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Journal J Am Heart Assoc

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Antithrombotic Therapy for Atrial Fibrillation and Coronary Artery Disease in Patients With Prior Atherothrombotic Disease: A Post Hoc Analysis of the AFIRE Trial.

Yasushi Matsuzawa, Kazuo Kimura, Satoshi Yasuda, Koichi Kaikita, Masaharu Akao, Junya Ako, Tetsuya Matoba, Masato Nakamura, Katsumi Miyauchi, Nobuhisa Hagiwara, Atsushi Hirayama, Kunihiko Matsui, Hisao Ogawa, ,

Background Among patients with atrial fibrillation and stable coronary artery disease, those with histories of atherothrombotic disease are at high-risk for future ischemic events. This study investigated the efficacy and safety of rivaroxaban monotherapy in patients with atrial fibrillation, coronary artery disease, and histories of atherothrombotic disease. Methods and Results ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020907]

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Supplementing Existing Societal Risk Models for Surgical Aortic Valve Replacement With Machine Learning for Improved Prediction.

Arman Kilic, Robert H Habib, James K Miller, David M Shahian, Joseph A Dearani, Artur W Dubrawski,

Background This study evaluated the role of supplementing Society of Thoracic Surgeons (STS) risk models for surgical aortic valve replacement with machine learning (ML). Methods and Results Adults undergoing isolated surgical aortic valve replacement in the STS National Database between 2007 and 2017 were included. ML models for operative mortality ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e019697]

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Are Unselected Risk Scores in the Cardiac Intensive Care Unit Needed?

P Elliott Miller, Jacob Jentzer, Jason N Katz,

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021940]

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Sex- and Age-Based Temporal Trends in Takotsubo Syndrome Incidence in the United States.

Varun K Pattisapu, Hua Hao, Yunxian Liu, Trevor-Trung Nguyen, Amy Hoang, C Noel Bairey Merz, Susan Cheng,

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e019583]

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Important Questions Deserve Rigorous Analysis: A Cautionary Note About Selection Bias.

Lucia C Petito, Louisa H Smith,

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e023234]

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Outcomes of Venoarterial Extracorporeal Membrane Oxygenation for Cardiac Arrest in Adult Patients in the United States.

George Gill, Jignesh K Patel, Diego Casali, Georgina Rowe, Hongdao Meng, Dominick Megna, Joanna Chikwe, Puja B Parikh,

Background Factors associated with poor prognosis following receipt of extracorporeal membrane oxygenation (ECMO) in adults with cardiac arrest remain unclear. We aimed to identify predictors of mortality in adults with cardiac arrest receiving ECMO in a nationally representative sample. Methods and Results The US Healthcare Cost and Utilization Project's National ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021406]

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Syndrome of Reversible Cardiogenic Shock and Left Ventricular Ballooning in Obstructive Hypertrophic Cardiomyopathy.

Mark V Sherrid, Daniel G Swistel, Iacopo Olivotto, Maurizio Pieroni, Omar Wever-Pinzon, Katherine Riedy, Richard G Bach, Mustafa Husaini, Sharon Cresci, Alex Reyentovich, Daniele Massera, Martin S Maron, Barry J Maron, Bette Kim,

Background Cardiogenic shock from most causes has unfavorable prognosis. Hypertrophic cardiomyopathy (HCM) can uncommonly present with apical ballooning and shock in association with sudden development of severe and unrelenting left ventricular (LV) outflow obstruction. Typical HCM phenotypic features of mild septal thickening, outflow gradients, and distinctive mitral abnormalities differentiate these ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021141]

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Prognostic Value of Transthoracic Doppler Echocardiography Coronary Flow Velocity Reserve in Patients With Asymmetric Hypertrophic Cardiomyopathy.

Milorad Tesic, Branko Beleslin, Vojislav Giga, Ivana Jovanovic, Jelena Marinkovic, Danijela Trifunovic, Olga Petrovic, Milan Dobric, Srdjan Aleksandric, Stefan Juricic, Nikola Boskovic, Miloje Tomasevic, Arsen Ristic, Dejan Orlic, Sinisa Stojkovic, Vladan Vukcevic, Goran Stankovic, Miodrag Ostojic, Ana Djordjevic Dikic,

Background Microvascular dysfunction might be a major determinant of clinical deterioration and outcome in patients with hypertrophic cardiomyopathy (HCM). However, long-term prognostic value of transthoracic Doppler echocardiography (TDE) coronary flow velocity reserve (CFVR) on clinical outcome is uncertain in HCM patients. Therefore, the aim of our study was to assess ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021936]

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Sex Differences in the Utilization and Outcomes of Cardiac Valve Replacement Surgery for Infective Endocarditis: Insights From the National Inpatient Sample.

