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Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis.

Vadim Pivniouk, Joao A Gimenes-Junior, Peace Ezeh, Ashley Michael, Oksana Pivniouk, Seongmin Hahn, Sydney R VanLinden, Sean P Malone, Amir Abidov, Dayna Anderson, Justyna Gozdz, Avery DeVries, Fernando D Martinez, Christian Pasquali, Donata Vercelli,

<h4>Background</h4>Microbial interventions against allergic asthma have robust epidemiologic underpinnings and the potential to recalibrate disease-inducing immune responses. Oral administration of OM-85, a standardized lysate of human airways bacteria, is widely used empirically to prevent respiratory infections and a clinical trial is testing its ability to prevent asthma in high-risk children. ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch.

Anna M Trier, Madison R Mack, Avery Fredman, Masato Tamari, Aaron M Ver Heul, Yonghui Zhao, Changxiong J Guo, Oshri Avraham, Zachary K Ford, Landon K Oetjen, Jing Feng, Carina Dehner, Dean Coble, Asima Badic, Satoru Joshita, Masato Kubo, Robert W Gereau, Jennifer Alexander-Brett, Valeria Cavalli, Steve Davidson, Hongzhen Hu, Qin Liu, Brian S Kim,

<h4>Background</h4>Chronic pruritus, or itch, is common and debilitating, but the neuro-immune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary for chronic itch remains poorly understood.<h4>Objectives</h4>We ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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COVID-19, Health Disparities, and What the Allergist-Immunologist Can Do.

Princess U Ogbogu, Elizabeth C Matsui, Andrea J Apter,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: a systematic review and network meta-analysis.

Paul Oykhman, Fernando Aleman Paramo, Prof Jean Bousquet, David W Kennedy, Romina Brignardello-Petersen, Derek K Chu,

<h4>Background</h4>Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory condition of the upper airways. Optimal management is unclear.<h4>Objective</h4>To compare the effects of monoclonal antibodies and ASA desensitization (ASA-D) for treatment of CRSwNP.<h4>Methods</h4>We searched MEDLINE, EMBASE, CENTRAL, ICTRP, FDA and EMA databases from inception to Aug 4, 2021 for RCTs comparing ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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The relevance of primary immunodeficiency registries on a global perspective.

Antonio Condino-Neto, Kathleen E Sullivan,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Upper Respiratory Tract Bacterial-Immune Interactions during Respiratory Syncytial Virus Infection in Infancy.

Christian Rosas-Salazar, Zheng-Zheng Tang, Meghan H Shilts, Kedir N Turi, Qilin Hong, Derek A Wiggins, Christian E Lynch, Tebeb Gebretsadik, James D Chappell, R Stokes Peebles, Larry J Anderson, Suman R Das, Tina V Hartert,

<h4>Background</h4>The risk factors determining short- and long-term morbidity following acute respiratory infection (ARI) due to respiratory syncytial virus (RSV) in infancy remain poorly understood.<h4>Objectives</h4>To examine the associations of the upper respiratory tract (URT) microbiome during RSV ARI in infancy with the acute local immune response and short- and long-term clinical ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses.

Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Béziat, Emmanuelle Bourrat, Oliver Schilling, Johann E Gudjonsson, Alain Hovnanian,

<h4>Background</h4>Netherton syndrome (NS) is a rare recessive skin disorder caused by loss-of-function mutations in SPINK5 encoding the protease inhibitor LEKTI. NS patients suffer from a severe skin barrier defect, display inflammatory skin lesions and superficial scaling with atopic manifestations. They present with typical ichthyosis linearis circumflexa (NS-ILC) or scaly erythroderma ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Real-time imaging of asthmatic epithelial cells identifies migratory deficiencies under Type-2 conditions.

Mingzhu Jin, Simon Watkins, Yolanda Larriba, Callen Wallace, Claudette St Croix, Xiuxia Zhou, Jinming Zhao, Shyamal Peddada, Sally E Wenzel,

<h4>Background</h4>The epithelium is increasingly recognized as a pathologic contributor to asthma and its phenotypes. Although delayed wound closure by asthmatic epithelial cells is consistently observed, underlying mechanisms remain poorly understood, partly due to difficulties in studying dynamic physiologic processes involving polarized multilayered cell systems. Although Type-2 immunity has been suggested ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Racial/Ethnic differences in eligibility for asthma biologics among pediatric populations.

Eric M Wohlford, Peter F Huang, Jennifer R Elhawary, Lauren A Millette, Maria G Contreras, Jonathan Witonsky, Cécile T J Holweg, Sam S Oh, Christine Lee, Christine Merenda, Ronald L Rabin, Richardae Araojo, Angel C Y Mak, Celeste S Eng, Donglei Hu, Scott Huntsman, Michael A LeNoir, Jose R Rodríguez-Santana, Luisa N Borrell, Esteban G Burchard,

<h4>Background</h4>Asthma is a heterogenous disease. Clinical blood parameters differ by race/ethnicity and are used to distinguish asthma subtypes and inform therapies. Differences in subtypes may explain population-specific trends in asthma outcomes. However, these differences in racial/ethnic minority pediatric populations are unclear.<h4>Objective</h4>Investigate the association of blood parameters and asthma subtypes with ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Structural racism and readmission for childhood asthma - a quest for causality.

