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Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase.

Pablo Lazcano, Michael W Schmidtke, Chisom Onu, Miriam L Greenberg,

Inositol is an essential metabolite that serves as a precursor for structural and signaling molecules. Although perturbation of inositol homeostasis has been implicated in numerous human disorders, surprisingly little is known about how inositol levels are regulated in mammalian cells. A recent study in mouse embryonic fibroblasts (MEFs) demonstrated that ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2022, :102363]

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Reisomerization of retinal represents a molecular switch mediating Na+ uptake and release by a bacterial sodium-pumping rhodopsin.

Tomotsumi Fujisawa, Kouta Kinoue, Ryouhei Seike, Takashi Kikukawa, Masashi Unno,

Sodium-pumping rhodopsins (NaRs) are membrane transporters that utilize light energy to pump Na+ across the cellular membrane. Within the NaRs, the retinal Schiff base chromophore absorbs light, and a photochemically-induced transient state, referred to as the "O intermediate", performs both the uptake and release of Na+. However, the structure of ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2022, :102366]

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