Agam Bansal, Paul C Cremer, Wael A Jaber, Penelope Rampersad, Venu Menon,

Background The data on the differential impact of sex on the utilization and outcomes of valve replacement surgery for infective endocarditis are limited to single-center and small sample size patient population. Methods and Results We utilized the National Inpatient Sample database to identify patients with a discharge diagnosis of infective ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020095]

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Long-Term (7-Year) Clinical Implications of Newly Unveiled Asymptomatic Abnormal Ankle-Brachial Index in Patients With Coronary Artery Disease.

Jong-Young Lee, Seung-Jae Lee, Seung-Whan Lee, Tae Oh Kim, Yujin Yang, Yeong Jin Jeong, Hanbit Park, Junghoon Lee, Junho Hyun, Ju Hyeon Kim, Pil Hyung Lee, Soo-Jin Kang, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park,

Background The long-term impact of newly discovered, asymptomatic abnormal ankle-brachial index (ABI) in patients with significant coronary artery disease is limited. Methods and Results Between January 2006 and December 2009, ABI was evaluated in 2424 consecutive patients with no history of claudication or peripheral artery disease who had significant coronary ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021587]

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Highly Selective PPARα (Peroxisome Proliferator-Activated Receptor α) Agonist Pemafibrate Inhibits Stent Inflammation and Restenosis Assessed by Multimodality Molecular-Microstructural Imaging.

Hiroshi Iwata, Eric A Osborn, Giovanni J Ughi, Kentaro Murakami, Claudia Goettsch, Joshua D Hutcheson, Adam Mauskapf, Peter C Mattson, Peter Libby, Sasha A Singh, Joan Matamalas, Elena Aikawa, Guillermo J Tearney, Masanori Aikawa, Farouc A Jaffer,

BACKGROUND New pharmacological approaches are needed to prevent stent restenosis. This study tested the hypothesis that pemafibrate, a novel clinical selective PPARα (peroxisome proliferator-activated receptor α) agonist, suppresses coronary stent-induced arterial inflammation and neointimal hyperplasia. METHODS AND RESULTS Yorkshire pigs randomly received either oral pemafibrate (30 mg/day; n=6) or control vehicle ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020834]

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Falling Through the Cracks: The Current Gap in the Health Care Transition of Patients With Kawasaki Disease: A Scientific Statement From the American Heart Association.

Nagib Dahdah, Samuel C Kung, Kevin G Friedman, Ariane Marelli, John B Gordon, Ermias D Belay, Annette L Baker, Dhruv S Kazi, Patience H White, Adriana H Tremoulet, ,

Background Health care transition (HCT) is a period of high vulnerability for patients with chronic childhood diseases, particularly when patients shift from a pediatric to an adult care setting. An increasing number of patients with Kawasaki disease (KD) who develop medium and large coronary artery aneurysms (classified by the American ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e023310]

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Sex Differences in Cardiovascular Research: A Scientometric Analysis.

Dominic Millenaar, Markus Dillmann, Tobias Fehlmann, Alexander Flohr, Roxana Mehran, Rasha Al-Lamee, Lucas Lauder, Christian Ukena, Michael Böhm, Andreas Keller, Felix Mahfoud,

Background We sought to investigate sex-specific differences in authorship of cardiovascular research over the past decade. Methods and Results All 387 463 cardiovascular publications between 2010 and 2019 were retrieved from Web of Science. Articles increased from 19 960 to 29 604 articles per year (<i>P</i>>0.001). The number of articles written by female ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021522]

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Dual Antiplatelet Therapy Using Cilostazol in Patients With Stroke and Intracranial Arterial Stenosis.

