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Are Video Games Effective to Promote Cognition and Everyday Functional Capacity in Mild Cognitive Impairment/Dementia Patients? A Meta-Analysis of Randomized Controlled Trials.

Filipa Ferreira-Brito, Filipa Ribeiro, Diana Aguiar de Sousa, João Costa, Cátia Caneiras, Luís Carriço,

<h4>Background</h4>Mild cognitive impairment (MCI) and dementia are associated with increased age. MCI is a clinical entity described as a transitional state between normal cognition and dementia. Video games (VGs) can potentially promote cognition and functional capacity since multiple cognitive domains are recruited during gameplay. However, there is still a lack ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Dementia and Parkinson's Disease: Risk Factors for 30-Day Mortality in Nursing Home Residents with COVID-19.

Jeanine J S Rutten, Janine van Kooten, Anouk M van Loon, Laura W van Buul, Karlijn J Joling, Martin Smalbrugge, Cees M P M Hertogh,

<h4>Background</h4>The COVID-19 pandemic has led to high mortality rates in nursing homes (NHs) in Europe. For adequate risk management and good prognostications, it is essential to identify mortality risk factors.<h4>Objective</h4>This study aimed to determine whether previously identified risk factors for 30-day mortality in Dutch NH residents with COVID-19 are unique ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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White Matter but not Gray Matter Volumes are Associated with Cognition in Community-Dwelling Chinese Populations.

Quan Wang, Ning Su, Jin Huang, Xinyu Liang, Jing Yuan, Ming Yao, Li-Xin Zhou, Zheng-Yu Jin, Shu-Yang Zhang, Li-Ying Cui, Gaolang Gong, Feng Tian, Yi-Cheng Zhu, Jun Ni,

<h4>Background</h4>Few studies have investigated the association between cognition and brain volume associated with cerebral small vessel disease (CSVD).<h4>Objective</h4>We investigated the association between cognition and brain volume and neuroimaging markers of CSVD in a community-dwelling population.<h4>Methods</h4>Participants (n = 993, age≥35 years) from the community-based Shunyi Study were included to investigate the association between ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Combining Multimodal Behavioral Data of Gait, Speech, and Drawing for Classification of Alzheimer's Disease and Mild Cognitive Impairment.

Yasunori Yamada, Kaoru Shinkawa, Masatomo Kobayashi, Vittorio Caggiano, Miyuki Nemoto, Kiyotaka Nemoto, Tetsuaki Arai,

<h4>Background</h4>Gait, speech, and drawing behaviors have been shown to be sensitive to the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, previous studies focused on only analyzing individual behavioral modalities, although these studies suggested that each of these modalities may capture different profiles of cognitive impairments associated ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Mindfulness-Based Training Does Not Improve Neuropsychological Outcomes in Mild Cognitive Impairment More Than Spontaneous Reversion Rates: A Randomized Controlled Trial.

Kinjal Doshi, Stacey Lee Henderson, Qianqian Fan, Kian Foong Wong, Julian Lim,

<h4>Background</h4>Current pharmacological and behavioral treatment options for mild cognitive impairment (MCI) are limited, motivating a search for alternative therapies that might slow the progression of cognitive decline.<h4>Objective</h4>We investigated the effectiveness of a cognition-focused mindfulness-based intervention.<h4>Methods</h4>An open-label, three arm randomized controlled trial was conducted at a public tertiary medical center. Older ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Differential Lipid Mediator Involvement in the Different Forms of Genetic Frontotemporal Dementia: Novel Insights into Neuroinflammation.

Aitana Sogorb-Esteve, Romain A Colas, Jesmond Dalli, Jonathan D Rohrer,

<h4>Background</h4>The pathophysiology of frontotemporal dementia (FTD) is poorly understood but recent studies implicate neuroinflammation as an important factor. However, little is known so far about the role of the resolution pathway, the response to inflammation that allows tissue to return to a homeostatic state.<h4>Objective</h4>We aimed to measure the concentrations of ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Key Intervention Categories to Provide Person-Centered Dementia Care: A Systematic Review of Person-Centered Interventions.

Wiebke Mohr, Anika Rädke, Adel Afi, David Edvardsson, Franka Mühlichen, Moritz Platen, Martina Roes, Bernhard Michalowsky, Wolfgang Hoffmann,

<h4>Background</h4>Person-centered care (PCC) is an important concept in many countries' national guidelines and dementia plans. Key intervention categories, i.e., a taxonomy of person-centered (PC)-interventions, to provide person-centered dementia care, are difficult to identify from literature.<h4>Objective</h4>This systematic review aimed to identify and categorize published PC-interventions into key intervention categories to guide ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Predictive Accuracy of Blood-Derived Biomarkers for Amyloid-β Brain Deposition Along with the Alzheimer's Disease Continuum: A Systematic Review.

