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Treatment of microvascular invasion in hepatocellular carcinoma with drug-loaded nanocomposite platform under synergistic effect of magnetic field/near-infrared light.

Daren Liu, Jinhong Wu, Huanbing Zhu, Xiuliang Zhu, Yun Jin, Yuanquan Yu, Xiaoxiao Zhang,

Despite progress in clinical treatment, microvascular invasion (MVI) remains a major factor for frequent recurrence and metastasis of hepatocellular carcinoma (HCC) after liver resection and surgery. Thus, this study constructed a target nanoplatform (αCD97-USPIO-Au-DDP) with magnetic field/near-infrared (NIR) light response using ultrasmall superparamagnetic iron oxide-gold nanoporous spheres (USPIO-Au) as multifunctional ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Computational tibial bone remodeling over a population after total knee arthroplasty: A comparative study.

Thomas Anijs, Sanne Eemers, Yukihide Minoda, David Wolfson, Nico Verdonschot, Dennis Janssen,

Periprosthetic bone loss is an important factor in tibial implant failure mechanisms in total knee arthroplasty (TKA). The purpose of this study was to validate computational postoperative bone response using longitudinal clinical DEXA densities. Computational remodeling outcome over a population was obtained by incorporating the strain-adaptive remodeling theory in finite ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Different grinding speeds affect induced regeneration capacity of human treated dentin matrix.

Min Li, Sen Yang, Jinlin Song, Tiwei Fu, Panpan Liang, Zhi Gao, Jing Tang, Lijuan Guo,

Human-treated dentin matrix (hTDM) is a biomaterial scaffold, which can induce implant cells to differentiate into odontoblasts and then form neo-dentin. However, hTDM with long storage or prepared by high-speed handpiece would not to form neo-dentin. In this research, we developed two fresh hTDM with different grinding speeds, which were ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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The passive behavior of biomedical alloys in simulated physiological solutions.

Bruce G Pound,

Passive alloys are commonly considered to exhibit a current that is essentially independent of potential over the passive range in neutral chloride solutions. However, the current-potential dependence of Ti and its alloys, CoCr alloys, and 316L stainless steel in buffered, simulated physiological solutions containing phosphate differs from that usually reported ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Evaluation of the in vivo acute toxicity of poly(thioether-ester) and superparamagnetic poly(thioether-ester) nanoparticles obtained by thiol-ene miniemulsion polymerization.

Paulo Emilio Feuser, Mariana de Melo Cardoso, Nathalia Coral Galvani, Rubya Pereira Zaccaron, Ligia Milanez Venturini, Flavia Karine Rigo, Ricardo Andrez Machado-de-Ávila, Paulo Cesar Lock Silveira, Claudia Sayer, Pedro Henrique Hermes de Araújo,

Poly(thioether-ester) (PTEe) nanoparticles obtained by thiol-ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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In vivo evaluation of bone repair guided with biological membrane based on polyhydroxybutyrate and norbixin.

Rayssilane C Sousa, Vicente G F Viana, Luiz F C Meneses, Antônio L M Maia Filho, Francisco E P Santos, Marleane M F Azevedo, Hélio M S Nascimento, Lucielma S S Pinto, Daniel F P Vasconcelos,

The present work aimed to synthesize and verify the effectiveness of the polyhydroxybutyrate and norbixin membrane as a scaffold in bone defects induced in the tibia of rats. Twenty-four male Rattus norvegicus rats were used, divided into control and membrane groups. After anesthesia, a bone defect was induced in the ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Toward allogenizing a xenograft: Xenogeneic cardiac scaffolds recellularized with human-induced pluripotent stem cells do not activate human naïve neutrophils.