Shinichiro Uchiyama, Kazunori Toyoda, Katsuhiro Omae, Ryotaro Saita, Kazumi Kimura, Haruhiko Hoshino, Nobuyuki Sakai, Yasushi Okada, Kortaro Tanaka, Hideki Origasa, Hiroaki Naritomi, Kiyohiro Houkin, Keiji Yamaguchi, Masanori Isobe, Kazuo Minematsu, Masayasu Matsumoto, Teiji Tominaga, Hidekazu Tomimoto, Yasuo Terayama, Satoshi Yasuda, Takenori Yamaguchi,

Background Long-term benefit of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been established in patients with intracranial arterial stenosis. We compared the efficacy and safety of DAPT with cilostazol and clopidogrel or aspirin to those of SAPT with clopidogrel or ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e022575]

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Impact of Peripheral Microvascular Endothelial Dysfunction on White Matter Hyperintensity.

Takumi Toya, Jaskanwal D Sara, Eugene L Scharf, Ali Ahmad, Valentina Nardi, Ilke Ozcan, Lilach O Lerman, Amir Lerman,

Background White matter hyperintensity (WMH), characterized by hyperintensities on T2-weighted fluid-attenuated inversion recovery brain magnetic resonance imaging, has been linked to an increased risk of ischemic stroke (IS). Endothelial dysfunction is an indicator of vascular dysfunction, predicting the risk of IS. This study aimed to investigate the association between endothelial ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021066]

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Drug-Eluting or Bare-Metal Stents for Left Anterior Descending or Left Main Coronary Artery Revascularization.

Raffaele Piccolo, Kaare H Bonaa, Orestis Efthimiou, Olivier Varenne, Philip Urban, Christoph Kaiser, Lorenz Räber, Adam de Belder, Wouter Remkes, Arnoud W J Van't Hof, Goran Stankovic, Pedro A Lemos, Tom Wilsgaard, Jörg Reifart, Alfredo E Rodriguez, Expedito E Ribeiro, Patrick W J C Serruys, Alex Abizaid, Manel Sabaté, Robert A Byrne, Jose M de la Torre Hernandez, William Wijns, Giovanni Esposito, Peter Jüni, Stephan Windecker, Marco Valgimigli, ,

Background New-generation drug-eluting stents (DES) reduce target-vessel revascularization compared with bare-metal stents (BMS), and recent data suggest that DES have the potential to decrease the risk of myocardial infarction and cardiovascular mortality. We evaluated the treatment effect of DES versus BMS according to the target artery (left anterior descending [LAD] ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e018828]

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Impact of Diastolic Interventricular Septal Flattening on Clinical Outcome in Patients With Severe Tricuspid Regurgitation.

Taku Omori, Mika Maeda, Shunsuke Kagawa, Goki Uno, Florian Rader, Robert J Siegel, Takahiro Shiota,

Background Little is known about the impact of diastolic interventricular septal flattening on the clinical outcome in patients with severe tricuspid regurgitation. This study sought to evaluate the association of diastolic interventricular septal flattening with clinical outcome in patients with severe tricuspid regurgitation. Methods and Results We retrospectively studied 407 ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021363]

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Inhibition of Aryl Hydrocarbon Receptor Attenuates Hyperglycemia-Induced Hematoma Expansion in an Intracerebral Hemorrhage Mouse Model.

Reng Ren, Qin Lu, Prativa Sherchan, Yuanjian Fang, Cameron Lenahan, Lihui Tang, Yi Huang, Rui Liu, John H Zhang, Jianmin Zhang, Jiping Tang,

Background Hyperglycemia is associated with greater hematoma expansion (HE) and worse clinical prognosis after intracerebral hemorrhage (ICH). However, the clinical benefits of intensive glucose normalization remain controversial, and there are no approved therapies for reducing HE. The aryl hydrocarbon receptor (AHR) has been shown to participate in hyperglycemia-induced blood-brain barrier ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e022701]

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Health Care Policy and Congenital Heart Disease: 2020 Focus on Our 2030 Future.

Devyani Chowdhury, Jonathan N Johnson, Carissa M Baker-Smith, Robert D B Jaquiss, Arjun K Mahendran, Valerie Curren, Aarti Bhat, Angira Patel, Audrey C Marshall, Stephanie Fuller, Bradley S Marino, Christina M Fink, Keila N Lopez, Lowell H Frank, Mishaal Ather, Natalie Torentinos, Olivia Kranz, Vivian Thorne, Ryan R Davies, Stuart Berger, Christopher Snyder, Arwa Saidi, Kenneth Shaffer,

The congenital heart care community faces a myriad of public health issues that act as barriers toward optimum patient outcomes. In this article, we attempt to define advocacy and policy initiatives meant to spotlight and potentially address these challenges. Issues are organized into the following 3 key facets of our ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020605]

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Bilirubin Nanoparticles Protect Against Cardiac Ischemia/Reperfusion Injury in Mice.

