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Time-Dependent Cardiovascular Treatment Benefit Model for Lipid-Lowering Therapies.

Irfan Khan, Eric D Peterson, Christopher P Cannon, Lauren E Sedita, Jay M Edelberg, Kausik K Ray,

Background With the availability of new lipid-lowering therapy options, there is a need to compare the expected clinical benefit of different treatment strategies in different patient populations and over various time frames. We aimed to develop a time-dependent model from published randomized controlled trials summarizing the relationship between low-density lipoprotein ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016506]

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A Better Predictor of Acute Kidney Injury After Cardiac Surgery: The Largest Area Under the Curve Below the Oxygen Delivery Threshold During Cardiopulmonary Bypass.

Tomoya Oshita, Arudo Hiraoka, Kosuke Nakajima, Ryosuke Muraki, Masahisa Arimichi, Genta Chikazawa, Hidenori Yoshitaka, Taichi Sakaguchi,

Background The aim of this study was to compare the predictive accuracy of acute kidney injury (AKI) after cardiac surgery using cardiopulmonary bypass for the largest area under the curve (AUC) below the oxygen delivery (DO2) threshold and the cumulative AUC below the DO2 threshold. Methods and Results From March ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015566]

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The Landscape of Cardiovascular Clinical Trials in the United States Initiated Before and During COVID-19.

Senthil Selvaraj, Stephen J Greene, Sameed Ahmed M Khatana, Ashwin S Nathan, Scott D Solomon, Deepak L Bhatt,

The Coronavirus Disease 2019 (COVID-19) pandemic has taken an unprecedented toll on the American healthcare system and economy. While numerous COVID-19 clinical trials have been initiated in hopes of curtailing its impact, most pre-existing clinical trials have been forced to suspend or limit activity, which itself can have significant consequences. ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e05453]

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Population Density Analysis of Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction in Japan.

Kyohei Yamaji, Shun Kohsaka, Taku Inohara, Yohei Numasawa, Hideki Ishii, Tetsuya Amano, Yuji Ikari,

Background Despite recent progress in the treatment of ST-segment-elevation myocardial infarction, data on geographic disparities application of the evidence-based therapy remain limited. Methods and Results The J-PCI (Japanese Percutaneous Coronary Intervention) registry is a nationwide registry to assure the quality of delivered care. Between January 2014 and December 2018, 209 521 ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :na]

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Cardio-Oncology in Era of the COVID-19 Pandemic and Beyond.

Daniel Addison, Courtney M Campbell, Avirup Guha, Arjun K Ghosh, Susan F Dent, Hani Jneid,

Coronavirus 2019 (COVID-19) has emerged as a global pandemic and public health crisis. Increasing waves of intermittent infectious outbreaks have dramatically influenced care among broad populations. Over the last two decades, there has been a rapid increase in cancer survival, with >400,000 new survivors each year. The increasingly common presence ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e05456]

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Prespecified Risk Criteria Facilitate Adequate Discharge and Long-Term Outcomes After Transfemoral Transcatheter Aortic Valve Implantation.

Mark S Spence, Jan Baan, Fortunato Iacovelli, Gian Luca Martinelli, Douglas F Muir, Francesco Saia, Alessandro Santo Bortone, Cameron G Densem, Colum G Owens, Frank van der Kley, Marije Vis, Martijn S van Mourik, Giuliano Costa, Lenka Sykorova, Claudia M Lüske, Cornelia Deutsch, Jana Kurucova, Martin Thoenes, Peter Bramlage, Corrado Tamburino, Marco Barbanti,

Background Despite the availability of guidelines for the performance of transcatheter aortic valve implantation (TAVI), current treatment pathways vary between countries and institutions, which impact on the mean duration of postprocedure hospitalization. Methods and Results This was a prospective, multicenter registry of 502 patients to validate the appropriateness of discharge ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016990]

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Feasibility and Safety of Laparoscopic-Guided Epicardial Access for Ventricular Tachycardia Ablation.

Andre A L Carmo, Silvia Zenobio, Bruno C Santos, Manoel O C Rocha, Antonio L P Ribeiro,

Background The usual approach to epicardial access in patients with Chagas cardiomyopathy and megacolon is surgical access to avoid bowel injury. However, there are concerns regarding its safety in cases of Chagas cardiomyopathy with reports of prolonged mechanical ventilation and high mortality in this clinical setting. The aim of this ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016654]

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Possible Link Between the ABO Blood Group of Bioprosthesis Recipients and Specific Types of Structural Degeneration.

Olivier Schussler, Nermine Lila, Juan Grau, Marc Ruel, Yves Lecarpentier, Alain Carpentier,

Background Pigs/bovines share common antigens with humans: α-Gal, present in all pigs/bovines close to the human B-antigen; and AH-histo-blood-group antigen, identical to human AH-antigen and present only in some animals. We investigate the possible impact of patients' ABO blood group on bioprosthesis structural valve degeneration (SVD) through calcification/pannus/tears/perforations for patients ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015909]

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Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.