Reem S Al-Hejailan, Razan H Bakheet, Mashael M Al-Saud, Mansour B Al-Jufan, Hussain M Al-Hindas, Somaya M Al-Qattan, Muhanna K Al-Muhanna, Ranjit S Parhar, Walter Conca, Jan Hansmann, Kate S Collison, Heike Walles, Futwan A Al-Mohanna,

The limited availability of human donor organs suitable for transplantation has resulted in ever-increasing patient waiting lists globally. Xenotransplantation is considered a potential option, but is yet to reach clinical practice. Although remarkable progress has been made in overcoming immunological rejection, issues with functionality are still to be resolved. Bioengineering ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Microstructure, corrosion rate, and mechanical properties of unidirectionally and cross-rolled Mg-0.375Ga and Mg-0.750Ga alloys.

Anabel A Hernández-Cortés, José C Escobedo-Bocardo, Dora A Cortés-Hernández, Ricardo H Vazquez-Montiel, J Salomón Peralta-Montes, José M Almanza-Robles,

The effect of unidirectional and cross rolling on the corrosion rate, texture, tensile properties and hemolysis of the Mg-0.375Ga and Mg-0.750Ga alloys was evaluated. Pure Mg and as-cast alloys were processed by unidirectional and cross rolling at 400°C to obtain a total thickness reduction of 50%. The corrosion rate was ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Advances in electrospun scaffolds for meniscus tissue engineering and regeneration.

Xiaoyu Wang, Yangfan Ding, Haiyan Li, Xiumei Mo, Jinglei Wu,

The meniscus plays a critical role in maintaining the homeostasis, biomechanics, and structural stability of the knee joint. Unfortunately, it is predisposed to damages either from sports-related trauma or age-related degeneration. The meniscus has an inherently limited capacity for tissue regeneration. Self-healing of injured adult menisci only occurs in the ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Dehydrated human amniotic membrane regulates tenocyte expression and angiogenesis in vitro: Implications for a therapeutic treatment of tendinopathy.

Sarah E Moreno, Michelle Massee, Thomas J Koob,

Tendon injuries are among the most common ailments of the musculoskeletal system. Prolonged inflammation and persistent vasculature are common complications associated with poor healing. Damaged tendon, replaced with scar tissue, never completely regains the native structural or biomechanical properties. This study evaluated the effects of micronized dehydrated human amnion/chorion membrane ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Electrospinning of cyanoacrylate tissue adhesives for human dural repair in endonasal surgery.

Brooke Campbell, Zoe Anderson, Daewoo Han, Ivanna Nebor, Jonathan Forbes, Andrew J Steckl,

Cerebral spinal fluid (CSF) leakage is a major postoperative complication requiring surgical intervention, resulting in prolonged healing and higher costs. Biocompatible polymers, such as cyanoacrylates, are currently used as tissue adhesives for closing surgical defects and incisions. Coupling these polymers with nanofiber technology shows promising results for generating nanofibers used ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Simple synthesis route for fabrication of protective photo-crosslinked poly(zwitterionic) membranes for application in non-enzymatic glucose sensing.

Adrian Olejnik, Jakub Karczewski, Anna Dołęga, Katarzyna Siuzdak, Adam Cenian, Katarzyna Grochowska,

This work focuses on the fabrication of non-enzymatic glucose sensing materials based on laser-formed Au nanoparticles embedded in Ti-textured substrates. Those materials possess good catalytic activity toward glucose oxidation in 0.1 × phosphate buffered saline as well as resistance to some interferants, such as ascorbic acid, urea, and glycine. The electrodes are ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Coinciding significance of the crystallographic orientation and nanostructuring on the biocompatibility of TZNT-Ag1 .5 alloy deformed by the cold rolling process.

Amir Zareidoost, Mardali Yousefpour,

In this study, the simultaneous significance of the crystallographic texture and nanostructuring on the cytocompatibility of as-cast (Ti<sub>55</sub> Zr<sub>25</sub> Nb<sub>10</sub> Ta<sub>10</sub> )<sub>98.5</sub> -Ag<sub>1.5</sub> alloy (at. %, TZNT-Ag<sub>1.5</sub> ), subjected to cold rolling up to 90% reduction, along with the changes of Young's modulus and hardness under cold rolling were investigated. ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Probability of survival and stress distribution of narrow diameter implants with different implant-abutment taper angles.

