy improve outcomes in extensive-disease small cell lung cancer after chemotherapy with complete/near-complete responders?

Esra Korkmaz Kirakli, Hasan Yilmaz, Cimen Akcay, Berna Komurcuoglu, Ufuk Yilmaz,

Background:In extensive-disease-small cell lung cancer (ED-SCLC), the median survival is 8-10 months and 2-year survival is <5%. Primary tumor progression occurs in 90% of patients approximately within 1 year. The role of consolidative thoracic radiotherapy (C-TRT) for the postchemotherapy residue with the aim of improving local control (LC) and survival ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):752-756]

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An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer.

Tao Liu, Wen-Zhou Liu, Yu Sun, Xiao-Han Bi, Hua-Fu Zhou,

Aim of Study:There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):718-725]

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Epidermal growth factor receptor-activating mutation(E746_T751>VP) in pancreatic ductal adenocarcinoma responds to erlotinib, followed by epidermal growth factor receptor resistance-mediating mutation (A647T): A case report and literature review.

Girijesh Kumar Patel, Josiah B Perry, Osama Abdul-Rahim, Arthur E Frankel, Daniel Cameron, William Taylor, Rodney P Rocconi, Laith Abushahin, Cindy Nelson, Ajay P Singh, Moh'd Khushman,

Despite recent advances in treatment with multidrug chemotherapy regimens, outcomes of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remain very poor. Treatment with targeted therapies has shown marginal benefits due to intrinsic or acquired resistance. Actionable mutations, while detected infrequently in patients with PDAC, are becoming increasingly used in personalized ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):950-954]

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Long-term survival of a patient with programmed death ligand 1-negative lung adenocarcinoma and oligoprogressive disease treated with nivolumab and stereotactic body radiation therapy.

Miguel J Sotelo, Santiago Cabezas-Camarero, Alejandro Riquelme, Coralia Bueno,

Immune-checkpoint inhibitors have shown to prolong survival in patients with metastatic non-small cell lung cancer. Programmed death ligand 1 (PD-L1) expression is associated with a higher probability of response, although some patients with PD-L1 negative tumors may also respond or show durable stabilizations. However, the optimal strategy after progression to ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):941-945]

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Diagnostic dilemma of a thumb swelling: An unpropitious turn of events.

Seetharama B Rao, Pooja K Suresh, Merwyn Fernandes, Laxman G G Prabhu, Saraswathy Sreeram, Rajendra Annappa,

Benign and malignant bone tumors arise in small bones of the hands and feet. Nevertheless, secondary deposits at these sites are extremely rare. We report a peculiar case of an adult man who presented with thumb swelling, which was later discovered to be a metastasis from renal cell carcinoma. Such ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):926-929]

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Prognostic factors and clinical course of extremity soft-tissue sarcomas.

Gülsen Pinar Soydemir, Zümrüt Bahat, Mustafa Kandaz, Emine Canyilmaz, Adnan Yöney,

Purpose:Although soft tissue constitutes half of the body weight, soft-tissue sarcomas (STSs) are less common than any other types of tumors. Materials and Methods:In this retrospective study, the prognostic factors and clinical courses of 64 patients with extremity STSs treated at our clinic between 1996 and 2012 were investigated. Results:Of ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):903-908]

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Heme oxygenase-1 in osteosarcoma.

Simmi Kharb, M Halder, Z S Kundu,

Aim of Study:The present study was planned to analyze serum heme oxygenase-1 levels in osteosarcoma patients. Materials and Methods:Twenty five histopathologically confirmed cases of osteosarcoma localized without metastasis of all the ages attending the Orthopedic Clinics were included in the study group and twenty five patients having musculoskeletal pain (age ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):874-877]

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Correlation of epidermal growth factor receptor mutation status in plasma and tissue samples of patients with non-small cell lung cancer.

Mee-Sook Roh, Neul-Bom Yoon, Seul Lee, Bo-Hyoung Kang, Soo-Jung Um, Dong-Hyun Lee, Choonhee Son,

Background:Somatic mutations of the gene encoding epidermal growth factor receptor (EGFR) are detected in approximately 30%-50% of patients with non-small cell lung cancers (NSCLC), so detection of EGFR mutation is the pivotal step of treatment in patients with advanced NSCLC. However, difficulty in obtaining sufficient tissue and bias from the ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):843-849]

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Association of cytokines levels with epidermal growth factor receptor mutation in lung cancer patients.

Priyanka Gaur, Sandeep Bhattacharya, Surya Kant, R A S Kushwaha, Gaurav Singh, Sarika Pandey,

Background:Lung cancer is one of the most frequent types of cancer and the leading cause of cancer-related deaths. Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (TK) being highly expressed in lung cancers. Activation of EGFR through oncogenic mutations leads to upregulation of gene expression that may heighten ... Read more >>

J Cancer Res Ther (Journal of cancer research and therapeutics)
[2020, 16(4):811-815]

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