Lin-Juan Du, Jian-Yong Sun, Wu-Chang Zhang, Yong-Li Wang, Hong Zhu, Ting Liu, Ming-Zhu Gao, Chen Zheng, Yu-Yao Zhang, Yuan Liu, Yan Liu, Shuai Shao, Xue-Qing Zhang, Qibin Leng, Johan Auwerx, Sheng-Zhong Duan,

Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that NCOR1 in macrophages plays important roles in metabolic regulation. However, the function of macrophage NCOR1 in response to myocardial infarction (MI) or vascular wire injury has not been elucidated. Methods and Results ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015862]

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Getting to the Heart and Soul of Chronic Kidney Disease.

Fatimah K Khalaf, Prabhatchandra Dube, Chrysan J Mohammed, David J Kennedy,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e017427]

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Impact of Self-Monitoring of Blood Pressure on Processes of Hypertension Care and Long-Term Blood Pressure Control.

Kelsey B Bryant, James P Sheppard, Natalia Ruiz-Negrón, Ian M Kronish, Valy Fontil, Jordan B King, Mark J Pletcher, Kirsten Bibbins-Domingo, Andrew E Moran, Richard J McManus, Brandon K Bellows,

Background Self-monitoring of blood pressure (SMBP) improves blood pressure (BP) outcomes at 12-months, but information is lacking on how SMBP affects hypertension care processes and longer-term BP outcomes. Methods and Results We pooled individual participant data from 4 randomized clinical trials of SMBP in the United Kingdom (combined n=2590) with ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016174]

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Cerebral Small-Vessel Disease and Risk of Incidence of Depression: A Meta-Analysis of Longitudinal Cohort Studies.

Yuanyuan Fang, Tingting Qin, Wenhua Liu, Lusen Ran, Yuan Yang, Hao Huang, Dengji Pan, Minghuan Wang,

Background Results of several longitudinal cohort studies suggested an association between cerebral small-vessel disease and depression. Therefore, we performed a meta-analysis to explore whether cerebral small-vessel disease imparts increased risk for incident depression. Methods and Results We searched prospective cohort studies relevant to the relationship between cerebral small-vessel disease and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016512]

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Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults.

Maria Odette Gore, Colby R Ayers, Amit Khera, Christopher R deFilippi, Thomas J Wang, Stephen L Seliger, Vijay Nambi, Elizabeth Selvin, Jarett D Berry, W Gregory Hundley, Matthew Budoff, Philip Greenland, Mark H Drazner, Christie M Ballantyne, Benjamin D Levine, James A de Lemos,

Background Current strategies for cardiovascular disease (CVD) risk assessment focus on 10-year or longer timeframes. Shorter-term CVD risk is also clinically relevant, particularly for high-risk occupations, but is under-investigated. Methods and Results We pooled data from participants in the ARIC (Atherosclerosis Risk in Communities study), MESA (Multi-Ethnic Study of Atherosclerosis), ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015410]

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Right-Sided Infective Endocarditis 2020: Challenges and Updates in Diagnosis and Treatment.

Hezzy Shmueli, Felix Thomas, Nir Flint, Gayatri Setia, Aleksandar Janjic, Robert J Siegel,

Compared with the extensive data on left-sided infective endocarditis (IE), there is much less published information on the features and management of right-sided IE. Right-sided IE accounts for 5% to 10% of all IE cases, and compared with left-sided IE, it is more often associated with intravenous drug use, intracardiac ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e017293]

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Effects of Sugar-Sweetened, Artificially Sweetened, and Unsweetened Beverages on Cardiometabolic Risk Factors, Body Composition, and Sweet Taste Preference: A Randomized Controlled Trial.

Cara B Ebbeling, Henry A Feldman, Sarah K Steltz, Nicolle L Quinn, Lisa M Robinson, David S Ludwig,

Background A 2018 American Heart Association science advisory indicated that, pending further research, artificially sweetened beverages (ASBs) may be an appropriate initial replacement for sugar-sweetened beverages (SSBs) during transition to unsweetened beverages (USBs). Methods and Results We randomly assigned 203 adults (121 males, 82 females; 91.6% retention), who habitually consumed ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015668]

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Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease.

Joseph Yang, Edward N Brody, Ashwin C Murthy, Robert E Mehler, Sophie J Weiss, Robert K DeLisle, Rachel Ostroff, Stephen A Williams, Peter Ganz,

Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart disease from the Heart and Soul cohort, we quantified 1054 plasma proteins using modified aptamers (SOMAscan) to: ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016463]

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Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease.