Markus J Ege,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Immunological memory to SARS-CoV-2 in convalescent COVID-19 patients at one-year post-infection.

Hongyan Hou, Yandi Zhang, Guoxing Tang, Ying Luo, Wei Liu, Chang Cheng, Yuhuan Jiang, Zhigang Xiong, Shiji Wu, Ziyong Sun, Shabei Xu, Xionglin Fan, Feng Wang,

<h4>Background</h4>Understanding the complexities of immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is key to gain insights into the durability of protective immunity against reinfection.<h4>Objective</h4>To evaluate the immune memory to SARS-CoV-2 in convalescent patients with longer follow-up time.<h4>Methods</h4>SARS-CoV-2-specific humoral and cellular responses were assessed in convalescent coronavirus disease ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Multi-ethnic genome-wide and HLA association study of total serum IgE.

Michelle Daya, Corey Cox, Nathalie Acevedo, Meher P Boorgula, Monica Campbell, Sameer Chavan, Michael H Cho, Gloria L David, Priyadarshini Kachroo, Jessica Lasky-Su, Xingnan Li, Caitlin P McHugh, Dandi Qiao, Nicholas Rafaels, Lisa A Beck, Eugene R Bleecker, Luis Caraballo, Adrienne L Cupples, Camila A Figueiredo, Richard L Gallo, Jon Hanifin, Nadia N Hansel, Tissa R Hata, Craig P Hersh, Jennifer Knight-Madden, Donald Y M Leung, Emma Guttman-Yassky, Deborah A Meyers, George O'Connor, Carole Ober, Peck Y Ong, Victor E Ortega, Amy S Paller, Nirupama Putcha, Robert M Reed, Lynda C Schneider, Edwin K Silverman, Mark K Slifka, Jonathan M Spergel, Ramachandran S Vasan, Karine A Viaud-Martinez, Harold Watson, Scott T Weiss, , Ingo Ruczinski, Terri H Beaty, Rasika A Mathias, Kathleen C Barnes,

<h4>Background</h4>Total serum IgE (tIgE) is an important intermediate phenotype of allergic disease. Whole genome genetic association studies across ancestries may identify important determinants of IgE.<h4>Objective</h4>By leveraging data from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) and the Atopic ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Occupational health disparities: The pandemic as prism and prod.

Emily Brigham, Drew Harris, Christopher Carlsten, Carrie A Redlich,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.

Maartje Blom, Rolf H Zetterström, Asbjørg Stray-Pedersen, Kimberly Gilmour, Andrew R Gennery, Jennifer M Puck, Mirjam van der Burg,

<h4>Background</h4>Public health newborn screening (NBS) programs continuously evolve, taking advantage of international shared learning. NBS for severe combined immunodeficiency (SCID) has recently been introduced in many countries. However, comparison of screening outcomes has been hampered by use of disparate terminology and imprecise or variable case definitions for non-SCID conditions with ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Neuroimaging and biomarker evidence of neurodegeneration in asthma.

Melissa A Rosenkranz, Douglas C Dean, Barbara B Bendlin, Nizar N Jarjour, Stephane Esnault, Henrik Zetterberg, Amanda Heslegrave, Michael D Evans, Richard J Davidson, William W Busse,

<h4>Background</h4>Epidemiological studies have shown that Alzheimer's disease and related dementias (ADRD) are seen more frequently with asthma, especially with greater asthma severity or exacerbation frequency.<h4>Objective</h4>To examine the changes in brain structure that may underlie this phenomenon, we examined diffusion-weighted magnetic resonance imaging (dMRI) and blood-based biomarkers of AD (p-Tau181), neurodegeneration ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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The curious history behind a biologic-enriched cat food: hyperimmune avian IgY as a means of oral adoptive passive immunization.

Joshua Steinberg,

IgY, the avian homolog to mammalian IgG, has therapeutic potential as an orally absorbed, transmucosally excreted, antigen-specific antibody. A new cat food product, admixed with anti-Fel d 1 IgY derived from hyperimmunized hen egg yolks, is intended to treat allergic rhinitis indirectly via specific neutralization of Fel d 1. Polyclonal ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.

