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Unraveling the Pivotal Role of Atropisomerism for Cellular Internalization.

Claire Donohoe, Fábio A Schaberle, Fábio M S Rodrigues, Nuno P F Gonçalves, Christopher J Kingsbury, Mariette M Pereira, Mathias O Senge, Lígia C Gomes-da-Silva, Luis G Arnaut,

The intrinsic challenge of large molecules to cross the cell membrane and reach intracellular targets is a major obstacle for the development of new medicines. We report how rotation along a single C-C bond, between atropisomers of a drug in clinical trials, improves cell uptake and therapeutic efficacy. The atropisomers ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2022, :]

Cited: 0 times

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A Ribonucleotide ↔ Phosphoramidate Reaction Network Optimized by Computer-Aided Design.

Andreas Englert, Julian F Vogel, Tim Bergner, Jessica Loske, Max von Delius,

A growing number of out-of-equilibrium systems have been created and investigated in chemical laboratories over the past decade. One way to achieve this is to create a reaction cycle, in which the forward reaction is driven by a chemical fuel and the backward reaction follows a different pathway. Such dissipative ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2022, :]

Cited: 0 times

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