Wen Ai, Soochan Bae, Qingen Ke, Shi Su, Ruijian Li, Yanwei Chen, Dohyun Yoo, Eesac Lee, Sangyong Jon, Peter M Kang,

Background Ischemia/reperfusion (I/R) injury causes overproduction of reactive oxygen species, which are the major culprits of oxidative stress that leads to inflammation, apoptosis, myocardial damage, and dysfunction. Bilirubin acts as a potent endogenous antioxidant that is capable of scavenging various reactive oxygen species. We have previously generated bilirubin nanoparticles (BRNPs) ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021212]

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Association of Preoperative Diuretic Use With Early Acute Kidney Injury in Infants With Biventricular Hearts Following Cardiac Surgery.

Steven L Rathgeber, Adrija Chakrabarti, Eva Kapravelou, Nicole Hemphill, Christine Voss, Cherry Mammen, Peter Skippen, Kevin C Harris,

Background Diuretics are used to manage congestive heart failure in infants with congenital heart disease. Adult data indicate that preoperative diuretic use increases the risk of cardiac surgery associated acute kidney injury (CS-AKI). We have sought to understand if preoperative diuretics in infants increases the risk of CS-AKI. Methods and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020519]

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Regional Disparity of Reperfusion Therapy for Acute Ischemic Stroke in Japan: A Retrospective Analysis of Nationwide Claims Data from 2010 to 2015.

Megumi Maeda, Haruhisa Fukuda, Ryu Matsuo, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi,

Background We aimed to determine whether a regional disparity exists in usage of reperfusion therapy (intravenous recombinant tissue plasminogen activator [IV rt-PA] and endovascular thrombectomy [EVT]) and post-reperfusion 30-day mortality in patients with acute ischemic stroke, and which regional factors are associated with their usage. Methods and Results We retrospectively ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021853]

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Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy.

Benedikt Schrage, Uwe Zeymer, Gilles Montalescot, Stephan Windecker, Pranas Serpytis, Christiaan Vrints, Janina Stepinska, Stefano Savonitto, Keith G Oldroyd, Steffen Desch, Georg Fuernau, Kurt Huber, Marko Noc, Steffen Schneider, Taoufik Ouarrak, Stefan Blankenberg, Holger Thiele, Peter Clemmensen,

Background Little is known about the impact of center volume on outcomes in acute myocardial infarction complicated by cardiogenic shock. The aim of this study was to investigate the association between center volume, treatment strategies, and subsequent outcome in patients with acute myocardial infarction complicated by cardiogenic shock. Methods and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e021150]

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Amyloid Deposits and Fibrosis on Left Ventricular Endomyocardial Biopsy Correlate With Extracellular Volume in Cardiac Amyloidosis.

Angela Pucci, Alberto Aimo, Veronica Musetti, Andrea Barison, Giuseppe Vergaro, Dario Genovesi, Assuero Giorgetti, Silvia Masotti, Chiara Arzilli, Concetta Prontera, Luigi Emilio Pastormerlo, Michele Alessandro Coceani, Marco Ciardetti, Nicola Martini, Cataldo Palmieri, Claudio Passino, Claudio Rapezzi, Michele Emdin,

Background The relative contribution of amyloid and fibrosis to extracellular volume expansion in cardiac amyloidosis (CA) has never been defined. Methods and Results We included all patients diagnosed with amyloid light-chain (AL) or transthyretin cardiac amyloidosis at a tertiary referral center between 2014 to 2020 and undergoing a left ventricular ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020358]

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Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART-CT Study.

Katharine A Kott, Marie-Christine Morel-Kopp, Stephen T Vernon, Yuki Takagi, Belinda A Di Bartolo, Karlheinz Peter, Jean Y Yang, Stuart M Grieve, Christopher Ward, Gemma A Figtree,

Background Although the association between dysregulated coagulation and atherosclerosis is well recognized, individual assays have been of minimal value in understanding disease susceptibility. Here we investigated the association of global coagulation profiles with coronary artery disease with consideration of sex differences. Methods and Results The study included patients from the ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e020604]

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