Melinda S Schaller, Mian Chen, Romain A Colas, Thomas A Sorrentino, Ann A Lazar, S Marlene Grenon, Jesmond Dalli, Michael S Conte,

Background Peripheral artery disease (PAD) is an advanced form of atherosclerosis characterized by chronic inflammation. Resolution of inflammation is a highly coordinated process driven by specialized pro-resolving lipid mediators endogenously derived from omega-3 fatty acids. We investigated the impact of a short-course, oral, enriched marine oil supplement on leukocyte phenotype ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016113]

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Dismal Outcomes and High Societal Burden of Mitral Valve Regurgitation in France in the Recent Era: A Nationwide Perspective.

David Messika-Zeitoun, Pascal Candolfi, Alec Vahanian, Vincent Chan, Ian G Burwash, Jean-François Philippon, Jean-Manuel Toussaint, Patrick Verta, Ted E Feldman, Bernard Iung, David Glineur, Thierry Mesana, Maurice Enriquez-Sarano,

Background Although US recent data suggest that mitral regurgitation (MR) is severely undertreated and carries a poor outcome, population-based views on outcome and management are limited. We aimed to define the current treatment standards, clinical outcomes, and costs related to MR at the nationwide level. Methods and Results In total, ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016086]

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High Mortality Rates Among Patients With Non-Traumatic Intracerebral Hemorrhage and Atrial Fibrillation on Antithrombotic Therapy Are Independent of the Presence of Cerebral Amyloid Angiopathy: Insights From a Population-Based Study.

Shiva P Ponamgi, Robert Ward, Christopher V DeSimone, Stephen English, David O Hodge, Joshua P Slusser, Jonathan Graff-Radford, Alejandro A Rabinstein, Samuel J Asirvatham, David Holmes,

Background Intracerebral hemorrhage (ICH) risk is higher in elderly patients with atrial fibrillation on antithrombotic therapy as well as those with cerebral amyloid angiopathy (CAA). We investigated if mortality among patients with atrial fibrillation on antithrombotic therapy presenting with non-traumatic ICH was influenced by underlying CAA. Methods and Results We ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016893]

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Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults: A Paradigm-Shifting Approach?

Albert D Osei, Michael J Blaha,

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e017790]

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Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Alessandro Di Minno, Roberta Lupoli, Ilenia Calcaterra, Paolo Poggio, Francesco Forte, Gaia Spadarella, Pasquale Ambrosino, Gabriella Iannuzzo, Matteo Nicola Dario Di Minno,

Background Bempedoic acid (BA) is a novel lipid-lowering drug. We performed a systematic review and meta-analysis on efficacy and safety of BA compared with standard treatment in patients with hypercholesterolemia. Methods and Results Studies were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases. Efficacy outcome was ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e05279]

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Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals.

Joonatan Palmu, Aaro Salosensaari, Aki S Havulinna, Susan Cheng, Michael Inouye, Mohit Jain, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Erkki Vartiainen, Tiina Laatikainen, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu J Niiranen,

Background Several small-scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable-adjusted association between gut metagenome and BP in a large, representative, well-phenotyped population sample. We performed a focused analysis to ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016641]

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Life Course Changes in Cardiometabolic Risk Factors Associated With Preterm Delivery: The 30-Year CARDIA Study.

Baiyang Sun, Marnie Bertolet, Maria M Brooks, Carl A Hubel, Cora E Lewis, Erica P Gunderson, Janet M Catov,

Background Women who deliver preterm infants (<37 weeks) have excess cardiovascular risk; however, it is unclear whether the unfavorable changes in the cardiometabolic profile associated with preterm delivery initiate before, during, or after childbearing. Methods and Results We identified 1306 women (51% Black) with births between baseline (1985-1986) and year 30 ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e015900]

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Outcomes of Reoperative Coronary Artery Bypass Graft Surgery in the United States.

Ayman Elbadawi, Mohamed Hamed, Islam Y Elgendy, Mohmed A Omer, Gbolahan O Ogunbayo, Michael Megaly, Ali Denktas, Ravi Ghanta, Ernesto Jimenez, Emanuel Brilakis, Hani Jneid,

Background There is a paucity of data on the trends and outcomes of reoperative coronary artery bypass graft (CABG) surgery during the current decade in the United States. Methods and Results We queried the National Inpatient Sample database (2002-2016) for all hospitalizations with isolated CABG procedure. We reported the temporal ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016282]

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Resource Utilization in the First 2 Years Following Operative Correction for Tetralogy of Fallot: Study Using Data From the Optum's De-Identified Clinformatics Data Mart Insurance Claims Database.

Michael L O'Byrne, Grace DeCost, Hannah Katcoff, Jill J Savla, Joyce Chang, Elizabeth Goldmuntz, Peter W Groeneveld, Joseph W Rossano, Jennifer A Faerber, Laura Mercer-Rosa,

Background Despite excellent operative survival, correction of tetralogy of Fallot frequently is accompanied by residual lesions that may affect health beyond the incident hospitalization. Measuring resource utilization, specifically cost and length of stay, provides an integrated measure of morbidity not appreciable in traditional outcomes. Methods and Results We conducted a ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, :e016581]

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