Alessandra Cianflone, Luigi Coppola, Peppino Mirabelli, Marco Salvatore,

<h4>Background</h4>An amyloid-β (Aβ) positron emission tomography (Aβ-PET) scan of the human brain could lead to an early diagnosis of Alzheimer's disease (AD) and estimate disease progression. However, Aβ-PET imaging is expensive, invasive, and rarely applicable to cognitively normal subjects at risk for dementia. The identification of blood biomarkers predictive of ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Stereological Changes in Microvascular Parameters in Hippocampus of a Transgenic Rat Model of Alzheimer's Disease.

Yaroslav Kolinko, Lucie Marsalova, Stephanie Proskauer Pena, Milena Kralickova, Peter R Mouton,

<h4>Background</h4>Microcirculatory factors play an important role in amyloid-β (Aβ)-related neuropathology in Alzheimer's disease (AD). Transgenic (Tg) rat models of mutant Aβ deposition can enhance our understanding of this microvascular pathology.<h4>Objective</h4>Here we report stereology-based quantification and comparisons (between- and within-group) of microvessel length and number and associated parameters in hippocampal subregions ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Association Between Anxiety and Cognitive Decline Over 12 Years in a Population-Based Cohort.

Scherazad Kootar, Md Hamidul Huque, Richard Arthur, Moyra Mortby, Kaarin J Anstey,

<h4>Background</h4>Findings on the associations between anxiety and cognitive decline are mixed and often confounded.<h4>Objective</h4>We studied whether anxiety symptoms were associated with the risk of cognitive decline after adequate adjustment of confounding factors.<h4>Methods</h4>Our study consists of 2,551 community-dwelling older adults recruited between the ages of 60-64 years and followed up for ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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A Novel Approach to the Treatment and Prevention of Alzheimer's Disease Based on the Pathology and Microbiology.

Herbert B Allen,

Utilizing the pathology and microbiology found in tissue from patients with documented Alzheimer's disease (AD), the pathogenesis of this fateful disorder has been made clear. Borrelia burgdorferi and Treponema denticola spirochetes enter the brain, mostly via neuronal pathways and the entorhinal circulation. These organisms easily pass through the blood-brain barrier ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-β Transport: A Population-Based Cross-Sectional Study.

Shan Wei, Suhang Shang, Liangjun Dang, Fan Gao, Yao Gao, Ling Gao, Chen Chen, Kang Huo, Jingyi Wang, Jin Wang, Qiumin Qu,

<h4>Background</h4>Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport.<h4>Objective</h4>The aim was to ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Latent Factor Structure of Outcome Measures Used in the HABIT® Mild Cognitive Impairment Intervention Programs.

Brittany DeFeis, Gelan Ying, Andrea M Kurasz, Liselotte De Wit, Priscilla Amofa, Melanie Chandler, Dona Locke, Anne Shandera-Ochsner, Vaishali Phatak, Glenn Smith,

<h4>Background</h4>In Alzheimer's disease and related disorders (ADRD) research, common outcome measures include cognitive and functional impairment, as well as persons with mild cognitive impairment (pwMCI) and care partner self-reported mood and quality of life. Studies commonly analyze these measures separately, which potentially leads to issues of multiple comparisons and/or multicollinearity ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Taurine and Camel Milk Modulate Neurobehavioral and Biochemical Changes in Aluminum Chloride-Induced Alzheimer's Disease in Rats.

Teslim S Abdulkadir, Fatima A Dawud, Ahmed Sherif Isa, Joseph O Ayo,

<h4>Background</h4>Alzheimer's disease (AD) is a neurodegenerative disease associated with deficiency in motor coordination, cognitive impairment, and excessive reactive oxygen species production in the brain.<h4>Objective</h4>The study evaluated effects of taurine and camel milk (CM) on neurobehavior, amyloid-beta peptide 1-42 (Aβ) expression, acetylcholinesterase, and superoxide dismutase activities in aluminum chloride (AlCl3) model ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease.