Mariana I M Freitas, Rafael S Gomes, Mirelle M Ruggiero, Edmara T P Bergamo, Estevam A Bonfante, Raissa M Marcello-Machado, Altair A Del Bel Cury,

This study evaluated the probability of survival, failure mode, and stress distribution of narrow diameter implants (NDIs) with internal implant-abutment conical connection comprised of different taper angles and thread designs. Sixty-three NDIs (Ø 3.5 × 8.5 mm) were divided according to the taper angle (TA), internal diameter (ID), and trapezoidal thread design (TD) ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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In vivo efficacy of 3D-printed elastin-gelatin-hyaluronic acid scaffolds for regeneration of nasal septal cartilage defects.

Abbas Shokri, Kousar Ramezani, Mohammad Reza Jamalpour, Chiman Mohammadi, Farshid Vahdatinia, Amin Doosti Irani, Esmaeel Sharifi, Rasool Haddadi, Shokoofeh Jamshidi, Leila Mohammadi Amirabad, Sanaz Tajik, Amir Yadegari, Lobat Tayebi,

Nasal septal cartilage perforations occur due to the different pathologies. Limited healing ability of cartilage results in remaining defects and further complications. This study sought to assess the efficacy of elastin-gelatin-hyaluronic acid (EGH) scaffolds for regeneration of nasal septal cartilage defects in rabbits. Defects (4 × 7 mm) were created in the nasal ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Development and characterization of monoterpene loaded microemulsions as novel scolicidal agents.

Mohaddeseh Abouhosseini Tabari, Milad Kashani Rad, Mohammad Reza Youssefi, Filippo Maggi, Marco Cespi, Lucia Pavoni, Giulia Bonacucina,

Cystic echinococcosis (CE) is one of the most important zoonotic diseases. The primary treatment is surgery and chemical sterilization of the parasitic layers by injection of a scolicidal agent. Available scolicidals possess side effects, and may cause postoperative complications. Several studies reported the scolicidal properties of monoterpene phenols and alcohols ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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New polyoxazoline loaded patches for hemostasis in experimental liver resection.

Edwin A Roozen, Michiel C Warlé, Roger M L M Lomme, Rosa P Félix Lanao, Harry van Goor,

A new cost-effective NHS functionalized polyoxazoline (POx) loaded polymer with strong hemostatic properties has been developed. In this study, we investigate POx loaded hemostatic patches regarding hemostatic efficacy, local inflammatory reaction and wound-healing, as compared to the non-POx treated blanks and commercially available hemostatic products. Hundred and ten rats divided ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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ePTFE-based biomedical devices: An overview of surgical efficiency.

Yaëlle Roina, Frédéric Auber, Didier Hocquet, Guillaume Herlem,

Polytetrafluoroethylene (PTFE) is a ubiquitous material used for implants and medical devices in general because of its high biocompatibility and inertness: blood vessel, heart, table jawbone, nose, eyes, or abdominal wall can benefit from its properties in case of disease or injury. Its expanded version, ePTFE is an improved version ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Influence of UV-irradiation intensity and exposure duration on the hemobiocompatibility enhancement of a novel synthesized phosphobetaine zwitterions polyethersulfone clinical hemodialysis membranes.

Ubong Eduok, Heloisa Camara, Amira Abdelrasoul, Ahmed Shoker,

To improve the biocompatibility of polyethersulfone (PES) membranes utilized for biomedical hemodialysis (HD) applications, surface grafting with hydrophilic polymers has become a reliable modification strategy. Like most photochemical catalyzed reactions, UV-assisted grafting is distinctly advantageous for inducing permanent surface chemistry, enhancing hydrophilicity, improving morphology, and surface charge of membranes. PES ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Integration of clinical perspective into biomimetic bioreactor design for orthopedics.