Veronika Kanderova, Tamara Svobodova, Simon Borna, Martina Fejtkova, Vendula Martinu, Jana Paderova, Michael Svaton, Jarmila Kralova, Eva Fronkova, Adam Klocperk, Stepanka Pruhova, Min Ae Lee-Kirsch, Ludmila Hornofova, Miroslav Koblizek, Petr Novak, Olga Zimmermannova, Zuzana Parackova, Anna Sediva, Tomas Kalina, Ales Janda, Jana Kayserova, Marcela Dvorakova, Milan Macek, Petr Pohunek, Petr Sedlacek, Ashleigh Poh, Matthias Ernst, Tomas Brdicka, Ondrej Hrusak, Jan Lebl,

<h4>Background</h4>Inborn errors of immunity (IEI) are genetic disorders characterized by various degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity or autoinflammation. The routine use of next-generation sequencing in the clinic has facilitated the identification of an ever-increasing number of IEI, revealing the roles of immunologically important genes ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Bronchial thermoplasty: The heat that reprograms the airways?

Jamila Chakir, Pierre-Alexandre Gagnon, Michel Laviolette,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Neighborhood-level variability in asthma-related emergency department visits in Central Texas.

R A Zárate, Corwin Zigler, Catherine Cubbin, Elizabeth C Matsui,

<h4>Background</h4>The extent to which asthma-related emergency department (ED) visit incidence rates vary from neighborhood to neighborhood and the predictors of neighorbood-level asthma ED visit burden are not well understood.<h4>Objective</h4>Our aim was to describe the census tract-level spatial distribution of asthma-related ED visits in Central Texas and identify neighborhood-level characteristics that ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Addressing disparities in biologic drug development in the United States.

Christopher Hvisdas, Margee Louisias, Tanya M Laidlaw, Ayobami Akenroye,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study.

Philippe Gevaert, Rebecca Saenz, Jonathan Corren, Joseph K Han, Joaquim Mullol, Stella E Lee, Randall A Ow, Rui Zhao, Monet Howard, Kit Wong, Lutaf Islam, Monica Ligueros-Saylan, Theodore A Omachi, Claus Bachert,

<h4>Background</h4>Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently remains uncontrolled despite maximal medical therapy and sinonasal surgery, presenting several unmet needs and challenges. Omalizumab previously demonstrated efficacy in CRSwNP in duplicate, phase 3, randomized, placebo-controlled trials (POLYP 1, POLYP 2).<h4>Objective</h4>This open-label extension evaluated continued efficacy, safety, and durability of response of ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells.

Yuzhi Yin, Yun Bai, Ana Olivera, Dean D Metcalfe,

<h4>Background</h4>CD25<sup>+</sup> human mast cells (huMCs) have been reported in patients with monoclonal mast cell diseases and in rare association with inflammation. However, the regulation of CD25 expression on huMCs and the possible biologic consequences remain poorly understood.<h4>Objective</h4>We sought to identify conditions which would up-regulate CD25 expression on huMCs and to ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Underrepresentation of Blacks and Hispanics in Allergy and Immunology training and certification pipeline.

Mahboobeh Mahdavinia, Amal Assa'ad, Michael R Nelson,

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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A genome-wide association meta-analysis identifies new Eosinophilic esophagitis loci.

Xiao Chang, Michael March, Frank Mentch, Kenny Nguyen, Joseph Glessner, Huiqi Qu, Yichuan Liu, Glen Furuta, Seema Aceves, Nirmala Gonsalves, Kari Nadeau, Antonella Cianferoni, Jonathan Spergel, Patrick Sleiman, Hakon Hakonarson,

<h4>Background</h4>Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus marked by eosinophilic infiltration. Cumulative evidence indicates that the risk of EoE involves the complex interplay of both genetic and environmental factors. As only a few genetic loci have been identified in EoE, the genetic underpinning of EoE remains ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Immunologic resilience and COVID-19 survival advantage.

Grace C Lee, Marcos I Restrepo, Nathan Harper, Muthu Saravanan Manoharan, Alisha M Smith, Justin A Meunier, Sandra Sanchez-Reilly, Aamir Ehsan, Anne P Branum, Caitlyn Winter, Lauryn Winter, Fabio Jimenez, Lavanya Pandranki, Andrew Carrillo, Graciela L Perez, Antonio Anzueto, Hanh Trinh, Monica Lee, Joan M Hecht, Celida Martinez, Raj T Sehgal, Jose Cadena, Elizabeth A Walter, Kimberly Oakman, Raymond Benavides, Jacqueline A Pugh, , Scott Letendre, Maristella Steri, Valeria Orrù, Edoardo Fiorillo, Francesco Cucca, Alvaro G Moreira, Nu Zhang, Elizabeth Leadbetter, Brian K Agan, Douglas D Richman, Weijing He, Robert A Clark, Jason F Okulicz, Sunil K Ahuja,

<h4>Background</h4>The risk of severe COVID-19 varies significantly among persons of similar age and is higher in males. Age-independent, sex-biased differences in susceptibility to severe COVID-19 may be ascribable to deficits in a sexually dimorphic protective attribute that we termed immunologic resilience (IR).<h4>Objective</h4>To examine whether deficits in IR that antedate or ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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