Elisa Colato, Konstantinos Chiotis, Daniel Ferreira, Mariam S Mazrina, Laetitia Lemoine, Rosaleena Mohanty, Eric Westman, Agneta Nordberg, Elena Rodriguez-Vieitez, ,

<h4>Background</h4>In Alzheimer's disease (AD), the abnormal aggregation of hyperphosphorylated tau leads to synaptic dysfunction and neurodegeneration. Recently developed tau PET imaging tracers are candidate biomarkers for diagnosis and staging of AD.<h4>Objective</h4>We aimed to investigate the discriminative ability of 18F-THK5317 and 18F-flortaucipir tracers and brain atrophy at different stages of AD, ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Metabolomic Alterations in the Blood and Brain in Association with Alzheimer's Disease: Evidence from in vivo to Clinical Studies.

Sirawit Sriwichaiin, Nipon Chattipakorn, Siriporn C Chattipakorn,

Alzheimer's disease (AD) has become a major health problem among the elderly population. Some evidence suggests that metabolic disturbance possibly plays a role in the pathophysiology of AD. Currently, the study of metabolomics has been used to explore changes in multiple metabolites in several diseases, including AD. Thus, the metabolomics ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Influence of White Matter Hyperintensities on Baseline and Longitudinal Amyloid-β in Cognitively Normal Individuals.

Fennie Choy Chin Wong, Seyed Ehsan Saffari, Chathuri Yatawara, Kok Pin Ng, Nagaendran Kandiah, ,

<h4>Background</h4>The associations between small vessel disease (SVD) and cerebrospinal amyloid-β1-42 (Aβ1-42) pathology have not been well-elucidated.<h4>Objective</h4>Baseline (BL) white matter hyperintensities (WMH) were examined for associations with month-24 (M24) and longitudinal Aβ1-42 change in cognitively normal (CN) subjects. The interaction of WMH and Aβ1-42 on memory and executive function were also ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Sex and Cardiovascular Function in Relation to Vascular Brain Injury in Patients with Cognitive Complaints.

Sanne Kuipers, Geert Jan Biessels, Jacoba P Greving, Raquel P Amier, Jeroen de Bresser, Esther E Bron, Wiesje M van der Flier, Rob J van der Geest, Astrid M Hooghiemstra, Robert J van Oostenbrugge, Matthias J P van Osch, L Jaap Kappelle, Lieza G Exalto, ,

<h4>Background</h4>Emerging evidence shows sex differences in manifestations of vascular brain injury in memory clinic patients. We hypothesize that this is explained by sex differences in cardiovascular function.<h4>Objective</h4>To assess the relation between sex and manifestations of vascular brain injury in patients with cognitive complaints, in interaction with cardiovascular function.<h4>Methods</h4>160 outpatient clinic ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Discrepancy Between the Degree of Cognitive Impairment and Brain Imaging Abnormalities in Alzheimer's Disease Patients Is Associated with Cognitive Reserve.

Tomohiko Sato, Haruo Hanyu, Yumi Koyama, Haruka Horita, Toshinori Aoki, Kentaro Hirao, Hidekazu Kanetaka, Soichiro Shimizu,

<h4>Background</h4>In Alzheimer's disease (AD) patients, the severity of cognitive impairment is thought to correlate with the degree of brain imaging abnormalities. However, some patients show only mild cognitive deficit, despite severe brain atrophy on magnetic resonance imaging (MRI) or marked hypoperfusion in the cerebral cortices on single-photon emission computed tomography ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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A Randomized Controlled Trial on the Effects of a 6-Month Home-Based Physical Activity Program with Individual Goal-Setting and Volunteer Mentors on Physical Activity, Adherence, and Physical Fitness in Inactive Older Adults at Risk of Cognitive Decline: The INDIGO Study.

Kay L Cox, Linda Clare, Elizabeth V Cyarto, Kathryn A Ellis, Christopher Etherton-Beer, Jenny Southam, David Ames, Leon Flicker, Osvaldo P Almeida, Dina LoGiudice, Danny Liew, Philip Vlaskovsky, Nicola T Lautenschlager,

<h4>Background</h4>Increasing physical activity (PA) in those who have memory concerns requires innovative approaches.<h4>Objective</h4>To compare in this randomized controlled trial (RCT) the effects on PA, adherence, and fitness of two approaches to deliver a 6-month home-based PA program in older, inactive individuals at risk of cognitive decline.<h4>Methods</h4>Individuals (n = 52) aged 60-85 years, ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Dihydroartemisinin Induces O-GlcNAcylation and Improves Cognitive Function in a Mouse Model of Tauopathy.