Victoria Drapal, Jordan M Gamble, Jennifer L Robinson, Candan Tamerler, Paul M Arnold, Elizabeth A Friis,

The challenges to accommodate multiple tissue formation metrics in conventional bioreactors have resulted in an increased interest to explore novel bioreactor designs. Bioreactors allow researchers to isolate variables in controlled environments to quantify cell response. While current bioreactor designs can effectively provide either mechanical, electrical, or chemical stimuli to the ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Effect of bioactive glasses containing strontium and potassium on dentin permeability.

Luisa Alegria Acevedo, Letícia Antonelo Campos, Iolanda Cristina Dechandt, Gustavo Alegria, Renato Luiz Siqueira, Edgar Dutra Zanotto, Francisco Carlos Serbena, Fabio André Santos,

Dentin hypersensitivity (DH) is characterized by pain caused by an external stimulus on exposed dentin. Different therapeutic approaches have been proposed to mitigate this problem; however, none of them provide permanent pain relief. In this study, we synthesized and characterized experimental bioactive glasses containing 3.07 mol% SrO or 3.36 mol% K<sub>2</sub> O ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Mechanical properties and in vitro bioactivity of silicon nitride ceramics with SiO2 , CaO, and MgO additions.

Celso Ricardo Sona Filho, Flávio Machado de Souza Carvalho, Cecilia Chaves Guedes-Silva,

Silicon nitride ceramics with SiO<sub>2</sub> , CaO, and MgO as sintering aids were investigated in view of biomedical applications. In the current study, samples with four different compositions were pressureless sintered at 1750<sup>°C</sup> for 1 h under a nitrogen atmosphere. The samples were evaluated concerning densification, microstructure, mechanical properties, and in ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Enhancement of the anticoagulant capacity of polyvinyl chloride tubing for cardiopulmonary bypass circuit using aluminum oxide nanoscale coating applied through atomic layer deposition.

Chen-Chie Wang, Li-Chun Wang, Kai-Chiang Yang, Miin-Jang Chen, Hsin-Chih Lin, Yin-Yi Han,

For cardiopulmonary bypass, the polyvinyl chloride (PVC) circuit which can initiate the activation of platelets and the coagulation cascade after blood cell contacting is the possible detrimental effect. Surface coating of the PVC tubing system can be an effective approach to enhance circuit's hemocompatibility. In this study, aluminum oxide (Al<sub>2</sub> ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Fabrication of collagen with polyhexamethylene biguanide: A potential scaffold for infected wounds.

Sripriya Ramasamy, Senthilkumar Muthusamy, Sureshbabu Nagarajan, Asha V Nath, Jayaraj Santiyagu Savarimuthu, Jayanthi Jayaprakash, Ragunathan Manikavali Gurunadhan,

Bacterial infection remains a great challenge in wound healing, especially in chronic wounds. Multidrug-resistant organisms are increasing in acute and chronic wound infections, which compromise the chance of therapeutics. Resistance to conventional antibiotics has created an urge to study new approach/system that can effectively control wound infection and enhance healing. ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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Influence of electron beam irradiation on extracellular matrix of the human allogeneic skin grafts.

Wojciech Łabuś, Diana Kitala, Agnieszka Klama-Baryła, Michał Szapski, Małgorzata Kraut, Wojciech Smętek, Justyna Glik, Marek Kucharzewski, Ewa Rojczyk, Alicja Utrata-Wesołek, Barbara Trzebicka, Urszula Szeluga, Michał Sobota, Ryszard Poloczek, Artur Kamiński,

The nonviable allogeneic human skin grafts might be considered as the most suitable skin substitutes in the treatment of extensive and deep burns. However, in accordance to biological security such grafts require the final sterilization prior to clinical application. The aim of the study was to verify the influence of ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, :]

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