Lei Xia, Yayan Pang, Junjie Li, Bin Wu, Yehong Du, Yuxin Chen, Man Luo, Yan Wang, Zhifang Dong,

<h4>Background</h4>Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology. Hyperphosphorylation modification promotes tau protein misfolding and aggregation into neurofibrillary tangles, leading to impairments of synaptic plasticity and learning and memory. However, very limited therapeutic strategies are available.<h4>Objective</h4>In the present study, we ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Reduced Synaptic and Intrinsic Excitability of a Subtype of Pyramidal Neurons in the Medial Prefrontal Cortex in a Mouse Model of Alzheimer's Disease.

Xiao-Qin Zhang, Le Xu, Si-Yu Yang, Lin-Bo Hu, Fei-Yuan Dong, Bing-Gui Sun, Hao-Wei Shen,

<h4>Background</h4>Abnormal morphology and function of neurons in the prefrontal cortex (PFC) are associated with cognitive deficits in rodent models of Alzheimer's disease (AD), particularly in cortical layer-5 pyramidal neurons that integrate inputs from different sources and project outputs to cortical or subcortical structures. Pyramidal neurons in layer-5 of the PFC ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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The Association of Periodontitis and Alzheimer's Disease: How to Hit Two Birds with One Stone.

Tom Werber, Zsofia Bata, Eniko Szabo Vaszine, Dalida Borbala Berente, Anita Kamondi, Andras Attila Horvath,

Alzheimer's disease (AD) is the leading cause of cognitive impairment in the elderly. Recent evidence suggests that preventive interventional trials could significantly reduce the risk for development of dementia. Periodontitis is the most common dental disease characterized by chronic inflammation and loss of alveolar bone and perialveolar attachment of teeth. ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Combining Low-Dose Radiation Therapy and Magnetic Resonance Guided Focused Ultrasound to Reduce Amyloid-β Deposition in Alzheimer's Disease.

Paolo Farace, Stefano Tamburin,

Amyloid-β deposition is one of the neuropathological hallmarks of Alzheimer's disease (AD), but pharmacological strategies toward its reduction are poorly effective.Preclinical studies indicate that low-dose radiation therapy (LD-RT) may reduce brain amyloid-β. Animal models and proof-of-concept preliminary data in humans have shown that magnetic resonance guided focused ultrasound (MRgFUS) can ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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Neuroscience20 (BRAIN20, SPINE20, and MENTAL20) Health Initiative: A Global Consortium Addressing the Human and Economic Burden of Brain, Spine, and Mental Disorders Through Neurotech Innovations and Policies.

Kevin Morris, Mohammad Nami, Joe F Bolanos, Maria A Lobo, Melody Sadri-Naini, John Fiallos, Gilberto E Sanchez, Teshia Bustos, Nikita Chintam, Marco Amaya, Susanne E Strand, Alero Mayuku-Dore, Indira Sakibova, Grace Maria Nicole Biso, Alejandro DeFilippis, Daniela Bravo, Nevzat Tarhan, Carsten Claussen, Alejandro Mercado, Serge Braun, Louis Yuge, Shigeo Okabe, Farhad Taghizadeh-Hesary, Konstantin Kotliar, Christina Sadowsky, P Sarat Chandra, Manjari Tripathi, Vasileios Katsaros, Brian Mehling, Maryam Noroozian, Kazem Abbasioun, Abbas Amirjamshidi, Gholam-Ali Hossein-Zadeh, Faridedin Naraghi, Mojtaba Barzegar, Ali A Asadi-Pooya, Sajad Sahab-Negah, Saeid Sadeghian, Margaret Fahnestock, Nesrin Dilbaz, Namath Hussain, Zoltan Mari, Robert W Thatcher, Daniel Sipple, Kuldip Sidhu, Deepak Chopra, Francesco Costa, Giannantonio Spena, Ted Berger, Deborah Zelinsky, Christopher J Wheeler, J Wesson Ashford, Reinhard Schulte, M A Nezami, Harry Kloor, Aaron Filler, Dawn S Eliashiv, Dipen Sinha, Antonio A F DeSalles, Venkatraman Sadanand, Sergey Suchkov, Ken Green, Barish Metin, Robert Hariri, Jason Cormier, Vicky Yamamoto, Babak Kateb,

Neurological disorders significantly impact the world's economy due to their often chronic and life-threatening nature afflicting individuals which, in turn, creates a global disease burden. The Group of Twenty (G20) member nations, which represent the largest economies globally, should come together to formulate a plan on how to overcome this ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2021, :]

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